Abstract: Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against viral infections. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.

Abstract: Embodiments of the present disclosure pertain to methods of identifying one or more characteristics of particles by (1) placing the particles on a surface; (2) exposing the particles to an ion to result in emissions from the particles; (3) measuring the emissions from the particles; (4) generating an emission profile from the measured emissions; and (5) correlating the generated emission profile to one or more characteristics of the particles

Abstract: The present invention includes meat chips and methods of making meat chips comprising: blending a meat product and a high oleic oil, and optionally a seasoning, into a meat batter; extruding the meat batter into a casing; cooking to the meat batter; slicing the meat batter into meat slices; and microwaving at a temperature not exceeding 200° F. the meat slices into a meat chip.

Abstract: A method of treating a cancer in a patient includes obtaining a sample from the patient, using a C-circle assay to detect a presence of an alternative lengthening of telomeres (ALT) phenotype in the sample, and administering an effect amount of at least one of PRIMA-1 or APR-246 to the patient.

Abstract: A nonlinear radar system includes a first antenna configured to generate and emit an incident signal having a first frequency, a transponder tag attached to an existing portable object, wherein the transponder tag includes an electromagnetic nonlinear element configured to be detected by the incident signal. Upon being detected by the incident signal, the transponder tag is configured to transmit a reflected return harmonic signal having a second frequency different from the first frequency, wherein the reflected return harmonic signal is an on-off keying (OOK) signal. A second antenna is configured to receive the reflected return harmonic signal having the second frequency. The transponder tag includes a conductive layer in electrical communication with the electromagnetic nonlinear element including a Schottky diode.

Abstract: The present invention includes a composition and method for decreasing Bacillus anthracis virulence or toxicity comprising: at least one inhibitor that decreases an expression of one or more host genes selected from G6pc, Rgs1, Fosl2, Hcar2, Cxcl2 and Cxcl3, or Serpine1 (PAI-1).

Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing a condition in a subject by administering to the subject a composition having alpha-methyl-L-tryptophan. In additional embodiments, the method further includes a step of instructing the subject to administer the composition in order to treat or prevent the condition in the subject. In some embodiments, the condition includes, without limitation, hyperglycemia, diet-induced diabetes, high-fat diet-induced diabetes, insulin resistance, metabolic syndrome, extra weight, obesity, hepatic steatosis, and combinations thereof. Additional embodiments of the present disclosure pertain to compositions for use in treating or preventing a condition in a subject. In some embodiments, the composition includes alpha-methyl-L-tryptophan.

Abstract: A method of treating a cancer in a patient includes obtaining a sample from the patient, using a C-circle assay to detect a presence of an alternative lengthening of telomeres (ALT) phenotype in the sample, and administering an effect amount of at least one of PRIMA-1 or APR-246 to the patient.

Abstract: A nonlinear radar system includes a handheld unit including a display screen, a first antenna configured to generate and emit an incident signal having a first frequency, and a second antenna configured to receive a reflected return harmonic signal having a second frequency, as well as a transponder tag is attached to an existing golf ball. Such a transponder tag is in communication with and responsive to the handheld unit, and includes an electromagnetic nonlinear element configured to be detected by the incident signal without the need for a line of sight. Upon being detected by the incident signal, the transponder tag is configured to transmit the reflected return harmonic signal having the second frequency different from the first frequency. The transponder tag is passive and does not require a power source other than incident radiation.

Abstract: The present invention includes methods for reducing biofilm present on a surface comprising contacting the surface with a composition under conditions wherein the presence of the biofilm on the surface is reduced and antibiotic activity is increased, wherein the composition comprises at least two glycoside hydrolases and an antibiotic.

Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing cancer in a subject by administering to the subject a composition that includes at least one of the compounds disclosed herein. The cancer to be treated or prevented can include, without limitation, lung cancer, breast cancer, cancers associated with an over-expression of a ral interacting protein, or combinations thereof. Further embodiments of the present disclosure pertain to the compositions of the present disclosure.

Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing a disorder in a subject by administering to the subject a composition that includes one or more of the following active components: a zinc finger protein ZPR1 (ZPR1), an analog thereof, a homolog thereof, a derivative thereof, or combinations thereof; an enhancer of expression of ZPR1, an analog thereof, a homolog thereof, or combinations thereof; nucleotides encoding ZPR1, an analog thereof, a homolog thereof, a derivative thereof, or combinations thereof; or combinations thereof. The disorder to be treated or prevented may be caused by at least one mutation in the Senataxin (SETX) gene, a downregulation of SETX protein levels, or may include a neurodegenerative disease or disorder. Further embodiments pertain to the aforementioned compositions, which may be suitable for use in treating or preventing one or more of the aforementioned disorders in a subject.

Abstract: The present invention includes nucleic acids, proteins, Chikungunya virus (CHIKV) Virus Like Particles (VLP), and methods of making a Chikungunya virus (CHIKV) Virus Like Particles (VLP) comprising: inserting one or more nucleic acids into a lentiviral backbone, wherein the nucleic acid encodes one or more Chikungunya virus (CHIKV) proteins; transfecting the one or more nucleic acids into the lentiviral backbone into a cell line; culturing the transfected cell line under conditions in which the Chikungunya virus (CHIKV) Virus Like Particles (VLP) are released from the cell line; and isolating the Chikungunya virus (CHIKV) Virus Like Particles (VLP) from a culture supernatant.

Abstract: Embodiments of the present disclosure pertain to bioink compositions that are operational to form an artificial tissue. The bioink may include materials that are completely or primarily derived from humans, such as human tissues. Additional embodiments of the present disclosure pertain to artificial tissues that include a plurality of cells and a bioink of the present disclosure, where the bioink is embedded with the cells, and the artificial tissue is in the form of a three-dimensional structure. Further embodiments of the present disclosure pertain to methods of making the artificial tissues of the present disclosure by applying a plurality of cells and a bioink onto a surface.

Abstract: Methods and compositions for enhancing or promoting germination of bacterial spores, and yeasts are disclosed herein. The composition of the present invention comprises an extract obtained from banana or any member belonging to the genus Musa that may be used alone or in a growth medium to promote and enhance germination of bacterial spores, growth of bacterial, yeast, and fungal cell cultures.

Abstract: An apparatus and method of separation of LOX and other commercially valuable components, such as LAr from liquefied air, which consists primarily of LN2. Strong magnetic field gradient and gravity are used to separate LOX from liquefied air, based upon the different magnetic properties of LOX and LN2. The apparatus and method employ a magnetic field gradient to levitate the LN2 and LAr diamagnetic components of liquid air while accelerating the paramagnetic LOX component toward the bottom to achieve oxygen separation. In other embodiments, a leak valve system can be used.

Abstract: Disclosed is a system and method for solid-state 2D optical phased arrays (OPAs), which are fabricated from In-rich In1-xGaxN/GaN multiple quantum wells (MQWs). In-rich InxGa1-xN alloys possess the unique properties of exceptionally high free-carrier-induced refractive index (n) change and low optical loss. InGaN/GaN MQW pixels play the role of using a very small fraction of a laser beam to modulate the phase of the laser beam. The phase of each MQW pixel in the OPA is controlled independently via electro-optic effect through the integration between OPA pixels with a Laterally Diffused MOSFET (LDMOS) integrated circuit driver to achieve the manipulation of the distribution of optical power in the far field. The present invention is applicable to a wide range of applications, including the operation of LIDAR systems, laser weapons, laser illuminators, and laser imaging systems.

Abstract: Disclosed is a system and method for a 24-GHz phased array for indoor smart radar comprising at least 6 horizontally placed antenna elements as a vertically placed 5-element series-fed microstrip patch array. The beam of the phased array can be continuously steered on the H-plane to different directions through a novel vector control array. Each element can adjust the phase and amplitude of the corresponding element of the horizontally placed linear array. The phased array system of the present invention may be fabricated on a single printed circuit board (PCB), and PIN diodes are used to realize beam steering by modulating the decomposed received signal. In order to compensate for the loss of the vector control array and reduce the noise figure, six low noise amplifiers (LNAs) are also used in the array. The present invention has the ability to continuously steer the beam on the H-plane.

Abstract: A method for generating microfractures in low carbonate mineral content shale reservoirs in which sulfate acid or persulfate compound (such as ammonium persulfate ((NH4)2S2O8)) injected into conventional fracturing fluid can react with shale carbonate components resulting in the precipitation reaction of gypsum crystal (CaSO4·2H2O) to occur.

Abstract: A kit for testing for a virus and interacting with a sensor are disclosed. For example, the kit can include a first container having a first media for conditioning, catalyst formation and rinsing of the sensor. The first media can comprise V mL of 1 M KOH. The kit can have a second container with a second media for negative control (baseline solution) for the sensor. The second media can comprise W ML of 0.01 M KOH. The kit can further include a third container having a third media for sample testing with the sensor. The third media can comprise X mL of 0.01 M KOH. The third container can receive Y mL of saliva to complete a Z mL total volume in the third container prior to sample testing. In some versions, a ratio V: W: X: Y: Z=1.0: 1.0: 0.9: 0.1: 1.0 can be used.