Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 11411536
    Abstract: Exemplary aspects are directed to a power-amplification circuit including multiple in-parallel circuit paths, each including a power amplifier driving an immittance converter. Current from each output of the respective immittance converters is combined for delivery to a load. In a more specific example, a control circuit may be used to modulate, such as by enabling or disabling power delivered from, one or more of the power amplifiers for fast, coarse resetting of the overall power delivered to the load, and/or to modulate one or more of the modulate immittance converters (e.g., via a phase or signal-timing adjustment) to finely tune the resetting of the overall power delivered to the load. Using the control circuit for providing both the coarse adjustment and the fine adjustment, and fast acting precise delivery of overall power delivered to a load may be realized for any of a variety of applications.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kawin Surakitbovorn, Juan Rivas-Davila, Lei Gu
  • Patent number: 11408689
    Abstract: Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to facilitate thermally-generated electromagnetic emissions from the object and in mid-infrared (IR) wavelengths.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: August 9, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaswath Pattabhi Raman, Shanhui Fan, Eden Rephaeli
  • Publication number: 20220241591
    Abstract: Systems and methods for deep brain stimulation using kinematic feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including an implantable neurostimulator, a first inertial measurement unit (IMU), a second IMU, and a controller, where the controller is communicatively coupled to the implantable neurostimulator, the first IMU, and the second IMU, and where the controller is configured to obtain kinematic data from the first IMU and the second IMU, identify an abnormal movement event based on the kinematic data, and modify deep brain stimulation provided by the implantable neurostimulator based on the identified abnormal movement event.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 4, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior University, University of Washington
    Inventors: Helen Bronte-Stewart, Yasmine Kehnemouyi, Matthew Petrucci, Jeffrey Herron, Johanna O'Day
  • Publication number: 20220246995
    Abstract: Provided herein are rechargeable alkali metal batteries comprising: an anode including an alkali metal; a cathode; and an electrolyte to support reversible plating and stripping of the alkali metal at the anode, wherein the electrolyte includes alkali metal ions, chloroaluminate anions (AlClri), and an additive including imide anions.
    Type: Application
    Filed: July 2, 2020
    Publication date: August 4, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hongjie DAI, Hao SUN, Guanzhou ZHU, Yuanyao LI
  • Publication number: 20220241594
    Abstract: Systems and methods for deep brain stimulation using beta burst feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including a neurostimulator, and a controller, where the controller is communicatively coupled to the neurostimulator and configured to obtain a plurality of neural activity signals from the neurostimulator, identify beta bursts within each neural activity signal, classify identified beta bursts as pathological or normal, and modify stimulation provided by the neurostimulator based on the classified beta bursts.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 4, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior University, University of Washington
    Inventors: Helen Bronte-Stewart, Matthew Petrucci, Ross Anderson, Raumin Neuville, Jordan Parker, Jeffrey Herron
  • Patent number: 11400117
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides T cells that are modified (e.g., genetically and/or functionally) to maintain functionality under conditions in which unmodified T cells display exhaustion. Compositions and methods disclosed herein find use in preventing exhaustion of engineered (e.g., chimeric antigen receptor (CAR) T cells) as well as non-engineered T cells thereby enhancing T cell function (e.g., activity against cancer or infectious disease).
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 2, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Crystal Mackall, Rachel Lynn, Evan Weber, Elena Sotillo
  • Patent number: 11400133
    Abstract: Provided herein are compositions and methods for alleviating cancer or infection in a subject by administering a therapeutically effective amount of a pharmaceutical composition comprising an isolated PD-1 variant polypeptide. The PD-1 variant polypeptide can inhibit the activity of PD-1 by, for example, competitive or non-competitive inhibition of the interaction between wild-type PD-1 and one or more of its ligands, PD-L1 and PD-L2.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: August 2, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Amato J. Giaccia, Mihalis S. Kariolis, Todd A. Aguilera
  • Patent number: 11400164
    Abstract: The invention provides an immunoconjugate of formula: or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 25, and “Ab” is an antibody construct that has an antigen binding domain that binds HER2. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: August 2, 2022
    Assignees: Bolt Biotherapeutics, Inc., The Board of Trustees of The Leland Stanford Junior University
    Inventors: Shelley Erin Ackerman, Michael N. Alonso, David Y. Jackson, Arthur Lee, Edgar George Engleman
  • Patent number: 11401620
    Abstract: Systems and methods for manufacturing and processing microwires for use as microelectrodes are disclosed. The disclosed techniques provide methods for creating microelectrode bundles with different organizations and patterns. Systems and methods of the present disclosure also provide methods for electrochemically modifying bundles of microelectrode ends.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: August 2, 2022
    Assignees: PARADROMICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Yifan Kong, Matthew R. Angle, Mina-Elraheb Hanna, Abdulmalik Obaid, Nicholas Melosh
  • Patent number: 11401562
    Abstract: Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: August 2, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Iwijn de Vlaminck, Michael Kertesz, Kiran Kaur Khush, Mark Alec Kowarsky, Lance Martin, Stephen R. Quake, Hannah Valantine
  • Publication number: 20220233563
    Abstract: Methods of treatment based on a neoplasm's responsiveness to anthracycline are provided. Chromatin accessibility or expression levels of chromatin regulatory genes are used in some instances to determine whether a neoplasm will respond to anthracycline treatment. Anthracyclines are utilized to treat various individuals' neoplasms and cancers, as determined by their anthracycline responsiveness.
    Type: Application
    Filed: March 30, 2020
    Publication date: July 28, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Gerald R. Crabtree, Christina Curtis, Jose A. Seoane Fernandez, Jacob G. Kirkland
  • Patent number: 11397167
    Abstract: Measuring local speed of sound for ultrasound by inducing ultrasound waves in a subject by focusing an ultrasound beam, using an ultrasound Tx transducer to propagate waves from a focal point to the surface, measuring a time of arrival of the waves using at least three single Rx transducer surface elements, signal traces recorded on individual Rx transducers are evenly sampled in time, an average speed of sound equals an arithmetic mean of local sound-speed values sampled along a wave path, each Rx transducer outputs a separate arrival time of the waves, computing a local speed of sound (ci) of waves from an average speed of sound (cavg) using a computer that receives arrival times, where c avg = 1 N ? ? i = 1 N ? c i , where ci=di/Ts, di is the length a tissue traveled during one sampling period Ts, and using ci to differentiate human disease, or with ultrasound measurements to differentiate degrees of human disease.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: July 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jeremy Joseph Dahl, Scott S. Hsieh, Marko Jakovljevic
  • Patent number: 11398026
    Abstract: Systems and methods for synthetic medical image generation in accordance with embodiments of the invention are illustrated. One embodiment includes a synthetic medical image generation system, including a processor, and a memory containing an image synthesis application, where the image synthesis application directs the processor to obtain source image data generated by at least one medical imaging device, where the source image data describes a functional medical image taken of a patient administered with a first imaging agent, and synthesize a predicted medical image of the patient that depicts the patient as if they were administered with a second imaging agent, wherein the first imaging agent and the second imaging agent are different imaging agents.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: July 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sarah M. Hooper, Mirwais Wardak, Sanjiv S. Gambhir
  • Patent number: 11398627
    Abstract: In some implementations, a cathode is formed by (1) providing a cathode additive including (a) a matrix including a lithium compound, and (b) metal nanostructures embedded in the matrix; and (2) combining the cathode additive with a cathode active material to form a mixture. In other implementations, a cathode is formed by (1) providing a cathode additive including a compound of lithium and at least one non-metal or metalloid; and (2) combining the cathode additive with a cathode active material to form a mixture.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi Cui, Yongming Sun
  • Publication number: 20220226491
    Abstract: The invention provides an immunoconjugate of formula (I) or (II). Antibody-adjuvant immunoconjugates of the invention, comprising an antibody construct that has an antigen binding domain that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants, demonstrate superior pharmacological properties over conventional antibody conjugates. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 21, 2022
    Applicants: Bolt Biotherapeutics, Inc., The Board of Trustees of The Leland Stanford Junior University
    Inventors: Shelley Erin Ackerman, Michael N. Alonso, David Dornan, Justin Kenkel, Romas Kudirka, Arthur Lee, Brian Safina, Matthew Zhou, Edgar George Engleman
  • Publication number: 20220228221
    Abstract: Diagnostics and treatments based on a colorectal cancer's genetic aberrations are provided. Combinations of various genes harboring genetic aberrations are used to molecularly subtype patients and in some instances to determine a colorectal cancer's metastatic potential. In some instances, a of colorectal cancer having a particular set of genes harboring genetic aberrations is treated with a targeted therapy specific targeting the oncogenic genes.
    Type: Application
    Filed: June 17, 2020
    Publication date: July 21, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Christina Curtis
  • Publication number: 20220226492
    Abstract: The invention provides an immunoconjugate of formula (I) or (II). Antibody-adjuvant immunoconjugates of the invention, comprising an antibody construct that has an antigen binding domain that binds human epidermal growth factor receptor 2 (“HER2”) linked to one or more adjuvants, demonstrate superior pharmacological properties over conventional antibody conjugates. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 21, 2022
    Applicants: Bolt Biotherapeutics, Inc., The Board of Trustees of The Leland Stanford Junior University
    Inventors: Shelley Erin Ackerman, Michael N. Alonso, David Dornan, Romas Kudirka, Arthur Lee, Brian Safina, Matthew Zhou, Edgar George Engleman
  • Patent number: 11390918
    Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: July 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
  • Patent number: 11391866
    Abstract: High quality factor electromagnetic metasurfaces are provided. The metasurface is configured to have in plane guided-mode resonances (e.g., corresponding to waveguide modes or the like). Coupling features are included in the metasurface that are configured to couple free-space radiation to the guided mode resonances. The resulting structures have a high-Q response to free-space radiation and can be used for various applications, such as beam splitting, beam steering, and beam focusing or defocusing.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: July 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David Russell Barton, III, Mark Lawrence, Jennifer A. Dionne, Jefferson Dixon
  • Patent number: 11390684
    Abstract: The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: July 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Joseph A. Mollick, Pearline Teo, Paul J. Utz