Patents Assigned to The Feinstein Institute for Medical Research
  • Treatment of inflammation using alpha 7 receptor-binding agonists
    Patent number: 9592228
    Abstract: Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from the macrophage, wherein the cholinergic agonist is selective for an ?7 nicotinic receptor. Methods for inhibiting an inflammatory cytokine cascade in a patient are also provided. The methods comprise treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is selective for an ?7 nicotinic receptor. Methods for determining whether a compound is a cholinergic agonist reactive with an ?7 nicotinic receptor are also provided. The methods comprise determining whether the compound inhibits release of a proinflammatory cytokine from a mammalian cell.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: March 14, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Hong Wang
  • Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer
    Patent number: 9567306
    Abstract: Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: February 14, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Yousef Al-Abed
  • Toe protecting cushion device
    Patent number: 9504593
    Abstract: Toe cushioning device for protecting a patient's toes. A toe cushion device includes two tubular cushions positioned in a transverse plane on the plantar side of a patient's toes during use. The toe cushion relieves foot or toe pain and conforms to the changing contour of the patient's foot and toes during use.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: November 29, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Jesse Roth, Gordon J. Berg
  • CD38 AS A PROGNOSTIC INDICATOR IN B CELL CHRONIC LYMPHOCYTIC LEUKEMIA
    Publication number: 20160304973
    Abstract: The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 20, 2016
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Nicholas Chiorazzi, Rajendra N. Darnle, Tarun Wasil
  • SAA domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
    Patent number: 9458232
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 4, 2016
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • Method for treating a neurological disorder associated with hypoxia using a small moleucule MIF inhibitor
    Patent number: 9457013
    Abstract: Methods are provided for treating pathologies associated with hypoxia with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk for pulmonary hypertension, with an MIF inhibitor. Methods are also provided for reating a subject having, or at risk from, a CNS disorder associated with hypoxia, with an MIF inhibitor. Methods are also provided of treating severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with an MIF inhibitor. Methods of diagnosing a subject with pulmonary hypertension are also provided.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: October 4, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Edmund Miller, Yousef Al-Abed, Yinzhong Zhang, Kai Fan Cheng
  • Method for treating glioblastomas and other tumors
    Patent number: 9440914
    Abstract: Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor radiation therapy on an astrocytoma in a subject. Also provided are methods of treating other solid tumor types, and tumor cell invasion, with guanylhydrazone compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 13, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Yousef Al-Abed, Marc Symons
  • TREATMENT OF INFLAMMATION BY NON-INVASIVE STIMULATION
    Publication number: 20160250097
    Abstract: Described herein are devices, systems and method for treating inflammatory disorders by modulating a subject's inflammatory reflex. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject in a manner which significantly reduces proinflammatory cytokines in the subject and/or provides a therapeutically effective treatment for the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 1, 2016
    Applicant: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Howland Shaw Warren, Michael Allen Faltys
  • Piperazines, pharmaceutical compositions and methods of use thereof
    Patent number: 9428522
    Abstract: Disclosed are novel piperazine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 30, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Roger B. Clark, Daniel Elbaum
  • Human B1 cells and uses thereof
    Patent number: 9371514
    Abstract: The present invention is directed to isolated populations of human natural immunoglobulin-producing B1 lymphocytes, wherein the B1 lymphocytes display surface biomarkers CD20, CD43 and CD27 and are either CD11b+ or GD11b?. The present invention is also directed to a method of isolating human natural immunoglobulin-producing B1 lymphocytes from a blood sample comprising isolating B lymphocytes from the sample that express surface biomarkers CD20, CD43 and CD27, and, optionally, CD11b. In addition, the present invention is directed to a methods for diagnosing a B1 cell disorder in a patient, determining the prognosis of a patient having a B1 cell disorder, and treating a patient having a B1 cell disorder.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: June 21, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Thomas L. Rothstein, Daniel O. Griffin, Nichol E. Holodick
  • MICROCHIP SENSOR FOR CONTINUOUS MONITORING OF REGIONAL BLOOD FLOW
    Publication number: 20160113518
    Abstract: A sensor is provided available for continuous monitoring of regional blood flow in a tissue, including cerebral tissue. Methods of monitoring regional blood flow using the sensor as well as systems and computer readable medium therefor are also provided.
    Type: Application
    Filed: October 21, 2015
    Publication date: April 28, 2016
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Raj K. Narayan, Chunyan Li
  • Milk fat globule epidermal growth factor—factor VIII and sepsis
    Patent number: 9321822
    Abstract: Provided are methods of treating a mammal undergoing sepsis or at risk for sepsis. Also provided are methods of preventing or treating a physiologic effect of sepsis in a mammal. Additionally provided is the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the treatment of a mammal having sepsis or at risk for sepsis.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: April 26, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang
  • Method of treating Tourette'S disorder with GABA-aminotransferase inactivators
    Patent number: 9254274
    Abstract: The present invention is a method of treating Tourette's Disorder (TD) using GABA ergic drugs that elevate the amount of stored presynaptic GABA and do not significantly increase GABA tone (a continuous background level of GABA signaling) in the brain. The administration of vigabatrin and/or (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid hydrochloride salt is expressly contemplated.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 9, 2016
    Assignees: Catalyst Pharmaceutical Partners, Inc., New York University, Feinstein Institute for Medical Research
    Inventors: Steven Miller, Jonathan D. Brodie, Stephen Dewey
  • INHIBITION OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN MELANOMA AND COLON CANCER
    Publication number: 20150361058
    Abstract: Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 17, 2015
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Yousef Al-Abed
  • Methods and systems for reducing inflammation by neuromodulation of T-cell activity
    Patent number: 9211409
    Abstract: Described herein are devices, systems and method of treating inflammation, including methods of treating a T-cell mediated disease. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering a T-cell modifying agent to modify the activity of splenic T-cells. Also described herein are systems for treating inflammation including an inflammatory reflex stimulation module and a T-cell response modifying module. The T-cell response modifying module typically modifies the response of splenic T-cells to enhance or otherwise regulate the effect of stimulation of the inflammatory reflex.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: December 15, 2015
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Mauricio Rosas-Ballina
  • HMGB1-BINDING BEADS AND USES THEREOF
    Publication number: 20150335763
    Abstract: Disclosed are therapeutic beads comprising agents, such as nucleic acids, that bind to high mobility group box 1 (HMGB1) and methods of treating subjects with conditions that would benefit from reducing the deleterious effects of HMGB1, such as inflammatory bowel diseases, comprising administering the beads to the gastrointestinal tract of the subjects.
    Type: Application
    Filed: January 9, 2014
    Publication date: November 26, 2015
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Sangeeta Chavan, Jacob Levine, Yehuda Tamari, Kevin J. Tracey, Huan Yang
  • Privacy curtain assembly with cleanable panels
    Patent number: 9144340
    Abstract: A privacy curtain assembly includes a main curtain portion. The main curtain portion includes a first side, a second side, and oppositely disposed leading edges located between the first and second sides. The privacy curtain assembly also includes at least one cleanable, wipable panel that is permanently affixed to one of the leading edges of the main curtain portion. The at least one panel is configured to be cleaned while permanently affixed to the main curtain portion.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: September 29, 2015
    Assignee: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Lorenz W. Mayer
  • Treatment of sepsis and inflammation with alphaadrenergic antagonists
    Patent number: 9107917
    Abstract: Provided are methods for treating a mammal undergoing sepsis, or at risk for sepsis. Also provided are methods of preventing or treating a physiological effect of sepsis in a mammal. Additionally provided are methods of inhibiting an inflammatory response in a mammal. Further provided is the use of an ?2A-adrenergic antagonist for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of an ?2A-adrenergic antagonist for the treatment of a mammal having sepsis or at risk for sepsis.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: August 18, 2015
    Assignee: The Feinstein Institute For Medical Research
    Inventor: Ping Wang
  • Treatment of inflammatory diseases by inhibiting cold-inducible RNA-binding protein (CIRP)
    Patent number: 9109023
    Abstract: Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. A method of treating a subject suffering from an inflammatory condition comprising administering to said subject a CIRP inhibitor is also described herein.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: August 18, 2015
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang
  • Bioactive scaffolds
    Patent number: RE46402
    Abstract: Provided are tissue scaffolds colonized by vertebrate cells expressing, a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal, using the tissue scaffolds. Additionally, methods of making the tissue scaffolds are provided.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: May 16, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Daniel A. Grande, James M. Mason, Arnold S. Breitbart