Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 11073511
    Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 27, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Fei Liu, Utkan Demirci, Sanjiv Sam Gambhir, Viswam S. Nair
  • Patent number: 11072655
    Abstract: Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: July 27, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ravindra Majeti, Irving L. Weissman, Siddhartha Jaiswal, Mark P. Chao
  • Patent number: 11074438
    Abstract: A method for predicting spatial positions of several key points on a human body in the near future in an egocentric setting is described. The method includes generating a frame-level supervision for human poses. The method also includes suppressing noise and filling missing joints of the human body using a pose completion module. The method further includes splitting the poses into a global stream and a local stream. Furthermore, the method includes combining the global stream and the local stream to forecast future human locomotion.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: July 27, 2021
    Assignees: TOYOTA RESEARCH INSTITUTE, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Karttikeya Mangalam, Ehsan Adeli-Mosabbeb, Kuan-Hui Lee, Adrien Gaidon, Juan Carlos Niebles Duque
  • Publication number: 20210217578
    Abstract: Improved aberration correction in multipass electron microscopy is provided by having Fourier images of the sample (instead of real images) at the reflection planes of the resonator. The resulting ?1 magnification of the sample reimaging can be compensated by appropriate sample placement or by adding compensating elements to the resonator. This enables simultaneous correction of lowest order chromatic and spherical aberration from the electron objective lenses. If real images of the sample are at the reflection planes of the resonator instead, only the lowest order chromatic aberration can be corrected.
    Type: Application
    Filed: May 28, 2019
    Publication date: July 15, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. KASEVICH, Stewart A. KOPPELL, Brannon KLOPFER, Thomas JUFFMANN, Marian MANKOS
  • Patent number: 11058371
    Abstract: A method of PET image reconstruction is provided that includes obtaining intra-patient tissue activity distribution and photon attenuation map data using a PET/MRI scanner, and implementing a Maximum Likelihood Expectation Maximization (MLEM) method in conjunction with a specific set of latent random variables, using an appropriately programmed computer and graphics processing unit, wherein the set of latent random variables comprises the numbers of photon pairs emitted from an electron-positron annihilation inside a voxel that arrive into two given voxels along a Line of Response (LOR), where the set of latent random variables results in a separable joint emission activity and a photon attenuation distribution likelihood function.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: July 13, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Alexander Mihlin, Craig S. Levin
  • Patent number: 11062490
    Abstract: A magnetic resonance imaging scan performs an MRI acquisition using an undersampling pattern to produce undersampled k-space data; adds the undersampled k-space data to aggregate undersampled k-space data for the scan; reconstructs an image from the aggregate undersampled k-space data; updates the undersampling pattern from the reconstructed image and aggregate undersampled k-space data using a deep reinforcement learning technique defined by an environment, reward, and agent, where the environment comprises an MRI reconstruction technique, where the reward comprises an image quality metric, and where the agent comprises a deep convolutional neural network and fully connected layers; and repeats these steps to produce a final reconstructed MRI image for the scan.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: July 13, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David Y. Zeng, Shreyas S. Vasanawala, Joseph Yitan Cheng
  • Publication number: 20210205042
    Abstract: A device for manipulating tissue at a vessel includes an elongated member having a proximal end and a distal end, a guide member at the distal end of the elongated member, the guide member having a blunt distal tip for engagement against an interior wall of the vessel, and a tissue cutting device at the distal end of the elongated member, wherein the tissue cutting device has a sharp tip that is proximal to the blunt distal tip of the guide member.
    Type: Application
    Filed: December 14, 2020
    Publication date: July 8, 2021
    Applicant: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Fletcher T. Wilson, Rhunjay James Yu
  • Patent number: 11053390
    Abstract: Various embodiments are directed to apparatuses and methods involving an elastomer material comprising a flexible polymer backbone with a particular ratio of at least first moieties and second moieties. The first moieties provide a first number of dynamic bonds resulting from interactions between the first moieties and the second moieties provide a second number of dynamic bonds resulting from interactions between the second moieties, the second number of dynamic bonds having a weaker bonding strength than the first number of dynamic bonds. The elastomer material, based on the ratio of the first moieties and second moieties, exhibits autonomous self-healing, a particular toughness, and is stretchable.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: July 6, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Jiheong Kang, Donghee Son
  • Patent number: 11046763
    Abstract: Methods are provided for treatment of lung cancers, particularly small cell lung cancer with targeted therapy, which optionally includes an agent that selectively blocks CD47 binding to SIRP?.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: June 29, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Kipp Andrew Weiskopf, Julien Sage, Irving L. Weissman
  • Patent number: 11045150
    Abstract: A digital processor system having one or more processors and memory obtains a time-domain signal representing brain activity, the time-domain signal having a time varying signal value. The system concurrently generates a set of acoustic parameters, including a plurality of time-varying acoustic parameters, where one or more of the plurality of time-varying acoustic parameters is modulated in accordance with at least the signal value of the time-domain signal. The system combines the concurrently generated set of acoustic parameters to produce a representation of an acoustic signal corresponding to the time-domain signal, where the acoustic signal, in audible form, manifests one or more audibly discernible variations across a plurality of stages of a brain activity event.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: June 29, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christopher D. Chafe, Josef Parvizi
  • Patent number: 11048990
    Abstract: One example is directed to a reader device having a first resonance circuit and being configured to interrogate one or more other remotely-located resonance circuits, each associated with a second resonance circuit which may be part of a passive sensor circuit. The first resonance circuit is operated to cause the inductively-coupled oscillating signal to be swept over a range of frequencies and therein cause a jump or sudden transition in a frequency of the oscillating signal while the first and second resonance circuits are in sufficient proximity for inductively-coupling via an oscillating signal via their respective resonance circuits. Sensing circuitry may be used to detect the jump or sudden transition in the frequency of the oscillating signal and, by way of or in response to an indication of timing and/or a set of inductively-related parameters, data is conveyed from the sensor to the reader device via the inductively-coupled oscillating signal.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: June 29, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Siavash Kananian, Ada Poon, Simiao Niu, Zhenan Bao, Naoji Matsuhisa, George Alexopoulos
  • Publication number: 20210187115
    Abstract: The invention provides an immunoconjugate of formula: (I), or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 50, “Adj” is an adjuvant moiety, and “Ab” is an antibody construct that has an antigen binding domain that binds EGFR. The invention also provides compositions comprising the immunoconjugate. The invention further provides methods of treating cancer with the immunoconjugate.
    Type: Application
    Filed: August 29, 2019
    Publication date: June 24, 2021
    Applicants: Bolt Biotherapeutics, Inc., The Board of Trustees of The Leland Stanford Junior University
    Inventors: Michael N. Alonso, Edgar George Engleman, David Y. Jackson, Arthur Lee, Shelley Erin Ackerman
  • Publication number: 20210194096
    Abstract: Embodiments of this disclosure include fuel cells, e.g., comprising an anode; a cathode; and an ion conducting membrane disposed between the anode and the cathode, wherein the anode includes an anode catalyst layer including an ionic compound of a base metal, which is a non-precious metal, and a non-metal, which is not oxygen. Further embodiments include methods of hypophosphite oxidation, e.g.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Adam Christopher Nielander, Thomas Francisco Jaramillo, Laurie A. King, Joel Sanchez
  • Publication number: 20210192342
    Abstract: Systems and methods for training photonic neural networks in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a set of one or more optical interference units (OIUs) of a photonic artificial neural network (ANN), wherein the method includes calculating a loss for an original input to the photonic ANN, computing an adjoint input based on the calculated loss, measuring intensities for a set of one or more phase shifters in the set of OIUs when the computed adjoint input and the original input are interfered with each other within the set of OIUs, computing a gradient from the measured intensities, and tuning phase shifters of the OIU based on the computed gradient.
    Type: Application
    Filed: May 10, 2019
    Publication date: June 24, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tyler William Hughes, Momchil Minkov, Ian Williamson, Shanhui Fan
  • Patent number: 11041868
    Abstract: Provided herein are several methods for selecting agents that bind to transmembrane receptors in a conformationally-selective way. In some embodiments, the method may comprise producing: a transmembrane receptor in an active conformation; and said transmembrane receptor in an inactive conformation and using cell sorting to select, from a population of cells comprising a library of cell surface-tethered extracellular capture agents, cells that are specifically bound to either the transmembrane receptor in its active conformation or the transmembrane receptor in its inactive conformation, but not both. In other embodiments, the method may comprise: contacting a GPCR with a population of cells that comprise a library of surface-tethered extracellular proteins; labeling the cell population with a conformationally-specific binding agent, e.g., a G-protein or mimetic thereof; and using cell sorting to select from the cell population cells that bind to the agent.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: June 22, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Aaron Michael Ring, Aashish Manglik, Andrew Kruse, Brian K. Kobilka
  • Patent number: 11040067
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: June 22, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • Publication number: 20210178189
    Abstract: Methods of beam angle optimization for intensity modulated radiotherapy (IMRT) treatment include determining beam's eye view (BEV) regions and a BEV region connectivity manifold by evaluating dose response of each region of interest for each vertex in a delivery coordinate space (DCS). The information contained in the BEV regions and the BEV region connectivity manifold is used to guide an optimizer to find optimal field geometries in the IMRT treatment. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicants: Varian Medical Systems International AG, The Board of Trustees of the Leland Stanford Junior University, Office of the General Counsel
    Inventors: Christopher Barry Locke, Santtu Ollila, Karl Kenneth Bush
  • Publication number: 20210178188
    Abstract: Methods of treatment trajectory optimization for radiotherapy treatment of multiple targets include determining beam's eye view (BEV) regions and a BEV region connectivity manifold for each target group of a plurality of target groups separately. The information contained in the BEV regions and the BEV region connectivity manifolds for all target groups is used to guide an optimizer to find optimal treatment trajectories. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicants: Varian Medical Systems International AG, The Board of Trustees of the Leland Stanford Junior University, Office of the General Counsel
    Inventors: Christopher Barry Locke, Santtu Ollila, Karl Kenneth Bush
  • Publication number: 20210177899
    Abstract: Methods and compositions for modifying allogeneic donor ?? T cells for use in the treatment of high risk leukemias are provided.
    Type: Application
    Filed: November 13, 2020
    Publication date: June 17, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew H. Porteus, Alice Bertaina, Volker Andreas Wiebking
  • Patent number: 11036299
    Abstract: A device to simulate kinesthetic pad opposition grip forces and weight for grasping virtual objects in a virtual reality is provided. The device includes a base, a sliding part, a braking mechanism and a swinging part with linear resonant actuators (e.g. voice coil actuators). The sliding part is connected with the base through a first prismatic joint which allows for single degree of freedom pinching motions for grasping an object. The swinging part connected to the sliding part and the base through revolute joints. The brake mechanism is used to create a grasping force. The linear resonant actuators provide both touch sensation at initial contact and sensation of weight when lifting the object.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: June 15, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Inrak Choi, Sean Follmer, Heather Culbertson