Patents Assigned to The Governors of the University of Alberta
  • Patent number: 11353764
    Abstract: An electrochromic (EC) device comprises a first electrode and a second electrode separated by an electrolyte. The first electrode comprises an electrochromic (EC) layer comprising a compound having the formula AiBjOk, where A comprises one or more elements selected from a group consisting of W, Mn, Mo, Co, Ni, Cs, and Zn, where B is different than A and comprises one or more elements selected from a group consisting of Mo, Ti, Nb, and V, where i and j have values that are greater than 0, and where k is a stoichiometric value that balances the formula. A is selected such that the EC layer has an improved optical contrast relative to BjOk and B is selected such that the EC layer has an improved specific charge capacity relative to AiOk.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: June 7, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Abdulhakem Elezzabi, Hai Zeng Li
  • Publication number: 20220169684
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: February 10, 2022
    Publication date: June 2, 2022
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 11343910
    Abstract: The development of stretchable, mechanically and electrically robust interconnects by printing an elastic, silver-based composite ink onto stretchable fabric. Such interconnects can have conductivity of 3000-4000 S/cm and are durable under cyclic stretching. In serpentine shape, the fabric-based conductor is enhanced in electrical durability. Resistance increases only ˜5 times when cyclically stretched over a thousand times from zero to 30% strain at a rate of 4% strain per second due to the ink permeating the textile structure. The textile fibers are wetted with composite ink to form a conductive, stretchable cladding of the silver particles. The e-textile can realize a fully printed, double-sided electronic system of sensor-textile-interconnect integration. The double-sided e-textile can be used for a surface electromyography (sEMG) system to monitor muscles activities, an electroencephalography (EEG) system to record brain waves, and the like.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: May 24, 2022
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Hyun-Joong Chung, Jana Rieger, Thanh-Giang La, Shide Qiu, Dylan Scott
  • Publication number: 20220155339
    Abstract: A method for assessing the quality of a tip of a scanning probe microscope (SPM) includes recording an SPM image, extracting a plurality of images of dangling bonds from the SPM image, feeding the extracted images of dangling bonds into a convolution neural network one image at a time, analyzing each of the plurality of images of dangling bonds using the convolution neural network, assigning each of the plurality of images of dangling bonds one of a sharp tip status or a double tip status, and determining whether the number of the plurality of images of dangling bonds of the SPM image assigned the double tip status exceeds a predetermined threshold. A method of automatically conditioning a tip of a scanning probe microscope (SPM) during imaging of a sample and a method of mass-producing atomistic quantum dots, qubits, or particular atom orbital occupation are also provided.
    Type: Application
    Filed: January 22, 2022
    Publication date: May 19, 2022
    Applicants: Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Mohammad Rashidi, Robert Wolkow
  • Patent number: 11324818
    Abstract: The present disclosure provides an immunogenic composition comprising: a) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; b) a T-cell epitope polypeptide comprising a T-cell epitope present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide. The present disclosure provides an immunogenic composition comprising: a) a polypeptide that comprises one or more T-cell epitopes present in an HCV protein other than E1 and E2; and b) a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: May 10, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, Abdolamir Landi, Michael Logan, John L. Law, Darren Hockman, Chao Chen
  • Patent number: 11325905
    Abstract: There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 10, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Dennis Hall, Michael Weinfeld, Sylvain Bernard, Tristan Verdelet, Timothy Morgan, Vikie Lamontagne, Zahra Shire, Afsaneh Lavasanifar
  • Patent number: 11320455
    Abstract: A method for assessing the quality of a tip of a scanning probe microscope (SPM) includes recording an SPM image, extracting a plurality of images of dangling bonds from the SPM image, feeding the extracted images of dangling bonds into a convolution neural network one image at a time, analyzing each of the plurality of images of dangling bonds using the convolution neural network, assigning each of the plurality of images of dangling bonds one of a sharp tip status or a double tip status, and determining whether the number of the plurality of images of dangling bonds of the SPM image assigned the double tip status exceeds a predetermined threshold. A method of automatically conditioning a tip of a scanning probe microscope (SPM) during imaging of a sample and a method of mass-producing atomistic quantum dots, qubits, or particular atom orbital occupation are also provided.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: May 3, 2022
    Assignees: The Governors of the University of Alberta, Quantum Silicon Inc.
    Inventors: Mohammad Rashidi, Robert Wolkow
  • Patent number: 11304651
    Abstract: A system is provided for monitoring patients with dysphagia, or swallowing impairments, that monitors muscle movement during intensive swallowing exercises to provide adjuvant visual feedback from surface electromyography.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: April 19, 2022
    Assignees: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, COVENANT HEALTH
    Inventors: Jana Maureen Rieger, Gabriela Constantinescu, Mark James Redmond, Dylan Kyle Scott, Benjamin Ronald King, Mark Vernon Fedorak, Herman Lundgren
  • Publication number: 20220102197
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Applicants: Quantum Silicon Inc., The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Patent number: 11274128
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 15, 2022
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 11268014
    Abstract: A method of recovering oil embedded in an underground matrix adjacent a depleted oil reservoir includes injecting a mixture of polymeric material into the depleted oil reservoir through an injection borehole, applying a pressure to the mixture to free the oil from the matrix and move the oil towards a production well, and drawing the oil from the depleted oil reservoir through the production well. The method additionally includes modeling a shear thickening of the polymeric mixture and an onset of the shear thickening. The model can be incorporated into commercial numerical simulators for predicting the injectivity and recovery due to viscoelastic thickening independently and thereby assist in quick screening polymers for oil recovery applications.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: March 8, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Japan Trivedi, Madhar Sahib Azad
  • Patent number: 11238725
    Abstract: A wireless sensor is provided for use in near-to-zero or zero-power consumption applications. The sensor includes a sensing circuit, a modulator connected to the sensing circuit and configured to modulate an input signal using variations in input impedance produced by the sensing circuit to produce a modulated output signal, and a transmitting element such as an antenna to transmit the modulated output signal to a receiver. In some implementations, the sensor includes a pilot sequence generator that may be powered by a received signal from a transmitting node. The input signal is thus modulated by both pilot data and the input impedance. The input signal may be received from the transmitting node. Alternatively, a power source may be provided in the wireless sensor for generating the input signal and/or pilot data.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: February 1, 2022
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Rashid Mirzavand Boroujeni, Mohammad Mahdi Honari Kalateh, Seyed Pedram Mousavi Bafrooei
  • Patent number: 11232976
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 25, 2022
    Assignees: National Research Council of Canada, The Governors of the University of Alberta, Quantum Silicon Inc.
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Patent number: 11230594
    Abstract: It is provided novel anti-galactofuranose antibodies and their use for diagnosis of and/or treating aspergillosis, and for the design of chimeric antigen receptor T-cells, wherein single chain variable fragment of the antibodies, such as a heavy chain variable region or a light chain variable region, is fused via a spacer and a transmembrane domain to a signaling endodomain to generate an expression cassette that will be integrated into a T cell.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: January 25, 2022
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Donald Christopher Sheppard, Benjamin Alfred William Rufus Ralph, Todd Lambert Lowary, Susmita Sarkar, Amira Ibrahim Aly Mohamed Khalil
  • Publication number: 20210373045
    Abstract: A method for assessing the quality of a tip of a scanning probe microscope (SPM) includes recording an SPM image, extracting a plurality of images of dangling bonds from the SPM image, feeding the extracted images of dangling bonds into a convolution neural network one image at a time, analyzing each of the plurality of images of dangling bonds using the convolution neural network, assigning each of the plurality of images of dangling bonds one of a sharp tip status or a double tip status, and determining whether the number of the plurality of images of dangling bonds of the SPM image assigned the double tip status exceeds a predetermined threshold. A method of automatically conditioning a tip of a scanning probe microscope (SPM) during imaging of a sample and a method of mass-producing atomistic quantum dots, qubits, or particular atom orbital occupation are also provided.
    Type: Application
    Filed: March 19, 2019
    Publication date: December 2, 2021
    Applicants: Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Mohammad Rashidi, Robert Wolkow
  • Patent number: 11186615
    Abstract: The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) E1 polypeptide and an HCV E2 polypeptide, where one or both of the E1 and E2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged E1/E2 heterodimer of the present disclosure. The present disclosure provides methods of producing untagged HCV E1/E2 heterodimers. The present disclosure provides HCV E1/E2 heterodimers, compositions comprising same, and methods of inducing an immune response to HCV.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: November 30, 2021
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, Darren Hockman, John L. Law, Chao Chen, Michael Logan
  • Publication number: 20210345600
    Abstract: Cryopreservation of endothelial cell monolayers is one of the major challenges in the cryopreservation of complex tissues. Human umbilical vein endothelial cells (HUVECs) in suspension are available commercially and recently their post-thaw cell membrane integrity was significantly improved by cryopreservation in 5% dimethyl sulfoxide (DMSO) and 6% hydroxyethyl starch (HES). However, cryopreservation of cells in monolayers has been elusive. The exact mechanisms of damage during cell monolayer cryopreservation are still under investigation. Here, we show that a combination of different factors contribute to significant progress in cryopreservation of cell monolayers. The addition of 2% chondroitin sulfate to 5% DMSO and 6% HES and cooling at 0.2 or 1° C./min led to high membrane integrity (97.3±3.2%) immediately after thaw when HUVECs were cultured on a substrate with a coefficient of thermal expansion similar to that of ice.
    Type: Application
    Filed: August 21, 2019
    Publication date: November 11, 2021
    Applicant: The Governors of the University of Alberta
    Inventors: Nasim ESKANDARI, Janet Anne W. ELLIOTT, Locksley E. MCGANN, John A. NYCHKA, Leah A. MARQUEZ-CURTIS
  • Patent number: 11142767
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: October 12, 2021
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Toshifumi Yokota, Yusuke Echigoya
  • Patent number: 11135586
    Abstract: Described here is a composition comprising amphiphilic silica nanoparticles, wherein the silica nanoparticles are partially fluorinated. Also described here is a method for droplet-based assay, comprising dispersing at least one aqueous droplet in a continuous fluorous phase in a microfluidic channel, wherein at least one amphiphilic silica nanoparticle is absorbed to the interface of the continuous fluorous phase and the aqueous droplet, and wherein the silica nanoparticle is partially fluorinated. Further described here is a method for droplet-based assay, comprising dispersing at least one aqueous phase droplet in a continuous fluorous phase in a microfluidic channel, wherein the continuous fluorous phase comprises at least one partially fluorinated amphiphilic particle adsorbed to an interface of the continuous fluorous phase and the aqueous phase droplet, and wherein the aqueous phase droplet comprises at least one hydrophilic polymer adsorbed to the amphiphilic particle at the interface.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: October 5, 2021
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Governors of the University of Alberta
    Inventors: Sindy Tang, Ming Pan, Fengjiao Lyu, Ratmir Derda
  • Patent number: 11119232
    Abstract: A computer-implemented method for seismic event localization includes: generating, with at least one processor, a vectorized snapshot matrix representing wave propagation data at a series of snapshots in time for a subterranean formation; computing a reduced orthonormal column basis matrix based on the vectorized snapshot matrix; constructing a reduced order wave propagation model based on the reduced orthonormal column basis matrix; receiving seismic data collected from a plurality of receivers at the subterranean formation; generating a time-domain coefficient matrix based on back propagation of the received seismic data and the reduced order wave propagation model; reconstructing time-reversed wavefield data based on the time-domain coefficient vector; and generating signals for outputting wavefield or seismic event location information based on the time-reversed wavefield data.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: September 14, 2021
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Zhenhua Li, Mirko Van Der Baan