Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20200251178
    Abstract: High throughput sequencing has facilitated a precipitous drop in the cost of whole genome human DNA sequencing, prompting predictions of a revolution in medicine via personalization of diagnostic and therapeutic strategies to individual genetics. Disclosed is a comprehensive series of methods for identification of genetic variants and medical genotypes, phasing genetic data and using Mendelian inheritance for quality control, and providing predictive genetic information about risk for rare disease phenotypes and response to pharmacological therapy in single individuals and father-mother-child trios.
    Type: Application
    Filed: February 3, 2020
    Publication date: August 6, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Frederick Dewey, Euan A. Ashley, James Priest, Megan Grove
  • Patent number: 10729816
    Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 4, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yunzhi Yang, Stuart B. Goodman, Yaser Shanjani
  • Patent number: 10729534
    Abstract: Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: August 4, 2020
    Assignees: The Board of Trustees of the Leland Stanford Junior University, United States Government as represented by the Department of Veterans Affairs
    Inventors: James Chang, Colin Woon, Hung Pham
  • Patent number: 10732108
    Abstract: Water soluble fluorogenic sensors for detecting a hydrazine analyte are provided. Aspects of the fluorogenic sensors include at least one water soluble group and a hydrazine reactive group. Methods of evaluating a sample for the presence of a hydrazine analyte and methods of detecting hydrazine diffusion across a phospholipid membrane are provided. Kits for practicing the subject methods are also provided.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: August 4, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noah Burns, Steven R. Shuken
  • Publication number: 20200241353
    Abstract: Provided are a grating device, a screen including the grating device, a method of manufacturing the screen, and a display apparatus including the screen. The grating device includes a transparent substrate and a diffraction grating arranged on the transparent substrate, the diffraction grating includes a plurality of meta-diffraction patterns, and each meta-diffraction pattern has a curved shape with a center of curvature provided in a direction parallel to the substrate. The screen includes a first polarizer, a second polarizer arranged next to the first polarizer, and a diffraction grating that is transparent to polarized light that has passed through the second polarizer and reflects polarized light having a polarization direction perpendicular to the polarized light, wherein the diffraction grating includes a plurality of meta-diffraction patterns, each meta-diffraction pattern having a curved shape with a center of curvature positioned in a travelling direction of incident light.
    Type: Application
    Filed: January 30, 2020
    Publication date: July 30, 2020
    Applicants: SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Sunghoon LEE, Mark L. BRONGERSMA, Brandon BORN
  • Publication number: 20200243912
    Abstract: An electrochemical device includes: (1) a compartment; (2) a container including a liquid reactant; and (3) a conveyance mechanism fluidly connected to the container and the compartment and configured to convey the liquid reactant from the container into the compartment, wherein the liquid reactant is a eutectic mixture of two or more different redox-active substances.
    Type: Application
    Filed: January 24, 2020
    Publication date: July 30, 2020
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Antonio BACLIG, William C. CHUEH, Andrey POLETAYEV, Victoria NG, Devi GANAPATHI, Emily PENN
  • Patent number: 10722174
    Abstract: Various aspects as described herein are directed to skin-conformal sensor devices and methods of using the same. As consistent with one or more embodiments, a sensor device includes an upper portion and lower portion. The upper portion includes a plurality of layers including at least one sensor. The lower portion includes a layer of microstructures configured and arranged to interface with skin of a subject and to interlock the skin with the at least one sensor.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: July 28, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Changhyun Pang, Zhenan Bao
  • Patent number: 10725290
    Abstract: Various embodiments are directed to an apparatus and methods of forming and/or using an apparatus comprising a plurality of device components. An example method includes geometrically optimizing a periodic or aperiodic device comprising a plurality of device components by optimizing a topology, for each device component, from a starting point to have particular optical properties for a particular optical response. Each device component includes a plurality of geometric structures. The optimization includes selecting the starting point for a continuous profile to have the particular optical properties for the particular optical response, iteratively converging the continuous profile to a discrete profile, and, while iteratively converging to the discrete profile, adjusting edges between boundaries of the device components by accounting for fabrication constraints.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: July 28, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jonathan A. Fan, David Sell, Jianji Yang
  • Patent number: 10725133
    Abstract: A method for generating a magnetic resonance image of an object in a magnetic resonance imaging (MRI) system, wherein the object contains at least one metallic implant is provided. The MRI system provides multiple excitations of at least part of the object. The MRI system reads out image signals from the object. The MRI system saves the readout image signals as image data. A field-map is generated from the image data using a goodness-of-fit process which uses a goodness-of-fit metric, matched-filter, and/or similar fitting techniques to fit expected signals from each excitation to the image data.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: July 28, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brady J. Quist, Brian A. Hargreaves
  • Patent number: 10723803
    Abstract: Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRP? on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: July 28, 2020
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America, as represented by the Secretary, Department of Health and Human Services, The Regents of the University of California
    Inventors: Kipp Andrew Weiskopf, Kim J. Hasenkrug, Cheryl A. Stoddart, Joseph McCrary McCune, Irving L. Weissman
  • Patent number: 10722718
    Abstract: A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: July 28, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Douglas Michael Ackermann, Daniel Palanker, James Donald Loudin, Garrett Cale Smith, Victor Wayne McCray, Brandon McNary Felkins
  • Patent number: 10718010
    Abstract: Provided herein is a method of sequencing hydroxymethyated cell-free DNA. In some embodiments, the method comprises adding an affinity tag to only hydroxymethyated DNA molecules in a sample of cfDNA, enriching for the DNA molecules that are tagged with the affinity tag; and sequencing the enriched DNA molecules.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: July 21, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Chunxiao Song, Stephen R. Quake
  • Patent number: 10716867
    Abstract: A composition includes a plurality of gold nanoparticles each having at least one surface. The gold nanoparticles have an average length of at least about 90 nm and an average width of at least about 25 nm.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 21, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Adam De La Zerda, Orly Liba, Elliott Sorelle, Bryan Knysh
  • Publication number: 20200227166
    Abstract: Methods to compute glycemia tests and applications thereof are described. Additional methods to compute risk of atherosclerotic cardiovascular disease and applications thereof are described. Generally, systems utilize analyte measurements to determine a glycemic status or cardiovascular disease risk, which can be used as a basis to treat individuals.
    Type: Application
    Filed: October 18, 2019
    Publication date: July 16, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sophia Miryam Schüssler-Fiorenza Rose, Kevin Contrepois, Wenyu Zhou, Samson Mataraso, Tejaswini Mishra, Michael Snyder, Kegan Moneghetti, Francois Haddad
  • Patent number: 10709400
    Abstract: A non-invasive method to predict post-surgery vascular graft failure is provided. Computer Tomography Angiography (CTA) images are obtained of a patient post-surgery. A personalized three-dimensional computer model of the patient is derived from the obtained CTA images. The personalized three-dimensional computer model distinguishes a Computational Fluid Dynamics (CFD) model coupled with a closed-loop Lumped Parameter Network (LPN). Post-surgery vascular graft predictors are calculated from the personalized three-dimensional computer model indicative, i.e. predictors, of the post-surgery vascular graft failure or vascular stenosis.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: July 14, 2020
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Muhammad Owais Khan, Andrew M. Kahn, Alison L. Marsden
  • Patent number: 10709481
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: July 14, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventor: Daniel H. Kim
  • Patent number: 10711242
    Abstract: According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: July 14, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Albrecht Stroh, M. Bret Schneider, Raag D. Airan
  • Patent number: 10712277
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes), methods of using Raman agents and Raman imaging devices to image or detect a signal, and the like.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: July 14, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjiv Sam Gambhir, Cristina Zavaleta
  • Patent number: 10712416
    Abstract: Various methods and systems are provided for reconstructing magnetic resonance images from accelerated magnetic resonance imaging (MRI) data. In one embodiment, a method for reconstructing a magnetic resonance (MR) image includes: estimating multiple sets of coil sensitivity maps from undersampled k-space data, the undersampled k-space data acquired by a multi-coil radio frequency (RF) receiver array; reconstructing multiple initial images using the undersampled k-space data and the estimated multiple sets of coil sensitivity maps; iteratively reconstructing, with a trained deep neural network, multiple images by using the initial images and the multiple sets of coil sensitivity maps to generate multiple final images, each of the multiple images corresponding to a different set of the multiple sets of sensitivity maps; and combining the multiple final images output from the trained deep neural network to generate the MR image.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: July 14, 2020
    Assignees: GE PRECISION HEALTHCARE, LLC, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Christopher Michael Sandino, Peng Lai, Shreyas Vasanawala, Joseph Yitan Cheng
  • Patent number: 10710971
    Abstract: A method for synthesizing a dicarboxylate containing an aromatic heterocycle is provided. A carboxylic acid containing a heterocycle is provided. A CO32? salt is provided to form a mixture, which converts the carboxylic acid containing an aromatic heterocycle to a carboxylate containing an aromatic heterocycle. CO2 gas is provided to the mixture. The mixture is heated to a temperature to at least partially melt the carboxylate containing an aromatic heterocycle.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: July 14, 2020
    Assignee: The Board of the Trustees of the Leland Stanford Junior University
    Inventors: Matthew W. Kanan, Aanindeeta Banerjee