Abstract: The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.

Abstract: A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.

Abstract: The present disclosure provides a copper nanowire composition. The copper nanowire composition includes copper nanowire having associated ligands with the structure HNR1R2, where R1 is hydrogen, alkyl group, or arylalkyl group, R2 is alkyl group or arylalkyl group, wherein the associated ligand has an amount of 100 wt % to 10000 wt % versus a weight of the copper nanowire.

Abstract: A method of removing pollutants from flue gas includes cooling the flue gas to remove condensed water. The flue gas is then compressed and dehydrated. The dehydrated flue gas is chilled to separate pollutants.

Abstract: Provided herein are nanoengineered biomaterial inks used to 3D print a biocompatible, flexible electronic device, for example, a hydrogel constructs a biocompatible, flexible electronic device or 3D printed wearable electronic devices. The biocompatible, flexible electronic device may be a crosslinked gelatin-SH-2D-MoS2 nanoassembly. Also provided are methods for nanoengineering a biomaterial ink and for determining a treatment for a subject in need thereof utilizing the biocompatible, flexible electronic device.

Abstract: An apparatus, method and system for real-time monitoring of underwater risers, cables, and mooring lines based on a Kalman filter. In an embodiment, the system is formed with sensors configured to sense an inclination of a riser segment between riser nodes of the riser between the upper end and the lower end. A data processing system is configured to employ a Kalman filter algorithm to produce real-time estimates of a deformed shape and a stress of the riser segment using the sensed inclination between the riser nodes.

Abstract: A wearable biosensor for real-time quantification of a biomarker in a biofluid includes at least one functional module. The functional module includes an iontophoresis induction module, a microfluidic layer, a plurality of multimodal biosensors, and a paperfluidic layer.

Abstract: In an embodiment. the present disclosure pertains to environmental biospecimen recovery after in-droplet gel encapsulation (eBRIDGE) platforms for co-culturing multiple microorganisms in gel microspheres and then transferring single-cell-derived clonal populations from within the gel microspheres into separate water-in-oil emulsion droplets for further processing and analysis. In some embodiments. the gel-encapsulated bacteria are released by lysing the gel matrix using an enzyme. The methods of the present disclosure provide a single workflow that goes from environmental microbial harvesting and amplification to functional interrogation of their characteristics.

Abstract: In an embodiment, the present disclosure pertains to a method of deposition of nanostructures with engineered patterns. In an additional embodiment, the present disclosure pertains to a method of preparing colloidal suspensions of hybrid nanoparticle systems (HNMS). In a further embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded carbon nanotube carbon fiber reinforced polymer (CNT-CFRP) hybrid composite. In another embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded graphene nanoplatelets (GNP) carbon fiber reinforced polymer (GNP-CFRP) hybrid composite. In a further embodiment, the present disclosure pertains to a method of making a hybrid cellulose nanocrystal (CNC)-graphene nanoplatelet(boron nitride nanobarb) (GNP-(BNNB))-carbon fiber (CF)Zpolyether ether ketone (PEEK) using spray-coating.

Abstract: An electric machine includes a stator having a plurality of stator teeth. Each stator tooth of the plurality of stator teeth includes a winding disposed there around. Each stator tooth of the plurality of stator teeth is shaped to receive a plurality of microchannels. The microchannels contain a circulating heat-transfer fluid; Each stator tooth of the plurality of stator teeth is thermally exposed to the heat-transfer fluid via the plurality of microchannels so as to effectuate heat removal from each stator tooth of the plurality of stator teeth.

Abstract: A hover-capable aircraft includes a body including a tubular strut, a first rotor assembly rotatably coupled to the body and positioned about the strut, wherein the first rotor assembly includes a first plurality of circumferentially-spaced blades, a first actuation assembly including a first plurality of electronically controlled actuators coupled to a first swashplate and configured to control the movement of the first swashplate relative to the body, and a control system coupled to the body and configured to control the first plurality of actuators, wherein the control system includes a cable extending through a passage formed in the tubular strut and in signal communication with the first plurality of actuators.

Abstract: A surge gate for blocking a surge of water includes a sleeve disposed below a waterline of the water, wherein the sleeve has an open upper end and a closed lower end, and a piston slidably disposed in the sleeve, wherein the piston is configured to rise vertically within the sleeve along a vertical axis between a first position with an upper end of the piston positioned below the waterline, and a second position with the upper end of the piston positioned above the waterline.

Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.

Abstract: A nanoscale positioning system for positioning a positionable component includes a motion platform including a first end, a second end, a shuttle positioned between the first end and the second end and configured to support the positionable component, a flexure member, and a fluid passage extending through the flexure member from the first end to the second end of the motion platform, and a pressure controller coupled to the motion platform and fluidically connected to the fluid passage, wherein the pressure controller is configured to selectably provide a fluid pressure in the fluid passage to flex the flexure member whereby the shuttle is displaced along a motion axis of the motion platform.

Abstract: NR4A1 ligands, pharmaceutical compositions including the NR4A1 ligands, and related methods of use are described. Methods of treating a disease or condition in an individual treatable by modulation of NR4A1 activity, comprising administering to the individual a therapeutically effective amount of a compound or a pharmaceutical composition described herein.

Abstract: A passive infrared (PIR) sensor system, includes a PIR sensor configured to produce an output signal in response to receiving infrared (IR) radiation, an electronic shutter positionable in a field of view (FOV) of the PIR sensor, wherein the electronic shutter includes a liquid crystal (LC) material, wherein the electronic shutter includes a first state providing a first transmissivity of IR radiation through the electronic shutter and a second state providing a second transmissivity of IR radiation through the electronic shutter that is less than the first transmissivity, and a shutter actuator configured to apply an actuation signal to the electronic shutter to actuate the electronic shutter between the first state and the second state.

Abstract: An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.

Abstract: A corrosion monitoring system includes a processor, and a memory in communication with the processor and having a control module, a potentiostat, coupled to a clamp with a first plate and a second plate. The control module includes instructions that, when executed by the processor, cause the processor to control the potentiostat to apply a voltage to the first plate and the second plate during an EIS test of a coating on a metal substrate disposed between the first plate and the second plate. The corrosion monitoring system also monitors or detects a change in at least one of a phase angle and an impedance of the applied voltage, and identifies a change in corrosion activation at the substrate for any coating system based, at least in part, on the change in the at least one of the phase angle and the impedance.

Abstract: A hydro-electrochemical power generator includes an interlayer having a first end and a second end opposite the first end, a first electrode in contact with the first end of the interlayer, wherein the first electrode includes a first material that is a corrodible metallic material, a second electrode in contact with the second end of the interlayer, wherein the second electrode includes a second material that is a corrodible metallic material, and at least one heat source coupled to one of the first electrode and the second electrode and configured to apply a temperature gradient across the first end and the second end of the interlayer, and wherein the first electrode and the second electrode are configured to output a non-zero electrical voltage in response to the application of the temperature gradient.

Abstract: Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts, and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided.