Patents Assigned to The Feinstein Institute for Medical Research
  • Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment
    Patent number: 9101593
    Abstract: Methods of treating a mammal at risk for ischemia-reperfusion injury are provided. The methods comprise administrating an adrenomedullin binding protein-1 (AMBP-1) to the mammal in sufficient amount to reduce the injury. Also provided are methods of treating a mammal at risk for ischemia-reperfusion injury to the bowel. The methods comprise administering adrenomedullin to the mammal in sufficient amount to reduce the injury.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 11, 2015
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang
  • Compounds and methods for treatment of systemic lupus erythematosus
    Patent number: 9096576
    Abstract: Small molecule compounds are provided for treating lupus as are methods of treating lupus using these compounds.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: August 4, 2015
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Yousef Al-Abed, Betty A. Diamond
  • Bioactive scaffolds
    Patent number: 9089117
    Abstract: Provided are tissue scaffolds colonized by vertebrate cells expressing a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal, using the tissue scaffolds. Additionally, methods of making the tissue scaffolds are provided.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: July 28, 2015
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Daniel A. Grande, James M. Mason
  • Prevention and treatment of inflammation and organ injury after ischemia/reperfusion using MFG-E8
    Patent number: 9018157
    Abstract: Provided are methods for preventing and treating inflammation and organ injury after ischemia/reperfusion, and methods for treating lung injury, comprising administering a milk fat globule epidermal growth factor-factor VIII (MFG-E8) to a subject. Also provided are pharmaceutical compositions comprising MFG-E8 in dosage form for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, and methods of preparing a pharmaceutical composition for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, comprising formulating MFG-E8 in a pharmaceutical composition.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: April 28, 2015
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang
  • C1q PEPTIDES AND USES THEREOF
    Publication number: 20150104472
    Abstract: Isolated C1q peptides, fusion proteins and compositions comprising such and fusion proteins comprising are provided. Isolated fusion proteins comprising X4WX5YX6 as defined herein and compositions comprising such are also provided. Methods of treating autoimmune disorders are provided.
    Type: Application
    Filed: July 15, 2014
    Publication date: April 16, 2015
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Betty A. Diamond
  • Methods for treatment of inflammatory diseases
    Patent number: 9005615
    Abstract: The present invention provides methods of treating inflammatory diseases in a subject comprising administering to the subject a therapeutically effective amount of an agent that inhibits pigment epithelium-derived factor (PEDF) and methods of screening for agents that inhibit PEDF.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: April 14, 2015
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Kevin Tracey, Sangeeta Chavan
  • SAA DOMAIN-SPECIFIC ANTIBODIES AND PEPTIDE ANTAGONISTS AND USE THEREOF TO TREAT INFLAMMATORY DISEASES
    Publication number: 20150023957
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 22, 2015
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
    Patent number: 8914114
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: December 16, 2014
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston
  • IDENTIFICATION AND USES OF BRAIN ACTIVITY NETWORKS
    Publication number: 20140350380
    Abstract: Methods for identifying networks correlating with placebo effects, progression of neurological disease symptoms, progression of pre-phenoconversion states of neurological diseases, and efficacious/non-efficacious candidate treatments for neurological diseases are provided.
    Type: Application
    Filed: September 18, 2012
    Publication date: November 27, 2014
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: David Eidelberg
  • ADRENOMEDULLIN AND ADRENOMEDULLIN BINDING PROTEIN FOR ISCHEMIA/REPERFUSION TREATMENT
    Publication number: 20140342988
    Abstract: Methods of treating a mammal at risk for ischemia-reperfusion injury are provided. The methods comprise administrating an adrenomedullin binding protein-1 (AMBP-1) to the mammal in sufficient amount to reduce the injury. Also provided are methods of treating a mammal at risk for ischemia-reperfusion injury to the bowel. The methods comprise administering adrenomedullin to the mammal in sufficient amount to reduce the injury.
    Type: Application
    Filed: February 28, 2014
    Publication date: November 20, 2014
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Ping Wang
  • MICROCHIP SENSOR FOR CONTINUOUS MONITORING OF REGIONAL BLOOD FLOW
    Publication number: 20140336476
    Abstract: A sensor is provided available for continuous monitoring of regional blood flow in a tissue, including cerebral tissue. Methods of monitoring regional blood flow using the sensor as well as systems and computer readable medium therefor are also provided.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 13, 2014
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Chunyan Li
  • METHOD FOR TREATING GLIOBLASTOMAS AND OTHER TUMORS
    Publication number: 20140323576
    Abstract: Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor radiation therapy on an astrocytoma in a subject. Also provided are methods of treating other solid tumor types, and tumor cell invasion, with guanylhydrazone compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 30, 2014
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Marc Symons, Anthony J. Hesketh, Samuel Z. Soffer
  • Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways
    Patent number: 8865641
    Abstract: A method of treating a fatty liver disease in a subject. The method comprises administering to the subject an effective amount of a cholinergic pathway stimulating agent, wherein the fatty liver disease is selected from non-alcoholic fatty liver (NAFL), alcoholic fatty liver (AFL), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH), NASH-associated liver fibrosis, ASH-associated liver fibrosis, non-alcoholic cirrhosis, and alcoholic cirrhosis.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: October 21, 2014
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Valentin A. Pavlov, Kevin J. Tracey
  • COMPOUNDS AND METHODS FOR TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20140309255
    Abstract: Small molecule compounds are provided for treating lupus as are methods of treating lupus using these compounds.
    Type: Application
    Filed: April 15, 2014
    Publication date: October 16, 2014
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Yousef Al-Abed, Betty A. Diamond
  • Monoclonal antibodies against HMGB1
    Patent number: 8846047
    Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: September 30, 2014
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
  • HMG1 antibody for treating inflammatory conditions
    Patent number: 8822169
    Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk of exhibiting sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: September 2, 2014
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Haichao Wang
  • METHOD FOR TREATING PATHOLOGIES ASSOCIATED WITH HYPOXIA USING MIF INHIBITORS
    Publication number: 20140242091
    Abstract: Methods are provided for treating pathologies associated with hypoxia with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk for pulmonary hypertension, with an MIF inhibitor. Methods are also provided for reating a subject having, or at risk from, a CNS disorder associated with hypoxia, with an MIF inhibitor. Methods are also provided of treating severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with an MIF inhibitor. Methods of diagnosing a subject with pulmonary hypertension are also provided.
    Type: Application
    Filed: May 13, 2014
    Publication date: August 28, 2014
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Edmund Miller, Yousef Al-Abed, Yinzhong Zhang, Kai Fan Cheng
  • TOE PROTECTING CUSHION DEVICE
    Publication number: 20140213954
    Abstract: Toe cushioning device for protecting a patient's toes. A toe cushion device includes two tubular cushions positioned in a transverse plane on the plantar side of a patient's toes during use. The toe cushion relieves foot or toe pain and conforms to the changing contour of the patient's foot and toes during use.
    Type: Application
    Filed: January 28, 2014
    Publication date: July 31, 2014
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Jesse Roth, Gordon J. Berg
  • FASTENER
    Publication number: 20140194937
    Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
    Type: Application
    Filed: January 2, 2014
    Publication date: July 10, 2014
    Applicants: The General Hospital Corporation dba Massachusetts General Hospital, THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Stanley E. Asnis, Peter D. Asnis
  • TREATMENT OF CUTANEOUS WOUNDS BY INHIBITING COLD SHOCK PROTEINS
    Publication number: 20140193412
    Abstract: Disclosed are methods of treating a subject suffering from a cutaneous wound comprising administering to the subject a CIRP inhibitor.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 10, 2014
    Applicant: The Feinstein Institute for Medical Research
    Inventors: Ping Wang, Weng-Lang Yang