Patents Assigned to The Johns Hopkins University
  • Publication number: 20230307130
    Abstract: Provided herein are methods of distinguishing between meiotic- and mitotic-origin aneuploidies in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: November 5, 2021
    Publication date: September 28, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Daniel ARIAD, Rajiv MCCOY, Manuel VIOTTI
  • Publication number: 20230290954
    Abstract: A composition for producing electrodes for lithium-sulfur batteries includes particles having a metal-organic framework structure and composition that define voids within the metal-organic framework structure; sulfur loaded into at least some of the voids defined by the metal-organic framework structure of the particles; graphene flakes obtained by polymer enhanced solvent exfoliation; and polymer residue from the polymer enhanced solvent exfoliation. A method of producing a composite electrode for a lithium-sulfur battery according to an embodiment of the current invention includes obtaining a composition according to an embodiment of the current invention and applying the composition to a substrate. An electrode for a lithium-sulfur battery includes a layer having the composition. A lithium-sulfur battery according to an embodiment of the current invention includes the electrode.
    Type: Application
    Filed: July 22, 2021
    Publication date: September 14, 2023
    Applicants: The Johns Hopkins University, Northwestern University
    Inventors: Avery E. Baumann, Van Sara Thoi, Julia R. Downing, Mark C. Hersam
  • Publication number: 20230278222
    Abstract: A robotic system for remote operation of human-controllable equipment includes a remotely operable robotic subsystem configured to be at least one of mounted on or arranged adjacent to the human-controllable equipment to be controlled, and a remote controller that is configured to be operated by a human. The remote controller emulates a control representation of the human-controllable equipment such that a human can provide commands using the control representation. The remotely operable robotic subsystem is configured to receive commands from the remote controller to thereby operate the human-controllable equipment.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 7, 2023
    Applicants: The Johns Hopkins University, University of Maryland
    Inventors: Russell H. Taylor, Axel Kriege, Peter Kazanides, Balazs Vagvolgyi, Anton Deguet, Mikhail Khrenov
  • Publication number: 20230270729
    Abstract: The use of P2X4 antagonists for the treatment of dry eye syndrome, more in particular substituted N-phenylacetamide compounds of general formula (I), pharmaceutical compositions and combinations comprising said compounds for use in the treatment or prophylaxis of dry eye syndrome and in particular dry eye, ocular neuropathic pain, ocular trauma and post-operative ocular pain.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 31, 2023
    Applicants: Bayer Aktiengesellschaft, The Johns Hopkins University
    Inventors: Stefan BĂ„URLE, William SCHUBERT, Jens NAGEL, Carsten TERJUNG, David FINIS, Samuel YIU, Hui LIN, Minjie CHEN, Stefanie SEO
  • Publication number: 20230272339
    Abstract: The present disclosure provides methods for generating retinal cell clusters for use in cellular component transfer therapy, retinal cell clusters generated by such methods, and compositions comprising such retinal cell clusters. The present disclosure also provides uses of the retinal cell clusters and compositions comprising thereof for preventing and/or treating inherited retinal degenerative diseases.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 31, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Mandeep SINGH, Seth Blackshaw, Robert Johnston, Jiang Qian, Ying Liu
  • Publication number: 20230270524
    Abstract: A marker for identifying a portion of a surgical margin includes a first element to attach the marker to the surgical margin of a surgical cavity located in a body of a patient, and a second element attached to the first element. The second element includes an indicator to uniquely identify the portion of the surgical margin through a radiological scan.
    Type: Application
    Filed: May 4, 2023
    Publication date: August 31, 2023
    Applicant: The John Hopkins University
    Inventors: Mehran HABIBI, Farhad SHIR
  • Publication number: 20230240641
    Abstract: A computer-implemented method, a computer system, and a non-transitory computer readable medium are provided that perform a method for determining an auscultation quality metric (AQM). The computer-implemented method includes obtaining an acoustic signal representative of pulmonary sounds from a patient; determining a plurality of derived signals from the acoustic signal; performing a regression analysis on the plurality of derived signals; and determining the AQM from the regression analysis.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 3, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Mounya ELHILALI, Annapurna KALA
  • Publication number: 20230242488
    Abstract: The invention of the instant application discloses spirocyclic guanidine compounds of general formula (I), shown below, and their use in methods of treating cancer
    Type: Application
    Filed: May 18, 2021
    Publication date: August 3, 2023
    Applicant: The Johns Hopkins University
    Inventors: Richard B.S. Roden, Ravi K. Anchoori
  • Publication number: 20230233860
    Abstract: A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response.
    Type: Application
    Filed: June 23, 2021
    Publication date: July 27, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Sridevi V. Sarma, Yun Guan, Claire Zurn, Christine Beauchene
  • Publication number: 20230238512
    Abstract: An electrode includes at least one of sulfur (S) or selenium (Se), and a functionalized metal organic framework (R-MOF), the functionalized metal organic framework (R-MOF) having a functional group (R) attached to an organic portion of a metal organic framework (MOF). The functionalized metal organic framework (R-MOF) is adapted to react with at least one of electrochemically accessible sulfur (S) or selenium (Se) to capture at least one of lithium polysulfide or sodium polysulfide via covalent attachment of sulfur (S) or selenium (Se), respectively, to the functional group (R) of the functionalized metal organic framework (R-MOF).
    Type: Application
    Filed: June 10, 2021
    Publication date: July 27, 2023
    Applicant: The Johns Hopkins University
    Inventors: David Burns, Avery E. Baumann, Van Sara Thoi
  • Publication number: 20230233077
    Abstract: Provided herein are methods of detecting a ophthalmologic genetic disease in a subject that include matching properties of captured images and/or videos with properties of an ocular pathology model that is trained on a plurality of reference images and/or videos of ocular cells of reference subjects, which properties of the ocular pathology model are indicative of the pathology. Related systems and computer program products are also provided.
    Type: Application
    Filed: June 29, 2021
    Publication date: July 27, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Tin Yan Alvin LIU, Zelia M. CORREA
  • Publication number: 20230233216
    Abstract: An attachment for a drill includes an inner housing configured to be coupled to the drill. The attachment also includes an outer housing positioned at least partially around the inner housing. The attachment also includes a vertical guide coupled to or integral with the inner housing. The attachment also includes a horizontal guide coupled to or integral with the outer housing. The attachment also includes a guide adapter configured to move along the vertical guide and the horizontal guide. The inner housing and the vertical guide are configured to move vertically with respect to the outer housing and the guide adapter, and the inner housing and the guide adapter are configured to move laterally with respect to the horizontal guide and the outer housing.
    Type: Application
    Filed: June 29, 2021
    Publication date: July 27, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Chad GORDON, Owen F. FRIESEN, Cristina I. ROMANY, Nathan W. SCOTT, Deborah I. WEIDMAN, Jing Lin CUI, Ku Chien LIN
  • Publication number: 20230210447
    Abstract: A sweat sensor includes a first conductor and a second conductor that are parallel with one another. The sweat sensor also includes a channel disposed between the first and second conductors. The channel is configured to receive a sample of sweat. A measure of capacitance between the first and second conductors changes based at least partially upon a volume of the sweat in the channel.
    Type: Application
    Filed: July 27, 2021
    Publication date: July 6, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Peter Charles SEARSON, Dong-Hoon CHOI, Dinh-Tuan PHAN
  • Publication number: 20230201833
    Abstract: Provided herein are magnetofluidic cartridges of use in a wide variety of sample analysis applications, including nucleic acid amplification assays. The magnetofluidic cartridges include sample inlet wells and sample analysis wells. Temperature sensitive materials are used to separate the sample inlet wells and sample analysis wells from one another prior to performing a given sample analysis application. Related magnetofluidic devices, kits, and methods are also provided.
    Type: Application
    Filed: May 27, 2021
    Publication date: June 29, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Tza-Huei Jeff WANG, Alexander Y. TRICK, Fan-En CHEN
  • Patent number: 11684661
    Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STatoxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: June 27, 2023
    Assignees: The Johns Hopkins University, South Dakota State University
    Inventors: David A. Sack, Weiping Zhang
  • Patent number: 11684700
    Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: June 27, 2023
    Assignee: The Johns Hopkins University
    Inventors: Xuesong Jiang, Sashank Reddy, Gerald Brandacher, Hai-Quan Mao, Justin Sacks, Xiaowei Li, Kevin Feng, Russell Martin, Georgia C. Yalanis, Ji Suk Choi
  • Publication number: 20230190796
    Abstract: Provided are cells, such as engineered cells, that express a prostate-specific membrane antigen (PSMA) or a modified form thereof. In some embodiments, the cell further contains a genetically engineered recombinant receptor, such as a chimeric antigen receptor, that specifically binds to an antigen. The present disclosure also provides methods of detecting, identifying, selecting or targeting cells expressing PSMA, such as in connection with administration of such cells to subjects, including methods of adoptive cell therapy, or in connection with methods of manufacturing engineered cells.
    Type: Application
    Filed: April 7, 2018
    Publication date: June 22, 2023
    Applicants: Juno Therapeutics, Inc., The Johns Hopkins University
    Inventors: David Jeffrey HUSS, Hyam I. LEVITSKY, Il MINN, Martin G. POMPER
  • Publication number: 20230197935
    Abstract: An electrode includes an electrically conductive porous graphene core; a silicon layer disposed on an internal surface of the porous graphene core; and an ion-conductive hybrid silicate layer disposed on the silicon layer.
    Type: Application
    Filed: March 16, 2021
    Publication date: June 22, 2023
    Applicant: The Johns Hopkins University
    Inventor: Mingwei Chen
  • Patent number: 11680297
    Abstract: The present inventors have identified specific oncogenic pathways preferentially activated in BRAF-mutated-melanoma cells and a pathway pattern that predicts resistance of BRAF-mutated melanoma to BRAF/MEK inhibitors, providing novel clinical implications for melanoma therapy. In one embodiment, a method comprises (a) testing a sample oiBRAF-mutated melanoma cells isolated from a patient and measuring the expression levels of genes expressed in the following oncogenic pathways: TNFa, EGFR, IFNa, hypoxia, IFNy, STAT3 and Myc; (b) calculating a 7-pathway activation pattern based on the measured expression levels of step (a); and (c) identifying the patient's resistance level to BRAF/MEK inhibitor treatment based on comparison of the calculated 7-pathway activation pattern to a reference.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: June 20, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Michael Mingzhao Xing, Dingxie Liu
  • Patent number: 11682760
    Abstract: Processes for preparing a niobate material include the following steps: (i) providing a niobium-containing source; (ii) providing a transitional metal source (TMS), a post-transitional metal source (PTMS), or both; (iii) dissolving (a) the niobium-containing source, and (b) the TMS, the PTMS, or both in an aqueous medium to form an intermediate solution; (iv) forming an intermediate paste by admixing an inert support material with the intermediate solution; (v) optionally coating the intermediate paste on a support substrate; and (vi) removing the inert support material by subjecting the intermediate paste to a calcination process and providing a transition-metal-niobate (TMN) and/or a post-transition-metal-niobate (PTMN). Anodes including a TMN and/or PTMN are also provided.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: June 20, 2023
    Assignee: The Johns Hopkins University
    Inventors: Konstantinos Gerasopoulos, Dajie Zhang, Matthew W. Logan