Patents Assigned to The Curators of University of Missouri
  • Patent number: 11214729
    Abstract: The present invention generally relates to the composition of particle gels for CO2-EOR and CO2 storage. More particularly, CO2 resistant particle gels are provided that can re-crosslink at subterranean conditions. These particle gels can be deployed to improve the conformance of CO2 flooding, CO2 huff-puff, or Water-Alternative-Gas (WAG). The applications may also involve CO2 storage, such as the blocking of CO2 leakage and similar CO2 processing.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: January 4, 2022
    Assignee: The Curators of the University of Missouri
    Inventors: Yifu Long, Baojun Bai, Thomas P. Schuman
  • Patent number: 11209176
    Abstract: A high efficiency, low noise thermoelectric dehumidifier that includes a heat pipe array, a condensing heat sink, an air intake duct, and a thermoelectric cooler. A first air flow is directed over the condensing heat sink that is cooled by the thermoelectric cool such that the first air flow is dehumidified by the cooled condensing heat sink. Heat is removed from a hot side of the thermoelectric cooler via the heat pipe array. A second air flow is directed over the heat pipe array such that the heat extracted from the hot side of the thermoelectric cooler is extracted and circulated back into the ambient environment.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: December 28, 2021
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Hongbin Ma, Willard Hanson, Zaichun Feng
  • Patent number: 11202840
    Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: December 21, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Dongsheng Duan, Yi Lai, Junling Zhao, Yongping Yue
  • Publication number: 20210384504
    Abstract: The present invention relates to various lithium ion battery cathodes as well as lithium ion batteries incorporating one or more of these cathodes. The present invention further relates to processes of preparing the lithium ion battery cathode.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: The Curators of the University of Missouri
    Inventors: Xinhua Liang, Yan Gao
  • Patent number: 11192094
    Abstract: Porous zeolite monolith compositions for the catalytic cracking of alkanes. The compositions may be prepared layer by layer using a 3D printer such that the compositions comprise a plurality of micropores and a plurality of mesopores and may be characterized by macro-meso-microporosity.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 7, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Ali A. Rownaghi, Xin Li, Fateme Rezaei
  • Patent number: 11186376
    Abstract: An aerial payload delivery system uses a cruciform parachute canopy that is connected to base by plurality of suspension lines including an adjustable control line. A control system includes an actuator to selectively adjust the length of the control line. By adjusting the length of the control line, the parachute can be selectively set to glide or descend substantially vertically subject to wind. In an embodiment, the suspension lines also include a short line and a plurality of long lines. The parachute is set to glide by adjusting the control line to be about the same length as the short line and set to vertically descend by adjusting the length of the control line to differ from the short line.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: November 30, 2021
    Assignees: The Government of the United States, as represented by the Secretary of the Army, The Curators of the University of Missouri, The United Sates of America, as represented by the Secretary of the Navy
    Inventors: Travis D. Fields, Oleg A. Yakimenko, Richard Benney
  • Patent number: 11167048
    Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 9, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Charles Jeffrey Smith, Rajendra Prasad Bandari
  • Patent number: 11168331
    Abstract: Provided are plants that express, or overexpress, a pPLAIII? protein. Constitutive or seed-specific expression of pPLAIII? protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIII? is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: November 9, 2021
    Assignees: Donald Danforth Plant Science Center, The Curators of the University of Missouri
    Inventors: Xuemin Wang, Maoyin Li
  • Patent number: 11162016
    Abstract: This invention is broadly concerned with compositions and processes for oilfield applications. More specifically, this invention relates to novel polymer constructed packages that, when pumped into a petroleum well, provide tunable characteristics of transformation and delayed self-assembly with each other under reservoir conditions to yield strong, elastic, bulk gel materials. The compositions comprise a polymer, assembling agents, and optional additives used for the re-assembly stage are uniformly-distributed within the initial gel particles. The polymer particle packages absorb water and swell upon exposure to water, thus exposing the “assembling agents” that enable re-assembly. Both swelling and re-assembly are proportionally controlled via compositions to be tunable to allow functional dispersion and subsequent self-assembly under various reservoir conditions.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: November 2, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Jingyang Pu, Baojun Bai, Thomas Schuman
  • Patent number: 11160906
    Abstract: The present invention provides a series of injectable bionanocomposites that may be delivered via injection to various tissue repair sites including myocardial infarction, intervertebral disc reconstruction, reconstruction of skeletal muscle, and musculoskeletal applications, urinary incontinence, adipose tissue engineering, and orthopedic applications such as osteoporosis, and meniscus and articular cartilage repair.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: November 2, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Sheila Ann Grant, David Grant, Daniel Grant
  • Patent number: 11160260
    Abstract: Methods for protecting porcine fetuses from infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The methods comprise breeding a female porcine animal with a male porcine animal. The female porcine animal comprises modified chromosomal sequences in both alleles of its CD163 gene, wherein the modified chromosomal sequences reduce the susceptibility of the female porcine animal to infection by PRRSV, as compared to the susceptibility to infection by PRRSV of a female porcine animal that does not comprise any modified chromosomal sequences in the alleles of its CD163 gene. The male porcine animal comprises at least one wild-type CD163 allele.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: November 2, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth
  • Patent number: 11147451
    Abstract: Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: October 19, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Marjorie Skubic, Marilyn J. Rantz, Mihail Popescu, Shuang Wang, Isaac J. Sledge, Rainer Dane A. Guevara, Elena Florea, James M. Keller
  • Patent number: 11150083
    Abstract: System and method for determining real-time sag and shape information of an electrical power line based on strain distribution along a length of an optical fiber associated with the power line. An embedded fiber coupled to an overhead transmission line measures strain using the backscatter of an optical signal, the optical signal is then interrogated using an interferometer.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 19, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Jie Huang, Rui Bo
  • Patent number: 11142675
    Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: October 12, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Hongbin Ma, Michael Merwin, Hao Bai, Xiaoqin Liu, Robert Riegler, Chris Vincent
  • Publication number: 20210310928
    Abstract: An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator.
    Type: Application
    Filed: March 23, 2021
    Publication date: October 7, 2021
    Applicant: The Curators of the University of Missouri
    Inventors: Jie Huang, Chen Zhu, Rex E. Gerald, II
  • Patent number: 11136580
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: October 5, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Christian Lorson, Erkan Osman
  • Patent number: 11116817
    Abstract: The present invention is directed to antimicrobial agents and compositions including the same. The antimicrobial agent can include a polypeptide or a peptidomimetic of the polypeptide. The polypeptide can have a net positive charge of at least about 3 at a pH of 7.0, and a hydrophobicity of greater than 25%.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: September 14, 2021
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Shuping Zhang, Ming Yang
  • Patent number: 11118981
    Abstract: A metasurface integrated microbolometer having a sensing layer (e.g., SixGeyO1-x-y). The presence of the metasurface provides selectivity with respect to wavelength, polarization and angle-of-incidence. The presence of the metasurface into the microbolometer affects conversion of electromagnetic to thermal energy, thermal response, electrical integration of the microbolometer, and the tradeoff between resistivity and temperature coefficient of resistance, thereby allowing the ability to obtain a sensing with high temperature coefficient of resistance with lower resistivity values than that of films without the metasurface. The presence of the metasurface removes the need for a Fabry-Perot cavity.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: September 14, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Mahmoud Almasri, Edward Kinzel
  • Patent number: 11083406
    Abstract: Systems and methods are described herein for determining that a patient has indications mild cognitive impairment (MCI) or early stage Alzheimer's disease (AD). Microperimetry is used to assess the functional integrity of the patient's retina. Optical Coherence Tomography is used to assess the structural integrity of the patient's retina. Reductions in the size and function of the patient's retina indicate that the patient may have MCI or early stage AD.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: August 10, 2021
    Assignee: The Curators of the University of Missouri
    Inventor: Peter Koulen
  • Publication number: 20210235933
    Abstract: A heat loss protection lid for a thermal liquid container system, wherein the heat loss protection lid comprises a central body, a liquid ingress opening formed within the central body, a liquid dispensing opening formed within one of a peripheral edge of the central body or a lip formed around the peripheral edge of the central body. and a concealed air intake hole.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 5, 2021
    Applicant: The Curators of the University of Missouri
    Inventor: Hongbin Ma