Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20230307102
    Abstract: Systems and methods for automated identification of STEMI in accordance with embodiments of the invention are illustrated. One embodiment includes a predictive electronic health record (EHR) system, including a processor, and a memory, the memory containing an EHR management application which configures the processor to obtain preliminary information about a patient via a terminal, store the preliminary information in an EHR, provide the preliminary information to a model trained to predict an emergency medical condition requiring immediate treatment, obtain a likelihood that the patient is suffering from an emergency medical condition from the machine learning model, and provide an alert when the likelihood exceeds a predetermined threshold. In many embodiments, the condition is STEMI, and the preliminary information comprises: age, sex, and at least one chief complaint.
    Type: Application
    Filed: March 28, 2023
    Publication date: September 28, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Maame Yaa A. B. Yiadom
  • Publication number: 20230306303
    Abstract: Systems and methods for crowdsourced machine learning in accordance with embodiments of the invention are illustrated. In many embodiments, particular crowdworkers from a plurality of crowdworkers who are able to perform with high accuracy and reliability (referred to herein as “super recognizers”) are identified and used to generate training data for machine learning models. In various embodiments, super recognizers are identified by providing a request to answer questions regarding a particular type of input to the plurality of crowdworkers and providing received answers to a machine learning model trained using expert-annotated inputs similar to the inputs provided to the crowdworkers.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 28, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dennis Paul Wall, Peter Yigitcan Washington
  • Publication number: 20230298758
    Abstract: Methods to compute gestational age and gestational health and applications thereof are described. Generally, systems utilize analyte measurements to determine a gestational age and gestational health, which can be used as a basis to perform interventions and treat individuals.
    Type: Application
    Filed: November 8, 2021
    Publication date: September 21, 2023
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Statens Serum Institut, The Regents of the University of California
    Inventors: Liang Liang, Michael P. Snyder, Mads Melbye, Songjie Chen, Larry Rand, Laura Jelliffe-Pawlowski, Xiaotao Shen
  • Publication number: 20230288398
    Abstract: Methods to compute gestational age and applications thereof are described. Generally, systems utilize analyte measurements derived from a urine sample to determine a gestational age, which can be used as a basis to perform interventions and treat individuals.
    Type: Application
    Filed: November 8, 2021
    Publication date: September 14, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kevin Contrepois, Michael P. Snyder, Songjie Chen, Nima Aghaeepour, Mohammad Sajjad Ghaemi
  • Publication number: 20230287503
    Abstract: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.
    Type: Application
    Filed: April 26, 2023
    Publication date: September 14, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen QUAKE, Hei-Mun Christina FAN
  • Publication number: 20230277967
    Abstract: Described here is an air filter comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter a removal efficiency for PM2.5 of at least 70% when a light transmittance is below 50%. Also described here is an electric air filter comprising a first layer adapted to receive a first electric voltage, wherein the first layer comprises an organic fiber coated with a conductive material. Further described is an air filter for high temperature filtration, comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter has a removal efficiency for PM2.5 of at least 70% at a temperature of a least 70° C.
    Type: Application
    Filed: December 20, 2022
    Publication date: September 7, 2023
    Applicant: Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi Cui, Rufan Zhang, Chong Liu, Po-Chun Hsu, Steven Chu
  • Publication number: 20230277646
    Abstract: Provided herein, inter alia, are complexes comprising nanoparticles attached to viral proteins or nucleic acids encoding said viral proteins. Methods for making and using said complexes are provided. Compositions including the complexes are contemplated to be useful for treating and/or preventing viral infections.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tarik F. MASSOUD, Ramasamy PAULMURUGAN, Uday SUKUMAR
  • Publication number: 20230277049
    Abstract: Endoscope systems with detachable scopes in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an endoscope system comprises an endoscope body and a detachable scope. The endoscope body comprises a cable capable of transmitting image data to a computing system, and a body connector. The detachable scope comprises a scope connector configured to couple with the body connector, and a tip, comprising an illumination module and an image sensor, wherein image data produced by the image sensor is transmitted to the endoscope body via the scope connector.
    Type: Application
    Filed: March 6, 2023
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Anna Sophie von Wendorff
  • Publication number: 20230281465
    Abstract: Systems and methods for spatial graph convolutions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting characteristics for molecules, wherein the method includes performing a first set of graph convolutions with a spatial graph representation of a set of molecules, wherein the first set of graph convolutions are based on bonds between the set of molecules, performing a second set of graph convolutions with the spatial graph representation, wherein the second set of graph convolutions are based on at least a distance between each atom and other atoms of the set of molecules, performing a graph gather with the spatial graph representation to produce a feature vector, and predicting a set of one or more characteristics for the set of molecules based on the feature vector.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Evan Nathaniel Feinberg, Vijay Satyanand Pande, Bharath Ramsundar
  • Publication number: 20230272465
    Abstract: Turning now to the drawings, systems and methods to enhance RNA transcription in a cost-effective manner and uses thereof are provided. One of the most common enzymes for RNA transcription is T7 RNA polymerase. Many embodiments increase RNA yield in transcription reactions by adding ribonucleoside vanadyl complex (VRC) to the transcription reaction. Various embodiments use VRC at low concentrations in an RNA transcription reaction. Reactions in accordance with many embodiments are capable of increasing RNA yield by approximately 2-fold or more.
    Type: Application
    Filed: July 13, 2021
    Publication date: August 31, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eesha Sharma, Ivan Zheludev
  • Publication number: 20230265440
    Abstract: The present disclosure provides methods and compositions for treating lysosomal storage disorders in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating therapeutic transgenes into the CCR5 locus.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 24, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Natalia Gomez-Ospina, Matthew H. Porteus, Samantha Glynne Scharenberg, Alvaro Amorin
  • Publication number: 20230267284
    Abstract: Systems and methods for automated response to natural language instructions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training an agent, the method including sampling an instruction and observation pair from a dataset, predicting a skill code, using a skill predictor, based on the instruction and observation pair, predicting, for each of a plurality of timesteps, a set of one or more actions based on the predicted skill code and a state history using a policy, and updating the skill predictor and the policy based on a comparison of the predicted set of actions and the observation. In many embodiments, the trained agent can then be used to carry out natural language instructions.
    Type: Application
    Filed: February 22, 2023
    Publication date: August 24, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Divyansh Garg, Skanda Vaidyanath
  • Publication number: 20230250485
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Application
    Filed: February 10, 2023
    Publication date: August 10, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Publication number: 20230242980
    Abstract: Processes and materials to protect nucleic acid molecules are described. Processes and materials to detect neoplasms from a biopsy are described. Processes and materials to build a sequencing library are described. Cell-free nucleic acids can be sequenced and the sequencing result can be utilized to detect sequences derived from a neoplasm.
    Type: Application
    Filed: August 24, 2022
    Publication date: August 3, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Maximilian Diehn, Arash Ash Alizadeh, Jacob J. Chabon, David M. Kurtz
  • Publication number: 20230245713
    Abstract: Embodiments herein describe systems and methods to predict biomolecule-ligand complexes and uses thereof. Many embodiments generate candidate poses and docking scores for ligands known to interact with a target protein as well as a candidate ligand. Based on similarities present in the candidate poses and docking scores, a pose for the candidate ligand is identified. Many embodiments determine whether a candidate ligand can bind to a target and, if so, determine an affinity. Many embodiments can be used for virtual screening or lead optimization.
    Type: Application
    Filed: May 27, 2021
    Publication date: August 3, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ron O. Dror, Joseph M. Paggi
  • Publication number: 20230235324
    Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.
    Type: Application
    Filed: July 22, 2022
    Publication date: July 27, 2023
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Intima Bioscience, Inc.
    Inventors: LEI S QI, Modassir S. Choudhry, Xueqiu Lin, Xiaoshu Xu
  • Publication number: 20230226696
    Abstract: Methods and systems to remotely operate robotic devices are provided. A number of embodiments allow users to remotely operate robotic devices using generalized consumer devices (e.g., cell phones). Additional embodiments provide for a platform to allow communication between consumer devices and the robotic devices. Further embodiments allow for training robotic devices to operate autonomously by training the robotic device with machine learning algorithms using data collected from scalable methods of controlling robotic devices.
    Type: Application
    Filed: November 2, 2020
    Publication date: July 20, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ajay U. Mandlekar, Yuke Zhu, Animesh Garg, Silvio Savarese, Fei-Fei Li
  • Publication number: 20230230657
    Abstract: Systems and methods of storing and retrieving K-mer data in a data structure are provided. In certain embodiments, the K-mer data is stored as an integer value that defines an address of a slot in the data structure. In many embodiments, each slot in the data structure stores the remaining portion of the K-mer that is not part of the prefix. Additional embodiments are directed to genetic or genomic analysis using a data structure for storing K-mer data.
    Type: Application
    Filed: September 21, 2020
    Publication date: July 20, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: HoJoon Lee, Hanlee P. Ji, Tsachy Weissman, Dmitri Pavlichin
  • Publication number: 20230225696
    Abstract: Systems and methods for non-invasively estimating right ventricular pressure are provided. Tricuspid regurgitation echocardiography Doppler signals can be acquired utilizing sonography. Digitization and interpolation of the tricuspid regurgitation Doppler signals can be utilized to estimate tricuspid regurgitation and right ventricular pressure and/or provide a metric for signal quality (quality control) as well as increase confidence in the right ventricular pressure estimates.
    Type: Application
    Filed: January 6, 2023
    Publication date: July 20, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Seraina Dual, Francois Haddad, Alison Marsden, Constance M. Verdonk, Myriam Amsallem
  • Publication number: 20230218749
    Abstract: Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
    Type: Application
    Filed: August 19, 2022
    Publication date: July 13, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Kari C. Nadeau