Patents Assigned to The George Washington University
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Patent number: 10738768Abstract: A satellite thruster increases satellite efficiency. The Linear Actuated ?CAT has a stepper motor to move the ablative electrode forward. A LabVIEW program and Arduino microcontroller are used to analyze the Linear Actuated ?CAT to determine how many steps are required for re-ignition, arc current, and the validity of the feed system. Results from testing show that micro-stepping the stepper motor is an effective way to replenish the cannibalized electrode for propellant.Type: GrantFiled: June 22, 2017Date of Patent: August 11, 2020Assignee: The George Washington UniversityInventors: Michael Keidar, George Teel, Samantha A. Hurley
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Patent number: 10737358Abstract: The metallurgical composition of a machine surface may be determined. Based on the composition of the surface layer and its substrate materials, a mixture of pure metal nanoparticles, each coated with a monomolecular organic layer adsorbed on its surface can be mixed with catalysts, reaction initiators, and/or other necessary ingredients for the repair action of the machine surface, depending on the specific machine, operational type, and/or the nature of the damage. The nanoparticles are applied to the machine surface, the organic monolayer wears away from the nanoparticles under shear stresses and the nanoparticles adhere to the machine surface to form a repair layer on the machine surface, thereby providing a repaired surface.Type: GrantFiled: February 21, 2012Date of Patent: August 11, 2020Assignee: The George Washington UniversityInventor: Stephen Hsu
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Patent number: 10736512Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.Type: GrantFiled: February 13, 2015Date of Patent: August 11, 2020Assignee: The George Washington UniversityInventors: Marco A. Mercader, Matthew W. Kay, Narine Sarvazyan
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Publication number: 20200237963Abstract: The present application relates to biocompatible polymers that exhibit a shape-memory effect, devices made using the materials and methods of producing such materials and devices.Type: ApplicationFiled: August 25, 2016Publication date: July 30, 2020Applicant: The George Washington University a Congressionally Chartered Not-for-Profit CorporationInventors: Shida Miao, Wei Zhu, Nathan J. Castro, Lijie G. Zhang
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Patent number: 10722301Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: GrantFiled: November 3, 2015Date of Patent: July 28, 2020Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 10716462Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.Type: GrantFiled: May 23, 2018Date of Patent: July 21, 2020Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Publication number: 20200212676Abstract: Waveforms in power grids typically reveal a certain pattern with specific features and peculiarities driven by the system operating conditions, internal and external uncertainties, etc. This prompts an observation of different types of waveforms at the measurement points (substations). An innovative next-generation smart sensor technology includes a measurement unit embedded with sophisticated analytics for power grid online surveillance and situational awareness. The smart sensor brings additional levels of smartness into the existing phasor measurement units (PMUs) and intelligent electronic devices (IEDs). It unlocks the full potential of advanced signal processing and machine learning for online power grid monitoring in a distributed paradigm.Type: ApplicationFiled: November 30, 2019Publication date: July 2, 2020Applicant: The George Washington UniversityInventors: Payman DEHGHANIAN, Shiyuan WANG
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Patent number: 10688223Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.Type: GrantFiled: July 14, 2017Date of Patent: June 23, 2020Assignee: The George Washington University, a Congressionally Chartered Not-for-Profit CorporationInventors: Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang
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Patent number: 10684274Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.Type: GrantFiled: January 12, 2017Date of Patent: June 16, 2020Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONLLY CHARTERED NOT-FOR-PROFIT CORPORATIONInventors: Alexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
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Patent number: 10663766Abstract: An electro-optical modulator using a graphene-based plasmonic slot is disclosed. The electro-optical modulator is comprised of a substrate layer, a dielectric spacer, a graphene layer, a first metal layer, and a second metal layer. The metal layers create a plasmonic slot that modulates between a light absorptive and light transparent state depending on the application of voltage across the modulator. Two or four graphene layers may be used to reduce power consumption and the size of the modulator.Type: GrantFiled: February 26, 2018Date of Patent: May 26, 2020Assignee: The George Washington UniversityInventors: Zhizhen Ma, Volker J. Sorger
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Patent number: 10661257Abstract: Carbon-doped graphitic carbon nitride (g-C3N4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-C3N4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. Carbon- and phosphorus-doped g-C3N4 compositions, when in the presence of UV or visible light, can be used in water treatment systems to photocatalytically degrade persistent organic micropollutants such as pharmaceuticals and personal care products (PPCPs), endocrine disrupting compounds (EDCs), pesticides, and herbicides. Carbon- and phosphorus-doped g-C3N4 compositions can also be applied to surfaces of household and public items to kill protozoa, eukaryotic parasites, algal pathogens, bacteria, fungi, prions, viruses, or other microorganisms, preventing the transfer thereof between users.Type: GrantFiled: February 16, 2017Date of Patent: May 26, 2020Assignee: The George Washington UniversityInventors: Danmeng Shuai, Qinmin Zheng
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Publication number: 20200140469Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.Type: ApplicationFiled: June 27, 2018Publication date: May 7, 2020Applicants: The George Washington University, Washington University in St. Louis, George Mason University, Saint Louis UniversityInventors: Cynthia Dowd, Xu WANG, Robert Carl BROTHERS, Audrey Ragan Odom JOHN, Rachel EDWARDS, Marvin MEYERS, Stacy ARNETT, Robin COUCH, Kenneth HEIDEL
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Publication number: 20200109453Abstract: Disclosures herein encompass methods of treating a subject with moderate to severe hidradenitis suppurativa (HS) encompassing the determination of differential gene expression to characterize HS severity followed by administration of a treatment specific for the stage of HS severity characterized in the subject.Type: ApplicationFiled: October 4, 2019Publication date: April 9, 2020Applicant: The George Washington UniversityInventors: Victoria SHANMUGAM, Derek JONES
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Patent number: 10611983Abstract: The present disclosure relates to new and optimized processes for the preparation of micro- and nano-scale capsules containing lubricant chemical additives. The present disclosure also relates to micro- and nano-scale capsules prepared by such processes, which are useful in a variety of applications, including automotive lubricants, diesel lubricants, industrial lubricants, metal-working lubricants, coolants, and process fluids. Micro-and nano-scale capsules prepared as described herein have the required properties that such capsules need to exhibit in order to function effectively and meet the requirements imposed by engine lubrication conditions. The microcapsules may be dispersed in a lubricating oil such that the lubricant exhibits improved stability and anti-wear performance, thereby improving engine fuel efficiency and performance.Type: GrantFiled: May 15, 2015Date of Patent: April 7, 2020Assignee: The George Washington UniversityInventors: Stephen M. Hsu, Fei Zhao
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Patent number: 10593349Abstract: A system and method for emotional interaction. The system includes a robot that uses behavioral analysis automation to provide treatment and assessment of emotional communication and social skills for children with autism. The system generates a dataset including speech signals of one or more speakers, and assigns at least one of a set of labels to each of the speech signals for the one or more speakers. The set of labels includes at least three levels of emotional dimensions, the emotional dimensions include at least activation, valence, and dominance, and the at least three levels of emotional dimensions include a high state, a neutral state, and a low state.Type: GrantFiled: June 16, 2017Date of Patent: March 17, 2020Assignee: The George Washington UniversityInventor: Chung Hyuk Park
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Patent number: 10585104Abstract: The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.Type: GrantFiled: September 20, 2016Date of Patent: March 10, 2020Assignees: The George Washington University, UT-Battelle, LLCInventors: Akos Vertes, Bennett N. Walker, Jessica A. Stolee, Scott T. Retterer
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Patent number: 10566491Abstract: An efficient solar cell and method of fabricating the same is disclosed. The solar cell includes an n-doped substrate layer. A p-doped buffer layer is disposed on the n-doped substrate layer. A quantum dot absorber stack is disposed on the buffer layer. The absorber stack includes at least one quantum dot layer and one p-doped spacer layer. A p-doped cap layer is disposed on the quantum dot absorber layer. The thickness of the quantum dot layer is less than an electron diffusion length from the depletion region formed by the n-doped substrate layer and the p-doped buffer layer. The quantum dot absorber layer allows for additional photo currents from two-photon absorption from the p-doped cap layer being exposed to a light source.Type: GrantFiled: June 6, 2013Date of Patent: February 18, 2020Assignees: The George Washington University, National Centre for Scientific ResearchInventors: Andrei Afanasev, Ara Kechiantz, Jean-Louis Lazzari
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Patent number: 10564512Abstract: Photonic data routing in optical networks is expected overcome the limitations of electronic routers with respect to data rate, latency, and energy consumption. However photonics-based routers suffer from dynamic power consumption, and non-simultaneous usage of multiple wavelength channels when microrings are deployed and are sizable in footprint. Here we show a design for the first hybrid photonic-plasmonic, non-blocking, broadband 5×5 router based on 3-waveguide silicon photonic-plasmonic 2×2 switches. The compactness of the router (footprint <200 ?m2) results in a short optical propagation delay (0.4 ps) enabling high data capacity up to 2 Tbps. The router has an average energy consumption ranging from 0.1˜1.0 fJ/bit depending on either DWDM or CDWM operation, enabled by the low electrical capacitance of the switch. The total average routing insertion loss of 2.Type: GrantFiled: February 5, 2018Date of Patent: February 18, 2020Assignee: The George Washington UniversityInventors: Shuai Sun, Volker J. Sorger, Tarek El-Ghazawi, Vikram K. Narayana
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Patent number: 10548943Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.Type: GrantFiled: June 13, 2019Date of Patent: February 4, 2020Assignee: The George Washington University a Congressionally Chartered Not-for-Profit CorporationInventor: Lakhmir S. Chawla
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Patent number: 10547681Abstract: Encoding a file into a plurality of chunks, wherein a subset of the plurality of chunks may be used to create a functional equivalent of the file. At least one additional chunk is created from the plurality of chunks. The at least one additional chunk is directed to be stored in a cache memory and the plurality of chunks are directed to be stored on at least one storage node. Upon demand for the file, at least one additional chunk is cased to be retrieved from the cache and at least a portion of the plurality of chunks are caused to be retrieved from the at least one storage node and the functional equivalent of the file is constructed through utilization of the at least one additional chunk and the portion of the plurality of chunks.Type: GrantFiled: June 30, 2016Date of Patent: January 28, 2020Assignees: Purdue Research Foundation, AT&T Intellectual Property I, L.P., The George Washington UniversityInventors: Yu Xiang, Yih-Farn Robin Chen, Vaneet Aggarwal, Tian Lan