Abstract: Effective management of cloud computing service levels (e.g. availability, performance, security) and financial risk is dependent on the cloud service provider's (CSP's) capability and trustworthiness. The invention applies industry cloud service level agreements (SLAs) with statistical and machine learning models for assessing CSPs and cloud services, and predicting performance and compliance against service levels. Cloud SLAs (ISO/IEC, EC, ENISA), cloud security requirements and compliance (CSA CCM, CAIQ), along with CSP performance (SLAs, cloud services) are analyzed via Graph Theory analysis and MCDA AHP to calculate CSP trustworthiness levels. CSP trustworthiness levels are input with CSP SLA content, cloud service performance measurements and configuration parameters into machine learning Regression analysis models to predict CSP cloud service performance and cloud SLA compliance, and enable model analysis and comparison.

Abstract: This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes.

Abstract: The ability to rapidly identify symmetry and anti-symmetry is an essential attribute of intelligence. Symmetry perception is a central process in human vision and may be key to human 3D visualization. While previous work in understanding neuron symmetry perception has concentrated on the neuron as an integrator, the invention provides the coincidence detecting property of the spiking neuron can be used to reveal symmetry density in spatial data. A synchronized symmetry-identifying spiking artificial neural network enables layering and feedback in the network. The network of the invention can identify symmetry density between sets of data and present a digital logic implementation demonstrating an 8×8 leaky-integrate-and-fire symmetry detector in a field-programmable gate array. The efficiency of spiking neural networks can be harnessed to rapidly identify symmetry in spatial data with applications in image processing, 3D computer vision, and robotics.

Abstract: A system and method for mapping metabolic data of a heart. The system has a light source directing light onto the heart, one or more lenses for focusing an image of the heart, and a fluorescent detector receiving the focused image and generating transients and/or waves to map metabolic cardiac data.

Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.

Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.

Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.

Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.

Abstract: A matrix thruster that may be used to reposition and/or stabilize a CubeSAT satellite. The matrix thruster includes a conductive plate with an opening, a plurality of wires within the opening, a power supply electrically connected to the conductive plate or each of the plurality of wires via an inductor, and an electrical switch. The electrical switch creates a current change that creates an electric potential spike across the inductor. The electric potential spike across the inductor initiates an arc discharge between one of the wires and the conductive plate, which forms plasma that ejects cathode particles from the matrix thruster. Using multiple wires (e.g., four titanium wires) extends the lifetime of the thruster, as each wire restores an inter-electrode film needed for the other wires to continue generating plasma.

Abstract: Waveforms in power grids typically reveal a certain pattern with specific features and peculiarities driven by the system operating conditions, internal and external uncertainties, etc. This prompts an observation of different types of waveforms at the measurement points (substations). An innovative next-generation smart sensor technology includes a measurement unit embedded with sophisticated analytics for power grid online surveillance and situational awareness. The smart sensor brings additional levels of smartness into the existing phasor measurement units (PMUs) and intelligent electronic devices (IEDs). It unlocks the full potential of advanced signal processing and machine learning for online power grid monitoring in a distributed paradigm.

Abstract: A method and system of adaptive cold atmospheric based treatment for diseased tissues, such as an area with cancerous cells, is disclosed. A plasma device generates a cold atmospheric plasma jet directed at the area having cancerous cells. A sensor is operable to sense the viability of the cancerous cells in the area. A controller is coupled to the plasma device and sensor. The controller is operative to control an initial plasma jet generated by the plasma device. The controller receives a sensor signal from the sensor to determine cell viability of the selected cells from the initial plasma jet. The controller adjusts the plasma jet based on the viability of the cancerous cells.

Abstract: An interconnection network for a processing unit having an array of cores. The interconnection network includes routers and adaptable links that selectively connect routers in the interconnection network. For example, each router may be electrically connected to one or more of the adaptable links via one or more multiplexers and a link controller may control the multiplexers to selectively connect routers via the adaptable links. In another example, adaptable links may be formed as part of an interposer and the link controller selectively connect routers via the adaptable links in the interposer using interposer switches. The adaptable links enable the interconnection network to be dynamically partitioned. Each of those partitions may be dynamically reconfigured to form a topology.

Abstract: Systems and methods are disclosed for reducing latency and power consumption of on-chip movement through an approximate communication framework for network-on-chips (“NoCs”). The technology leverages the fact that big data applications (e.g., recognition, mining, and synthesis) can tolerate modest error and transfers data with the necessary accuracy, thereby improving the energy-efficiency and performance of multi-core processors.

Abstract: The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Abstract: A modular micro-cathode arc thruster for use in satellites. An exemplary satellite has a plurality of stacked modular arc thrusters, each having an external anode, an internal cathode, and an insulator therebetween. The arc thrusters are situated in a housing, wherein the housing has an opening to eject exhausted thrusters. Once an arc thruster is expended, the push rod ejects that arc thruster and the next arc thruster takes its place.

Abstract: Systems and methods for hyperspectral analysis of cardiac tissue are provided. In some embodiments, a method for visualizing ablation lesions includes illuminating at one or more illumination wavelengths a surface of tissue having an ablation lesion; collecting a spectral data set comprising spectral images of the illuminated tissue acquired at multiple spectral bands each at one or more acquisition wavelengths; distinguishing between the ablation lesion and an unablated tissue based on one or more spectral differences between the ablation lesion and unablated tissue; and creating a composite image of the tissue showing the ablation lesion and the unablated tissue.

Abstract: Software-based data planes for network function virtualization may use a modular approach in which network functions are implemented as modules that can be composed into service chains. Infrastructures that allow these modules to share central processing unit resources are particularly appealing since they support multi-tenancy or diverse service chains applied to different traffic classes. Systems, methods, and apparatuses introduce schemes for load balancing considering central processing unit utilization of a next hop device when processing a packet that uses a service chain.

Abstract: Cloud simulation or validation system allows for the simulation of a future node that may be deployed on a piece of hardware. The system may attempt to simulate the operating system for node-A on top of the hardware for node-A, including basic network connectivity. When a host is booted up with the simulated configuration, validation scripts may be run to verify that the site is correctly prepped for cloud deployment. With its pre-staged RAM-based OS temporarily loaded into the host's RAM memory, any set of OS-based scripts, tools or binaries, may be executed for simulation and validation based upon the intended role of the host onto which the cloud simulation or validation system configuration is loaded.

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: Disclosures herein encompass methods of treating a subject with moderate to severe hidradenitis suppurativa (HS) encompassing the determination of differential gene expression to characterize HS severity followed by administration of a treatment specific for the stage of HS severity characterized in the subject.