Abstract: The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

Abstract: A radar assembly and a method for operating the radar assembly is disclosed, where a first frequency comb generator is arranged in the transmitting unit between the first oscillator and the transmitting antenna and a second frequency comb generator is arranged in the receiving unit between the second oscillator and the first mixer. On the transmitter side a first frequency comb generator is controlled with the first oscillator frequency in order to generate a primary signal containing a plurality of frequency components, on the receiver side a second frequency comb generator is controlled with a second oscillator frequency in order to generate an output signal containing a plurality of frequency components, the output signal generated in such a way is mixed with a third oscillator frequency, and the intermediate frequency is generated by mixing the received reflected signal with the mixed signal.

Abstract: A shaped article, a method for making it, and its use. The shaped article is formed from flat fiber material and has a bottom (2), a body (4), and an opening, which is surrounded by a circumferential flange (6). The shaped article (1) comprises a flange stabilizer (10) attached to the second flat side (18) of the flange (6) facing the bottom (2). The flange stabilizer (10) is disc-shaped and has an inner contour (12) corresponding to the desired cross-sectional shape of the shaped article (1) in the region of the opening and can be slipped over the body (4) in the region of the bottom (2) and up to the flange (6). The flat sides (16, 18) of the flange stabilizer (10) extend essentially parallel to the flange (6), defining and stabilizing the cross-sectional shape of the body (4) in the region of the opening and the flange.

Abstract: An arrangement for adjusting a powder flow in relation to the central longitudinal axis of an energy beam for a working head which is formed for powder application welding. There is a device for the two-dimensional or three-dimensional alignment of the powder supply in relation to the central longitudinal axis of the energy beam in a plane oriented at right angles to the central longitudinal axis of the energy beam. From one side, a linear beam is directed to the region in which the particles of the powdery material meet one another. At right angles thereto, there is arranged an optical detector array for locally resolved detection of intensities connected to an electronic evaluation unit designed to determine the shape, size and/or length of an irradiated region in which locally resolved intensities which exceed a predefinable threshold have been detected with the optical detector array.

Abstract: The invention relates to a device comprising: at least one tool module (4) having a quick-coupling interface (19); at least one support having a quick-coupling interface (19) and designed to hold the at least one tool module; and at least one data processing unit designed for computer-assisted tool management. The support for holding the tool module (4) comprises at least one support frame (16), at least one interface (21) for computer-assisted tool module identification, and at least one sensor unit. The support frame comprises at least one quick-coupling interface (19) for a tool module. The tool module comprises at least one implement (18) for use outdoors, at least one suspension that is compatible with the quick-coupling point on the support frame, at least one computer-readable storage medium (22) for computer-readable data, and at least one interface for transmission of computer-readable data.

Abstract: The invention relates to a method for classifying spectra of objects having complex information content after recording of the spectra involving the use of a method for preprocessing data and of a method, associated with the data preprocessing, for classification with the calculation of a classifier. After the recording of the spectra and the preprocessing of the spectra, a multiple classification method is thereby performed with at least two different methods for the data preprocessing of the spectra and the method, assigned to the respective data preprocessing, for classification.

Abstract: The invention relates to a computer-implemented method for the optical sensing, the detection and the quantification of relevant conditions and/or their changes with respect to at least one target object, wherein at least one target object is temporarily positioned opposite an optical sensor device, and wherein the fault conditions of the fault classes deviate from the optimal condition. The method is characterized particularly in that the background and the target object are distinguished by means of a higher rate of change of the image information of the background in comparison with the rate of change of the image information of the target object.

Abstract: The invention relates to a method for the biotechnological production of the blue-green fungus pigment xylindein from fungus biomass in a bioreactor, the reactor contents being inoculated with biomass that is uncoloured. The invention also relates to the use of uncoloured biomass of the fungus culture Chlorociboria sp. for inoculation in the biotechnological production of the blue-green fungus pigment xylindein.

Abstract: The invention provides methods for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).

Abstract: The present invention provides the modular design and assembly of novel targeting bio-conjugates, exclusively assembled by means of biotin-biotin binding element conjugation, comprising mono-biotinylated cell binding component, a tetrameric biotin-binding element, and mono-biotinylated payload for therapeutic and diagnostic purposes. In addition, there is provided a method of delivering the payload, such as therapeutic oligonucleotides, via mono-biotinylated targeting devices, such as antibodies or ligands, into eukaryotic cells by means of receptor-mediated endocytosis. The targeting bio-conjugates are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: The invention relates to a liquid metal-ion beam system (1) or liquid metal electron beam system, including: a conductive emitter electrode (2), a conductive extractor electrode (3) opposite to the emitter electrode (2), a liquid metal reservoir (4) which is fluidically connected to the emitter electrode (2) for transporting liquid metal to the emitter electrode (2), a control unit (5) which is configured to apply a periodically varying operating voltage between emitter electrode (2) and extractor electrode (3).

Abstract: An electronic circuit having a semiconductor device is provided that includes a heterostructure, the heterostructure including a first layer of a compound semiconductor to which a second layer of a compound semiconductor adjoins in order to form a channel for a 2-dimensional electron gas (2DEG), wherein the 2-dimensional electron gas is not present. In aspects, an electronic circuit having a semiconductor device is provided that includes a III-V heterostructure, the III-V heterostructure including a first layer including GaN to which a second layer adjoins in order to form a channel for a 2-dimensional electron gas (2DEG), and having a purity such that the 2-dimensional electron gas is not present. It is therefore advantageous for the present electronic circuit to be enclosed such that, in operation, no light of wavelengths of less than 400 nm may reach the III-V heterostructure and free charge carriers may be generated by these wavelengths.

Abstract: Embodiments are directed to the field of ceramics and relate to electron-emitting ceramics such as those which can be used as cathode material for electron emissions in space flight systems, for example. Embodiments specify an electron-emitting ceramic which has an improved temperature conductivity with a simultaneously continuous electron emission. The electron-emitting ceramic contains at least>70 vol. % C12A7 electride and a proportion of Zr, Hf, V, Nb, Ta, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, In, Sn, Sb, Te, Tl, Pb, or Bi as metal and/or with Ti, wherein the proportion of the metals lies between>0 and<30 vol. %, and the ceramic has a density of at least 85% of the theoretical density of the ceramic and the ceramic contains 0 to maximally 10 vol. % production-specific impurities.

Abstract: A phase and phase/amplitude spatial light modulator arrangement for generating a complex-valued light field with a spatial light modulator, a phase element and an optical system. The phase and amplitude spatial light modulator arrangement is configured to generate a light field that is adjustable in amount and phase. A method realizes operation of a combined spatial light modulator for generating a complex-valued light field. Here, the method includes adapting an optical characteristic in several areas of a phase element. A further method realizes operation of an optical arrangement for modulating different light wavelengths by adjusting several wave influences in several areas of a phase modulator. A last method realizes operation of an optical arrangement by adjusting an amplitude spatial light modulator for modulating light intensities in at least two optical paths.

Abstract: A classifying device for classifying cells in real-time, comprising: as alignment unit configured to align a cell to be classified along the cell's major axis; and a classifying unit configured to classify the aligned cell using a multilayer perceptron, MLP; wherein the MLP classifies the aligned cell based on one or more images of the aligned cell. By executing the classifying device, an improved and efficient cell classification in real-time based on cell images can be provided, while labelling of the cells to be classified can be avoided.

Abstract: A method for producing bipolar plates for fuel cells, one metal strip or two metal strips is/are guided through a second or third device. The second device is designed to carry out fine cleaning and/or nitriding of the metal strip, and the third device carries out surface coating on one side of a surface with a metal layer that improves adhesion. Applying a carbon layer in a fourth device. The metal strips are then shaped, during which process channels are formed. The shaped metal strips are moved and positioned such that surface regions come into contact with one another. Joining is performed with a laser beam, which is directed into a gap between the shaped metal strips moved towards one another. The individual steps in the devices, like shaping and joining, are carried out in a continuous process.

Abstract: The present invention relates to a method for producing a substrate (2) which is coated with an alkali metal (1), in which method a promoter layer (3) which is composed of a material which reacts with the alkali metal (1) by at least partial chemical reduction of the promoter layer (3) is applied to a surface of the substrate (2) and a surface of the promoter layer (3) is acted on by an alkali metal (1) and then the alkali metal (1) is converted into the solid phase and a coating containing the alkali metal is formed.

Abstract: To determine the sex of a bird egg, a hole is produced at the blunt end of the bird egg, wherein the hole affects the calcareous shell and the outer shell membrane, whereas the inner shell membrane remains intact. In the region of the hole at the blunt end, beneath the intact inner shell membrane, at least one blood vessel is registered and the blood therein is excited by means of a preset incident radiation, the back-scattered radiation of which blood is measured, detected and evaluated for the sex determination.

Abstract: The present invention provides the modular design and assembly of novel targeting bio-conjugates, exclusively assembled by means of biotin-biotin binding element conjugation, comprising mono-biotinylated cell binding component, a tetrameric biotin-binding element, and mono-biotinylated payload for therapeutic and diagnostic purposes. In addition, there is provided a method of delivering the payload, such as therapeutic oligonucleotides, via mono-biotinylated targeting devices, such as antibodies or ligands, into eukaryotic cells by means of receptor-mediated endocytosis. The targeting bio-conjugates are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: The invention relates to alkaline secondary batteries. The secondary battery contains a cathode, an anode and an electrolyte, said secondary battery being arranged between the cathode and anode and comprises an alkali metal ion conductive contact to the cathode and to the carbon layer of the anode. The anode contains or consists of a carbon layer, whereby the carbon layer, alone or in combination with an electrically conductive substrate, forms with an electrically conductive contact.