Patents Assigned to Tel Hashomer Medical Research and Infrastructure and Services Ltd.
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Patent number: 10555963Abstract: Disclosed is the use of a klotho protein or related compounds (especially KL1 or KL1 analogue) for treatment, and especially treatment of cancer, alone or together with other active pharmaceutical ingredients such as chemotherapeutic agents.Type: GrantFiled: March 25, 2012Date of Patent: February 11, 2020Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Ido Wolf, Tamar Rubinek, Bella Kaufman, Lilach Abramovitch
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Patent number: 10508136Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: GrantFiled: August 10, 2017Date of Patent: December 17, 2019Assignee: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.Inventor: Amir Zlotkin
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Patent number: 10500038Abstract: According to an aspect of some embodiments of the invention, there is provided a method of deploying an expandable prosthetic mitral valve in a subject, the method comprising: deploying a first component of the prosthetic mitral valve in a left atrium; deploying a second component of the prosthetic mitral valve in a left ventricle; and approximating the first and the second components so that leaflets of a native mitral valve are trapped between the first and the second components.Type: GrantFiled: May 20, 2012Date of Patent: December 10, 2019Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Boris Orlov, Ehud Raanani
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Patent number: 10499926Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.Type: GrantFiled: April 14, 2015Date of Patent: December 10, 2019Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., The Trendlines Group Ltd.Inventors: Abraham Tsur, Sharon Farber, Roy Mashiach, Yosef Hazan, David Shashar, Avshalom Shenhav
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Patent number: 10499866Abstract: A method of diagnosing breast cancer, the method comprising: acquiring a contrast enhanced region of interest (CE-ROI) comprised in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; generating a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI; and using a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.Type: GrantFiled: August 4, 2016Date of Patent: December 10, 2019Assignee: Tel Hashomer Medical Research, Infrastructure and Services Ltd.Inventors: Miriam Sklair-Levy, Arnaldo Mayer, Shmuel Yitzhak Pfeffer
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Patent number: 10465004Abstract: The invention provides antibodies or an antigen-binding portion thereof, which recognize the human Frizzled 7 receptor. Further, the invention provides methods of using these antibodies for the treatment cancer in a subject.Type: GrantFiled: January 1, 2015Date of Patent: November 5, 2019Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Benjamin Dekel, Naomi Pode-Shakked, Orit Harai-Steinberg, Michal Mark-Danieli, Einav Vax
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Patent number: 10456295Abstract: The present disclosure provides a device, an assembly comprising the device and a method making use of same, the device comprising an elongated member extending between a first end and a second end, and a segment proximal to the second end extending along a longitudinal axis X, said segment comprises at least one depression axially extending along at least a portion of said segment and an external surface having a circumference C; and one or more blades with a cutting edge peripheral to C and the one or more blades extending along at least part of said segment; the first end comprising an engagement element for engagement with a grip unit comprising a rotor to cause rotation of said device about said axis upon actuation of the rotor and the second end comprising a tissue piercing tip. The device, assembly and method are useful in creating a channel in a biological soft tissue, such as a drainage channel in the sclero-corneal junction area of the eye. This may be useful in reducing intra-ocular pressure.Type: GrantFiled: June 13, 2013Date of Patent: October 29, 2019Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., SANOCULIS LTD.Inventors: Vadim Shmukler, Yoseph Glovinsky
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Publication number: 20190321020Abstract: A device for manipulating the left atrial appendage (LAA) of a heart, including: an elongated and hollow guide instrument which is shaped and sized to be transvascularly and transseptally introducible into the left atrium (LA); a suction channel passing through the guide instrument, the suction channel terminating with a concave holder, wherein the suction channel and the concave holder are shaped and sized to be enclosed within a lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of the guide instrument after reaching the LA, and wherein the concave holder is configured to radially expand; a loop fastener shaped and sized to be enclosed within the lumen of the guide instrument during the transvascular and transseptal introduction into the LA and to forwardly extend from the lumen of said guide instrument.Type: ApplicationFiled: May 10, 2019Publication date: October 24, 2019Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventor: Leonid STERNIK
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Publication number: 20190276513Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.Type: ApplicationFiled: March 19, 2019Publication date: September 12, 2019Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.Inventors: Genady KOSTENICH, Mor ORON-HERMAN, Arie ORENSTEIN, Talia SHEKHTER ZAHAVI, Ehud GAZIT, Yoseph SALITRA, Ludmila BUZHANSKY
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Patent number: 10363169Abstract: A system and method are presented for use in delivering electromagnetic radiation to a limbal area of an eye, for example for treatment of glaucoma. The system includes an illumination unit, a beam shaping device and a control unit. The illumination unit includes a first source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having first optical properties to be delivered to the limbal area of a patient's eye to interact therewith and produce a desired effect, and a second source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having second optical properties. The beam shaping device when accommodated in an optical path of said first and second beams defines one or more regions along a path substantially aligned with a limbus of the patient's eye.Type: GrantFiled: November 6, 2012Date of Patent: July 30, 2019Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Michael Belkin, Mordechai Goldenfeld
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Publication number: 20190217125Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.Type: ApplicationFiled: September 5, 2017Publication date: July 18, 2019Applicants: Board of Regents, The University of Texas System, TEL-HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. AT THE CHAIM SHEBA MEDICAL CENTERInventors: Dirk BARTKOSKI, Dror ALEZRA, Mohammad SALEHPOUR, Thomas BUCHHOLZ
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Publication number: 20190153031Abstract: An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.Type: ApplicationFiled: June 2, 2017Publication date: May 23, 2019Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Nicola MAGGIO, Joab CHAPMAN, Efrat SHAVIT STEIN
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Patent number: 10292689Abstract: A device for manipulating a body part, comprises: a) an elongated guide instrument provided with a tip suitable to be positioned in close juxtaposition with a tissue at a desired location of the said body part; and b) a suction channel terminating in or near said tip.Type: GrantFiled: July 9, 2012Date of Patent: May 21, 2019Assignee: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventor: Leonid Sternik
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Patent number: 10292816Abstract: A prosthetic mitral valve with a frame comprises at least one arm shaped to deploy among a region of chordae tendineae of the native mitral valve to deflect these chords in order to pull the native valve leaflets around the frame to avoid paravalvular leaks. The frame may be made from two parts that are connected by sutures. The prosthetic valve may be deployed by a catherer comprising a deployment clamp attached to the valve frame where the deployment clamp is actuable to induce rotation of the frame.Type: GrantFiled: May 20, 2013Date of Patent: May 21, 2019Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventors: Ehud Raanani, Boris Orlov, Boaz Harari, Oded Meiri, Lichen Rozitsky
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Patent number: 10285852Abstract: Disclosed are methods of subretinal delivery of therapeutic compositions to the eye of a mammal. Also disclosed are devices useful for the subretinal delivery of therapeutic compositions to the eye of a mammal.Type: GrantFiled: November 28, 2011Date of Patent: May 14, 2019Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., THE CHAIM SHEBA MEDICAL CENTERInventor: Ygal Rotenstreich
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Publication number: 20190134097Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.Type: ApplicationFiled: November 29, 2018Publication date: May 9, 2019Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventor: Sarah FERBER
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Publication number: 20190133519Abstract: A method of monitoring a malignant tissue response to cancer treatment, including: acquiring, throughout a treatment course, one or more thermal images of the treated malignant tissue; processing the one or more thermal images to detect changes in the malignant tissue following the treatment; and analyzing the processed images to determine an effect of the treatment on the malignant tissue based on said detected changes.Type: ApplicationFiled: December 27, 2018Publication date: May 9, 2019Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd., Afeka Yissumim Ltd.Inventors: Israel GANNOT, Oshrit HOFFER, Dror ALEZRA, Merav A. BEN-DAVID, Eyal KATZ
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Patent number: 10275680Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: GrantFiled: October 18, 2012Date of Patent: April 30, 2019Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels, Yael Mardor
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Patent number: 10264962Abstract: A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.Type: GrantFiled: May 4, 2018Date of Patent: April 23, 2019Assignee: Tel Hashomer Medical Research Infrastructure and Services, Ltd.Inventors: Ygal Rotenstreich, Mordecai Rosner
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Patent number: 10266579Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.Type: GrantFiled: September 10, 2015Date of Patent: April 23, 2019Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmila Buzhansky