Patents Assigned to The Curators of University of Missouri
  • Patent number: 10624982
    Abstract: Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 21, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • Publication number: 20200103537
    Abstract: A system for detecting gamma radiation by neutron activation of a material includes a switchable radiation source and at least a first detector. The switchable radiation source includes a primary source assembly having an alpha particle emitter, and a target assembly in which, upon irradiation of the target assembly by alpha particles from the primary source assembly, secondary radiation comprising neutrons is produced. An alignment, proximity or exposure of the primary source assembly relative to the target assembly is adjustable to control irradiation of the target assembly by the primary source assembly and thereby selectively irradiate a material under interrogation with the secondary radiation. The first detector is configured to detect gamma radiation prompted by neutron activation of the material under interrogation.
    Type: Application
    Filed: November 15, 2019
    Publication date: April 2, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Hyoung K. Lee, Kyle Paaren
  • Publication number: 20200101447
    Abstract: Porous zeolite monolith compositions for the catalytic cracking of alkanes. The compositions may be prepared layer by layer using a 3D printer such that the compositions comprise a plurality of micropores and a plurality of mesopores and may be characterized by macro-meso-microporosity.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Ali A. Rownaghi, Xin Li, Fateme Rezaei
  • Publication number: 20200087346
    Abstract: Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI can mediate internalization of the apoptotic KLA peptide to PSMA-positive LNCaP cells and induce cell death. Moreover, a FAM-labeled GTI peptide shows a high and specific tumor uptake in nude mice bearing human prostate cancer xenografts. It was demonstrated that the GTI peptide can be employed as a PSMA-specific ligand for prostate cancer diagnosis and/or for targeted drug delivery to prostate cancer cells.
    Type: Application
    Filed: August 8, 2019
    Publication date: March 19, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Kun Cheng, Wei Jin
  • Patent number: 10591418
    Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: March 17, 2020
    Assignees: The Curators of the University of Missouri, Clemson University
    Inventors: Yinfa Ma, Honglan Shi, Qingbo Yang, Hai Xiao
  • Patent number: 10566638
    Abstract: A radiolytic electrochemical system that comprises a cathode, an anode that comprises a semiconductor, an aqueous electrolyte solution disposed between the cathode and anode, and ionizing radiation, wherein the ionizing radiation splits water molecules and forms solvated free radicals that migrate to the anode or cathode, depending upon a radical's charge, and participate in redox reactions at the anode and cathode thereby producing electrical current capable of performing work when the anode and cathode are electrically connected.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 18, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Jae Wan Kwon, Baek Hyun Kim
  • Patent number: 10556393
    Abstract: A method of manufacturing a tire is provided that includes curing the tire (10) in a curing press (12) and applying microwave energy at a given frequency band into the tire. The interaction between the microwave energy and the tire is monitored to obtain a complex reflection coefficient. A root-mean-squared error is calculated using the measured complex reflection coefficient and a reference reflection coefficient. The reference reflection coefficient is from a fully cured tire made from the same material as the tire. Continuous monitoring of the interaction takes place to obtain the complex reflection coefficient along with continuous calculation of the root-mean-squared error at different times during the curing of the tire in the curing press. The calculated root-mean-squared errors are used to determine whether to stop the curing of the tire in the curing press.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: February 11, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: David Judd, Frank Gramling, Reza Zoughi, Mohammad Tayeb Ghasr
  • Patent number: 10548580
    Abstract: A surgical instrument can be introduced to the abdominal cavity through a current trocar puncture to place a suture in the deep facia and peritoneum of the anterior abdominal wall. The instrument is lightweight and easy to use, and can be operated quickly and efficiently to close the trocar puncture wound in a simple and economical manner. The instrument is used to suture the deep facia and peritoneum of the anterior abdominal wall on opposite sides of the trocar puncture wound inside the abdomen to close the trocar puncture wound.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: February 4, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Roger de la Torre, Jaya Ghosh, Ellie Koehly, Yaw Sarpong
  • Patent number: 10548319
    Abstract: The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 4, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: George W. Gokel, Mohit B. Patel
  • Patent number: 10548989
    Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: February 4, 2020
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Feng Chen, Barney Yoo, Jason Lewis, Ulrich Wiesner, Kai Ma
  • Patent number: 10542911
    Abstract: A system for elucidating physiological characteristics of laryngeal adductor reflex (LAR) responses in a human or animal subject's larynx's vocal folds (VFs) includes a pressure pulsing component to provide a stable and adjustable pulse of pressure to the larynx, a control system component in functional communication with the pressure pulsing component to control or regulate one or more aspects of the timing, magnitude and number of pulses of pressure delivered by the pressure pulsing component during respiratory cycles, and a respiratory sensor component to detect and/or determine physiological characteristics of the subject's LAR response. The method includes evoking a LAR response in the subject and determining one or more physiological measurements including duration, velocity, and angles of motion of the subject's VFs during the LAR response. The present disclosure provides for enhanced endoscopic field of view of the larynx and delivering stimuli over a wider range of controlled parameters.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: January 28, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Teresa Lever, Cameron Hinkel
  • Patent number: 10547044
    Abstract: A dry electrode manufacturing process employed for low cost battery through a dry mixing and formation process. A thermal activation renders the dry fabricated electrode comparable to conventional slurry casted electrodes. The dry electrode mixture results from a combination of a plurality of types of constituent particles, including at least an active charge material and a binder, and typically a conductive material such as carbon. The process heats the deposited mixture to a moderate temperature for activating the binder for adhering the mixture to the substrate; and compresses the deposited mixture to a thickness for achieving an electrical sufficiency of the compressed, deposited mixture as a charge material in a battery.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: January 28, 2020
    Assignees: Worcester Polytechnic Institute, The Curators of the University of Missouri
    Inventors: Yan Wang, Zhangfeng Zheng, Brandon Ludwig, Heng Pan
  • Patent number: 10537089
    Abstract: A system and method for thermally exchanging heat between waste air being expelled from a poultry barn and fresh outside/outdoor ambient air being introduced into the poultry barn.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 21, 2020
    Assignees: The Curators of the University of Missouri, Heartland Farm Energy LLC
    Inventors: Tingsheng Xu, Yunsheng Xu
  • Publication number: 20200018544
    Abstract: In general, the present invention is directed to processes for separating a vapor comprising a first component and a second component using high-pressure density-driven separation. The present invention further relates to various processes for the capture of carbon dioxide. In particular, various processes of the present invention relate to the separation of carbon dioxide from flue gas of combustion processes. The invention also applies to upgrading fuel gases containing carbon dioxide. The invention also applies to separation of hydrogen from fuel gas vapor solutions.
    Type: Application
    Filed: February 14, 2018
    Publication date: January 16, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: William Jacoby, Reza Espanani
  • Publication number: 20200008623
    Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 9, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Hongbin Ma, Michael Merwin, Hao Bai, Robert Riegler, Christopher Vincent, Susan Liu
  • Patent number: 10526651
    Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 7, 2020
    Assignees: Whitehead Institute for Biomedical Research, The Curators of the University of Missouri
    Inventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar, Antony A. Cooper, Cole M. Haynes
  • Patent number: 10512394
    Abstract: The present invention discloses a new and improved endoscopic-enabled mouth gag for routine ENT procedures, such as adenoidectomy and nasopharyngeal biopsy. The invention modifies the existing mouth gag, provides a stable and adjustable placement for an endoscopic device potentially employed during an ENT procedure, and is to replace the outdated surgical method where the surgical field is visualized indirectly via a handheld mirror (with or without the preexisting mouth gag). The inventive endoscopic-enabled mouth gag not only provides enhanced visualization of the surgical field for a clinician, assistants, and trainees, but also enables a clinician to perform the procedure bimanually (with both hands).
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: December 24, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Eliav Gov-Ari, Alexander Madinger
  • Patent number: 10516170
    Abstract: A catalyst obtained by first preparing a cermet material with the general formula ABOx, wherein A is selected from the group consisting of Co, Cu, Ni, Ti, and combinations thereof, wherein B is selected from the group consisting of Mo, W, Ce, and combinations thereof, wherein A and B are different elements, and wherein x is a nonzero number ranging from 3 to 7 and represents the moles of O. Next, the cermet is activated in a reducing atmosphere to yield metal particles dispersed within and/or on the cermet.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: December 24, 2019
    Assignee: The Curators of the University of Missouri
    Inventor: Fatih Dogan
  • Patent number: 10490679
    Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: November 26, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
  • Patent number: 10485584
    Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 26, 2019
    Assignees: Lekarska fakulta v Plzni, Univerzita Karlova (Faculty of Medicine in Pilsen, Charles University), The Curators of the University of Missouri, Chonbuk National University, Division of Biotechnology, College of Environmental and Bioresources, Ceska zemedelska univerzita v Praze, Institute of Animal Science
    Inventors: Jan Nevoral, Young-Joo Yi, Katerina Zamostna-Adamkova, Jaroslav Petr, Peter Sutovsky, Milena Kralickova