Patents Assigned to The Johns Hopkins University
  • Patent number: 10982287
    Abstract: Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: April 20, 2021
    Assignees: The Johns Hopkins University, University of Torino
    Inventors: Victor Velculescu, Eniko Papp, Vilmos Adleff, Andrea Bertotti, Livio Trusolino
  • Patent number: 10984527
    Abstract: A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one substructure; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit stores an anatomical atlas comprising data encoding spatial information of the at least one substructure in the tissue region, and a pathological atlas corresponding to an abnormality of the tissue region, wherein the signal processing system is adapted to automatically identify, using the imaging signal, the anatomical atlas, and the pathological atlas, a presence of the abnormality or a pre-cursor abnormality in the subject under observation.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: April 20, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Susumu Mori, Michael I. Miller, Kenichi Oishi
  • Publication number: 20210106667
    Abstract: Vaccine design, polycistronic vaccine constructs, compositions, and methods comprising nucleic acids (DNA, RNA), peptides, proteins and derivatives thereof, including cells and cell-lines, for enhanced antigen-specific vaccination.
    Type: Application
    Filed: May 3, 2019
    Publication date: April 15, 2021
    Applicants: DUKE UNIVERSITY, THE JOHNS HOPKINS UNIVERSITY
    Inventors: YOU-WEN HE, HEQIANG SUN, THOMAS AUGUST, JUN LIU, YADONG WEI
  • Patent number: 10975431
    Abstract: This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: April 13, 2021
    Assignee: The Johns Hopkins University
    Inventors: Victor E. Velculescu, Stephen Cristiano, Alessandro Leal, Jillian A. Phallen, Jacob Fiksel, Vilmos Adleff, Robert B. Scharpf
  • Publication number: 20210105233
    Abstract: A messaging server may receive message data which may comprise message information, a plurality of recipients, and/ or patient identifying information. The messaging server may generate one or more messages which may be formatted according to different endpoint protocols, ranked, and/or addressed to separate recipients. The messaging server may send the messages using the same protocol as the protocol used for formatting the message, in order of rank, and/or to recipients determined based on the patient identifying information.
    Type: Application
    Filed: June 5, 2017
    Publication date: April 8, 2021
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Cao-Ly TRAN, Dwight RAUM, John W. SCOTT, Joshua G. SPANGLER, Kelly L. BYSTRY, Kirby S. SMITH, Marc A. AMICK, Philip J. GIANUZZI, Charles E. SCHMITT
  • Patent number: 10966998
    Abstract: Cancer therapies that combine epigenetic modulating agent(s) with immune modulating agent(s), which were remarkably identified to provide an improved treatment regimen over single agent therapy, are disclosed. In particular embodiments, the invention provides for improved treatment of NSCLC in patients via administration of exemplary immune modulating agents anti-PD-1 antibody or anti-PD-L1 antibody, which were observed to show enhanced activity in combination with the exemplary epigenetic modulating agent 5-deoxyazacytidine. Further, expression markers of responsive neoplastic cells are also disclosed.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: April 6, 2021
    Assignee: The Johns Hopkins University
    Inventors: Stephen B. Baylin, Drew M. Pardoll, Suzanne L. Topalian
  • Patent number: 10967076
    Abstract: A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 6, 2021
    Assignee: The Johns Hopkins University
    Inventors: Peter C. Van Zijl, Dmitri Artemov, Kannie Wai Yan Chan, Yoshinori Kato, Michael T. McMahon, Guanshu Liu
  • Patent number: 10967046
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. Accordingly, in one aspect, the present invention provides prodrug compositions. In certain embodiments, a prodrug composition comprises a prostate-specific antigen (PSA)-activated pro-aerolysin (PA), wherein a PSA cleavable linker replaces the native furin cleavage site within PA; and human serum albumin (HSA) or a fragment thereof fused to the N-terminus of the PSA-activated PA.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: April 6, 2021
    Assignee: The Johns Hopkins University
    Inventors: John T. Isaacs, Samuel R. Denmeade, W. Nathaniel Brennen
  • Patent number: 10962551
    Abstract: Chimeric proteins comprising an N-terminal domain derived from an N-terminal nucleotide binding domain of TDP-43 and a C-terminal domain derived from a splicing repressor are described. These proteins may be administered to a subject to treat or prevent disease manifesting TDP-43 proteinopathy such as inclusion body myocytosis, amyotrophic lateral sclerosis (ALS), or frontotemporal dementia (FTD).
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: March 30, 2021
    Assignee: The Johns Hopkins University
    Inventors: Philip C. Wong, Jonathan P. Ling
  • Patent number: 10959618
    Abstract: The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a CRT therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for CRT therapy. The method allows for quantitative assessment and estimation of mechanical contraction patterns, tissue viability, and venous anatomy from CT scans combined with electrical activation patterns from Body Surface Potential Mapping (BSPM). This multi-modal method is therefore capable of integrating electrical, mechanical, and structural information about cardiac structure and function in order to guide lead placement of CRT therapy devices. The method generates regional electro-mechanical properties overlaid with cardiac venous distribution and scar tissue.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 30, 2021
    Assignee: The Johns Hopkins University
    Inventors: Fady Dawoud, Karl H. Schuleri, Amir Pourmorteza, Albert C. Lardo, Elliot McVeigh
  • Publication number: 20210085399
    Abstract: Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.
    Type: Application
    Filed: October 21, 2020
    Publication date: March 25, 2021
    Applicant: The Johns Hopkins University
    Inventors: Natalia A. Trayanova, Kathleen Mcdowell
  • Patent number: 10956151
    Abstract: An example method for determining a software classification is provided. The example method may include determining a plurality of substream boundaries including a first substream boundary within a representation of a software binary, and segmenting the representation of the software binary into a plurality of substreams. The example method may further include generating a first count string for a first substream based on operational class token counts in a tokenization of the first substream, where the tokenization of the first substream may be based on a mapping of commands within the first substream to operational classes. The example method may further include performing a first count string comparison with a reference database to determine a first count string match, where the first count string comparison being based on the first count string, and classifying the software binary based on the first count string match.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: March 23, 2021
    Assignee: The Johns Hopkins University
    Inventors: Margaret F. Lospinuso, Sakunthala Harshavardhana, Laura J. Glendenning, Kathleen N. McGill, Robert M. Seng, Tzuhsiu Chiou, Sterling E. Vinson
  • Patent number: 10954273
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: March 23, 2021
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Patent number: 10953464
    Abstract: Functionalized metallic feedstock and three-dimensional articles formed therefrom via an additive manufacturing process are provided. The functionalized metallic feedstock includes a plurality of discrete metallic substrates including a first metallic substrate having a first surface area, in which at least a portion of the first surface area comprises a functionalizing agent selected to render the first metallic substrate resistant to corrosion.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: March 23, 2021
    Assignee: The Johns Hopkins University
    Inventors: Steven M. Storck, Rengaswamy Srinivasan, Paul J. Biermann
  • Patent number: 10952754
    Abstract: The present invention provides a drill guide for orthopedic surgery. The drill guide is configured to facilitate drilling of a bone tunnel with a correct and repeatable placement. The drill guide is designed for drilling of the femoral bone during knee surgery. More particularly, in certain embodiments the drill guide is designed for ACL repair and replacement surgery. In a preferred embodiment of the present invention, the guide has 5 members: a center rail, a side rail, an anteromedial slider, a femoral slider, and a center pin.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: March 23, 2021
    Assignee: The Johns Hopkins University
    Inventors: Mohit Singhala, Matthew Lerner, Polly Charlene Ma, Andrew Jann, Rachel An, Bashir Ahmed Zikria
  • Patent number: 10954257
    Abstract: The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2?, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: March 23, 2021
    Assignees: The Johns Hopkins University, Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.
    Inventors: Barbara Slusher, Rana Rais, Lukas Tenora, Pavel Majer, Andrej Jancarik
  • Publication number: 20210079472
    Abstract: The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of ADPKD in an individual.
    Type: Application
    Filed: August 31, 2020
    Publication date: March 18, 2021
    Applicants: Athena Diagnostics, Inc., The Johns Hopkins University
    Inventors: Terry J. Watnick, Miguel Garcia-Gonzalez, Gregory G. Germino, Jeffery G. Jones
  • Publication number: 20210077837
    Abstract: An unpowered respiratory protective headset for personal protective equipment and personal protective bodysuits with an unpowered respiratory protective headset, the unpowered respiratory protective headset having a respiratory mask having a flexible mask body having an interface section and defining a mask air inlet and a mask air outlet, an inhalation valve in the mask air inlet and an exhalation valve in the mask air outlet, and a hood having a hood body and a transparent face shield attached to the hood body. The hood has an air inlet and an air outlet and the air inlet, the mask air inlet, the mask air outlet and the air outlet are configured relative to each other to direct air flow across an inner surface of the transparent face shield to prevent or reduce fogging of the transparent face shield during inhalation and exhalation by a subject.
    Type: Application
    Filed: May 7, 2020
    Publication date: March 18, 2021
    Applicant: The Johns Hopkins University
    Inventors: Youseph Yazdi, Matthew Petney, William A.L. Patterson, Laura Scavo, Patience Osei
  • Publication number: 20210077195
    Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The system may include a dual camera system that captures near-infrared (NIR) images and point cloud images of a tissue or other substance that includes NIR markers. The system may generate a three-dimensional (3D) path based on identified positions of the NIR markers, may filter the generated path, and may generate a 3D trajectory for controlling the articulated arm of a robot having a tool to create an incision along the filtered path. In a shared control mode, an operator may generate manually control commands for the robot to guide the tool along such a path, while automated control commands are generated in parallel. One or more allocation functions may be calculated based on calculated manual and automated error models, and shared control signals may be generated based on the allocation functions.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 18, 2021
    Applicants: University of Maryland, College Park, The Johns Hopkins University, Children's National Medical Center
    Inventors: Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann, Michael Kam
  • Patent number: 10947197
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: March 16, 2021
    Assignee: The Johns Hopkins University
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals