Patents Assigned to The George Washington University
  • Patent number: 10765722
    Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: September 8, 2020
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir S. Chawla
  • Patent number: 10738768
    Abstract: A satellite thruster increases satellite efficiency. The Linear Actuated ?CAT has a stepper motor to move the ablative electrode forward. A LabVIEW program and Arduino microcontroller are used to analyze the Linear Actuated ?CAT to determine how many steps are required for re-ignition, arc current, and the validity of the feed system. Results from testing show that micro-stepping the stepper motor is an effective way to replenish the cannibalized electrode for propellant.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 11, 2020
    Assignee: The George Washington University
    Inventors: Michael Keidar, George Teel, Samantha A. Hurley
  • Patent number: 10737358
    Abstract: The metallurgical composition of a machine surface may be determined. Based on the composition of the surface layer and its substrate materials, a mixture of pure metal nanoparticles, each coated with a monomolecular organic layer adsorbed on its surface can be mixed with catalysts, reaction initiators, and/or other necessary ingredients for the repair action of the machine surface, depending on the specific machine, operational type, and/or the nature of the damage. The nanoparticles are applied to the machine surface, the organic monolayer wears away from the nanoparticles under shear stresses and the nanoparticles adhere to the machine surface to form a repair layer on the machine surface, thereby providing a repaired surface.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: August 11, 2020
    Assignee: The George Washington University
    Inventor: Stephen Hsu
  • Patent number: 10736512
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: August 11, 2020
    Assignee: The George Washington University
    Inventors: Marco A. Mercader, Matthew W. Kay, Narine Sarvazyan
  • Publication number: 20200237963
    Abstract: The present application relates to biocompatible polymers that exhibit a shape-memory effect, devices made using the materials and methods of producing such materials and devices.
    Type: Application
    Filed: August 25, 2016
    Publication date: July 30, 2020
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Shida Miao, Wei Zhu, Nathan J. Castro, Lijie G. Zhang
  • Patent number: 10722301
    Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: July 28, 2020
    Assignees: The George Washington University, 460Medical, Inc.
    Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
  • Patent number: 10716462
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: July 21, 2020
    Assignees: The George Washington University, 460Medical, Inc.
    Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
  • Publication number: 20200212676
    Abstract: Waveforms in power grids typically reveal a certain pattern with specific features and peculiarities driven by the system operating conditions, internal and external uncertainties, etc. This prompts an observation of different types of waveforms at the measurement points (substations). An innovative next-generation smart sensor technology includes a measurement unit embedded with sophisticated analytics for power grid online surveillance and situational awareness. The smart sensor brings additional levels of smartness into the existing phasor measurement units (PMUs) and intelligent electronic devices (IEDs). It unlocks the full potential of advanced signal processing and machine learning for online power grid monitoring in a distributed paradigm.
    Type: Application
    Filed: November 30, 2019
    Publication date: July 2, 2020
    Applicant: The George Washington University
    Inventors: Payman DEHGHANIAN, Shiyuan WANG
  • Patent number: 10688223
    Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 23, 2020
    Assignee: The George Washington University, a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang
  • Patent number: 10684274
    Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: June 16, 2020
    Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONLLY CHARTERED NOT-FOR-PROFIT CORPORATION
    Inventors: Alexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
  • Patent number: 10661257
    Abstract: Carbon-doped graphitic carbon nitride (g-C3N4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-C3N4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. Carbon- and phosphorus-doped g-C3N4 compositions, when in the presence of UV or visible light, can be used in water treatment systems to photocatalytically degrade persistent organic micropollutants such as pharmaceuticals and personal care products (PPCPs), endocrine disrupting compounds (EDCs), pesticides, and herbicides. Carbon- and phosphorus-doped g-C3N4 compositions can also be applied to surfaces of household and public items to kill protozoa, eukaryotic parasites, algal pathogens, bacteria, fungi, prions, viruses, or other microorganisms, preventing the transfer thereof between users.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 26, 2020
    Assignee: The George Washington University
    Inventors: Danmeng Shuai, Qinmin Zheng
  • Patent number: 10663766
    Abstract: An electro-optical modulator using a graphene-based plasmonic slot is disclosed. The electro-optical modulator is comprised of a substrate layer, a dielectric spacer, a graphene layer, a first metal layer, and a second metal layer. The metal layers create a plasmonic slot that modulates between a light absorptive and light transparent state depending on the application of voltage across the modulator. Two or four graphene layers may be used to reduce power consumption and the size of the modulator.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: May 26, 2020
    Assignee: The George Washington University
    Inventors: Zhizhen Ma, Volker J. Sorger
  • Publication number: 20200140469
    Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.
    Type: Application
    Filed: June 27, 2018
    Publication date: May 7, 2020
    Applicants: The George Washington University, Washington University in St. Louis, George Mason University, Saint Louis University
    Inventors: Cynthia Dowd, Xu WANG, Robert Carl BROTHERS, Audrey Ragan Odom JOHN, Rachel EDWARDS, Marvin MEYERS, Stacy ARNETT, Robin COUCH, Kenneth HEIDEL
  • Publication number: 20200109453
    Abstract: Disclosures herein encompass methods of treating a subject with moderate to severe hidradenitis suppurativa (HS) encompassing the determination of differential gene expression to characterize HS severity followed by administration of a treatment specific for the stage of HS severity characterized in the subject.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 9, 2020
    Applicant: The George Washington University
    Inventors: Victoria SHANMUGAM, Derek JONES
  • Patent number: 10611983
    Abstract: The present disclosure relates to new and optimized processes for the preparation of micro- and nano-scale capsules containing lubricant chemical additives. The present disclosure also relates to micro- and nano-scale capsules prepared by such processes, which are useful in a variety of applications, including automotive lubricants, diesel lubricants, industrial lubricants, metal-working lubricants, coolants, and process fluids. Micro-and nano-scale capsules prepared as described herein have the required properties that such capsules need to exhibit in order to function effectively and meet the requirements imposed by engine lubrication conditions. The microcapsules may be dispersed in a lubricating oil such that the lubricant exhibits improved stability and anti-wear performance, thereby improving engine fuel efficiency and performance.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 7, 2020
    Assignee: The George Washington University
    Inventors: Stephen M. Hsu, Fei Zhao
  • Patent number: 10593349
    Abstract: A system and method for emotional interaction. The system includes a robot that uses behavioral analysis automation to provide treatment and assessment of emotional communication and social skills for children with autism. The system generates a dataset including speech signals of one or more speakers, and assigns at least one of a set of labels to each of the speech signals for the one or more speakers. The set of labels includes at least three levels of emotional dimensions, the emotional dimensions include at least activation, valence, and dominance, and the at least three levels of emotional dimensions include a high state, a neutral state, and a low state.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: March 17, 2020
    Assignee: The George Washington University
    Inventor: Chung Hyuk Park
  • Patent number: 10585104
    Abstract: The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: March 10, 2020
    Assignees: The George Washington University, UT-Battelle, LLC
    Inventors: Akos Vertes, Bennett N. Walker, Jessica A. Stolee, Scott T. Retterer
  • Patent number: 10564512
    Abstract: Photonic data routing in optical networks is expected overcome the limitations of electronic routers with respect to data rate, latency, and energy consumption. However photonics-based routers suffer from dynamic power consumption, and non-simultaneous usage of multiple wavelength channels when microrings are deployed and are sizable in footprint. Here we show a design for the first hybrid photonic-plasmonic, non-blocking, broadband 5×5 router based on 3-waveguide silicon photonic-plasmonic 2×2 switches. The compactness of the router (footprint <200 ?m2) results in a short optical propagation delay (0.4 ps) enabling high data capacity up to 2 Tbps. The router has an average energy consumption ranging from 0.1˜1.0 fJ/bit depending on either DWDM or CDWM operation, enabled by the low electrical capacitance of the switch. The total average routing insertion loss of 2.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: February 18, 2020
    Assignee: The George Washington University
    Inventors: Shuai Sun, Volker J. Sorger, Tarek El-Ghazawi, Vikram K. Narayana
  • Patent number: 10566491
    Abstract: An efficient solar cell and method of fabricating the same is disclosed. The solar cell includes an n-doped substrate layer. A p-doped buffer layer is disposed on the n-doped substrate layer. A quantum dot absorber stack is disposed on the buffer layer. The absorber stack includes at least one quantum dot layer and one p-doped spacer layer. A p-doped cap layer is disposed on the quantum dot absorber layer. The thickness of the quantum dot layer is less than an electron diffusion length from the depletion region formed by the n-doped substrate layer and the p-doped buffer layer. The quantum dot absorber layer allows for additional photo currents from two-photon absorption from the p-doped cap layer being exposed to a light source.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: February 18, 2020
    Assignees: The George Washington University, National Centre for Scientific Research
    Inventors: Andrei Afanasev, Ara Kechiantz, Jean-Louis Lazzari
  • Patent number: 10548943
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: February 4, 2020
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir S. Chawla