Patents Assigned to Tel Hashomer Medical Research and Infrastructure and Services Ltd.
  • Methods for hematopoietic precursor mobilization
    Patent number: 9610331
    Abstract: Methods of modulating mobilization of cells from the bone marrow are provided. In a specific embodiment there is provided a method of increasing mobilization of hematopoietic precursors from the bone marrow to the peripheral blood in a subject in need thereof, the method comprising: (a) administering to the subject an agent which downregulates an activity or expression of a coagulation factor or an effector thereof; and (b) harvesting the hematopoietic precursors from the peripheral blood.
    Type: Grant
    Filed: September 5, 2010
    Date of Patent: April 4, 2017
    Assignees: Yeda Research and Development Co. Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Anna Aronovich, Dalit Tchorsh-Yutsis, Gideon Rechavi, Yair Reisner
  • ANTIBODIES TO CEACAM1 AND KINASE INHIBITORS FOR TREATING BRAF-MUTATED CELLS
    Publication number: 20160376374
    Abstract: Pharmaceutical compositions comprising anti-CEACAM1 antibodies and kinase inhibitors are provided as well as methods for their use in treating cancer.
    Type: Application
    Filed: January 1, 2015
    Publication date: December 29, 2016
    Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Gal Markel, Jacob Schachter
  • Breath analysis of pulmonary nodules
    Patent number: 9528979
    Abstract: The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: December 27, 2016
    Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD., TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Hossam Haick, Nir Peled
  • Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders
    Patent number: 9492480
    Abstract: In accordance with the present disclosure there are provided iron oxide nanoparticles for use in the treatment of non-infectious inflammatory disorders. Also provided by the present disclosure is a method of treatment of non-infectious inflammatory disorders making use of such particles, pharmaceutical compositions and kits comprising such particles.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: November 15, 2016
    Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD
    Inventors: Jonathan Leor, Tamar Ben-Mordechai, Shimrit Adutler-Lieber, Rimona Margalit, Inbar Elron-Gross, Yifat Glucksam-Galnoy
  • Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
    Patent number: 9481894
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: November 1, 2016
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • COMPOSITIONS AND METHODS FOR EXPRESSING RECOMBINANT POLYPEPTIDES
    Publication number: 20160251410
    Abstract: Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been contacted with an agent which downregulates an expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and contacting the cell with a polynucleotide encoding the recombinant polypeptide of interest. Also provided is a method comprising contacting a cell with an agent which downregulates expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and a polynucleotide encoding the recombinant polypeptide of interest. Also provided are isolated cells, cell cultures and articles of manufacture for recombinant expression of a recombinant polypeptide of interest.
    Type: Application
    Filed: September 3, 2014
    Publication date: September 1, 2016
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Tel Hashomer Medical Research Infrastructure and Services Ltd.
    Inventors: Boaz TIROSH, Maya DADIANI
  • ANTI CEACAM1 ANTIBODIES AND METHODS OF USING SAME
    Publication number: 20160176966
    Abstract: A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
    Type: Application
    Filed: January 8, 2016
    Publication date: June 23, 2016
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Gal Markel, Rona Ortenberg, Jacob Schachter
  • A DEVICE FOR DELIVERY OF COMPOSITIONS TO THE EYE
    Publication number: 20160143776
    Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.
    Type: Application
    Filed: August 1, 2014
    Publication date: May 26, 2016
    Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Ygal ROTENSTREICH
  • Gene expression signature for classification of kidney tumors
    Patent number: 9340823
    Abstract: The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 17, 2016
    Assignees: Rosetta Genomics, Ltd., Tel Hashomer Medical Research Infrastructure and Services Ltd.
    Inventors: Nitzan Rosenfeld, Yael Spector, Eddie Friedman, Zohar Dotan
  • Anti CEACAM1 antibodies and methods of using same
    Patent number: 9261507
    Abstract: A method for diagnosing a cancer characterized by over expression of CEACAM1 using an anti-CEACAM1 antibody or antibody fragment that recognizes CEACAM1 and comprises the same CDR sequences in the same orientation as the CDRs of the antibody produced from a hybridoma cell which has been deposited under ATCC Accession Number PTA-9974.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: February 16, 2016
    Assignees: Tel Hashomer Medical Research Infrastructure and Services LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Gal Markel, Rona Ortenberg, Jacob Schachter
  • METHODS AND KITS FOR PREDICTING PROGNOSIS OF MULTIPLE SCLEROSIS
    Publication number: 20160032393
    Abstract: Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Anat ACHIRON, Michael GUREVICH
  • METHOD AND SYSTEM FOR PROCESSING AN IMAGE
    Publication number: 20160027162
    Abstract: A method of processing an image having a plurality of picture-elements is disclosed. The method comprises: preprocessing the image to selectively enhance contrast of some picture-elements of the image, and employing a companding procedure for the preprocessed image, thereby providing a processed image. The contrast enhancement optionally and preferably features a mapping function having a plateau region for diminishing image data with intensity levels below an intensity threshold, thereby providing a preprocessed image.
    Type: Application
    Filed: July 27, 2015
    Publication date: January 28, 2016
    Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Hedva SPITZER, Yuval BARKAN, Lonia KANELOVITCH, Itzchak YACOV, Arie RUNDSTEIN, Miriam SKLAIR-LEVY
  • Microrna patterns for the diagnosis, prognosis and treatment of melanoma
    Patent number: 9238838
    Abstract: The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: January 19, 2016
    Assignees: Ramot at Tel Aviv University Ltd., Tel Hashomer Medical Research Infrastructure and Services Ltd.
    Inventors: Gal Markel, Eyal Greenberg, Jacob Schachter
  • METHOD AND SYSTEM OF CLASSIFYING MEDICAL IMAGES
    Publication number: 20150363672
    Abstract: A method of generating a category model for classifying medical images. The method comprises providing a plurality of medical images each categorized as one of a plurality of categorized groups, generating an index of a plurality of visual words according to a distribution of a plurality of local descriptors in each the image, modeling a category model mapping a relation between each visual word and at least one of the categorized groups according to the index, and outputting the category model for facilitating the categorization of an image based on local descriptors thereof.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 17, 2015
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel HaShomer Medical Research Infrastructure and Services Ltd., Bar-IIan Research And Development Company Ltd.
    Inventors: Hayit GREENSPAN, Jacob GOLDBERGER, Uri AVNI, Eli KONEN, Michal SHARON
  • Method for treating psoriasis
    Patent number: 9180152
    Abstract: The invention is a method for treating psoriasis in a subject suffering from psoriasis. The method includes orally administering to the subject a pharmaceutically-effective amount of crude Dunaliella powder.
    Type: Grant
    Filed: December 5, 2010
    Date of Patent: November 10, 2015
    Assignees: NIKKEN SOHONSHA CORPORATION, TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Aviv Shaish, Dror Harats, Shoshana Greenberger
  • METHODS OF PREDICTING CLINICAL COURSE AND TREATING MULTIPLE SCLEROSIS
    Publication number: 20150315646
    Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.
    Type: Application
    Filed: May 5, 2015
    Publication date: November 5, 2015
    Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Anat ACHIRON, Michael GUREVICH
  • PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME
    Publication number: 20150315253
    Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY, YDYNLY, FDYNFY, FDYNLY, FDYNWY, YDWNLY, YDWHLY and WDYNLY, extracted from organisms such as aquatic organisms and mossor any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
    Type: Application
    Filed: May 8, 2015
    Publication date: November 5, 2015
    Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd.
    Inventors: Amir ZLOTKIN, Hen Kestenboim
  • ASSESSMENT OF BLOOD-BRAIN BARRIER DISRUPTION
    Publication number: 20150265210
    Abstract: A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.
    Type: Application
    Filed: June 1, 2015
    Publication date: September 24, 2015
    Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: David ISRAELI, Yael Mardor, Talila Volk
  • PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME
    Publication number: 20150259390
    Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
    Type: Application
    Filed: May 29, 2015
    Publication date: September 17, 2015
    Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd.
    Inventor: Amir ZLOTKIN
  • Method and system of classifying medical images
    Patent number: 9122955
    Abstract: A method of generating a category model for classifying medical images. The method comprises providing a plurality of medical images each categorized as one of a plurality of categorized groups, generating an index of a plurality of visual words according to a distribution of a plurality of local descriptors in each the image, modeling a category model mapping a relation between each visual word and at least one of the categorized groups according to the index, and outputting the category model for facilitating the categorization of an image based on local descriptors thereof.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 1, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd., Bar-Ilan University
    Inventors: Hayit Greenspan, Jacob Goldberger, Uri Avni, Eli Konen, Michal Sharon