Patents Assigned to The Johns Hopkins University
  • Publication number: 20220257266
    Abstract: An intracranial access device includes a housing having an operator-facing side and a patient-facing side and an opening therethrough extending from the operator-facing side to the patient-facing side. The device further includes at least one fastener configured to secure the device to a cranium of a patient. The device further includes a drill mounted to a surface of the housing and a cauterizer. The device may further include a number of sensors arranged on the patient-facing side of the housing and configured to identify a hemorrhage location.
    Type: Application
    Filed: July 16, 2020
    Publication date: August 18, 2022
    Applicants: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Johns Hopkins University
    Inventors: David L. Brody, David Blodgett, Carissa Rodriguez, Timothy Sleasman, Michael J. Fitch, Adam Cohen, Max R. Basescu, Kevin C. Wolfe, Jared M. Wormley
  • Patent number: 11413299
    Abstract: The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: August 16, 2022
    Assignees: The Johns Hopkins University, University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: David Hackam, Chhinder P. Sodhi, Peter Wipf
  • Patent number: 11418900
    Abstract: A tinnitus treatment device may include a sound generation unit configured to generate an electrical stimulus, and an open earphone operably coupled to the sound generation unit to produce acoustic vibrations based on the electrical stimulus. The open earphone may include an auditory passage and the open earphone may be insertable into an ear canal of a person such that the auditory passage enables sound to pass substantially unobstructed by the device into the ear canal of the person. The sound generation unit may be configured to be adjustable to tune the electrical stimulus based on a characteristic of tinnitus symptoms experienced by the person.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: August 16, 2022
    Assignee: The Johns Hopkins University
    Inventors: Dawnielle Farrar-Gaines, Bradford J. May, Howard W. Francis
  • Publication number: 20220249008
    Abstract: A device may receive electroencephalography data relating to one or more cerebral regions. The device may generate, based on the electroencephalography data, a cortical stimulation mapping model of the one or more cerebral regions, wherein the cortical stimulation mapping model includes one or more virtual inputs and one or more virtual outputs corresponding to the one or more cerebral regions. The device may apply a virtual impulse to the one or more virtual inputs. The device may determine a virtual after-discharge from the one or more virtual outputs, wherein the virtual after-discharge includes information relating to an electrical response to the virtual impulse. The device may generate, based on the virtual after-discharge, an index that maps a magnitude of the virtual after-discharge to the one or more cerebral regions. The device may cause an action to be performed based on the index.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 11, 2022
    Applicant: The Johns Hopkins University
    Inventors: Adam LI, Sridevi V. SARMA
  • Publication number: 20220254352
    Abstract: An audio analysis platform may receive a portion of an audio input, wherein the audio input corresponds to audio associated with a plurality of speakers. The audio analysis platform may process, using a neural network, the portion of the audio input to determine voice activity of the plurality of speakers during the portion of the audio input, wherein the neural network is trained using reference audio data and reference diarization data corresponding to the reference audio data. The audio analysis platform may determine, based on the neural network being used to process the portion of the audio input, a diarization output associated with the portion of the audio input, wherein the diarization output indicates individual voice activity of the plurality of speakers. The audio analysis platform may provide the diarization output to indicate the individual voice activity of the plurality of speakers during the portion of the audio input.
    Type: Application
    Filed: August 31, 2020
    Publication date: August 11, 2022
    Applicants: The Johns Hopkins University, Hitachi, Ltd.
    Inventors: Yusuke FUJITA, Shinji WATANABE, Naoyuki KANDA, Shota HORIGUCHI
  • Patent number: 11406353
    Abstract: Ultrasound is typically performed with the use of an external transcutaneous probe that emits ultrasonic energy and measures the timing of reflected waves, thus allowing measurement of fluid flow or formation of a two-dimensional image. Clinically, the modality is limited by attenuation of the signal with increasing depth of penetration of the ultrasound into tissues, as well as by similarities in echo-genicity between different tissues. The present invention includes a system in which an intravascular probe actively transmits ultrasound that can then be detected by in-line piezoelectric transducers without reflection. This signal can be overlaid onto traditional B-mode or Doppler representation. Furthermore, the present invention includes a signal processing system that will display a real-time graphical representation of the vascular anatomy in order to assist the surgeon or procedural radiologist in the placement of central venous catheters.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignee: The Johns Hopkins University
    Inventors: Fizan Abdullah, Seth Goldstein, Emad Boctor
  • Patent number: 11406666
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 9, 2022
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Patent number: 11410349
    Abstract: A respiratory motion estimation method (30) includes reconstructing emission imaging data (22) to generate a reconstructed image (50). The emission imaging data comprises lines of response (LORs) acquired by a positron emission tomography (PET) imaging device or projections acquired by a gamma camera. One or several assessment volumes (66) are defined within the reconstructed images. The emission imaging data are binned into time interval bins based on time stamps of the LORs or projections. A displacement versus time curve (70) is generated by computing, for each time interval bin, a statistical displacement metric of the LORs or projections that both are binned in the time interval bin and intersect the motion assessment volume. The motion assessment volume may be selected to overlap a motion assessment image feature (60) identified in the reconstructed image.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 9, 2022
    Assignees: KONINKLIJKE PHILIPS N.V., THE JOHNS HOPKINS UNIVERSITY
    Inventors: Benjamin Tsui, Patrick Olivier
  • Publication number: 20220241076
    Abstract: An orthopaedic implant with a medical dosing capability is disclosed herein. The orthopaedic implant may include a structure configured to interact with a bone of the patient. The orthopaedic implant may include a reservoir associated with the structure to hold a medical substance for treating a health condition of the patient. The orthopaedic implant may include a dosing mechanism to release the medical substance to treat the health condition.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 4, 2022
    Applicant: The Johns Hopkins University
    Inventors: Jarred A. BRESSNER, Mikhail OSANOV, Adam LEVIN
  • Publication number: 20220240881
    Abstract: A device may obtain first information relating to one or more first lung nodules identified in first imaging of a chest of a patient and second information relating to one or more second lung nodules identified in second imaging of the chest of the patient. The device may provide the first information and the second information to a machine learning model. The device may determine, using the machine learning model, a risk of lung cancer associated with the patient based on an elapsed time between performance of the first imaging and the second imaging and differences between the first information and the second information. The risk of lung cancer may have an inverse correlation to the elapsed time and a direct correlation to the differences.
    Type: Application
    Filed: June 23, 2020
    Publication date: August 4, 2022
    Applicants: The Johns Hopkins University, Provincial Health Services Authority
    Inventors: Peng HUANG, Yuliang LI, Stephen LAM
  • Patent number: 11400070
    Abstract: A method of treating or inhibiting degeneration of a retina of a subject in need thereof comprising administering an effective amount of a compound of metipranolol, or a metabolite thereof, to an organ, a tissue, or the subject, wherein the degeneration of the retina is caused by an ocular disease. In some embodiments, the compound, or a metabolite thereof, is administered topically, orally, or parenterally. In some embodiments, a drug delivery vehicle comprising a dosage of the compound, or the metabolite of, is delivered parenterally via intravitreal injection. In further embodiments, the dosage may range from 0.5 ?g/day-15 ?g/day.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: August 2, 2022
    Assignees: Alimera Sciences, Inc., The Johns Hopkins University
    Inventors: Kenneth E. Green, Peter Campochiaro, Yogita Kanan
  • Patent number: 11403554
    Abstract: An artificial intelligence testing apparatus may include processing circuitry configured to execute instructions that, when executed, cause the apparatus to create initial sample points based on a simulation received at the apparatus, and employ cyclic evaluation of the simulation until a stopping criteria is met. Employing the cyclic evaluation includes running the simulation at design points for a set of queries associated with a current iteration of the cyclic evaluation, training a set of meta-models of parameter space associated with the simulation for the current iteration, computing a set of metrics for the current iteration, and employing a selected sampling approach to select a new set of design points for a next iteration of the cyclic evaluation.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 2, 2022
    Assignee: The Johns Hopkins University
    Inventors: Matthew B. Wagner, David R. Witman, Peter A. Sevich, Patrick J. Trainor, Liam R. Cusack, William A. Patterson
  • Patent number: 11400146
    Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: August 2, 2022
    Assignees: The Johns Hopkins University, South Dakota State University
    Inventors: David A. Sack, Weiping Zhang
  • Patent number: 11401380
    Abstract: Polyethylene glycol (PEG)-b-poly(?-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: August 2, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jordan Green, Jayoung Kim, Stephany Tzeng
  • Patent number: 11401178
    Abstract: Described are methods of removing phosphorous from aqueous solutions using copper-substituted aluminosilicate materials. The copper-substituted aluminosilicate materials are copper-substituted zeolites that are recyclable and have desirable recovery efficiencies. Also described are methods of making copper-substituted aluminosilicate materials, using copper-substituted aluminosilicate materials, systems using copper-substituted aluminosilicate materials, and methods of using these systems.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: August 2, 2022
    Assignee: The Johns Hopkins University
    Inventors: Chao Wang, Michael Manto, Pengfei Xie
  • Publication number: 20220234730
    Abstract: A fuselage may include abase plate including one or more attachment points for securing the base plate to an unmanned aerial vehicle, a cover removably securable to the base plate, and a cargo compartment disposed in a space between the base plate and the cover at a balance point of the unmanned aerial vehicle. Accordingly, a container to transport cargo may be positioned within the cargo compartment at the balance point of the unmanned aerial vehicle, and the cargo compartment and/or the container may include one or more devices to regulate an environment within the container (e.g., with respect to temperature, vibrations, humidity, and/or the like).
    Type: Application
    Filed: June 26, 2020
    Publication date: July 28, 2022
    Applicant: The Johns Hopkins University
    Inventors: Jeffrey STREET, Timothy AMUKELE
  • Patent number: 11395805
    Abstract: The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 26, 2022
    Assignee: The Johns Hopkins University
    Inventors: Hai-Quan Mao, Jose Luis Santos, Yong Ren, John-Michael Williford
  • Patent number: 11394377
    Abstract: An embodiment in accordance with the present invention provides a system and method of physically modulating a digital signal across a medium. A signal is sent one bit at a time (serially) as a period of high voltage followed by a period of low voltage. The present invention includes several major advantages. One advantage is that the code to execute the method is very lightweight. Another advantage is that the signals require no synchronization source. The signals of the present invention function as their own synchronization.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: July 19, 2022
    Assignee: The Johns Hopkins University
    Inventor: Joseph T. Carrigan
  • Publication number: 20220218889
    Abstract: An aspiration device to be used with an irrigation-aspiration handpiece may comprise a curved body having a radius of curvature based on a human equatorial lens diameter, an interface adapted to attach the curved body to a first end of an aspiration lumen in the irrigation-aspiration handpiece, and multiple aspiration ports formed in the curved body. The multiple aspiration ports may be adapted to draw material into the aspiration lumen when a suction source is used to apply vacuum pressure at a second of the aspiration lumen while the aspiration lumen is attached to the aspiration device. The multiple aspiration ports may be arranged to distribute the vacuum pressure over an aggregate surface area of the multiple aspiration ports while the suction source applies the vacuum pressure.
    Type: Application
    Filed: April 23, 2020
    Publication date: July 14, 2022
    Applicant: The Johns Hopkins University
    Inventors: Albert S. JUN, Joaquin Octavio DE ROJAS, Jan MCGLUMPHY, Todd RICHMOND
  • Patent number: 11382714
    Abstract: An ultrasound-detectable marker, ultrasound system, and methods for monitoring vascular flow and patency are disclosed. The ultrasound-detectable marker comprises one or more resorbable polymers, one or more non-resorbable polymers, one or more non-polymeric materials, or any combinations thereof. The ultrasound-detectable marker is adapted for placement underneath, adjacent to, or above one or more vessels at a postoperative site, such as a vascular anastomosis site. Further, the ultrasound imaging system includes certain user guiding software and/or health analysis software for use with the ultrasound-detectable marker.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 12, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Devin O'Brien-Coon, Kaitlyn Harfmann, Ting Yu Lai, David Narrow, Adam Lightman, Youseph Yazdi