Patents Assigned to The Doshisha
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Publication number: 20160331736Abstract: Provided is an agent for treating or preventing a corneal endothelial disorder wherein cell proliferation is required. More specifically, provided is an agent for treating or preventing a corneal endothelial disorder, wherein cell proliferation is required, said agent comprising a p38MAP kinase inhibitor. In a preferred embodiment, the corneal endothelial disorder is a wound. In a preferred embodiment, the p38MAP kinase inhibitor is soluble in water. The p38MAP kinase inhibitor may comprise 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazole-5-yl]pyridine (SB203580) or a salt thereof.Type: ApplicationFiled: November 13, 2014Publication date: November 17, 2016Applicant: The DoshishaInventors: Noriko KOIZUMI, Naoki OKUMURA, Shigeru KINOSHITA
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Publication number: 20160317528Abstract: The present invention provides an agent for treating or preventing a disease, a disorder or a condition of a corneal endothelium, said agent comprising a corneal endothelial cell and a myosin II-specific inhibitor. More specifically, the myosin II-specific inhibitor is blebbistatin. The disease, the disorder or the condition is typically a disorder associated with Fuchs endothelial corneal dystrophy or corneal endothelial dysfunction (bullous keratopathy). Also provided is a method for treating or preventing a corneal endothelial disease, said method comprising a step of administering an effective amount of a myosin II-specific inhibitor together with a corneal endothelial cell to a subject.Type: ApplicationFiled: December 27, 2013Publication date: November 3, 2016Applicants: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, THE DOSHISHA, SENJU PHARMACEUTICAL CO., LTD.Inventors: Noriko KOIZUMI, Naoki OKUMURA, Shigeru KINOSHITA
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Publication number: 20160296505Abstract: The present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress. Specifically, the present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress in the corneal epithelium, the drug containing a TGF?-signal inhibitor. As a preferred TGF?-signal inhibitor, the drug contains 4-[4-(1,3-benzodioxole-5-yl)-5-(2-pyridinyl)-1H-imidazole-2-yl]benzamide.Type: ApplicationFiled: October 30, 2014Publication date: October 13, 2016Applicants: Kyoto Prefectural Public University corporation, The Doshisha, Senju Pharmaceutical Co., Ltd.Inventors: Noriko KOIZUMI, Naoki OKUMURA, Shigeru KINOSHITA
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Patent number: 9370884Abstract: A resin molding apparatus includes a pair of metal molds respectively arranged so as to be insulated from the ground with insulating materials, and a molding portion including the pair of metal molds and to which a resin material is provided. At least one metal mold of the pair of metal molds is provided with electrodes at two points flanking the molding portion. A high frequency current generator capable of applying high frequency current having a frequency of about 10 kHz or more is connected to the two electrodes.Type: GrantFiled: March 10, 2010Date of Patent: June 21, 2016Assignees: THE DOSHISHA, HIDEYUKI KUWAHARAInventors: Hideyuki Kuwahara, Tsutao Katayama, Kazuto Tanaka
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Publication number: 20160168733Abstract: Provided is a chlorine evolution method which includes contacting an anode with chloride based aqueous solution and generating chlorine as a main reaction at the anode, in which a main reaction of the anode is chlorine evolution, and the chlorine evolution anode which is low in potential of the anode for chlorine evolution, thereby being able to decrease an electrolytic voltage and lower an electric energy consumption rate. The chlorine evolution anode of the present invention is a chlorine evolution anode in which chlorine evolution from an aqueous solution is a main reaction of the anode and also in which a catalytic layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.Type: ApplicationFiled: February 19, 2016Publication date: June 16, 2016Applicant: THE DOSHISHAInventor: Masatsugu MORIMITSU
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Patent number: 9258850Abstract: A heating chamber is divided into a plurality of spaces by barrier sections including a conductive material. Phase shifters having different lengths with respect to a direction and including a dielectric body having permittivity higher than air are inserted in positions of a terminal section, in the spaces except for at least one space, to differentiate positions of bottoms of standing microwaves formed in the respective spaces from each other with respect to the direction. In addition, impedance adjusters having different lengths with respect to the direction and including a dielectric body having permittivity higher than air are inserted in positions on an upstream side of a region passed by the object to be heated, in the spaces except for at least one space, to reduce differences in impedance of the spaces from an entrance of the heating chamber to the terminal section including the phase shifters.Type: GrantFiled: November 27, 2012Date of Patent: February 9, 2016Assignees: MURATA MACHINERY, LTD., THE DOSHISHAInventors: Shinzo Yoshikado, Yoshihiro Shojo, Isao Fukuda
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Publication number: 20160000855Abstract: The present invention provides a novel oxidized protein hydrolase activity enhancing agent. The oxidized protein hydrolase activity enhancing agent of the present invention contains at least one kind of plant extract obtained from a plant selected from the group consisting of water chestnut, stevia, rosemary, thyme, chrysanthemum, savory, mugwort, chestnut, spearmint, marjoram, peppermint, lemon balm, allspice, perilla, basil, and caraway.Type: ApplicationFiled: February 14, 2014Publication date: January 7, 2016Applicants: ARKRAY, INC., THE DOSHISHAInventors: Masayuki Yagi, Yoshikazu Yonei, Kiyofumi Takayama, Hiroshige Kawai
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Patent number: 9188177Abstract: A brake disc is provided capable of effectively reducing the generation of noise such as brake noise by making specifications relating to lightening holes different from each other between two brake disc plates. In the brake disc, two brake disc plates are laminated so as to slide on each other by vibration during braking, and specifications relating to one or more selected from lightening holes, plate thickness, diameter, and warpage are made different from each other between the brake disc plates. In addition, lightening holes are formed on at least one of the brake disc plates, and one or more specifications selected from the number of lightening holes, the shapes of the lightening holes, the sizes of the lightening holes, and the arrangement positions of the lightening holes are made different from each other between the brake disc plates.Type: GrantFiled: February 16, 2012Date of Patent: November 17, 2015Assignees: SUNSTAR ENGINEERING INC., THE DOSHISHAInventors: Toru Fujii, Kazuya Okubo, Kiyotaka Obunai, Yoshihisa Kubota, Hideaki Okada, Tsuyoshi Nakatsuji
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Publication number: 20150202256Abstract: The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.Type: ApplicationFiled: July 3, 2013Publication date: July 23, 2015Applicants: Kyoto Prefectural Public University Corporation, Senju Pharmaceutical Co., Ltd., The DoshishaInventors: Takahiro Nakamura, Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita, Kana Tominaga, Satoshi Kawasaki
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Patent number: 9045525Abstract: A primary object of the present invention is to develop a compound that specifically inhibits the production of A? protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease. This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of ?CTF; a ?-secretase activity inhibitor containing the polypeptide; ?-secretase activity inhibitor; A? protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.Type: GrantFiled: January 16, 2013Date of Patent: June 2, 2015Assignee: THE DOSHISHAInventors: Yasuo Ihara, Satoru Funamoto, Toru Sasaki
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Patent number: 8965263Abstract: A microwave heating device enhances heating efficiency by a simple configuration. A microwave is led from one end of a conductive heating chamber in direction d2. The heating chamber is provided with an opening. A pair of conveying members are provided. A member to be heated sandwiched between the conveying members is moved in direction d1, and passes through the opening in direction d1 non-parallel to microwave traveling direction d2.Type: GrantFiled: March 14, 2013Date of Patent: February 24, 2015Assignees: Murata Machinery, Ltd., The DoshishaInventors: Shinzo Yoshikado, Yoshihiro Shojo, Isao Fukuda
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Publication number: 20150044178Abstract: The present invention provides a method for the normalized culturing of corneal endothelial cells. More specifically, the present invention provides a culture-normalizing-agent of a corneal endothelial cell, comprising a fibrosis inhibitor. In detail, the present invention provides a culture-normalizing agent comprising a transforming growth factor (TGF) ? signal inhibitor. The present invention also provides a culture medium for culturing a corneal endothelial cell normally, which comprises the culture-normalizing agent according to the present invention and corneal endothelium culture components. The present invention also provides a method for culturing a corneal endothelial cell normally, comprising the step of culturing a corneal endothelial cell using the culture-normalizing agent according to the present invention or the culture medium according to the present invention.Type: ApplicationFiled: December 27, 2012Publication date: February 12, 2015Applicants: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SENJU PHARMACEUTICAL CO., LTD., THE DOSHISHAInventors: Shigeru Kinoshita, Noriko Koizumi, Naoki Okumura
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Patent number: 8951401Abstract: Dense carbon films are deposited on a conductive substrate by placing the substrate acting as anode in a molten salt electrolyte bath containing a source of carbide ion and applying DC current across the substrate and a counter electrode acting as cathode also placed in the molten salt electrolyte bath. The carbide ions are electrochemically oxidized to deposit a carbon film on the surface of the substrate.Type: GrantFiled: May 28, 2010Date of Patent: February 10, 2015Assignees: Toyota Boshoku Kabushiki Kaisha, I'msep Co., Ltd., Sec Carbon, Limited, The DoshishaInventors: Tokujiro Nishikiori, Hiroaki Amahashi, Kouji Kuroda, Yasuhiko Ito, Naohiro Yasuda
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Publication number: 20150027899Abstract: Provided is an anode for electroplating which uses an aqueous solution as an electrolytic solution, and the anode which is low in potential when compared with a conventional anode, able to decrease an electrolytic voltage and an electric energy consumption rate and may also be used as an anode for electroplating various types of metals, and which is low in cost. Also provided is a method for electroplating which uses an aqueous solution as an electrolytic solution, in which the anode is low in potential and electrolytic voltage, thereby making it possible to decrease the electric energy consumption rate. The anode for electroplating of the present invention is an anode for electroplating which uses an aqueous solution as an electrolytic solution, in which a catalytic layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.Type: ApplicationFiled: August 31, 2012Publication date: January 29, 2015Applicant: THE DOSHISHAInventor: Masatsugu Morimitsu
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Patent number: 8931286Abstract: A thermoacoustic device 1 for improving heat exchange efficiency is provided which has a first stack 3a including stack constituent elements 3eL and 3eH laminated together, and a first high-temperature side heat exchanger 4 and a first low-temperature side heat exchanger 5, which are provided at two ends of the first stack 3a, in which a self-excited acoustic wave is generated by a temperature difference between the first high-temperature side heat exchanger 4 and the first low-temperature side heat exchanger 5 and is then converted to thermal energy in a stack 3b provided between a second high-temperature side heat exchanger 6 and a second low-temperature side heat exchanger 7.Type: GrantFiled: April 22, 2005Date of Patent: January 13, 2015Assignee: The DoshishaInventors: Yoshiaki Watanabe, Shinichi Sakamoto
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Publication number: 20140371152Abstract: A primary object of the present invention is to develop a compound that specifically inhibits the production of A? protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease. This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of ?CTF; a ?-secretase activity inhibitor containing the polypeptide; ?-secretase activity inhibitor; A? protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.Type: ApplicationFiled: January 16, 2013Publication date: December 18, 2014Applicant: THE DOSHISHAInventors: Yasuo Ihara, Satoru Funamoto, Toru Sasaki
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Publication number: 20140326550Abstract: A brake disc is provided capable of effectively reducing the generation of noise such as brake noise by making specifications relating to lightening holes different from each other between two brake disc plates. In the brake disc, two brake disc plates are laminated so as to slide on each other by vibration during braking, and specifications relating to one or more selected from lightening holes, plate thickness, diameter, and warpage are made different from each other between the brake disc plates. In addition, lightening holes are formed on at least one of the brake disc plates, and one or more specifications selected from the number of lightening holes, the shapes of the lightening holes, the sizes of the lightening holes, and the arrangement positions of the lightening holes are made different from each other between the brake disc plates.Type: ApplicationFiled: February 16, 2012Publication date: November 6, 2014Applicants: THE DOSHISHA, SUNSTAR ENGINEERING INC.Inventors: Toru Fujii, Kazuya Okubo, Kiyotaka Obunai, Yoshihisa Kubota, Hideaki Okada, Tsuyoshi Nakatsuji
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Patent number: 8831500Abstract: A microwave heating device includes a microwave generating portion outputting a microwave, a conductive heating chamber into which the microwave is led and having a short-circuited terminal end in a traveling direction of the microwave, and a tuner provided between the microwave generating portion and the heating chamber. The heating chamber has an opening for passing a member to be heated therethrough. The tuner re-reflects the microwave reflected at the terminal end of the heating chamber onto the heating chamber side. The microwave output end of the microwave generating portion and the tuner are connected by a square tubular waveguide made of a conductive material. The tuner and the terminal end of the heating chamber are connected by a square tubular waveguide, which is made of a conductive material except for the opening for passing the member to be heated therethrough.Type: GrantFiled: October 31, 2012Date of Patent: September 9, 2014Assignees: Murata Machinery, Ltd., The DoshishaInventors: Shinzo Yoshikado, Yoshihiro Shojo, Ryosuke Tahara, Isao Fukuda
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Publication number: 20140249180Abstract: A tau aggregation inhibitor reduces tau aggregation in cells. The tau aggregation inhibitor can include a catechol structure-containing compound or a salt thereof, and the catechol structure-containing compound can be one of isoprenaline, dopamine, dobutamine, levodopa, levodopa/carbidopa, trimetoquinol, hexoprenaline, methyldopa, and droxidopa. One example of the catechol structure-containing compound is isoprenaline, which can be d-enantiomer of isoprenaline or d/l-racemic mixture of isoprenaline. Tauopathies to be prevented or treated by the inhibitor include AD, Down's syndrome, Pick's disease, corticobasal degeneration, and progressive supranuclear palsy.Type: ApplicationFiled: October 3, 2012Publication date: September 4, 2014Applicants: National Center for Geriatrics and Gerontology, THE DOSHISHAInventors: Akihiko Takashima, Yoshiyuki Soeda, Hiroyuki Nagata, Yasuo Ihara, Tomohiro Miyasaka, Hachiro Sugimoto
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Publication number: 20140231249Abstract: Provided is a chlorine evolution anode in which a main reaction of the anode is chlorine evolution, and the chlorine evolution anode which is low in potential of the anode for chlorine evolution, thereby being able to decrease an electrolytic voltage and lower an electric energy consumption rate. The chlorine evolution anode of the present invention is a chlorine evolution anode in which chlorine evolution from an aqueous solution is a main reaction of the anode and also in which a catalytic layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.Type: ApplicationFiled: August 31, 2012Publication date: August 21, 2014Applicant: THE DOSHISHAInventor: Masatsugu Morimitsu