Abstract: The present invention includes a method of observing and evaluating bacterial infections within the lymph nodes of animals presented for harvest comprising: inoculating at one or more sites of an animal a known amount of a pathogen, wherein the one or more inoculation sites comprise lymph node drainage areas, and at one or more time points obtaining one or more lymph node biopsies to determine the extent of the pathogen in the lymph nodes.

Abstract: The present invention determines one or more properties of a soil sample by scanning a soil sample using a visible near infrared diffuse reflectance (VisNIR) spectroradiometer, scanning the soil sample using a x-ray fluorescence (PXRF) spectrometer, receiving a diffuse reflectance spectra from the VisNIR spectroradiometer and an elemental data from the PXRF spectrometer, determining one or more properties of the soil sample using one or more processors and a predictive model that relates the diffuse reflectance spectra and the elemental data to the one or more properties, and providing the one or more properties of the soil sample to one or more input/output interface.

Abstract: The present invention includes a method of inhibiting or reducing mTOR signaling or inhibition of indoleamine dioxygenase-1 (IDO1) in a subject with a proliferative disease, which comprises administering to the subject having or suspected to have the proliferative disease, a therapeutically or prophylactically effective amount of the compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof.

Abstract: An energetic material comprising an elemental fuel, an oxidizer or other element, and a carbon nanofiller or carbon fiber rods, where the carbon nanofiller or carbon fiber rods are substantially homogeneously dispersed in the energetic material. Methods of tailoring the electrostatic discharge sensitivity of an energetic material are also disclosed. Energetic materials including the elemental fuel, the oxidizer or other element, and an additive are also disclosed, as are methods of reducing ignition sensitivity of the energetic material including the additive. The additive is combined with the elemental fuel and a metal oxide to form the energetic material. The energetic material is heated at a slow rate to render inert the energetic material to ignition while the energetic material remains ignitable when heated at a fast rate.

Abstract: Disclosed is a system for determining fecundity of an embryo utilizing a non¬ invasive grading of early stage embryos (pre-hatching) based upon specific gravity, density and/or estimated weight. The system allows 100% recovery of embryos and can detect differences in growth potential at the earliest stages of development. The system may further enhance the development of embryos by utilization of microfluidic effects during use. The disclosed system supports a wide variety of scenarios for human and animal reproductive technologies and related products and services.

Abstract: The present invention includes a method of introducing a pathogenic infection into one or more peripheral lymph nodes of an animal for testing of meat, comprising: inoculating at one or more peripheral lymph node drainage areas the animal with a known amount of a known pathogen; harvesting one or more peripheral lymph nodes from the animal; grinding meat or meat trimmings and the one or more peripheral lymph nodes into ground meat; and determining a ratio of a number of peripheral lymph nodes infected to the weight of the meat or meat trimmings used to create the ground meat, wherein the infected ground meat can be used to test interventions against the known pathogen in a grinding process.

Abstract: A method and composition for the diagnosis of and treatment of prostate cancer including a recombinant AKAP-4 tumor-associated antigen loaded antigen presenting cell that generates an AKAP-4 specific cytotoxic T lymphocyte specific for one or more prostate cancer cells.

Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.

Abstract: The present invention includes compositions and methods for the treatment of cancer comprising an antineoplastic drug and an inhibitor of chromosome maintenance region 1 (CRM1) protein expression or activity, wherein the inhibitor of CRM1 enhances the anti-neoplastic effect of the antineoplastic drug.

Abstract: A process of producing liquid oil from shale gas condensate reservoirs and, more particularly, to increase liquid oil production by huff-n-puff in shale gas condensate reservoirs. The process includes performing a huff-n-puff gas injection mode and flowing the bottom-hole pressure lower than the dew point pressure.

Abstract: Described is a naked-tufted seed mutant line of Gossypium hirsutum L., developed from lines initially produced by chemical mutagenesis, which significantly reduces the formation of linters on the surface of the cotton seed. In a preferred embodiment, the lines carrying the naked seed mutation have reduced seed coat neps, reduced short fiber content, improved yarn quality, increased seed oil content, and improved AFIS fiber maturity. The naked-tufted seed of the mutant line significantly reduces the time and energy required for ginning, oil extraction, and reduces the need to delint the cotton seed prior to planting. In a preferred embodiment, the mutant is incorporated into a well-adapted commercial cultivar of upland cotton.

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

Abstract: Disclosed is a system and method for controlling handheld devices without contact by interacting with their wireless charging coils or other inductive coil antennae. The present disclosure utilizes the interaction between human body and the coil wherein the coil is used to send alternating magnetic field to interact with a control signal, such as a hand, instead of simply using the coil in the smart phone as a power receiver. The hand movement in front of the wireless charging coil changes the coil's conductivity distribution, which creates effective coil impedance also known as reflected impedance.

Abstract: Embodiments of the invention include systems, methods, and computer-readable mediums for optimizing the placement of wells in a reservoir. Embodiments include, for example, determining for a reservoir a productivity index for each coordinate of a reservoir using reservoir metrics associated with the reservoir, generating a grid pattern of the reservoir using the productivity index with time values extracted for each coordinate, determining a total dynamic productivity index for each coordinate, and determining placement of one or more wells responsive to the total dynamic productivity index and minimum spacing between the one or more wells. Embodiments further include, for example, generating a production analysis report for the reservoir that includes an assessment of well placement and generating a wells placement map using one or more total dynamic productivity index indicators.

Abstract: A multilateral well placement methodology is provided for hydrocarbon reservoirs utilizing transshipment network optimization to best fit productivity conditions in the reservoir. Multilateral well trajectories are generated which ensure contact with hydrocarbon rich pockets in the reservoir. Different levels of branching for lateral wells are also permitted.

Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.

Abstract: Disclosed is a system and method for both consumer and utility scale energy extraction from flow-based energy sources. The passive system may utilize directing perforations on a surface in order to create and air jet vortex generators. Alternatively the system may provide for flow through discrete orifices aligned with the span of an aerodynamic assembly in a co-flow direction, utilizing a Coanda effect. Further additional configurations include directing flow through a perforated surface skin that is near the trailing edge on the suction side. Even further are embodiments for blowing air directly out of the trailing edge of an airfoil. The disclosed systems and methods support a wide variety of scenarios for fluid flow energy extraction, such as wind or water flow, as well as for related products and services.

Abstract: The present invention includes compositions, methods of making and using the compositions for modulating the immune response in a subject by providing a vaccine composition having a pollen/spore disposed in a pharmaceutical carrier for delivery to a subject, wherein the pollen/spore comprises multiple pores that connect an outer surface of the pollen/spore to an inner cavity and one or more antigens disposed on the outer surface, in the inner cavity, in the multiple pores, or a combination thereof, wherein the one or more antigens modulate an immune responses in the subject.

Abstract: An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.

Abstract: A computerized method for designing a discrete droplet microfluidic system: (a) provides an initial set of droplet based networks; (b) codes each droplet based network into a data structure such that all the data structures form a current set of data structures; (c) creates new data structures by performing one or more genetic operators on the current set of data structures; (d) adds new data structures to the current set of data structures; (e) creates a new set of data structures that satisfies one or more design parameters; (f) replaces the current set of data structures with the new set of data structures; (g) repeats steps (c), (d), (e) and (f) until the new set of data structures has been created a third number of times; and (h) displays/outputs the current set of data structures as possible designs for the discrete droplet microfluidic system to one or more output devices.