Patents by Assignee The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 9765837
    Abstract: A variable stiffness spring is provided that includes a dielectric diaphragm having a biaxially pre-strained film, where the dielectric diaphragm includes an out-of-plane stiffness at zero voltage, a first electrode disposed on a first side of the dielectric diaphragm and a second electrode disposed on a second side of the dielectric diaphragm, where the out-of-plain stiffness is relaxed by an applied voltage between the first electrode and the second electrode.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: September 19, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjay K Dastoor, Mark R Cutkosky
  • Patent number: 9765143
    Abstract: Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, acute leukemia cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 19, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Siddhartha Jaiswal, Irving L. Weissman, Ravindra Majeti, Mark P. Chao
  • Patent number: 9765402
    Abstract: Combinations of reductive dehalogenase (rdh) genes are a distinguishing genomic feature of closely-related organohalogen-respiring bacteria. This feature can be used to deconvolute the population structure of organohalogen-respiring bacteria in complex environments and to identify relevant subpopulations, which is important for tracking interspecies dynamics needed for successful site remediation. The present disclosure encompasses embodiments of a nanoliter qPCR platform to identify organohalogen-respiring bacteria by quantitatively identifying major orthologous reductive dehalogenase gene groups.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: September 19, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Koshlan Mayer-Blackwell, Alfred M. Spormann
  • Patent number: 9763899
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. is topically applied to the surface of tissues during episodes of graft rejection.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 19, 2017
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans Affairs, The Johns Hopkins University
    Inventors: Mark R. Nicolls, Xinguo Jiang, Geoffrey C. Gurtner, Gregg L. Semenza, Jayakumar Rajadas
  • Patent number: 9766224
    Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: September 19, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
  • Patent number: 9759729
    Abstract: Necrotizing Enterocolitis (NEC) biomarkers, NEC biomarker panels, and methods for obtaining a NEC signature for a sample are provided. Also provided are methods, compositions, and kits for making a Necrotizing Enterocolitis (NEC) assessment of an individual, e.g. for diagnosing NEC in a patient, prognosing NEC in a patient, treating an NEC patient, etc. These methods find use in a number of applications, such as diagnosing and treating infants who are suspected of having NEC, intestinal perforation (IP), or sepsis.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: September 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl G. Sylvester, Guozhong Tao
  • Patent number: 9757587
    Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: September 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • Patent number: 9758392
    Abstract: A system combines complete, ultra-thin cells into a monolithic and robust framework necessary for desalination applications which yields orders of magnitude faster desalination. The electrode pairs are located so that a flow of feed water flows through or around the electrode pairs with the flow perpendicular to sequentially applied electric potentials. The system is controlled to charge the series of electrode pairs sequentially or phased. That means the charging of the second electrode pair is delayed with regard to the charging of the first electrode pair and the charging of a third electrode pair is delayed with respect to the charging of the second electrode pair.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: September 12, 2017
    Assignees: Lawrence Livermore National Security, LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael Stadermann, Yatian Qu, Juan G. Santiago, Ali Hemmatifar
  • Patent number: 9758589
    Abstract: Methods are provided to enhance the efficacy of antibody therapy directed to tumor cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: September 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Holbrook Kohrt, Roch Houot, Ronald Levy, Arash Ash Alizadeh, Matthew J. Goldstein, James Torchia
  • Publication number: 20170253644
    Abstract: The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.
    Type: Application
    Filed: May 1, 2017
    Publication date: September 7, 2017
    Applicants: VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of Michigan
    Inventors: Jan Steyaert, Els Pardon, Toon Laeremans, Brian Kobilka, Soren G.F. Rasmussen, Sebastien Granier, Roger K. Sunahara
  • Publication number: 20170252354
    Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.
    Type: Application
    Filed: April 26, 2017
    Publication date: September 7, 2017
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. Blau, Andrew Tri Van Ho, Adelaida R. Palla
  • Patent number: 9753007
    Abstract: A method and system are presented for fast and efficient isolation, purification and quantitation of nucleic acids from complex biological samples using isotachophoresis in microchannels. In an embodiment, a sieving medium may be used to enhance selectivity. In another embodiment, PCR-friendly chemistries are used to purify nucleic acids from complex biological samples and yield nucleic acids ready for further analysis including for PCR. In another embodiment, small RNAs from biological samples are extracted, isolated, preconcentrated and quantitated using on-chip ITP with a high efficiency sieving medium. The invention enables fast concentration and separation (takes 10s to 100s of seconds) of nucleic acids with high selectivity and using lower volumes of reagents (order of 10s of ?L to focus less than 1 ?g/?L of nucleic acid).
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: September 5, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Robert D. Chambers, Juan G. Santiago, Alexandre Persat, Reto B. Schoch, Mostafa Ronaghi
  • Patent number: 9753224
    Abstract: Methods are known for implementing general optical functions using wave splitters. However, these methods rely on these wave splitters having maximal extinction ratio, which is difficult to achieve in practice. The present invention provides methods for automatically adjusting wave splitters to provide maximal extinction ratio.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 5, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: David A. B. Miller
  • Patent number: 9752150
    Abstract: Methods and compositions are provided for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal. Aspects of the methods include inhibiting H2A deubiquitinating enzyme activity in cells, e.g. by administering an effective amount of an H2A deubiquitinating enzyme antagonist. Also provided are screens to identify therapeutics for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 5, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael F. Clarke, Maddalena Adorno
  • Publication number: 20170249547
    Abstract: Systems and methods in accordance with embodiments of the invention enable identifying informative features within input data using a neural network data structure. One embodiment includes a data structure describing a neural network that comprises a plurality of neurons; wherein the processor is configured by the feature application to: determine contributions of individual neurons to activation of a target neuron by comparing activations of a set of neurons to their reference values, where the contributions are computed by dynamically backpropagating an importance signal through the data structure describing the neural network; extracting aggregated features detected by the target neuron by: segmenting the determined contributions; clustering into clusters of similar segments; aggregating data to identify aggregated features of input data that contribute to the activation of the target neuron; and displaying aggregated features of input data to highlight important features.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 31, 2017
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Avanti Shrikumar, Peyton Greis Greenside, Anshul Kundaje
  • Patent number: 9744369
    Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: August 29, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ada Shuk Yan Poon, Alexander Jueshyan Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
  • Patent number: 9748581
    Abstract: A method of growing crystals on two-dimensional layered material is provided that includes reversibly hydrogenating a two-dimensional layered material, using a controlled radio-frequency hydrogen plasma, depositing Pt atoms on the reversibly hydrogenated two-dimensional layered material, using Atomic Layer Deposition (ALD), where the reversibly hydrogenated two-dimensional layered material promotes loss of methyl groups in an ALD Pt precursor, and forming Pt-O on the reversibly hydrogenated two-dimensional layered material, using combustion by O2, where the Pt-O is used for subsequent Pt half-cycles of the ALD process, where growth of Pt crystals occurs.
    Type: Grant
    Filed: February 28, 2015
    Date of Patent: August 29, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Georgi Diankov, Jihwan An, Joonsuk Park, David J. K. Goldhaber, Friedrich B. Prinz
  • Patent number: 9748421
    Abstract: A wafer-scale multiple carbon nanotube transfer process is provided. According to one embodiment of the invention, plasma exposure processes are performed at various stages of the fabrication process of a carbon nanotube device or article to improve feasibility and yield for successive transfers of nanotubes. In one such carbon nanotube transfer process, a carrier material is partially etched by a plasma process before removing the carrier material through, for example, a wet etch. By applying the subject plasma exposure processes, fabrication of ultra-high-density nanotubes and ultra-high-density nanotube grids or fabrics is facilitated. The ultra-high-density nanotubes and ultra-high-density nanotube grids or fabrics fabricated utilizing embodiments of the invention can be used, for example, to make high-performance carbon nanotube field effect transistors (CNFETs) and low cost, highly-transparent, and low-resistivity electrodes for solar cell and flat panel display applications.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: August 29, 2017
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Subhasish Mitra, Nishant P. Patil, Chung Chun Wan, H.-S. Philip Wong
  • Patent number: 9745590
    Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: August 29, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. Kay, Zhi-Ying Chen
  • Patent number: 9747633
    Abstract: A method and related computer program product for customizing price-related options for printing a compilation of works, including the steps of: compiling the compilation of works; setting different options for customers to print the compilation of works with different prices; and allowing a customer to change one or more of the options to print the compilation of works with a price based on the customer's needs and budget.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: August 29, 2017
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventors: Michael Genesereth, Frances Lee, Roland Vogl, Toshiro Fujimori, David Asao, Daniel Barber, Philip Wu