Abstract: The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.

Abstract: A primary object of the present invention is to develop a compound that specifically inhibits the production of A? protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease. This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of ?CTF; a ?-secretase activity inhibitor containing the polypeptide; ?-secretase activity inhibitor; A? protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.

Abstract: A microwave heating device enhances heating efficiency by a simple configuration. A microwave is led from one end of a conductive heating chamber in direction d2. The heating chamber is provided with an opening. A pair of conveying members are provided. A member to be heated sandwiched between the conveying members is moved in direction d1, and passes through the opening in direction d1 non-parallel to microwave traveling direction d2.

Abstract: The present invention provides a method for the normalized culturing of corneal endothelial cells. More specifically, the present invention provides a culture-normalizing-agent of a corneal endothelial cell, comprising a fibrosis inhibitor. In detail, the present invention provides a culture-normalizing agent comprising a transforming growth factor (TGF) ? signal inhibitor. The present invention also provides a culture medium for culturing a corneal endothelial cell normally, which comprises the culture-normalizing agent according to the present invention and corneal endothelium culture components. The present invention also provides a method for culturing a corneal endothelial cell normally, comprising the step of culturing a corneal endothelial cell using the culture-normalizing agent according to the present invention or the culture medium according to the present invention.

Abstract: Dense carbon films are deposited on a conductive substrate by placing the substrate acting as anode in a molten salt electrolyte bath containing a source of carbide ion and applying DC current across the substrate and a counter electrode acting as cathode also placed in the molten salt electrolyte bath. The carbide ions are electrochemically oxidized to deposit a carbon film on the surface of the substrate.

Abstract: Provided is an anode for electroplating which uses an aqueous solution as an electrolytic solution, and the anode which is low in potential when compared with a conventional anode, able to decrease an electrolytic voltage and an electric energy consumption rate and may also be used as an anode for electroplating various types of metals, and which is low in cost. Also provided is a method for electroplating which uses an aqueous solution as an electrolytic solution, in which the anode is low in potential and electrolytic voltage, thereby making it possible to decrease the electric energy consumption rate. The anode for electroplating of the present invention is an anode for electroplating which uses an aqueous solution as an electrolytic solution, in which a catalytic layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.

Abstract: A thermoacoustic device 1 for improving heat exchange efficiency is provided which has a first stack 3a including stack constituent elements 3eL and 3eH laminated together, and a first high-temperature side heat exchanger 4 and a first low-temperature side heat exchanger 5, which are provided at two ends of the first stack 3a, in which a self-excited acoustic wave is generated by a temperature difference between the first high-temperature side heat exchanger 4 and the first low-temperature side heat exchanger 5 and is then converted to thermal energy in a stack 3b provided between a second high-temperature side heat exchanger 6 and a second low-temperature side heat exchanger 7.

Abstract: A primary object of the present invention is to develop a compound that specifically inhibits the production of A? protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease. This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of ?CTF; a ?-secretase activity inhibitor containing the polypeptide; ?-secretase activity inhibitor; A? protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.

Abstract: A brake disc is provided capable of effectively reducing the generation of noise such as brake noise by making specifications relating to lightening holes different from each other between two brake disc plates. In the brake disc, two brake disc plates are laminated so as to slide on each other by vibration during braking, and specifications relating to one or more selected from lightening holes, plate thickness, diameter, and warpage are made different from each other between the brake disc plates. In addition, lightening holes are formed on at least one of the brake disc plates, and one or more specifications selected from the number of lightening holes, the shapes of the lightening holes, the sizes of the lightening holes, and the arrangement positions of the lightening holes are made different from each other between the brake disc plates.

Abstract: A microwave heating device includes a microwave generating portion outputting a microwave, a conductive heating chamber into which the microwave is led and having a short-circuited terminal end in a traveling direction of the microwave, and a tuner provided between the microwave generating portion and the heating chamber. The heating chamber has an opening for passing a member to be heated therethrough. The tuner re-reflects the microwave reflected at the terminal end of the heating chamber onto the heating chamber side. The microwave output end of the microwave generating portion and the tuner are connected by a square tubular waveguide made of a conductive material. The tuner and the terminal end of the heating chamber are connected by a square tubular waveguide, which is made of a conductive material except for the opening for passing the member to be heated therethrough.

Abstract: A tau aggregation inhibitor reduces tau aggregation in cells. The tau aggregation inhibitor can include a catechol structure-containing compound or a salt thereof, and the catechol structure-containing compound can be one of isoprenaline, dopamine, dobutamine, levodopa, levodopa/carbidopa, trimetoquinol, hexoprenaline, methyldopa, and droxidopa. One example of the catechol structure-containing compound is isoprenaline, which can be d-enantiomer of isoprenaline or d/l-racemic mixture of isoprenaline. Tauopathies to be prevented or treated by the inhibitor include AD, Down's syndrome, Pick's disease, corticobasal degeneration, and progressive supranuclear palsy.

Abstract: Provided is a chlorine evolution anode in which a main reaction of the anode is chlorine evolution, and the chlorine evolution anode which is low in potential of the anode for chlorine evolution, thereby being able to decrease an electrolytic voltage and lower an electric energy consumption rate. The chlorine evolution anode of the present invention is a chlorine evolution anode in which chlorine evolution from an aqueous solution is a main reaction of the anode and also in which a catalytic layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.

Abstract: There is provided a thermoacoustic device 1 which has in a loop tube 2, a first stack 3a between a first high-temperature side heat exchanger 4 and a first low-temperature side heat exchanger 5, and a second stack 3b provided between a second high-temperature side heat exchanger 6 and a second low-temperature side heat exchanger 7, so that heat at the first stack side is prevented from being transported to the second stack side even when a large acoustic wave is generated in the tube. In the device, self-excited standing and traveling waves are generated by heating the first high-temperature side heat exchanger 4, and by the standing and traveling waves, the second low-temperature side heat exchanger 7 is cooled. a piezoelectric film 81 is provided to suppress an acoustic streaming and/or a direct-current type flow of a working fluid.

Abstract: The present invention relates to an insulin preparation that contains a self-assembling peptide. More specifically, the present invention is an insulin preparation containing a self-assembling peptide of SEQ ID NO:1.

Abstract: A problem to be solved is to enhance the charge and discharge characteristics and rate characteristics of a B-type titanium oxide (TiO2(B)) powder by a simple treatment and to provide a B-type titanium oxide powder that can be suitably used as a negative electrode material for a lithium ion battery. A B-type titanium oxide powder is allowed to undergo a reaction under a fluorine-containing gas atmosphere at 0° C. to 200° C. for 1 minute to 10 days to obtain a surface-fluorinated B-type titanium oxide powder. It is preferred that the fluorination treatment is performed at 0.01 atm to 2 atm. It is preferred that a gas containing a fluorine compound selected from a fluorine (F2) gas, a nitrogen trifluoride (NF3) gas, a perfluorotrimethylamine (N(CF3)3) gas, a chlorine trifluoride (ClF3) gas and the like is used as the fluorine-containing gas.

Abstract: A microwave heating device enhances heating efficiency by a simple configuration. A microwave is led from one end of a conductive heating chamber in direction d2. The heating chamber is provided with an opening. A pair of conveying members are provided. A member to be heated sandwiched between the conveying members is moved in direction d1, and passes through the opening in direction d1 non-parallel to microwave traveling direction d2.

Abstract: In a rotation device using a hydraulic actuator, a rotation angle range is increased. A placement member rotatably coupled to a rotary member has a projecting part on an upper face. A hydraulic actuator is arranged on a projecting face of the projecting part; the actuator and the rotary member coupled with a wire material. The projecting part is formed such that it becomes higher from a leading edge on the side of the rotary member to an intermediate portion in the longitudinal direction, and becomes lower from the intermediate portion to a trailing edge. Thereby, when fluid is supplied to the actuator and shortens the actuator length, a tip of the actuator moves along the projecting face of the projecting part, and is located high, separated from the upper face of the placement member such that the rotation angle range of the rotary member becomes large.

Abstract: The disclosed is an arteriosclerosis evaluating apparatus capable of easily separating pulse wave data detected at one measurement site into an incident wave and a reflected wave and capable of easily determining and evaluating the degree of arteriosclerosis. The pulse wave transmitted through an artery is detected at one site of a living body by a pulse wave detection device, and the detected pulse wave is fitted with a fitting function by a breakdown device so that the detected pulse wave can be broken down into an incident wave and a reflected wave. The degree of arteriosclerosis is evaluated from the amplitude intensities (i.e., peak intensities) of the incident wave and the reflected wave broken down from the pulse wave.

Abstract: Provided is an anode for electrowinning in a sulfuric acid based electrolytic solution. The anode produces oxygen at a lower potential than a lead electrode, lead alloy electrode, and coated titanium electrode, thereby enabling electrowinning to be performed at a reduced electrolytic voltage and the electric power consumption rate of a desired metal to be reduced. The anode is also available as an anode for electrowinning various types of metals in volume with efficiency. The anode is employed for electrowinning in a sulfuric acid based electrolytic solution and adopted such that a catalyst layer containing amorphous ruthenium oxide and amorphous tantalum oxide is formed on a conductive substrate.

Abstract: A producing method includes a preparing step of preparing a chemical compound having at least one of elements of alkali metals and alkali earth metals along with platinum, and a reducing step of reducing the prepared chemical compound with a reducing agent to form platinum nanoparticles.