Abstract: A cathode unit for a solid-state battery and a method for producing the cathode unit. The cathode unit has a layer made of a composite material (2) which has an electrode material, a solid electrolyte material, an electrically conductive conducting additive and polyetrafluoroethylene as a binder. The composite material contains less than 1 wt. % polyetrafluoroethylene and the polyetrafluoroethylene is present, at least in part, as fibrillated polyetrafluoroethylene.

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: A method for producing bipolar plates for fuel cells, one metal strip or two metal strips is/are guided through a second or third device. The second device is designed to carry out fine cleaning and/or nitriding of the metal strip, and the third device carries out surface coating on one side of a surface with a metal layer that improves adhesion. Applying a carbon layer in a fourth device. The metal strips are then shaped, during which process channels are formed. The shaped metal strips are moved and positioned such that surface regions come into contact with one another. Joining is performed with a laser beam, which is directed into a gap between the shaped metal strips moved towards one another. The individual steps in the devices, like shaping and joining, are carried out in a continuous process.

Abstract: The invention relates to a multicore processor and a method for dynamically adjusting a supply voltage and a clock frequency, with which an individual supply voltage and dock frequency adjustment, which depends on a current computing load, is facilitated for each processor core of a multicore processor. Thus, an assembly is disclosed where a local queue memory unit which is connected to the processor core, the internal memory unit, and the level converter is arranged in a voltage-variable region of the processor element in order to store events to be processed by the processor core. The invention is also directed to a method in that the required supply voltage U and the required clock frequency f are adjusted for each cycle in a controlled manner by the processor core of the respective processor element depending on the detection of a number of events to be processed which are stored in an internal queue memory unit.

Abstract: The bipolar plate of the invention for electrochemical cells, especially for proton-exchange membrane (PEM) fuel cells, is made with a metallic substrate and on the surface is made with an electrical contact resistance-reducing, carbon-based layer, a layer system or a boundary layer which is made of a near-surface, primarily sp2-bonded, carbon-based layer having a carbon fraction ranging from 50% to 100%, this layer being applied on a metallic substrate surface that is modified relative to the starting material. There may also be a surface region of the substrate in the form of an edge layer made with nitride and/or carbon by nitriding and/or carburizing. On the surface which is in touching contact with a gas-permeable element within the electrochemical cell, the metallic substrate may have a structuring made with elevations and/or depressions in the respective surface.

Abstract: A radar assembly and a method for operating the radar assembly is disclosed, where a first frequency comb generator is arranged in the transmitting unit between the first oscillator and the transmitting antenna and a second frequency comb generator is arranged in the receiving unit between the second oscillator and the first mixer. On the transmitter side a first frequency comb generator is controlled with the first oscillator frequency in order to generate a primary signal containing a plurality of frequency components, on the receiver side a second frequency comb generator is controlled with a second oscillator frequency in order to generate an output signal containing a plurality of frequency components, he output signal generated in such a way is mixed with a third oscillator frequency, and the intermediate frequency is generated by mixing the received reflected signal with the mixed signal.

Abstract: The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.

Abstract: The invention relates to a method for classifying spectra of objects having complex information content after recording of the spectra involving the use of a method for preprocessing data and of a method, associated with the data preprocessing, for classification with the calculation of a classifier. After the recording of the spectra and the preprocessing of the spectra, a multiple classification method is thereby performed with at least two different methods for the data preprocessing of the spectra and the method, assigned to the respective data preprocessing, for classification.

Abstract: The invention relates to a method for forming and detecting security elements on the surface of a component and/or in a component, in which at least one layer or at least one region that is preferably formed of a magnetic material or of a material different from the component material is formed on the surface of the component and/or in the component that is formed of a magnetic or of a nonmagnetic material in a locally and geometrically defined manner. At least one ablated track, at least one heat-affected region and/or at least one remelted treatment track are/is formed by a locally and geometrically defined ablation of material or input of energy on/at the surface of a component along a predefined contour corresponding to the respective security feature.

Abstract: The invention provides methods and means for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: Systems and methods for evaluating one or more characteristics or parameters of a material, such as a soft material (e.g., hydrogel, human cell, UV-curable polymer, etc.). Methods include incorporating a plurality of magnetic nanowires into the material to form a test solution. The test solution is subjected to a magnetic field. A change in the magnetic nanowires in response to the magnetic field is recorded. A characteristic of the material is determined based upon the recorded change. In some embodiments, the applied magnetic field causes the magnetic nanowires to rotate from an initial orientation to a stimulated orientation, with the change in orientation being indicative of a stiffness (e.g., internal stiffness) of the material.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: An arrangement for adjusting a powder flow in relation to the central longitudinal axis of an energy beam for a working head which is formed for powder application welding. There is a device for the two-dimensional or three-dimensional alignment of the powder supply in relation to the central longitudinal axis of the energy beam in a plane oriented at right angles to the central longitudinal axis of the energy beam. From one side, a linear beam is directed to the region in which the particles of the powdery material meet one another. At right angles thereto, there is arranged an optical detector array for locally resolved detection of intensities connected to an electronic evaluation unit designed to determine the shape, size and/or length of an irradiated region in which locally resolved intensities which exceed a predefinable threshold have been detected with the optical detector array.

Abstract: A generally time-varying boundary surface between a plurality of flowing fluids having different refractive indices, e.g. the boundary surface between water and air with an open water surface, produces an optical disturbance. Optical flow measurement procedures that occur through the boundary surface are affected by this disturbance, which can lead to significant measurement deviations or can even completely prevent a measurement from being made. The invention contributes to solving this metrological problem by proposing arrangements and methods for instantaneous, hardware-based correction of optical disturbances caused by a fluctuating boundary surface. For this purpose, a wavefront modulator is introduced into the beam path of the optical measuring method, the modulator actively compensating for the optical disturbance by means of a control system. The invention makes it possible to perform optical flow measurements through a fluctuating boundary surface.

Abstract: The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.

Abstract: The invention relates to methods for producing hydrophobized, doped or non-doped mixed metal oxide nanoparticles or doped metal oxide nanoparticles by flame spray pyrolysis, wherein a combustible precursor solution A, containing at least two metal alkyloates of general formula Me(OOC—R)x with differing metals Me, or a combustible precursor solution B containing at least one metal alkyloate of general formula Me(OOC—R)x and at least one metal salt containing a metal ion Me and at least one metal salt containing a metal ion Me, with Me selected from metal ions of the subgroups of the periodic system of the elements, with R=alkyl or aryl, wherein the alkyl chain is branched or straight, and wherein x corresponds to the oxidation step of the metal ion, is used in stoichiometric excess relative to a quantity of oxygen, and wherein a combustion ratio ? of 3.5 bis 0.4 is established, and hydrophobized nanoparticles and the use thereof.

Abstract: Method and a device for the optical in ovo sex determination of fertilized and incubated birds' eggs. The method includes monitoring formation of at least one identifiable blood vessel, creating a hole in the shell of the egg, finding and irradiating the blood vessel with at least one laser beam source emitting an excitation wavelength, recording backscatter radiation of the irradiated blood vessel and evaluating backscatter radiation from recorded spectral intensity of fluorescence radiation in a spectral range redshifted to an excitation wavelength. Sex-specific properties of male and female blood are contained in the intensity and spectral profile of the recorded fluorescence radiation. where intensity levels for male blood has an evaluable value distinct from that of female blood. Further, determining the sex of the bird egg from difference values of the fluorescence intensity and displaying the sex determined for the embryo in the egg.

Abstract: The invention relates to a method for operating an internal combustion engine installed in a vehicle, in particular a diesel engine, in which the instantaneous concentration of a pollutant contained in the exhaust gas, in particular the NOx concentration in the exhaust gas, is measured or calculated in the flow direction after an exhaust gas aftertreatment. Using the determined pollutant concentration, the predefined distance- and/or power-based compliance with pollutant limiting values in mg/km or mg/kWh are monitored by means of specifically influencing the operating parameters of the internal combustion engine and/or an exhaust gas after treatment system in regulated form.

Abstract: The system according to the invention for haptic interaction with virtual objects comprises a visualisation unit for visualising virtual objects and the user's hand, a haptic output unit for reproducing haptic impressions at least by means of force feedback on fingertips of the user's hand, and a data processing unit for processing input data and controlling the visualisation unit and the output unit. The output unit has at least two movement-coupled segments of the interaction region, a finger-based positioning system, and a global positioning system, as well as a sensor system and actuator system. The movement-coupled segments are designed as touch surfaces, and each movement-coupled segment is assigned to one fingertip of the user's hand and can be moved by the latter. The position of the fingertip on the movement-coupled segment can be changed.