Patents Assigned to The George Washington University
  • Patent number: 11221541
    Abstract: A digital-to-analog converter has a first interface coupled to a second interface through one or more modulation circuits. The circuits include a first coupler connected to the first interface; a first waveguide with a first lead connected to the first coupler, a first end, and a first length running therebetween. The first lead and the first end are coupled by a first switch. The circuits also include: a second coupler connected to the first interface; a second waveguide having a second lead connected to the second coupler, a second end, and a second length running therebetween, the second lead and the second end coupled by a second switch along the second length; and an optical combiner connected to the ends of the waveguides. The second interface is connected to the optical combiner of the modulation circuits. Output from the second interface is an optical signal capable of carrying binary information.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: January 11, 2022
    Assignee: The George Washington University
    Inventors: Jonathan K. George, Volker J. Sorger
  • Patent number: 11213614
    Abstract: Biphasic tissue constructs that include a scaffold having one or more channels, a vascular portion comprising a hydrogel at least partially disposed in the one or more channels, and a first bioactive growth factor and a second bioactive growth factor different from the first bioactive growth factor, the first bioactive growth factor localized to the scaffold and the second bioactive growth factor localized to the vascular portion. The first bioactive growth factor may be bone morphogenetic protein 2 (BMP2) peptide and the second bioactive growth factor may be vascular endothelial growth factor (VEGF) peptide.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 4, 2022
    Assignee: The George Washington University
    Inventors: Lijie G. Zhang, Haitao Cui, Wei Zhu
  • Patent number: 11211913
    Abstract: A device employing the generation and enhancement of surface acoustic waves on a highly doped p-type III-V semiconductor substrate (e.g., GaAs, GaSb, InAs, or InGaAs). The device includes two SiO2/ZnO islands, each including a SiO2 buffer layer deposited on the doped p-type III-V semiconductor substrate and a ZnO layer deposited on the SiO2 buffer layer. An input interdigital transducers (IDT) and an output IDT are each patterned on one of the SiO2/ZnO islands. The IDTs generates surface acoustic waves along an exposed surface of the highly doped p-type III-V semiconductor substrate. The surface acoustic waves improve the photoelectric and photovoltaic properties of the device. The device is manufactured using a disclosed technique for propagating strong surface acoustic waves on weak piezoelectric materials. Also disclosed is a photodetector developed using that technique.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: December 28, 2021
    Assignee: The George Washington University
    Inventors: Boqun Dong, Mona Zaghloul
  • Patent number: 11160767
    Abstract: The present disclosure provides methods, pharmaceutical compositions, dosing regimens, and kits comprising 4,4?-trans-dihydroxystilbene (DHS), including methods of treating cancer in a subject and methods of decreasing or reversing resistance to a DNA damaging agent in a subject.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: November 2, 2021
    Assignee: The George Washington University, a Congressionally Chartered Not-For-Profit Corporation
    Inventors: Chi-Wei Chen, Yongming Li, Zhiyong Han, Wenge Zhu
  • Patent number: 11158845
    Abstract: The present disclosure relates to an improved process for the synthesis of nanomaterials and composites from Zintl phases. The nanomaterials and composites are useful, for example, as ion storage materials.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: October 26, 2021
    Assignee: The George Washington University
    Inventors: Michael J. Wagner, Nathan A. Banek
  • Patent number: 11137784
    Abstract: A linear regulator operates in the manner of a linear voltage regulator, but with the functionality of a switching converter. This concept enables DC voltage up-conversion with no switching, more efficient step down of large voltage steps, and requires no expensive and bulky additional components. An optocoupler device transfers power between light emitting and photovoltaic devices.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: October 5, 2021
    Assignee: The George Washington University
    Inventor: Matthew Lumb
  • Patent number: 11131661
    Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 28, 2021
    Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION
    Inventors: Alexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
  • Patent number: 11098072
    Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 24, 2021
    Assignees: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, Washington University, George Mason University, St. Louis University
    Inventors: Cynthia Dowd, Xu Wang, Robert Carl Brothers, Audrey Ragan Odom John, Rachel Edwards, Marvin Meyers, Stacy Arnett, Robin Couch, Kenneth Heidel
  • Patent number: 11096983
    Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 6.5 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: August 24, 2021
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir S. Chawla
  • Patent number: 11096584
    Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 24, 2021
    Assignees: The George Washington University, 460Medical, Inc.
    Inventors: Marco A. Mercader, Narine Sarvazyan, Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana
  • Publication number: 20210238696
    Abstract: The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.
    Type: Application
    Filed: April 9, 2021
    Publication date: August 5, 2021
    Applicants: Duke University, George Washington University
    Inventors: Jennifer Freedman, Yanru Wang, Hongliang Liu, Qingyi Wei, Daniel George, Steven Patierno, Bi-Dar Wang, Norman Lee
  • Patent number: 11077962
    Abstract: A thruster for a micro-satellite is disclosed. The thruster includes a cathode composed of a propellant material and an anode composed of ablative material. The thruster includes a housing having a proximate end and an opposite distal end having a thrust channel. The housing holds the anode and the cathode. A pulsed voltage source is coupled between the cathode and the anode causing current sufficient to create ablation of the anode and a plasma jet including ablated particles from the anode to be emitted from the thrust channel.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 3, 2021
    Assignee: The George Washington University
    Inventors: Michael Keidar, George Lewis Teel, Joseph Nicholas Lukas, Jonathan Kolbeck
  • Patent number: 11066706
    Abstract: The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample from said subject; detecting RNA expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 20, 2021
    Assignee: The George Washington University, A Congressionally Chartered Not-For-Profit Corporation
    Inventors: Lakhmir S. Chawla, Timothy A. McCaffrey
  • Patent number: 11035792
    Abstract: A nanohole array (NHA)-based plasmonic sensor (e.g., gas/condensed phase sensor), their preparation, and their use to detect and analyze samples, especially mixtures of chemicals/bio-chemicals.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: June 15, 2021
    Assignees: The George Washington University, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
    Inventors: Yangyang Zhao, Mona Zaghloul, Stephen Semancik, Kurt D. Benkstein
  • Patent number: 11020744
    Abstract: A handheld system includes a reference pressure source configured to generate a reference pressure. The handheld system also includes a primary pressure source coupled to the reference pressure source. The primary pressure source is configured to generate a primary pressure in a primary pressure range. The primary pressure is less than the reference pressure, and the primary pressure is induced by the reference pressure source. The handheld system also includes a secondary pressure source coupled to the primary pressure source. The secondary pressure source is configured to generate a secondary pressure in a secondary pressure range. The secondary pressure is less than the primary pressure, and the secondary pressure is induced by the primary pressure source.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 1, 2021
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Zhenyu Li, Baichen Li
  • Patent number: 11020933
    Abstract: The present invention relates to techniques for lowering friction between moving surfaces of, for example, an internal combustion engine. Friction reduction is achieved by adding texture modifications to surfaces that come in contact with each other. Texture modifications that reduce friction in accordance with the present invention include dimples of varying geometries and depths ion the surfaces of components. The present invention also relates to the fabrication technique for applying the texture to the surfaces. In another embodiment, the patterned soft mask is applied onto a large surface (flat or curved including cylindrical rollers surfaces) to be followed by electrochemical etching to imprint the textures onto the component And, in another embodiment, a diamond-like-carbon (DLC) film may be applied to the turbine component to also reduce friction.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: June 1, 2021
    Assignee: The George Washington University
    Inventors: Stephen M. Hsu, Yang Jing, Yufei Mo, Dongyun Hua, Ming Chen
  • Patent number: 11013462
    Abstract: An electrocardiogram (ECG) sensor has a flexible thin ring-shaped substrate configured to be worn about a patient's finger. The substrate has an inner surface and an outer surface opposite the inner surface. A first ECG electrode is positioned at the outer surface of said substrate and a second ECG electrode is positioned at the inner (or outer) surface of the said substrate in contact with the finger (or the adjacent finger if the electrode is on the outer surface), whereby the two ECG electrodes receives a single-lead ECG signal when the first electrode is touched to the patient's body. Touching different locations on the body or wearing multiple rings can provide multi-lead ECG measurements. The ring shape can be converted to a wearable patch for continuous ECG measurements.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 25, 2021
    Assignee: The George Washington University
    Inventors: Zhenyu Li, Quan Dong, Mona Zaghloul
  • Patent number: 10981976
    Abstract: The present invention features anti-HERV-K monoclonal antibodies or antigen-binding portions thereof. The present invention also features uses of the antibodies for treating HIV infection or HIV-associated conditions or diseases.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 20, 2021
    Assignees: University of Rochester, Oregon Health & Science University, George Washington University
    Inventors: James J. Kobie, Jonah B. Sacha, Douglas F. Nixon
  • Patent number: 10982285
    Abstract: The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: April 20, 2021
    Assignees: DUKE UNIVERSITY, THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Jennifer Freedman, Yanru Wang, Hongliang Liu, Qingyi Wei, Daniel George, Steven Patierno, Bi-Dar Wang, Norman Lee
  • Publication number: 20210062266
    Abstract: Methods and kits for diagnosing and/or treating a lower respiratory infection in a subject include obtaining a biological sample from the subject; detecting RNA expression levels of one or more biomarkers in the biological sample and comparing the expression levels of the one or more three biomarkers to at least one invariant control marker wherein an increase or decrease in the level of expression of the one or more biomarkers as compared to the at least one invariant control marker is indicative of a lower respiratory infection.
    Type: Application
    Filed: October 27, 2020
    Publication date: March 4, 2021
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Timothy A. McCaffrey, Lakhmir S. Chawla