Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20240081920
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • Publication number: 20240084335
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: September 29, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Publication number: 20240086444
    Abstract: Systems and methods for generating knowledge graphs and text summaries from document databases are provided. In one embodiment, a system for generating knowledge graphs and text summaries includes: a device, including: a processor; and a memory containing a knowledge graph and text summary generating application, where the knowledge graph and text summary generating application directs the processor to: query a global network of biomedical relationships; construct a knowledge graph and a citation graph; apply processes to learn local context-based weights and compute summarizations; and provide results via a display.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Stefano Emanuele Rensi
  • Patent number: 11926865
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: March 12, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev
  • Patent number: 11926783
    Abstract: A method of electrochemical redox refrigeration includes inducing a flow of an electrochemical refrigerant that is in contact with a first electrode to a second electrode; applying an electrical potential difference between the first electrode and the second electrode, wherein the electrochemical refrigerant is oxidized at one of the first electrode and second electrode and reduced at another of the first electrode and second electrode; wherein the first electrode is at least partially thermally isolated from Joule heating in the electrochemical refrigerant and from activation losses in the second electrode by an action of the flow of the electrochemical refrigerant.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Arunava Majumdar, Ian S. McKay
  • Patent number: 11929171
    Abstract: Methods to compute glycemia tests and applications thereof are described. Additional methods to compute risk of atherosclerotic cardiovascular disease and applications thereof are described. Generally, systems utilize analyte measurements to determine a glycemic status or cardiovascular disease risk, which can be used as a basis to treat individuals.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sophia Miryam Schüssler-Fiorenza Rose, Kevin Contrepois, Wenyu Zhou, Samson Mataraso, Tejaswini Mishra, Michael Snyder, Kegan Moneghetti, Francois Haddad
  • Patent number: 11925226
    Abstract: A textile includes: (1) a matrix; and (2) particulate fillers dispersed within the matrix. The textile has a transmittance of infrared radiation at a wavelength of 9.5 ?m of at least about 40%, and the textile has a weighted average reflectivity of radiation over a wavelength range of 0.3 ?m to 2 ?m of at least about 40%.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Yi Cui, Shanhui Fan, Lili Cai, Alex Y. Song, Wei Li, Po-Chun Hsu
  • Patent number: 11929512
    Abstract: An electrode catalyst for an Oxygen Reduction Reaction (ORR) is provided that includes a transition metal nitride layer on a substrate, an ORR surface oxide layer deposited on the transition metal nitride layer, where the ORR surface oxide layer includes from sub-monolayer to 20 surface oxide monolayers.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Melissa E. Kreider, Michaela Burke Stevens, Alessandro Gallo, Hadi Abroshan, Seoin Back, Samira Siahrostami, Jens K. Nørskov, Laurie A. King, Thomas Francisco Jaramillo
  • Publication number: 20240077475
    Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
    Type: Application
    Filed: October 18, 2023
    Publication date: March 7, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Matthew S. BOGYO, Martijn VERDOES, Leslie OFORI, Nimali P. WITHANA
  • Publication number: 20240076618
    Abstract: Methods of differentiating pluripotent stem cells into thymic epithelial progenitor cells are provided.
    Type: Application
    Filed: January 13, 2022
    Publication date: March 7, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Katja G. WEINACHT, Hui Gai
  • Patent number: 11918550
    Abstract: Methods are provided for the treatment of cancer by administering a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells, which may be provided in a combination with a retinoic acid to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. The cancer may be resistant to retinoic acid.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jiangbin Ye, Haowen Jiang, Yang Li
  • Patent number: 11921118
    Abstract: Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: March 5, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Andrew Yang, Anton Wyss-Coray, Kyle Brewer
  • Patent number: 11918370
    Abstract: Many embodiments of the invention include systems and methods for evaluating motion from a video, the method includes identifying a target individual in a set of one or more frames in a video, analyzing the set of frames to determine a set of pose parameters, generating a 3D body mesh based on the pose parameters, identifying joint positions for the target individual in the set of frames based on the generated 3D body mesh, predicting a motion evaluation score based on the identified join positions, providing an output based on the motion evaluation score.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ehsan Adeli-Mosabbeb, Mandy Lu, Kathleen Poston, Juan Carlos Niebles
  • Patent number: 11919574
    Abstract: An apparatus includes a substrate, at least one type of tuning material, and a composite material. The substrate has an interface surface or material that manifests, in response to light in a color spectrum, a particular color and a first thermal load. The particular color is associated with the first thermal load. The at least one type of tuning material manifests, in response to light in the color spectrum, the particular color and a second thermal load. The particular color is associated with the second thermal load. The first thermal load is different from the second thermal load. The composite material includes the interface surface or material and the at least one type of tuning material. The composite material manifests, in response to light in the color spectrum, the particular color and a tuned thermal load which is different than the first thermal load and the second thermal load.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Wei Li, Yu Shi, Shanhui Fan, Zhen Chen
  • Patent number: 11923873
    Abstract: In certain examples, methods and semiconductor structures are directed to an apparatus including a photon emitter such as an LED which operates over an emission wavelength range and a photo-voltaic device arranged relative to the photon emitter to provide index-matched optical coupling between the photo-voltaic device and the photon emitter for an emission wavelength range of the photon emitter.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shanhui Fan, Bo Zhao, Sid Assawaworrarit, Parthiban Santhanam, Meir Orenstein
  • Publication number: 20240065564
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Application
    Filed: October 26, 2023
    Publication date: February 29, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Patent number: 11912998
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: February 27, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Patent number: 11909050
    Abstract: An anode includes: (1) a current collector; and (2) an interfacial layer disposed over the current collector. The interfacial layer includes an ion-conductive organic network including anionic coordination units, organic linkers bonded through the anionic coordination units, and counterions dispersed in the ion-conductive organic network.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Zhiao Yu, Dawei Feng, Min Ah Lee, Yi Cui, Allen Pei
  • Patent number: 11905333
    Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Irving L. Weissman, Agnieszka Czechowicz, Deepta Bhattacharya, Daniel Kraft
  • Patent number: 11903969
    Abstract: Methods and compositions for modifying allogeneic donor ?? T cells for use in the treatment of high risk leukemias are provided.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew H. Porteus, Alice Bertaina, Volker Andreas Wiebking