Patents Assigned to The Johns Hopkins University
  • Patent number: 11072828
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3? untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3? UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: July 27, 2021
    Assignees: The Johns Hopkins University, UMC UTRECHT HOLDING B.V.
    Inventors: Zachary Kaminsky, Marco Paul Maria Boks
  • Patent number: 11066630
    Abstract: The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Onur Kilic, Steven An, Andre Levchenko
  • Patent number: 11067635
    Abstract: An example battery cell diagnostic apparatus is provided that may include control circuitry, a current source, measurement circuitry, and a first and a second multiplexer. The control circuitry may be configured to control the first multiplexer to electrically connect the measurement circuitry to a battery cell and control the second multiplexer to electrically connect the current source to the battery cell to apply a current, output from the current source, at each of a set of frequencies to the battery cell. The control circuitry may also be configured to receive measurements from the measurement circuitry at each of the frequencies, which may include respective frequencies that correlate to an electrolytic resistance of the battery cell, an anode impedance of the battery cell, and a cathode impedance of the battery cell. Similar measurements may also be taken for each cell in a battery.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Rengaswamy Srinivasan, Bliss G. Carkhuff
  • Patent number: 11066416
    Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: July 20, 2021
    Assignees: The Johns Hopkins University, Rapafusyn Pharmaceuticals, Inc.
    Inventors: Jun Liu, Sam Hong, Brett R. Ullman, Joseph E. Semple, Kana Yamamoto, Puneet Kumar, Magesh Sadagopan, Jennifer C. Schmitt
  • Patent number: 11066455
    Abstract: The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Xinzhong Dong, Hao-Jui Weng
  • Patent number: 11067449
    Abstract: A multispectral imager includes processing circuitry, an illumination assembly, a detector assembly, and a focusing assembly. The illumination assembly includes an array of illumination elements controlled by the processing circuitry to illuminate a scene. The detector assembly includes a detector array controlled by the processing circuitry to capture images from the scene at different wavelengths. The focusing assembly includes a lens and is controlled by the processing circuitry to adjust a focal point for the detector array. The processing circuitry generates and processes the images from the scene, taken at different wavelengths and focal points, combines the images to form a multispectral image cube for the scene, and determines a composition of an object within the scene based on a spectral profile of the multispectral image cube.
    Type: Grant
    Filed: September 5, 2020
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Jorge I. Nunez Sanchez, Rachel L. Klima, Scott L. Murchie, Seppo J. Lehtonen, John D. Boldt, Jacob M. Greenberg, Bryan J. Maas, Kyle L. Anderson, Trevor W. Palmer, Heidi E. Warriner
  • Patent number: 11059775
    Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 13, 2021
    Assignees: The Johns Hopkins University, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY
    Inventors: Barbara Slusher, Rana Rais, Jan Vavra, Tomas Tichy, Pavel Majer, Andrej Jancarik, Lukas Tenora
  • Patent number: 11059855
    Abstract: The present invention provides a new methodology combining MD simulations and database-guided high-throughput screening to rationally design pore forming membrane-active peptides. The present inventive methodology is able to allow tuning of a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions. The present inventive methods will ultimately allow de novo design of membrane-active peptides for a wide range of biomedical applications, including for example, antimicrobial agents.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Charles H. Chen, Martin B. Ulmschneider
  • Patent number: 11060064
    Abstract: The present invention relates to the area of in vitro cell populations useful for generating vascular networks in vitro and are suitable for use in vivo for regeneration of vascular tissue. In some embodiments, the bipotent cell population of the present invention comprise endothelial cells and pericytes that express vascular endothelial cadherin and are 95% or more positive for CD105 and CD146, and which work syergistically to recreate vascular tissues in vitro.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: July 13, 2021
    Assignee: The Johns Hopkins University
    Inventors: Sharon Gerecht, Sravanti Kusuma
  • Patent number: 11058541
    Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Chad Gordon
  • Patent number: 11061032
    Abstract: The presently disclosed fluidic sensor system and method comprise multifunctional nanoprobe-enabled capture for early detection of chemical and/or biological pathogens in a liquid sample. This sensor system and method can be used for food and environmental monitoring.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Chao Wang, Kellogg Schwab, Charles Young
  • Patent number: 11059043
    Abstract: A microfluidic system includes a microfluidic chip including a channel layer and a fluid control layer operatively connected to the channel layer, the channel layer having one or more fluid channels. The one or more channels are configured to contain a plurality of droplets. A valve control system is provided to control flow of fluid through the one or more fluid channels in the channel layer. The microfluidic system also includes a droplet impedance detection and feedback control system operatively connected to the valve control system. The droplet impedance detection and feedback control system is configured to detect at least a position of at least one droplet in a fluid channel and to send a signal to the valve control system to operate a particular valve at a particular time based on the detected position of the at least one droplet.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 13, 2021
    Assignees: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-Huei Wang, Brant Axt, Yi-Fan Hsieh, Helena C. Zec, Aniruddha Kaushik, Kuangwen Hsieh, Yue Yun
  • Publication number: 20210205032
    Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The method includes determining a first confidence indicator based on a manual control mode for the articulating member, determining a second confidence indicator based on an autonomous control mode for the articulating member, generating an allocation function based on the first confidence indicator and the second confidence indicator, and generating a control command for the articulating member based on the allocation function.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Applicants: University of Maryland, College Park, The Johns Hopkins University, Children's National Medical Center
    Inventors: Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann
  • Patent number: 11056338
    Abstract: A method for printing a semiconductor material includes depositing a molten metal onto a substrate in an enclosed chamber to form a trace having a maximum height of 15 micrometers, a maximum width of 25 micrometers to 10 millimeters, and/or a thin film having a maximum height of 15 micrometers. The method further includes reacting the molten metal with a gas phase species in the enclosed chamber to form the semiconductor material.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: July 6, 2021
    Assignee: The Johns Hopkins University
    Inventor: Jarod C. Gagnon
  • Patent number: 11053468
    Abstract: A method of cell culture and a method of generating organoids is provided. The methods utilize a cell culture system which includes a multiwell culture plate having shafts for mixing culture media within wells of the culture plate. The multiwell culture plate includes a base substrate having a plurality of culture wells, and a shaft operably associated with each culture well, each shaft being configured to mix media present in each culture well and having a gear adapted to operably associate with a gear on a shaft associated with an adjacent culture well. The system further includes a motor having a drive shaft in operable communication with the shaft gears of the multiwell culture plate. The system can be widely used as a standard platform to generate stem cell-derived human organoids for any tissue and for high-throughput drug screenings, toxicity testing, and modeling normal human organ development and diseases.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 6, 2021
    Assignee: The Johns Hopkins University
    Inventors: Hongjun Song, Guoli Ming, Mingxi Max Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian
  • Patent number: 11052261
    Abstract: The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: July 6, 2021
    Assignee: The Johns Hopkins University
    Inventors: Harikrishna Tandri, Ronald David Berger, Seth Weinberg, Leslie Tung, Henry Halperin, David Hunter
  • Patent number: 11045473
    Abstract: Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine salvage pathway in prostate of the individual and ii) a polyamine analogue. The methods are for use in individuals who have been diagnosed with, or are suspected of having or at risk for developing androgen sensitive prostate cancer (AS-CaP), or Castration recurrent CaP (CR-CaP), or benign prostate hyperplasia (BPH). The disclosure includes use of inhibitors of methylthioadenosine phosphorylase (MTAP), and a polyamine analog that upregulates polyamine catabolism by increasing spermidine/spermine N1-acetyl transferase (SAT1) activity, such as methyl-thio-DADMe-Immucillin (MTDIA), and 1),N(11)-bisethylnorspermine (BENSpm), respectively. Pharmaceutical formulations that contain a combination of the inhibitor of the methionine salvage pathway and a polyamine analogue are included, as are kits that contain such agents.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 29, 2021
    Assignees: Health Research, Inc., The Johns Hopkins University
    Inventors: Dominic Smiraglia, Haley Affronti, Robert Casero
  • Publication number: 20210186526
    Abstract: Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula including a cutting surface positioned at or adjacent the distal end, the cutting surface being oriented at an angle, the angle being greater than 90 degrees relative to the longitudinal axis of the cannula, and the harvested bone is adapted to move from a position adjacent to the cutting surface through the cannula into the bone receptacle. The cutting surface of the cannula may be positioned at or adjacent the distal end, and positioned at least in part radially outward of the outer face of the cannula. The cannula may include a cutting surface positioned at or adjacent the distal end and an occluding geometry that partially occludes the distal end of the cannula adjacent the cutting surface. In addition, a suction port may be provided in communication with the bone receptacle.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 24, 2021
    Applicant: The Johns Hopkins University
    Inventors: Maxim Budyansky, Neil Shah, Akhil Jay Khanna, Khaled M. Kebaish, Lee H. Riley, III
  • Patent number: 11039780
    Abstract: The present invention is directed to a computer application for seizure detection using biometric data and responsivity testing. The computer application collects biometric data and responsiveness test results from biometric sensors and an interactive user interface in order to identify and confirm seizures and monitor for severity, duration, and permit logging and notification. The computer application collects data such as heart rate, movement, and responsivity testing results. The computer application facilitates caregiver notification of seizures at or before seizure onset if the user has a warning aura and/or during prolonged or severe seizures (e.g. long duration or convulsive movements).
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: June 22, 2021
    Assignee: The Johns Hopkins University
    Inventors: Gregory Krauss, Nathan Crone
  • Patent number: 11041865
    Abstract: The present invention relates to the field of myocardial injury. More specifically, the present invention provides methods and compositions useful in the diagnosis, prognosis and/or assessment of myocardial injury. In a specific embodiment, a method comprises the steps of (a) diagnosing a subject as having myocardial injury based on the statistically significant over expression of one or more markers described herein compared to a baseline value, wherein the markers are measured in a biological sample obtained from the subject; and (b) treating the subject with one or more of an anti-thrombolysis agent, coronary bypass surgery or angioplasty.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: June 22, 2021
    Assignees: THE JOHNS HOPKINS UNIVERSITY, CEDARS-SINAI MEDICAL CENTER
    Inventors: Qin Fu, Jennifer Eileen Van Eyk, Vidya Venkatraman