Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 10310246
    Abstract: Improved image quality by structured illumination or pivoting illumination and faster image acquisition are both achieved. A line light enters first to fifth virtual pixels of a grating light valve, and first to fifth lights are emitted respectively from the first to fifth virtual pixels. The intensities and phases of the first to fifth 0th-order lights respectively depend on the arrangements of sub-pixels included in the first to fifth virtual pixels. The first to n-th 0th-order lights are extracted respectively from the first to n-th lights, and the first to n-th 0th-order lights are converted respectively into first to fifth light sheets. The first to fifth light sheets are created at a portion to be illuminated. The arrangements of the sub-pixels included in the first to fifth pixels are controlled such that a structured light sheet or pivoting light sheet is created at the portion to be illuminated.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 4, 2019
    Assignees: Screen Holdings Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ryosuke Itoh, Olav Solgaard, Stephen Sanborn Hamann
  • Patent number: 10302924
    Abstract: An optical device, such as a microscope, is disclosed that can be assembled from flat materials. The optical device can be assembled via a series of folds of a flat material. The optical microscope can include a stage for supporting a sample, an optic stage, and a light source. The optic stage can include one or more lenses. The optical microscope can be capable of obtaining simultaneous images from different forms of microscopy. The optical microscope may have bright field and filter field viewing capabilities wherein a user shifts from bright field to filter field by lateral movement of the stage containing a lens and a light source that cooperate to provide either the bright field or the filter field.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 28, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manu Prakash, James Stanley Cybulski, James C. Clements
  • Patent number: 10301387
    Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 28, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne Kathrin Volkmer, Jens-Peter Volkmer, Irving L. Weissman
  • Publication number: 20190155396
    Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Applicants: Google LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jaime Lien, Erik M. Olson, Patrick M. Amihood, Ivan Poupyrev
  • Patent number: 10294297
    Abstract: The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are provided for treating an individual in need thereof (e.g., an individual who is obese and/or has diabetes) by administering an anti-NMU/NMUR agent (e.g., an anti-NMU antibody). For example, methods and compositions are provided for increasing circulating insulin in an individual. Methods and compositions are also provided for detecting neuromedin U (NMU) (e.g., in a biological sample such as serum). Methods and compositions are also provided for predicting whether an individual will develop diabetes and/or PDAC, and for identifying an individual who would benefit from administration of an anti-NMU/NMUR agent.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 21, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Seung K. Kim, Sangbin Park, Ronald Alfa, Cecile Jacovetti
  • Patent number: 10292592
    Abstract: A system and method for monitoring biological parameters in freely moving animals that, in the illustrative embodiment, comprises a two-color optical measurement/recording system that is combined with a fluorescent protein reporter of cellular membrane potentials and a fluorescent protein that is insensitive to such cellular membrane potentials. The two wavelengths are used to un-mix physiological artifacts in recordings that occur in freely moving animals.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: May 21, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jesse D. Marshall, Mark J. Schnitzer
  • Patent number: 10292738
    Abstract: The present invention provides systems and methods for stabilizing or adjusting the position of at least one spinal motion segment.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: May 21, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Daniel H. Kim
  • Patent number: 10287632
    Abstract: The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 14, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lian Chye Winston Koh, Stephen R. Quake, Hei-Mun Christina Fan, Wenying Pan
  • Patent number: 10289802
    Abstract: Methods and systems for determining progression and other characteristics of microarray expression levels and similar information, alternatively using a network or communications medium or tangible storage medium or logic processor.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 14, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peng Qiu, Andrew J. Gentles, Sylvia K. Plevritis, Garry Nolan, Karen Sachs
  • Patent number: 10286049
    Abstract: In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation. In another aspect, the present invention provides a method of purifying tumor cells from a subject in preparation for vaccination.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: May 14, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Alexander Filatenkov
  • Patent number: 10285658
    Abstract: Systems and methods for detecting complex networks in MRI image data in accordance with embodiments of the invention are illustrated. One embodiment includes an image processing system, including a processor, a display device connected to the processor, an image capture device connected to the processor, and a memory connected to the processor, the memory containing an image processing application, wherein the image processing application directs the processor to obtain a time-series sequence of image data from the image capture device, identify complex networks within the time-series sequence of image data, and provide the identified complex networks using the display device.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: May 14, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Leanne Maree Williams
  • Patent number: 10285976
    Abstract: Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: May 14, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: Paul L. Bollyky, Nadine Nagy, Thomas Wight, Hedwich F. Kuipers
  • Publication number: 20190137425
    Abstract: A high-gain and low-noise negative feedback control (“feedback control”) system can detect charge transfer in quantum systems at room temperatures. The feedback control system can attenuate dissipative coupling between a quantum system and its thermodynamic environment. The feedback control system can be integrated with standard commercial voltage-impedance measurement system, for example, a potentiostat. In one aspect, the feedback control system includes a plurality of electrodes that are configured to electrically couple to a sample, and a feedback mechanism coupled to a first electrode of the plurality of electrodes. The feedback mechanism is configured to detect a potential associated with the sample via the first electrode. The feedback mechanism provides a feedback signal to the sample via a second electrode of the plurality of electrodes, the feedback signal is configured to provide excitation control of the sample at a third electrode of the plurality of electrode.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitanya Gupta, Ross Walker, Boris Murmann, Roger Howe
  • Publication number: 20190139435
    Abstract: Systems and methods in accordance with embodiments of the invention utilize technology to facilitate student question creation. Interactive platforms such as mobile phones or tablets can allow questions to be written, saved, and communicated electronically. In one embodiment, a method for collaboratively generating a question includes generating question data in response to input of a question and answer choices on a first device, sending the question data to a repository, sending the question data from the repository to a second device, displaying the question and answer choices on the second device, generating revised question data in response to input that changes the question, sending the revised question data to the repository, sending the revised question data to a third device, displaying the question and answer choices on the third device, receiving input of the selection of answer choices on the third device, and providing feedback whether the selection is correct.
    Type: Application
    Filed: October 2, 2018
    Publication date: May 9, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Hong Suk Kim
  • Patent number: 10278744
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: May 7, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim, J. Christopher Flaherty
  • Patent number: 10283327
    Abstract: An apparatus for generating a flow of reactive gas for decontaminating a material, surface or area, comprises a first electrode member comprising a first plurality of conductive surfaces and a second electrode member comprising a second plurality of conductive surfaces. The second electrode member is arranged in spaced relationship with the first electrode member to define a reactor channel. The conductive surfaces are exposed to the reactor channel so as to form air gaps between the first plurality of conductive surfaces and the second plurality of conductive surfaces. An air blower generates a flow of air through the reactor channel.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 7, 2019
    Assignees: The Board of Trustees of the Leland Stanford Junior University, CentraleSupélec
    Inventors: Christophe O. Laux, Johan O. Andreasson, Luke C. Raymond, Diane Rusterholtz-Duval, David Pai, Deanna Lacoste, Florent Sainct, Sebastien Mannai, Florian Girschig, Pierpaolo Toniato, Erwan Pannier, Augustin Tibère-Inglesse
  • Patent number: 10284762
    Abstract: A system for guidance of an imaging device may include a handheld imaging device, a multidirectional feedback device, and a control unit in communication with the multidirectional feedback device and the handheld imaging device. The control unit may be configured to receive a target location, determine an initial position and pose of the handheld imaging device, calculate a position and pose deviation relative to said initial position and pose, translate said position and pose deviation into control data, and transmit said control data to the multidirectional feedback device, wherein the multidirectional feedback device uses control data to provide an operator with feedback to guide the handheld imaging device towards the target.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: May 7, 2019
    Assignees: Clear Guide Medical, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Philipp Jakob Stolka, Pezhman Foroughi, Matthew C. Rendina, Gregory Donald Hager, Allison Mariko Okamura
  • Patent number: 10278929
    Abstract: Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPis of a target protein.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: May 7, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Isabella A. Graef, Mamoun M. Alhamadsheh
  • Patent number: 10284356
    Abstract: A wireless communication device includes, in part, an analog interference cancellation circuit and a controller. The analog cancellation circuit includes a multitude of delay paths each including a delay element and a variable attenuator. The controller dynamically varies the attenuation level of each of the variable attenuators in accordance with the frequency response characteristic of that attenuator to remove a portion of a self-interference signal present in a signal received by the device. The device measures the frequency response characteristic of the communication channel, used in determining the attenuation levels, via one or more preamble symbols. A second portion of the self-interference signal is removed by the device using a multitude of samples of a transmitted signal and a multitude of samples of a signal to be transmitted.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: May 7, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dinesh Bharadia, Sachin Katti, Emily McMilin, Mayank Jain, Jung Il Choi, Kannan Srinivasan
  • Patent number: 10273510
    Abstract: Described here is a method for increasing the transfer of a gas substrate in microbial fermentation, comprising incubating an emulsion comprising an oil phase and an aqueous phase droplet dispersed in the oil phase, and supplying the gas substrate to the oil phase, wherein the aqueous phase droplet comprises a microorganism, and wherein the emulsion is stabilized by a surfactant or an amphiphilic particle that is adsorbed to an interface of the oil phase and the aqueous phase. Also described is an emulsion for microbial fermentation, comprises an oil phase and an aqueous phase droplet dispersed in the oil phase, wherein the aqueous phase droplet comprises a microorganism, wherein the emulsion comprises a gas substrate externally-supplied to the oil phase, and wherein the emulsion is stabilized by a surfactant or an amphiphilic particle that is adsorbed to an interface of the oil phase and the aqueous phase.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: April 30, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sindy Tang, Craig Criddle, Jaewook Myung, Minkyu Kim