Patents Assigned to The George Washington University
  • Patent number: 10322160
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: June 18, 2019
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir Chawla
  • Patent number: 10318680
    Abstract: An optical-electronic device can be controlled by a bias voltage to simulate an electronic component such as a resistor, capacitor, inductor with resistor, or capacitor with resistor. The optical-electronic device can be connected in a network to perform computations, model problems, simulate properties such as physical properties (for instance heat transfer), and achieve circuit performances to carry out computations in the analog domain, all at faster speed with smaller size and at less energy.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: June 11, 2019
    Assignee: The George Washington University
    Inventors: Tarek El-Ghazawi, Volker J. Sorger, Shuai Sun, Abdel-Hameed A. Badawy, Vikram K. Narayana
  • Patent number: 10300484
    Abstract: A handheld system includes a reference pressure source configured to generate a reference pressure. The handheld system also includes a primary pressure source coupled to the reference pressure source. The primary pressure source is configured to generate a primary pressure in a primary pressure range. The primary pressure is less than the reference pressure, and the primary pressure is induced by the reference pressure source. The handheld system also includes a secondary pressure source coupled to the primary pressure source. The secondary pressure source is configured to generate a secondary pressure in a secondary pressure range. The secondary pressure is less than the primary pressure, and the secondary pressure is induced by the primary pressure source.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 28, 2019
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Zhenyu Li, Baichen Li
  • Patent number: 10289448
    Abstract: A traffic management mechanism can employ a two-tiered approach for managing background traffic based on prioritizing tasks by remaining time flexibility then scheduling prioritized tasks using linear programming.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 14, 2019
    Assignees: AT&T Intellectual Property I, L.P., George Washington University
    Inventors: Moo-Ryong Ra, Rajesh Krishna Panta, Tian Lan, Shijing Li
  • Publication number: 20190137398
    Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 9, 2019
    Applicant: The George Washington University
    Inventors: Emilia ENTCHEVA, Aleksandra KLIMAS
  • Patent number: 10272056
    Abstract: The present application relates to methods of treating a subject with a disease or disorder associated with a mitochondrial deficit, comprising: determining at least one of a type or degree of the mitochondrial deficit in the subject; and administering an amount of a butyrate compound to the subject based at least partially on the determining step so as to promote Adenosine triphosphate (ATP) production in the subject as well as to methods of screening for compounds that restore cellular mitochondrial activity.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 30, 2019
    Assignee: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation
    Inventors: Anne Chiaramello, Martine Uittenbogaard
  • Patent number: 10256600
    Abstract: The Hybrid Photonic Plasmonic Interconnect (HyPPI) combines both low loss photonic signal propagation and passive routing with ultra-compact plasmonic devices. These optical interconnects therefore uniquely combine fast operational data-bandwidths (in hundreds of Gbps) for light manipulation with low optical attenuation losses by hybridizing low loss photonics with strong light-matter-interaction plasmonics to create, modulate, switch and detect light efficiently at the same time. Initial implementations were considered for on-chip photonic integration, but also promising for free space or fiber-based systems. In general two technical options exist, which distinguished by the method the electric-optic conversion is executed: the extrinsic modulation method consists of an continuous wave source such as an LED or laser operating at steady power output, and signal encoding is done via an electro-optic modulator downstream of the source in the interconnect.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 9, 2019
    Assignee: The George Washington University
    Inventors: Shuai Sun, Volker J. Sorger, Tarek El-Ghazawi, Vikram K. Narayana, Abdel-Hameed A. Badawy
  • Patent number: 10245806
    Abstract: The present invention relates to techniques for lowering friction between moving surfaces of, for example, an internal combustion engine. Friction reduction is achieved by adding texture modifications to surfaces that come in contact with each other. Texture modifications that reduce friction in accordance with the present invention include dimples of varying geometries and depths ion the surfaces of components. The present invention also relates to the fabrication technique for applying the textures to the surfaces. In another embodiment, the patterned soft mask is applied onto a large surface (flat or curved including cylindrical rollers surfaces) to be followed by electrochemical etching to imprint the textures onto the component. And, in another embodiment, a diamond-like-carbon (DLC) film may be applied to the turbine component to also reduce friction.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 2, 2019
    Assignee: The George Washington University
    Inventors: Stephen M. Hsu, Yang Jing, Yufei Mo, Dongyun Hua, Ming Chen
  • Publication number: 20190030056
    Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Applicants: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALL A CONGRESSIOY CHARTERED NOT-FOR-PROFIT CORPORATIO, WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Cynthia DOWD, Audrey ODOM, Rachel Edwards, Robert BROTHERS
  • Patent number: 10185824
    Abstract: A system detects a covert timing channel on a combinational structure or a memory structure. The system identifies the events behind conflicts, and constructs an event train based on those events. For combinational structures, the system detects recurrent burst patterns in the event train. The system determines that a covert timing channel exists on the combinational structure if a recurrent burst pattern is detected. For memory structures, the system detects oscillatory patterns in the event train. The system determines that a covert timing channel exists on the memory structure if an oscillatory pattern is detected.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: January 22, 2019
    Assignee: The George Washington University
    Inventors: Guru Prasadh V. Venkataramani, Jie Chen
  • Patent number: 10168309
    Abstract: A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: January 1, 2019
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERICE, GEORGE MASON UNIVERSITY, THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Abhishek Motayed, Geetha Aluri, Albert V. Davydov, Mulpuri V. Rao, Vladimir P. Oleshko, Ritu Bajpai, Mona E. Zaghloul
  • Patent number: 10166268
    Abstract: The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: January 1, 2019
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: David Mendelowitz, Vivek Jain, Heather Jameson, Jay Shawn Kimbro
  • Publication number: 20180370659
    Abstract: A thruster for a micro-satellite is disclosed. The thruster includes a cathode composed of a propellant material and an anode composed of ablative material. The thruster includes a housing having a proximate end and an opposite distal end having a thrust channel. The housing holds the anode and the cathode. A pulsed voltage source is coupled between the cathode and the anode causing current sufficient to create ablation of the anode and a plasma jet including ablated particles from the anode to be emitted from the thrust channel.
    Type: Application
    Filed: December 6, 2016
    Publication date: December 27, 2018
    Applicant: The George Washington University
    Inventors: Michael Keidar, George Lewis Teel, Joseph Nicholas Lukas, Jonathan Kolbeck
  • Publication number: 20180344800
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Application
    Filed: August 7, 2018
    Publication date: December 6, 2018
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir CHAWLA
  • Patent number: 10139382
    Abstract: A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: November 27, 2018
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERICE, GEORGE MASON UNIVERSITY, THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Abhishek Motayed, Geetha Aluri, Albert V. Davydov, Mulpuri V. Rao, Vladimir P. Oleshko, Ritu Bajpai, Mona E. Zaghloul
  • Patent number: 10107271
    Abstract: A thruster for a micro-satellite is disclosed. The thruster includes a voltage source, an inductor and a resistor. A switching device is coupled to the inductor and the resistor. The thruster includes an exterior electrode composed of a first propellant, an insulator located coaxially within the exterior electrode and an interior electrode composed of a second propellant located coaxially to the insulator and the exterior electrode. An exterior housing has a proximate end and an opposite distal end with a thrust channel. The exterior housing holds the exterior electrode, the insulator and the interior electrode. The switching device is coupled to either the exterior electrode or the interior electrode. The switching device is switched to pulse voltage from the inductor to create an arc between the exterior electrode and the interior electrode. Either the exterior electrode or the interior electrode may serve as a cathode to generate a plasma jet.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: October 23, 2018
    Assignee: The George Washington University
    Inventors: Michael Keidar, Dereck Chiu, Taisen Zhuang, George Teel, Alexy Shashurin
  • Publication number: 20180263935
    Abstract: The present application relates to methods of treating a subject with a disease or disorder associated with a mitochondrial deficit, comprising: determining at least one of a type or degree of the mitochondrial deficit in the subject; and administering an amount of a butyrate compound to the subject based at least partially on the determining step so as to promote Adenosine triphosphate (ATP) production in the subject as well as to methods of screening for compounds that restore cellular mitochondrial activity.
    Type: Application
    Filed: April 1, 2016
    Publication date: September 20, 2018
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Anne Chiaramello, Martine Uittenbogaard
  • Patent number: 10076238
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: September 18, 2018
    Assignees: The George Washington University, LuxCath, LLC
    Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
  • Publication number: 20180228470
    Abstract: Enhancing chondrogenesis at a desired site by the application of ultrasound in the presence of microbbubles. A biomimetic scaffold may be seeded with stem cells capable of undergoing chondrogenesis and provided to the site and then subjected to ultrasound excitation in the presence of microbubbles.
    Type: Application
    Filed: November 27, 2017
    Publication date: August 16, 2018
    Applicant: The George Washington University
    Inventors: Mitra ALIABOUZAR, Kausik SARKAR, Lijie Grace ZHANG
  • Patent number: 10028995
    Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: July 24, 2018
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir Chawla