Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20190216342
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Publication number: 20190217113
    Abstract: Systems and methods for treatment of neurological conditions using implantable neurostimulators in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating neurological conditions, including obtaining image data of a patient's brain, where the image data describes neuronal activations within the patient's brain, determining a location on the patient's brain to implant a neurostimulator, and surgically implanting a neurostimulator at the location, and applying a stimulation protocol to the brain at the location using the neurostimulator to treat the neurological condition. An additional embodiment includes an implantable neurostimulator configured to apply an aTBS protocol to a patient's brain.
    Type: Application
    Filed: December 10, 2018
    Publication date: July 18, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Publication number: 20190217112
    Abstract: Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, were brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.
    Type: Application
    Filed: December 10, 2018
    Publication date: July 18, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Publication number: 20190217116
    Abstract: Systems and methods for treatment of neurological conditions using aTBS in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating neurological conditions, including generating a personalized accelerated theta burst stimulation (aTBS) target representing a location in a patient's brain related to a neurological condition, placing a TMS device relative to the patient's brain such that the focus of the magnetic field is over the aTBS target, applying TMS to the aTBS target according to an aTBS protocol to the brain using the TMS device to alleviate the neurological condition.
    Type: Application
    Filed: December 10, 2018
    Publication date: July 18, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Patent number: 10354202
    Abstract: An algorithm according to an embodiment of the present invention provides for latent signal detection of adverse events. Embodiments infer the presence of adverse drug events from large observational databases housed by the FDA, WHO, and other governmental organizations. The disclosed algorithms do not require the adverse event to be reported explicitly. Instead, the algorithms infer the presence of adverse events through more common secondary effects. In an embodiment, machine learning techniques are used for this purpose.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: July 16, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nicholas Tatonetti, Russ B. Altman, Guy Haskin Fernald
  • Patent number: 10354050
    Abstract: A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: July 16, 2019
    Assignee: THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Charles A. Taylor, Hyun Jin Kim, Jessica S. Coogan
  • Patent number: 10350430
    Abstract: Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: July 16, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • Patent number: 10342608
    Abstract: An ablation therapy system is disclosed comprising an ablation catheter system for treating atrial fibrillation (AF). The ablation catheter system comprises a catheter body including a lumen for receiving a visualization catheter, an ablation element for ablating tissue in a patient's heart having abnormal electrical activity, a support assembly for supporting the ablation element, the support assembly being supported by the catheter assembly. The support assembly includes a lumen to receive the visualization catheter, wherein the support assembly is configured to rotate and/or pivot with respect to the catheter body.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 9, 2019
    Assignee: The Board Of Trustees Of The Leland Stanford Junior University
    Inventors: Paul Wang, Bryant Lin, Matthew Siljander
  • Patent number: 10347359
    Abstract: With the advent of low cost, high-throughput whole genome sequencing (“next generation sequencing”), tools are available to assay human genetic variation contributing to inherited disease syndromes. A method is disclosed for prioritization of genetic variants, and identification of disease genes, using network modeling of gene associations.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: July 9, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Frederick E. Dewey, Euan A. Ashley
  • Patent number: 10344332
    Abstract: Biomarkers and methods of using them for aiding diagnosis, prognosis, and treatment of critically ill patients are disclosed. In particular, the invention relates to the use of biomarkers for prognosis of mortality in critically ill patients with sepsis, severe trauma, or burns.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: July 9, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Purvesh Khatri, Timothy E. Sweeney
  • Patent number: 10344094
    Abstract: Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: July 9, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Irving L. Weissman, Stephen Willingham, Doris Po Yi Ho, Piero D. Dalerba, Kelly Marie McKenna, Jens-Peter Volkmer
  • Publication number: 20190201657
    Abstract: A device for stimulation of a patient with acoustic stimulation signals includes a stimulation unit for generating acoustic stimulation signals and a control unit for controlling the stimulation unit. The control unit is configured so that it determines a bandwidth of an auditory filter with a frequency of a predetermined tone as a center frequency, wherein this bandwidth is a reference bandwidth. The control unit determines a frequency of a first acoustic therapy signal such that a measure of coverage between the reference bandwidth around the frequency of the predetermined tone and a first bandwidth of an auditory filter with the frequency of the first acoustic therapy signal as a center frequency assumes a predetermined first value, and controls the stimulation unit such that the stimulation unit generates the first acoustic therapy signal.
    Type: Application
    Filed: July 20, 2017
    Publication date: July 4, 2019
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Forschungszentrum Jülich GmbH
    Inventors: Gerald R. POPELKA, Peter Alexander TASS
  • Publication number: 20190207274
    Abstract: A method of battery state monitoring includes: (1) providing a battery cell and at least one ultrasonic actuator and at least one ultrasonic sensor mounted to the battery cell; (2) using the ultrasonic actuator, generating a guided wave that propagates in-plane of the battery cell; (3) using the ultrasonic sensor, receiving an arriving wave corresponding to the guided wave; and (4) determining a state of the battery cell based on the arriving wave.
    Type: Application
    Filed: June 21, 2017
    Publication date: July 4, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Purim LADPLI, Fu-Kuo CHANG
  • Patent number: 10339653
    Abstract: An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological image record including the quantitative features, imaging parameters of the radiological image and clinical parameters and storing the radiological image record in a data structure containing a plurality of radiological image records. In addition, the method includes receiving a request with the patient's radiological image or information related thereto, analyzing the data structure to determine a statistical relationship between the request and the radiological image records and generating a patient report with a diagnosis, a prognosis or a recommended treatment regimen for the patient's disease based on a result of analyzing the data structure.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 2, 2019
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Stichting Maastricht Radiation Oncology ‘Maastro Clinic’
    Inventors: Robert J. Gillies, Steven A. Eschrich, Robert A. Gatenby, Philippe Lambin, Andreas L. A. J. Dekker, Sandy A. Napel, Sylvia K. Plevritis, Daniel L. Rubin
  • Patent number: 10341640
    Abstract: Among other aspects, various embodiments include encoding wavelength-based characteristics, in addition to three-dimensional positions, of a plurality of objects of a plurality of different wavelengths directly in an image of the objects.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yoav Shechtman, William E. Moerner, Lucien Weiss
  • Patent number: 10337059
    Abstract: The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dNTP) in the presence of appropriate reagents (DNA polymerase, and polymerase reaction buffer). Alternatively, or in addition, a change in pH resulting from the incorporation of nucleotides in the DNA polymerase reaction is measured. A device is provided having delivery channels for appropriate reagents, including dNTPs, which may be delivered sequentially or in a mixture. Preferably, the dNTPs are added in a predetermined sequence, and the dNTP is incorporated or not depending on the template sequence.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hesaam Esfandyarpour, Mostafa Ronaghi
  • Patent number: 10338205
    Abstract: A backscatter tag communicate device includes, in part, a receiver configured to receive a WiFi packet conforming to a communication protocol defining a multitude of codewords, a mapper configured to map at least a first subset of the multitude of codewords disposed in the packet to a second multitude of codewords defined by the protocol, and a frequency shifter configured to shift a frequency of the second multitude of codewords such that the frequency shifted codewords are characterized by a single sideband spectrum. The communication protocol may be the 802.11b communication protocol. The mapper may optionally map the first subset of the multitude of codewords by changing phases of the first subset of the multitude of codewords.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pengyu Zhang, Dinesh Bharadia, Kiran Joshi, Sachin Katti
  • Patent number: 10337062
    Abstract: Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paul Giresi, Jason D. Buenrostro, Howard Y. Chang, William J. Greenleaf
  • Patent number: 10338319
    Abstract: A modified directional coupler structure is used to provide a controllable time delay or phase shift for radiation propagating through the structure. A longitudinal displacement of the interaction region of the directional coupler relative to one or both of the waveguides of the directional coupler provides this effect. Double flexure arrangements can be used to provide longitudinal displacement with substantially no corresponding lateral displacement (or vice versa). In some embodiments, lateral and longitudinal displacement of the waveguides of the directional coupler are independently adjustable to provide full control of the power splitting and phase shift/time delay of the directional coupler.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: David A. B. Miller
  • Patent number: 10335521
    Abstract: Described generally herein are tissue therapy devices, which may comprise a sealant layer and a suction apparatus. The sealant layer functions so as to create a sealed enclosure between it and the surface of a patient by forming, preferably, an airtight seal around an area of tissue that requires negative pressure therapy. The tissue therapy device may comprise a suction apparatus. The suction apparatus is typically in fluid communication with the sealant layer and functions so as to reduce the amount of pressure present underneath the sealant layer. The reduced pressure is self-created by the suction apparatus. Together the sealant layer and the suction apparatus preferably create a closed reduced pressure therapy system. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of the air molecules under the sealant layer.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Moshe Pinto, Dean Hu, Kenton Fong