Patents Assigned to Texas A & M University System
  • Patent number: 10889596
    Abstract: Pateamine A derivatives, pharmaceutical compositions that include the derivatives, and methods for treating chronic lymphocytic leukemia using the derivatives.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: January 12, 2021
    Assignee: The Texas A&M University System
    Inventors: Daniel Romo, Kenneth G. Hull, Mingzhao Zhu, Omar Robles
  • Publication number: 20210002739
    Abstract: A controlled thermal coefficient product manufacturing system and method is disclosed. The disclosed product relates to the manufacture of metallic material product (MMP) having a thermal expansion coefficient (TEC) in a predetermined range. The disclosed system and method provides for a first material deformation (FMD) of the MMP that comprises at least some of a first material phase (FMP) wherein the FMP comprises martensite randomly oriented and a first thermal expansion coefficient (FTC). In response to the FMD at least some of the FMP is oriented in at least one predetermined orientation. Subsequent to deformation, the MMP comprises a second thermal expansion coefficient (STC) that is within a predetermined range and wherein the thermal expansion of the MMP is in at least one predetermined direction. The MMP may be comprised of a second material phase (SMP) that may or may not transform to the FMP in response to the FMD.
    Type: Application
    Filed: September 21, 2020
    Publication date: January 7, 2021
    Applicant: The Texas A&M University System
    Inventors: James Alan Monroe, Ibrahim Karaman, Raymundo Arroyave
  • Publication number: 20210002245
    Abstract: Gracilin A congeners and methods for their use as immunosuppressive and neuroprotective agents.
    Type: Application
    Filed: March 5, 2019
    Publication date: January 7, 2021
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Daniel Romo, Mikail E. Abbasov, Eva Lopez Alonso, Maria Amparo Alfonso Rancano, Miguel Luis Botana Lopez
  • Publication number: 20200407884
    Abstract: A method of producing carbon fibers includes (a) treating lignin to produce a precursor lignin having an increased uniformity. The increased uniformity is defined by (i) an increased linear structure as evidenced by an increased percentage of linkages selected from uncondensed ?-O-4? interunitery linkages or condensed ?-5? linkages, (ii) a reduced polydispersity index (PDI), or (iii) an increased amount of multiple intermolecular hydrogen bonding relative to the lignin prior to treating. In addition, the method includes (b) forming precursor fibers from the precursor lignin. Further, the method includes (c) subjecting the precursor fibers to thermostabilization or carbonization to produce the carbon fibers.
    Type: Application
    Filed: February 26, 2019
    Publication date: December 31, 2020
    Applicant: The Texas A&M University System
    Inventors: Joshua Shuhua Yuan, Qiang Li
  • Patent number: 10870662
    Abstract: Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are ?-amino pateamine A derivatives that lack the C5-methyl group of pateamine A.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: December 22, 2020
    Assignee: The Texas A&M University System
    Inventors: Daniel Romo, Ken Hull, Mingzhao Zhu, Omar Robles
  • Publication number: 20200387419
    Abstract: Disclosed are various embodiments for optimized sensor deployment and fault detection in the context of agricultural irrigation and similar applications. For instance, a computing device may execute a genetic algorithm (GA) routine to determine an optimal sensor deployment scheme such that a mean-time-to-failure (MTTF) for the system is maximized, thereby improving communication of sensor measurements. Moreover, in various embodiments, a centralized fault detection scheme may be employed and a soil moisture of a field can be determined by statistically inferring soil moistures at locations of faulty nodes using spatial and temporal correlations.
    Type: Application
    Filed: December 11, 2018
    Publication date: December 10, 2020
    Applicant: The Texas A&M University System
    Inventors: Yanxiang YANG, Jiang HU, Dana O. PORTER, Thomas H. MAREK, Charles C. HILLYER, Lijia SUN
  • Publication number: 20200385629
    Abstract: The present disclosure provides nanosized scale inhibitors (NSI) that can extend a well treatment lifetime with high scale inhibitor retention and the ability to provide slow and sustained scale inhibitor release. The NSI can be in the form of particles where the particle size is in the nanometer range, the NSI can be suitable for applications in both formation rock and fractures. During hydraulic fracturing, the NSI can be mixed and pumped with the fracturing fluid into formation rock and fractures as a one-step process to cut the treatment cost, and the NSI can penetrate readily into the secondary fracture networks created in tight shale formations.
    Type: Application
    Filed: December 8, 2017
    Publication date: December 10, 2020
    Applicant: The Texas A&M University System
    Inventors: Jenn-Tai Liang, Huili Guan
  • Publication number: 20200378744
    Abstract: A circuit for generating a swept source optical coherence tomography (SS-OCT) imaging calibration clock. The circuit comprises a first photodetector configured to convert an SS-OCT optical calibration signal to an SS-OCT electrical calibration signal, a first analog-to-digital converter (ADC) coupled to the first photodetector and configured to convert the SS-OCT electrical calibration signal to a sequence of SS-OCT calibration signal digital values, a processing unit coupled to the first ADC that, when initiated, is configured to demodulate the sequence of SS-OCT calibration signal digital values to obtain a sequence of SS-OCT wave number digital values, where each SS-OCT wave number digital value corresponds to one of the SS-OCT calibration signal digital values, and a level crossing sampler that is configured to track a wave number associated with the SS-OCT optical calibration signal and to generate an SS-OCT calibration clock pulse.
    Type: Application
    Filed: April 25, 2018
    Publication date: December 3, 2020
    Applicant: The Texas A&M University System
    Inventors: Sebastian Hoyos, Oscar Joseu Pacheco Barajas, Amir Tofighi Zavareh
  • Patent number: 10851503
    Abstract: An end treatment for a guardrail safety system includes a terminal portion of a guardrail beam comprising a downstream end and upstream end, a first tension cable coupled to an upstream end of the terminal portion. An extruder configured to receive at least a portion of the guardrail beam and at least a portion of the first tension cable, and a terminal support post installed adjacent the roadway at an upstream end of the terminal portion of the guardrail beam. The extruder includes a narrowing throat providing a channel in which at least a portion of the guardrail beam is disposed. The narrowing throat is configured to flatten the guardrail beam in response to a collision with a vehicle moving the extruder in a downstream direction along the guardrail beam. The terminal support post coupled to an upstream end of the first tension cable.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: December 1, 2020
    Assignee: The Texas A&M University System
    Inventors: Dean C. Alberson, D. Lance Bullard, Jr., C. Eugene Buth, Roger P. Bligh, Akram Y. Abu-Odeh
  • Patent number: 10842858
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: November 24, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM, THE UNIVERSITY OF GUELPH
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
  • Publication number: 20200360929
    Abstract: An automated fully integrated on-chip ultra-high-throughput droplet microfluidic screening platform (PolyChip) has been developed that integrates the cultivation and manipulation of cells (e.g., microbial) communities with “on the fly” sorting and analyses. The PolyChip system enables continuous operation of the entire process, from cell-encapsulated droplet generation, culture, merging with other cell-encapsulated droplets, culture, merging with reagent-laden droplets, culture, followed by detection and sorting.
    Type: Application
    Filed: January 25, 2019
    Publication date: November 19, 2020
    Applicant: The Texas A&M University System
    Inventors: Adrian R. Guzman, Arum Han, Paul J. de Figueiredo
  • Patent number: 10838419
    Abstract: A payload platform includes a platform and a castor assembly coupled to the platform. The castor assembly includes a body, a first wheel coupled to the body, and a second wheel coupled to the body. The first wheel and the second wheel are individually actuatable. A sensor is coupled to the body. A control unit is operably coupled to the sensor and operably coupled to the first wheel and to the second wheel. The sensor detects an area surrounding the platform, determines presence of obstacles, and transmits a signal to the control unit corresponding to the area surrounding the platform. The control unit directs the first wheel and the second wheel to rotate in a prescribed manner so as to achieve a prescribed movement of the platform.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: November 17, 2020
    Assignee: The Texas A&M University System
    Inventors: John L. Junkins, Manoranjan Majji, Jeremy Davis, James Doebbler
  • Patent number: 10836809
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: November 17, 2020
    Assignee: The Texas A&M University System
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • Publication number: 20200353203
    Abstract: A therapeutic device comprises a sensor positioned proximate to a user and configured to receive a plurality of signals, and a processor coupled to the sensor and configured to determine a biomarker describing a biological characteristic of the user based on the plurality of signals, and determine whether the user is likely to experience an impending sleep disorder episode within a predetermined period of time based on the biomarker.
    Type: Application
    Filed: December 7, 2018
    Publication date: November 12, 2020
    Applicant: The Texas A&M University System
    Inventors: Satish Bukkapatnam, Kahkashan Afrin, Vu Nguyen
  • Patent number: 10828393
    Abstract: Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: November 10, 2020
    Assignees: The Texas A&M University System, Board of Regents, The University of Texas System
    Inventors: Venu Varanasi, Pranesh Aswath, Philip Kramer, Megen Velten, Azhar Ilyas
  • Patent number: 10813359
    Abstract: The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: October 27, 2020
    Assignee: THE TEXAS A & M UNIVERSITY SYSTEM
    Inventor: Gregory A. Sword
  • Patent number: 10813991
    Abstract: The present disclosure provides a recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome for treatment of diseases in poultry. Also provided are immunogenic compositions comprising such recombinant viral vectors and methods for preventing or inhibiting Marek's disease in combination with at least a second disease in poultry.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 27, 2020
    Assignee: The Texas A&M University System
    Inventors: Sanjay M. Reddy, Blanca M. Lupiani
  • Publication number: 20200332312
    Abstract: The present disclosure relates, according to some embodiments, to pathogen resistant plants, compositions, organisms, systems, and methods. For example, a composition may comprise a heterologous peptide (e.g., a defensin peptide) and/or a nucleic acid (e.g., a defensin nucleic acid). A pathogen resistant plant may comprise, in some embodiments, a heterologous defensin peptide and/or an expressible nucleic acid encoding a heterologous defensin peptide.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 22, 2020
    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: T. Erik MIRKOV, Kranthi Kiran MANDADI
  • Publication number: 20200324892
    Abstract: A flapping-wing aircraft includes a support frame, a motor coupled to the support frame, a pair of wings coupled to the support frame, and a linkage assembly coupled to the support frame and configured to translate an output torque of the motor into flapping motion of the wings, wherein the linkage assembly includes a first link coupled to a rotational output of the motor, a second link pivotably coupled to the first link at a first pivot joint, a third link pivotably coupled to the second link at a second pivot joint, and a fourth link pivotably coupled to the support frame and slidably coupled to the third link, and wherein the fourth link is coupled to a first wing of the pair of wings.
    Type: Application
    Filed: December 20, 2018
    Publication date: October 15, 2020
    Applicant: The Texas A&M University System
    Inventors: Moble Benedict, David A. Coleman
  • Patent number: 10792351
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: October 6, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis