Patents Assigned to Tel Hashomer Medical Research and Infrastructure and Services Ltd.
-
Patent number: 11617769Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.Type: GrantFiled: April 1, 2020Date of Patent: April 4, 2023Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventor: Sarah Ferber
-
Publication number: 20230051170Abstract: Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.Type: ApplicationFiled: January 25, 2021Publication date: February 16, 2023Applicants: KIDNEYCURE LTD, TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTDInventors: Masha SIMANOVSKY, Benjamin DEKEL
-
Patent number: 11564836Abstract: An apparatus includes a laser source and a scanner. The laser source is configured to generate electromagnetic radiation. The scanner scans at least part of a limbal area of an eye with the electromagnetic radiation generated by the laser source, thereby directing the electromagnetic radiation through an entire thickness of the limbal area of the eye without any contact with the eye and irradiating one or more regions of a trabecular meshwork of the eye with the electromagnetic radiation.Type: GrantFiled: May 23, 2019Date of Patent: January 31, 2023Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Michael Belkin, Mordechai Goldenfeld
-
Patent number: 11547525Abstract: An endotracheal tube cleaning device, including a rod, and a cleaning head coupled to a distal end of the rod, including a low friction-generating surface; and a high friction-generating surface, wherein the low friction-generating surface contacts an inner surface of the endotracheal tube when moved along the tube in a first direction and the high friction-generating surface contacts the inner surface of the endotracheal tube when moved in a second, opposite direction.Type: GrantFiled: June 6, 2019Date of Patent: January 10, 2023Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventors: Amihay Shinfeld, Yoav Paz, Emanuel Mendes, Joseph Feldman
-
Patent number: 11534126Abstract: Apparatus for diagnosing breast cancer, the apparatus comprising a controller having a set of instructions executable to: acquire a contrast enhanced region of interest (CE-ROI) in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; determine a texture neighborhood for each of a plurality of X-ray pixels in the CE-ROI, the texture neighborhood for a given X-ray pixel of the plurality of X-ray pixels extending to a bounding pixel radius of BPR pixels from the given pixel; generate a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI that are located within the texture neighborhood; and use a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.Type: GrantFiled: February 1, 2021Date of Patent: December 27, 2022Assignee: Tel HaShomer Medical Research, Infrastructure and Services Ltd.Inventors: Miriam Sklair-Levy, Arnaldo Mayer, Shmuel Yitzhak Pfeffer
-
Patent number: 11517348Abstract: A guide device for TMJ arthroscopy including one or more pairs of arms pivotly connected at one end to a working cannula holder and defining a working cannula axis; and at the opposite end to at one or more arms via one or more pivot connections to form with the arm one or more adjustable parallelograms, an end of the arm is connected to an irrigation cannula holder defining an irrigation cannula axis, the irrigation cannula axis intersecting with the working cannula axis at an intersection, intersection and one or more of the pivot connections between connecting the arms are located at opposing vertices of one or more of the adjustable parallelograms.Type: GrantFiled: May 3, 2018Date of Patent: December 6, 2022Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventor: Waseem Abboud
-
Patent number: 11497793Abstract: Compositions and methods for treating malignant gliomas such as glioblastoma are provided, comprising a combination of a peptide conjugate comprising an amino acid sequence derived from the N-terminus of the receptor PAR-1, and the chemotherapeutic agent temozolomide.Type: GrantFiled: April 16, 2019Date of Patent: November 15, 2022Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Joab Chapman, Efrat Shavit-Stein
-
Publication number: 20220358157Abstract: A method for providing medical diagnostics comprises providing access to one or more platforms capable of distributing one or more applications for implementing a method. The method comprises retrieving, with the aid of a processor, one or more images from an image database or an imaging device. The one or more images can define a set of images. Next, with the aid of a processor, whether each of the images is of medical interest to a reviewing physician is determined. One or more images can then be provided to a display and analysis system for review by a reviewing physician. The one or more images can be provided with an image that is representative of the set of images.Type: ApplicationFiled: July 14, 2022Publication date: November 10, 2022Applicants: RadLogics, Inc., TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.Inventors: Moshe BECKER, Robert M. FOLEY, Eliahu KONEN, Arnaldo MAYER
-
Patent number: 11471325Abstract: An apparatus for use in tissue removal from a body organ is presented. The apparatus comprises a hand-held probe device, a rotating motor device and a connection assembly configured for removably interconnecting between the hand-held probe device and the rotating motor device. The hand-held probe device is disposable and comprises a housing having proximal and distal ends, a rotatable cutting tool extending distally from the distal end of the housing and being configured for cutting and removing tissue during rotation, and a transmission assembly passing inside the housing between the proximal and distal ends and being configured for transmitting rotational power to the rotatable cutting tool. The connection assembly is configured for engaging between the rotating motor device and the transmission assembly to thereby controllably rotate the cutting tool and remove tissue.Type: GrantFiled: September 27, 2016Date of Patent: October 18, 2022Assignees: SANOCULIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND Services Ltd.Inventors: Gilad Lavi, Yoseph Glovinsky, Vadim Shmukler, Nir Israeli
-
Patent number: 11446323Abstract: A method of treating a disease associated with fibrosis is disclosed. The method comprises administering to the subject a therapeutically effective amount of exosomes isolated from a hepatic cell-conditioned medium. Administration of agents isolated from the exosomes for treatment of fibrotic diseases is also contemplated.Type: GrantFiled: August 30, 2018Date of Patent: September 20, 2022Assignee: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Ziv Ben-Ari, Michal Safran, Maya Sultan
-
Patent number: 11389544Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.Type: GrantFiled: January 19, 2017Date of Patent: July 19, 2022Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Talia Shekhter Zehavi, Ehud Gazit, Mor Herman-Oron, Genady Kostenich, Arie Orenstein
-
Publication number: 20220197938Abstract: A method for providing medical diagnostics comprises providing access to one or more platforms capable of distributing one or more applications for implementing a method. The method comprises retrieving, with the aid of a processor, one or more images from an image database or an imaging device. The one or more images can define a set of images. Next, with the aid of a processor, whether each of the images is of medical interest to a reviewing physician is determined. One or more images can then be provided to a display and analysis system for review by a reviewing physician. The one or more images can be provided with an image that is representative of the set of images.Type: ApplicationFiled: March 10, 2022Publication date: June 23, 2022Applicants: RadLogics, Inc., TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.Inventors: Moshe BECKER, Robert M. FOLEY, Eliahu KONEN, Arnaldo MAYER
-
Patent number: 11351397Abstract: Apparatus for performing a procedure at a target site of a patient's body, the apparatus comprising: a continuous positive airway pressure (CPAP) apparatus that provides CPAP to the patient's lungs; a medical device for performing the procedure at the target site; and a controller that controls the CPAP apparatus to provide CPAP to the patient's lungs during performance of the procedure.Type: GrantFiled: October 22, 2014Date of Patent: June 7, 2022Assignee: Tel Hashomer Medical Research, Infrastructure and Services Ltd.Inventors: Jeffrey Goldstein, Nir Peled, Zvi Symon
-
Publication number: 20220162284Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.Type: ApplicationFiled: February 3, 2022Publication date: May 26, 2022Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.Inventors: Genady KOSTENICH, Mor ORON-HERMAN, Arie ORENSTEIN, Talia SHEKHTER ZAHAVI, Ehud GAZIT, Yoseph SALITRA, Ludmilla BUZHANSKY
-
Publication number: 20220146311Abstract: A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.Type: ApplicationFiled: January 24, 2022Publication date: May 12, 2022Applicants: Bar-Ilan University, Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Yuval GARINI, Irena BRONSHTEIN-BERGER, Iris BARSHACK
-
Patent number: 11308147Abstract: A method for providing medical diagnostics comprises providing access to one or more platforms capable of distributing one or more applications for implementing a method. The method comprises retrieving, with the aid of a processor, one or more images from an image database or an imaging device. The one or more images can define a set of images. Next, with the aid of a processor, whether each of the images is of medical interest to a reviewing physician is determined. One or more images can then be provided to a display and analysis system for review by a reviewing physician. The one or more images can be provided with an image that is representative of the set of images.Type: GrantFiled: March 7, 2014Date of Patent: April 19, 2022Assignees: RADLOGICS, INC., TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.Inventors: Moshe Becker, Robert M. Foley, Eliahu Konen, Arnaldo Mayer
-
Publication number: 20220096591Abstract: Cultures of Delftia bacteria are disclosed. Antimicrobial agents derived therefrom are also disclosed.Type: ApplicationFiled: December 13, 2021Publication date: March 31, 2022Applicants: Ministry of Health, State of Israel, Sami Shamoon College of Engineering (R.A), Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Israel NISSAN, Noa Lea TEJMAN-YARDEN, Chaim RUBINOVITZ, Yakov DAVIDOV, Galia RAHAV, Ari ROBINSON, Yoram SHOTLAND
-
Patent number: 11266389Abstract: A device for manipulating the left atrial appendage (LAA) of a heart, including: an elongated and hollow guide instrument which is shaped and sized to be transvascularly and transseptally introducible into the left atrium (LA); a suction channel passing through the guide instrument, the suction channel terminating with a concave holder, wherein the suction channel and the concave holder are shaped and sized to be enclosed within a lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of the guide instrument after reaching the LA, and wherein the concave holder is configured to radially expand; a loop fastener shaped and sized to be enclosed within the lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of said guide instrument.Type: GrantFiled: May 10, 2019Date of Patent: March 8, 2022Assignee: Tel HaShomer Medical Research infrastructure and Services Ltd.Inventor: Leonid Sternik
-
Patent number: 11261230Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.Type: GrantFiled: June 28, 2020Date of Patent: March 1, 2022Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmila Buzhansky
-
Patent number: 11260246Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.Type: GrantFiled: December 3, 2020Date of Patent: March 1, 2022Assignees: Board of Regents, The University of Texas System, Tel-Hashomer Medical Research Infrastructure and Services Ltd. at the Chaim Sheba Medical CenterInventors: Dirk Bartkoski, Dror Alezra, Mohammad Salehpour, Thomas Buchholz