Patents Assigned to The Johns Hopkins University
  • Patent number: 10736593
    Abstract: An X-ray diagnostic apparatus according to the embodiment includes an X-ray tube, an X-ray detector, image generating unit generating time-series medical images of vasoganglion in a predetermined organ of a subject, region setting unit setting a first upstream and downstream region of a stenosis location in a first blood vessel in the vasoganglion on the medical images, curve generating unit generating a stenosis upstream and downstream curve indicating a change in pixel value in the time-series based on pixel values included in the first upstream and downstream region respectively, stenosis index generating unit generating a stenosis index indicating the degree of stenosis in the first blood vessel based on the stenosis upstream and downstream curve, and display unit displaying the stenosis index.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 11, 2020
    Assignees: Canon Medical Systems Corporation, The Johns Hopkins University
    Inventors: Jingwu Yao, Takuya Sakaguchi, Jeff Trost, Richard T. George, Joao A. C. Lima, Omair Yousuf
  • Patent number: 10737779
    Abstract: A vehicle for aerial-aquatic locomotion is provided. The vehicle may include a propeller, an electric motor operably coupled to the propeller and configured to rotate the propeller, a maneuvering assembly configured to change an attitude and altitude of the vehicle, and a controller operably coupled to the electric motor and the maneuvering assembly. The controller may be configured to receive a command for the vehicle to exit a first medium and enter a second medium, compute or retrieve a hybrid trajectory, and control the electric motor and the maneuvering assembly to maneuver the vehicle in accordance with the hybrid trajectory.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: August 11, 2020
    Assignee: The Johns Hopkins University
    Inventor: Joseph L. Moore
  • Patent number: 10739366
    Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tza-huei J. Wang, Tushar Dnyandeo Rane, Helena Claire Zec, Wen-Chy Chu
  • Patent number: 10738066
    Abstract: The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2?, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: August 11, 2020
    Assignees: The Johns Hopkins University, Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.
    Inventors: Barbara Slusher, Rana Rais, Lukas Tenora, Pavel Majer, Andrej Jancarik
  • Patent number: 10736854
    Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: August 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
  • Patent number: 10736974
    Abstract: Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: August 11, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray, Ying Chen, Xing Yang
  • Patent number: 10730916
    Abstract: The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: August 4, 2020
    Assignee: The Johns Hopkins University
    Inventors: Xuhang Li, Heng Zhu
  • Patent number: 10729786
    Abstract: Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (CF) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. The nanoparticle gene carriers also contain one or more mucus resistant polymers. In a particular preferred embodiment, the nanoparticle gene carrier is a nanoparticle formed from one or more nucleic acids, PEI, and a mucus-resistant/diffusive graft copolymer composed of a PEI backbone functionalize by one or more PEG side chains. The nanoparticle gene carriers can efficiently diffuse through CF mucus, and can effectively serve as a vehicle to administer one or more nucleic acids to a patient suffering from CF.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: August 4, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jung Soo Suk, Justin Scot Hanes
  • Patent number: 10731161
    Abstract: The presently disclosed subject matter provides a novel approach for the treatment, prevention, and diagnosis of Cap-Snatching virus infections, particularly all classes of human influenza, including pandemic influenza. The methods involve the use of constructs for RNA-interference (RNAi).
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: August 4, 2020
    Assignee: The Johns Hopkins University
    Inventors: Christopher E. Bradburne, Lucy M. Carruth
  • Patent number: 10730828
    Abstract: The disclosed subject matter provides N-hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: August 4, 2020
    Assignees: Cardioxyl Pharmaceuticals, Inc., The Johns Hopkins University
    Inventors: Vincent Jacob Kalish, Lisa Marie Frost, Frederick Arthur Brookfield, Stephen Martin Courtney, John P. Toscano
  • Patent number: 10734565
    Abstract: An electric generator device is provided that includes a thermoelectric array, a base plate, and an electric power output. The thermoelectric array may include a hot side portion and a cold side portion. The base plate may be configured to receive heat from a heat source to be transferred to the hot side portion of the thermoelectric array. The electric power output may be electrically coupled to the thermoelectric array. The thermoelectric array may be configured to convert a temperature differential into an electric voltage for output to the electric power output. The power generation housing may be configured to hold a heat rejection substance that absorbs heat from the cold side portion of the thermoelectric array to facilitate generation of the temperature differential between the hot side portion and the cold side portion of the thermoelectric array.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 4, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jonathan M. Pierce, Rama Venkatasubramanian, Geza Dezsi, Drew P. Seker, Craig B. Leese
  • Patent number: 10729337
    Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: August 4, 2020
    Assignees: The Johns Hopkins University, Boston Scientific Scimed Inc.
    Inventors: Qian Liu, Nichaluk Leartprapun, Jackline Wanjala, Soumyadipta Acharya, Andrew Bicek, Viachaslau Barodka, Umang Anand, Majd Alghatrif, David Kass, B. Westbrook Bernier, Chao-Wei Hwang, Peter Johnston, Trent Langston
  • Patent number: 10722221
    Abstract: The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools ensures that tissue damage at a site targeted for biopsy is negligible. As such, large numbers of microtools may be deployed ensuring that a true statistical sampling of biologic tissue is performed.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 28, 2020
    Assignee: The Johns Hopkins University
    Inventors: Anthony N. Kalloo, David H. Gracias, Florin M. Selaru, Evin Gultepe, Mouen A. Khashab
  • Patent number: 10717750
    Abstract: PSMA-targeted PET/SPECT agents for imaging PSMA-positive cancer and or tumor neovasculature and PSMA-targeted radiotherapeutic agent for the treatment of PSMA-positive cancer or tumor neovasculature are disclosed. Methods of imaging PSMA expressing tumors, or cells and kits also are disclosed.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: July 21, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray
  • Patent number: 10721569
    Abstract: A middle ear implant includes a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft that connects the first and second interface portions, a carrier plate removably mounted in one of the first or second interface portions, and a removable sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The removable sensor is configured to provide a DC signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures, and provide an AC signal output indicative of a frequency response of the implant. The removable sensor is disposed at a portion of the carrier plate.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: July 21, 2020
    Assignee: The Johns Hopkins University
    Inventors: Dawnielle Farrar-Gaines, George L. Coles, Jr., Howard W. Francis
  • Patent number: 10709740
    Abstract: Disclosed is a composition including: an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (BMSCs), wherein the BMSCs express neuronal markers, and wherein the neuronal markers are PGP9.5, NSE, Tuj1, HuC/D and neuronal nitric oxide synthase (nNOS). Methods of preparing the BMSCs are also provided. In addition, the present disclosure is directed to a method of treating an enteric nervous system-related disorder including: administering to a subject in need thereof a pharmaceutical composition including the in vitro pre-conditioned BMSC population and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: July 14, 2020
    Assignees: THE JOHNS HOPKINS UNIVERSITY, UNION HOSPITAL, TONGJI MEDICAL COLLEGE, HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xuhang Li, Xiaohua Hou, Rong Lin
  • Patent number: 10711027
    Abstract: Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 14, 2020
    Assignee: The Johns Hopkins University
    Inventors: Marc M. Greenberg, Rakesh Paul
  • Patent number: 10704108
    Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: July 7, 2020
    Assignees: The Johns Hopkins University, Duke University
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, D. Williams Parsons, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Nickolas Papadopoulos, Victor Velculescu, Giovanni Parmigiani, Rachel Karchin, Sian Jones, Hai Yan, Darell Bigner, Chien-Tsun Kuan, Gregory J. Riggins
  • Patent number: 10704105
    Abstract: Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 7, 2020
    Assignee: The Johns Hopkins University
    Inventors: Yardena Samuels, Victor Velculescu, Kenneth Kinzler, Bert Vogelstein
  • Patent number: 10695427
    Abstract: The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors with or without chemotherapeutic agents for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 30, 2020
    Assignee: The Johns Hopkins University
    Inventors: Qiongyu Guo, Jordan J. Green, Randall A. Meyer, Corey J. Bishop, Anand Kumar, Gregg L. Semenza