Abstract: (Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro; and R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro; provided that at least one of R1 or R2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.

Abstract: A method for increasing and/or modulating the yield shear stress of an electrorheological fluid includes applying a sufficient electric field to the fluid to cause the formation of chains of particles, and then applying a sufficient pressure to the fluid to cause thickening or aggregation of the chains. An apparatus for increasing and/or modulating the transfer or force or torque between two working structures includes an electrorheological fluid and electrodes through which an electric field is applied to the fluid such that particles chains of particles are formed in the fluid and, upon application of pressure to the fluid, the chains thicken or aggregate and improve the force or torque transmission.

Abstract: Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells.

Abstract: &agr;, &bgr;-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents:

Abstract: The present invention relates to microcapsules comprising a wall and an aqueous core comprising various active agents, and prepared by the interfacial reaction in aqueous medium of Lewis acid and base wall-forming reactants.

Abstract: A device for obtaining multiple biopsy samples from a body cavity is provided, comprising: a flexible hollow tube having a sample port; a moveable helical cutting element extending within the tube, wherein the cutting element is capable of severing, entrapping and carrying forward multiple biopsy samples; a means for maneuvering the cutting element along the tube; a removable seal secured to the distal end of the tube; and a vacuum port configured to be connected to a vacuum source.

Abstract: A device for obtaining multiple biopsy samples from a body cavity is provided, comprising: a flexible hollow tube having a sample port; a moveable helical cutting element extending within the tube, wherein the cutting element is capable of severing, entrapping and carrying forward multiple biopsy samples; a means for maneuvering the cutting element along the tube; a removable seal secured to the distal end of the tube; and a vacuum port configured to be connected to a vacuum source.

Abstract: (Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, and fluoro; and R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, and fluoro; provided that at least one of R1 or R2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.

Abstract: Transgenic non-human animals and transgenic non-human stem cells are described having a functionally disrupted A-myb locus. Targeting constructs used to produce such transgenic stem cells and animals, and methods and targeting constructs for inactivating an endogenous A-myb gene locus, are also provided. Also provided are methods for generating transgenic sperm and transgenic nonhuman animals harboring a desired transgene.

Abstract: The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.

Abstract: This invention relates to a composition comprising a glucosamine material and an analgesic compound such as a nonsteroidal anti-inflammatory drug (NSAID) and/or an opioid analgesic and its use for treatment of pain in pharmaceutical or veterinary applications. When the components of the compositions are administered within certain ratios, the analgesic efficacy of the composition is super-additive (synergistic) relative to the analgesic efficacy of the analgesic compound alone.

Abstract: Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.

Abstract: Antiviral compounds and the water-soluble salts thereof have formula (I), wherein n is from 1 to 8; R1 is selected from the group consisting of (a), wherein m is zero, 1, 2 or 3; and (b), wherein q is from 1 to 20; R2 is independently selected from the group consisting of oxygen and sulfur; R3 is independently selected from the group consisting of hydrogen and hydroxyl; and R4 is selected from the group consisting of hydrogen, hydroxyl and (b); R5 is selected from the group consisting of hydroxyl and (b); R6 is selected from the group consisting of (c), (d) et (e), wherein x is from 1 to 20; provided that one of R1, R4 and R5 is (b) wherein R6 is defined as above; or water soluble salt thereof.

Abstract: Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of such tumor cells, while sparing normal cells.

Abstract: A dental bur for use in repair of a carious lesion has a working surface including cutting elements which deflect or abrade upon encountering material having a hardness at or above a preselected hardness, wherein said preselected hardness is below the hardness of normal dentin and is generally below a hardness corresponding to the lower limit of hardness of pre-carious dentin to be retained in painless procedures.

Abstract: The present invention provides a new simple polymeric matrix tablet that delivers highly soluble drugs over long periods of time and is easy to manufacture. More specifically, the drug is first granulated with or encapsulated in a swellable polymer, such as a gum, to form a granule. This granule is disposed in a matrix of a more swellable, erodible polymer, such as HPMC or Polyethyleneoxide, and optionally includes pectin. The more swellable erodible polymer has a diffusion rate coefficient which is greater than the diffusion rate coefficient of the relatively less swellable polymer. It is this difference in diffusion rate coefficients between the first and second polymers which controls the rate of drug release and allows the system to approach zero order drug delivery over the drug release period. Other advantages which the present invention holds over existing systems including ease of manufacturing and reproducibility of release profiles under well defined hydrodynamic conditions.

Abstract: Peptide analogs of the high molecular weight kininogen domain 5 are potent inhibitors of angiogenesis. The peptides have the formula X1-(HGLGHGHEQQHGKGH)-X2  (I) wherein X1 is from zero to 25 amino acids; X2 is from zero to 60 amino acids. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.

Abstract: Antiviral compounds have the formula wherein m is zero, 1, 2 or 3; n is from 1 to 8, preferably 1, 2 or 3; most preferably 1 or 2; R is independently selected from the group consisting of  provided that all R may not be R1 is independently selected from the group consisting of hydroxyl and hydrogen; R2 is independently selected from the group consisting of oxygen and sulfur; or water soluble salts thereof.

Abstract: A dental bur for use in examining anomalies and in restoration of decayed areas of teeth with a bur head having a generally elongate conical shaped body with a base and an opposed vertex. Cutting members are located about the outer surface of the body between the base and vertex and extend along the outer surface of the bur head which has a length of at least 1.5 millimeters.

Abstract: Gel electrolytes for electrochromic and electrochemical devices wherein in one embodiment polymeric gelling agents/atactic or syndiotactic, and isotactic PMMA, and a lithium salt in a suitable solvent are dissolved at a temperature above the gelation point and cooled to form a gel electrolyte. In another embodiment a preelectrolyte film is formed by casting a solution of a mixture of stereocomplexed PMMA with a plasticizer (a complexing low molecular weight polar solvent) in a non-complexing volatile solvent (e.i., CClH3), followed by the activation of the film in a liquid electrolyte which includes a lithium salt and low molecular weight complexing solvents to form the completed gel electrolyte.