Patents Assigned to The Governors of the University of Alberta
  • Patent number: 12005116
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: June 11, 2024
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
  • Patent number: 11998608
    Abstract: There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-?-pyranose each pair of units joined by a C1-C2 or a C1-C3 link, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-?-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal against infection by a Brucella organism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-Brucella antibody.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: June 4, 2024
    Assignees: THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS, THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: John McGiven, Laurence Howells, Lucy Duncombe, David Bundle, Satadru Sekhar Mandal, Susmita Sarkar
  • Publication number: 20240169245
    Abstract: A quantum random number generator (QRNG) that includes at least one potential well and an electron detector outputting unique signals for quantized electron occupations as a source of random numbers. The at least one potential well including at least one exactingly placed dangling bond (DB) that is biased via a control wire. The DB extends from a silicon atom or from a germanium atom. Additionally, a method of operating the quantum random number generator includes measuring the unique signals as low/high current values or times between output transitions to assign maximal and minimal values leading to a constant stream of the source of random numbers.
    Type: Application
    Filed: March 18, 2022
    Publication date: May 23, 2024
    Applicants: Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Robert A. Wolkow, Roshan Achal, Lucian Livadaru
  • Publication number: 20240145612
    Abstract: A waveguide assembly integrated with a semiconductor wafer is provided. The waveguide assembly includes a waveguide channel defined by internal walls of the wafer lined with a metallic layer, and having at least one port for transmission of the RF signal into or out of the waveguide channel. The waveguide assembly also includes a semiconductor obstacle member disposed in the waveguide channel. The waveguide assembly may be fabricated using etching and deposition processes for semiconductor devices. In use, selectively varying either one or both of frequency or power level of electromagnetic radiation applied to the obstacle member varies electrical conductance of the obstacle member, and thereby varies the electrical impedance of the obstacle member to transmission of the RF signal through the waveguide channel. The waveguide assembly may be used for switching, attenuating, routing, filtering, and transforming the RF signal.
    Type: Application
    Filed: November 9, 2023
    Publication date: May 2, 2024
    Applicants: Purdue Research Foundation, The Governors of the University of Alberta
    Inventors: Thomas R. Jones, Dimitrios Peroulis, Alden N. Fisher, Douglas W. Barlage
  • Patent number: 11955172
    Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: April 9, 2024
    Assignees: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
  • Patent number: 11939302
    Abstract: The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: March 26, 2024
    Assignee: The Governors of the University of Alberta
    Inventors: James A. Nieman, Jack Jhamandas, Bing Bai, Alexandr Belovodskiy, Wen Fu, Mostofa Hena, Michael Houghton, Appan Srinivas Kandadai, Ryoichi Kimura, Kamlesh Kumar Sahu, D. Lorne Tyrrell
  • Patent number: 11891603
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: February 6, 2024
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Toshifumi Yokota, Yusuke Echigoya
  • Patent number: 11849540
    Abstract: The development of stretchable, mechanically and electrically robust interconnects by printing an elastic, silver-based composite ink onto stretchable fabric. Such interconnects can have conductivity of 3000-4000 S/cm and are durable under cyclic stretching. In serpentine shape, the fabric-based conductor is enhanced in electrical durability. Resistance increases only ˜5 times when cyclically stretched over a thousand times from zero to 30% strain at a rate of 4% strain per second due to the ink permeating the textile structure. The textile fibers are ‘wetted’ with composite ink to form a conductive, stretchable cladding of the silver particles. The e-textile can realize a fully printed, double-sided electronic system of sensor-textile-interconnect integration. The double-sided e-textile can be used for a surface electromyography (sEMG) system to monitor muscles activities, an electroencephalography (EEG) system to record brain waves, and the like.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: December 19, 2023
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Hyun-Joong Chung, Jana Rieger, Thanh-Giang La, Shide Qiu, Dylan Scott
  • Patent number: 11833228
    Abstract: Beta-hydroxybutyric acid-based radiopharmaceuticals, pharmaceutical compositions comprising same, methods for preparing same, and methods of using same for diagnostic imaging and non-imaging tracer studies are provided.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: December 5, 2023
    Assignee: The Governors Of The University Of Alberta
    Inventors: Stephanie Mattingly, Frank Wuest, Ralf Schirrmacher, Melinda Wuest, Eugene Fine
  • Patent number: 11819822
    Abstract: A silica monolith nested in a polymer sponge may be formed by applying a hydrolyzed mixture of siloxanes to a melamine-formaldehyde sponge, and may be used in methods of solid phase extraction.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: November 21, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Xing-Fang Li, Zhongshan Liu
  • Publication number: 20230338919
    Abstract: Compositions and methods of preparing sorbent compositions (SCs) and protonated sorbent compositions (PSCs) for use in concentrating lithium from native brines are described. In particular, SCs of the general formula Li1.3-1.6Mn1.6-1.7O4, methods of preparing the SCs and PSCs that have improved properties for lithium extraction and concentration over single and multiple cycles are described.
    Type: Application
    Filed: December 18, 2020
    Publication date: October 26, 2023
    Applicants: E3 METALS CORP., THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Daniel ALESSI, Salman SAFARIMOHSEN-ABAD
  • Publication number: 20230331905
    Abstract: Curing agents for epoxy monomers are prepared from the partial esterification of citric acid with certain alkyl or alkenyl alcohols. These curing agents, which contain mixtures of unreacted citric acid and monoalkyl or monoalkenyl citrate, and which are substantially free of trialkyl or trialkenyl citrate, are used without co-solvents for preparing biobased resins from plant oil-derived epoxides. The resulting biobased resins can in turn be used to prepare thermo set materials and biocomposites.
    Type: Application
    Filed: September 21, 2021
    Publication date: October 19, 2023
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Jonathan CURTIS, Vinay PATEL
  • Patent number: 11773129
    Abstract: The present invention provides a method of preventing or treating atherosclerosis or a symptom thereof comprising administering to a subject in need thereof a specific inhibitor of neuraminidase 1 (neu1); neuraminidase 3 (neu3); or a bispecific inhibitor of neu1 or neu3 of formula I; (I) and a compound of formula I.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: October 3, 2023
    Assignees: The Governors of the University of Alberta, Valorisation HSJ, Limited Partnership
    Inventors: Christopher Cairo, Alexey Pchejetski, Tianlin Guo
  • Patent number: 11761331
    Abstract: A method of quantifying a viscoelastic effect of a polymer on residual oil saturation (Sor) including calculating an extensional capillary number (Nce) using flux, pore-scale apparent viscosity, and interfacial tension to account for the polymer's viscoelastic forces that are responsible for Sor reduction. The polymer is used polymer flooding during enhanced oil recovery. An extensional capillary number is calculated for a plurality of polymer materials, which are then compiled in a database. Also provided is a reservoir simulator for predicting the Sor reduction potential of the viscoelastic polymer, which includes a database of calculated extensional capillary numbers for a plurality of polymers. The database includes a curve generated from the calculated extensional capillary numbers for a plurality of polymers properties, flux rates, formation nature, oil viscosities, and rheological behaviors.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: September 19, 2023
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Madhar Sahib Azad, Japan Trivedi
  • Publication number: 20230287514
    Abstract: A method of detecting lung cancer in a subject involves: a) determining in a serum sample, the expression level of one or more miRNAs; b) determining in a urine sample, the concentration of one or more metabolites; c) comparing the expression level of the one or more miRNAs with the expression level of the one or more miRNAs in a normal control; d) comparing the concentration of the one or more metabolites with the concentration of the one or more metabolites in a normal control; e) determining whether the subject has lung cancer in accordance with the result of steps (c) and (d); wherein a difference in the expression level of the one or more miRNAs relative to the expression level of the normal control, and a difference in the concentration of the one or more metabolites relative to the concentration of the normal control, are indicative of lung cancer; and f) treating the subject with a cancer management program based on the determination in step (e).
    Type: Application
    Filed: March 8, 2023
    Publication date: September 14, 2023
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, ALBERTA HEALTH SERVICES
    Inventors: Eric L.R. BÉDARD, Wilson ROA
  • Patent number: 11749558
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: September 5, 2023
    Assignees: Quantum Silicon Inc., The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Publication number: 20230270134
    Abstract: A process for producing a protein concentrate from grain is described. The process includes the steps of dehulling the grain to produce dehulled grain, milling the dehulled grain to produce whole grain flour, removing fiber from the whole grain flour to produce fiber-depleted flour, and removing starch from the fiber-depleted flour, thereby producing a fibre reduced protein concentrate. The protein concentrate is significantly reduced in fiber, making it suitable for further refinement via aqueous salt or alkali extraction or other purification methods.
    Type: Application
    Filed: July 15, 2021
    Publication date: August 31, 2023
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: Thavaratnam VASANTHAN
  • Patent number: 11740161
    Abstract: A filter for mimicking regional lung deposition is provided that includes filter layers of fibrous filter material stacked coaxially and an outer ring portion encircling the fibrous filter material and securing the filter layers together. The fibrous filter material is formed for fibers having a fiber diameter, and the filter has a tunable filter efficiency. A regional lung deposition system capable of measuring constant flow or variable flow is provided that includes a throat simulation device, a filter housing downstream of and in fluid communication with the throat simulation device, a breath simulator downstream of and in fluid communication with the filter housing, and a an above-referenced filter positioned within the filter housing. Also provided is a filter housing for use in the regional lung deposition system that includes a conical housing having a small inner diameter at a first end and a large inner diameter at a second end.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: August 29, 2023
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Warren H. Finlay, Conor A. Ruzycki, Andrew R. Martin, Cagri Ayranci, Scott E. Tavernini
  • Patent number: 11719694
    Abstract: The present disclosure provides methods and compositions that find use in identifying presence of an advanced stage autoimmune liver disease (ALD) is a subject diagnosed as having ALD. Also provided here are methods and compositions that find use in monitoring effectiveness of treatment of an ALD patient receiving a treatment for the ALD. Also provided here are methods and compositions that find use in identifying subjects suffering from a relapse of ALD. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject having ALD.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: August 8, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Ferrucio Bonino, Maurizia Rossana Brunetto, Aldo Montano-Loza, Ana Clementin
  • Patent number: 11714934
    Abstract: A method of modeling an equivalent wind turbine generator (WTG) system for a wind farm having a plurality of WTG units includes determining an impact factor of each WTG unit of the plurality of WTG units, determining an equivalent single WTG unit model parameters of the wind farm based on the impact factor of each WTG unit, and determining an effective wind speed of the wind farm to use as the equivalent WTG input wind speed. The method produces a model of static and/or dynamic wind farm behavior. Additionally, a software configured to execute a method of modeling an equivalent wind turbine generator (WTG) system for a wind farm having a plurality of WTG units.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: August 1, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Sayed Ali Khajehoddin, Ahmadreza Tabesh, Navid Shabanikia