Patents Assigned to The National University of Singapore
  • ULTRA-HIGH-THROUGHPUT MICROFLUIDIC ENZYME SCREENING PLATFORM FOR ENZYME DEVELOPMENT
    Publication number: 20210318315
    Abstract: Systems and methods for screening enzyme variants are described, wherein the enzyme variants may catalyze a reaction that is cofactor-dependent or cofactor-independent.
    Type: Application
    Filed: April 13, 2021
    Publication date: October 14, 2021
    Applicant: National University of Singapore
    Inventors: Zhi Li, Chia-Hung Chen, Kang Zhou, Jun Li, Ji Liu, Akbar Vahidi Khalfekandi, Guoyun Sun, Yuting Wen, Kaiyun Tian
  • Compounds useful in inhibiting human trefoil factor 3
    Patent number: 11141402
    Abstract: Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 12, 2021
    Assignees: National University of Singapore, University of Mysore, Bangalore University
    Inventors: Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppal Subbegowda, Basappa, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa
  • Temperature independent LCD polarization rotators
    Patent number: 11143901
    Abstract: A method and circuit for operating a liquid crystal device, LCD, based polarisation rotator. The method comprises the steps of tracking a capacitance value of the LCD rotator; and controlling a driver setting to the LCD rotator based on the tracked capacitance value to achieve temperature independent operation.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: October 12, 2021
    Assignee: National University of Singapore
    Inventors: Euk Jin Alexander Ling, Rakhitha Chandrasekara, Kadir Durak
  • Nanostructured iron/carbon for scavenging oxygen
    Patent number: 11134707
    Abstract: The invention is directed to a nanostructured composite material comprising a mixture of at least one metal particle such as iron and a carbon material from biomass such as D-glucose, D-glucosamine hydrochloride or a-cyclodextrin. The invention is also directed to a composition comprising the composite material comprising the composite material and an inorganic salt, and a method for synthesizing the composite material comprising immersing the carbon material into a solution of metal ions, drying the impregnated carbon particle and subjecting the impregnated carbon particle to a carbothermal reduction process. The nanostructured composite material is useful as an oxygen scavenging layer in a multi-layer film which comprises the oxygen scavenging layer and an oxygen barrier layer that retards the permeation of oxygen from an external environment.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: October 5, 2021
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Xu Li, Yu Yuan Chieng, Siew Yee Wong, Suxi Wang, Jen-Yi Huang, Weibiao Zhou
  • Solid electrolyte
    Patent number: 11133527
    Abstract: The present invention relates to a solid electrolyte comprising a first polymer which is a polyvinyl acetal or polyvinyl acetate, or a copolymer having vinyl acetal and/or vinyl acetate units, doped with a sodium or lithium salt. The solid electrolyte may be used as an ionically conductive membrane in a battery such a Li-air battery.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: September 28, 2021
    Assignee: National University of Singapore
    Inventors: Dorsasadat Safanama, Stefan Nikolaus Adams
  • Derivatives of PPD useful for coloring hair and skin
    Patent number: 11129782
    Abstract: The is provided a compound of formula I or II or physiologically acceptable salts or solvates, or oxidised derivatives thereof: where R1 to R3, R13 and R14 are as defined herein. Also disclosed herein are methods of dyeing hair or (temporarily) tattooing the skin using the compounds of formula I or II (or physiologically acceptable salts or solvates, or oxidised derivatives thereof) in a suitable composition.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: September 28, 2021
    Assignees: National University of Singapore, Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd
    Inventors: Giorgia Pastorin, Paul Bigliardi, Suresh Valiyaveettil, Gopalakrishnan Venkatesan, Arup Sinha, Yuri Herbert Dancik, Mei Bigliardi-Qi
  • Anti oligosaccharide antibody
    Patent number: 11124579
    Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: September 21, 2021
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chong Kok Teo, Andre Boon Hwa Choo, Wee Joo Chng
  • Vapor Deposition Of Carbon-Based Films
    Publication number: 20210280420
    Abstract: Methods of forming graphene hard mask films are disclosed. Some methods are advantageously performed at lower temperatures. The substrate is exposed to an aromatic precursor to form the graphene hard mask film. The substrate comprises one or more of titanium nitride (TiN), tantalum nitride (TaN), silicon (Si), cobalt (Co), titanium (Ti), silicon dioxide (SiO2), copper (Cu), and low-k dielectric materials.
    Type: Application
    Filed: March 3, 2020
    Publication date: September 9, 2021
    Applicants: Applied Materials, Inc., National university of Singapore
    Inventors: Bhaskar Jyoti Bhuyan, Andrea Leoncini
  • Molecular Layer Deposition of Amorphous Carbon Films
    Publication number: 20210277516
    Abstract: Methods of forming carbon polymer films are disclosed. Some methods are advantageously performed at lower temperatures. The substrate is exposed to a first carbon precursor to form a substrate surface with terminations based on the reactive functional groups of the first carbon precursor and exposed to a second carbon precursor to react with the surface terminations and form a carbon polymer film. Processing tools and non-transitory memories to perform the process are also disclosed.
    Type: Application
    Filed: March 12, 2020
    Publication date: September 9, 2021
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Bhaskar Jyoti Bhuyan, Mark Saly, Ahbijit Basu Mallick, Eugene Yu Jin Kong, Bo Qi
  • Proton conductive two-dimensional amorphous carbon film for gas membrane and fuel cell applications
    Patent number: 11114674
    Abstract: Described is a fuel cell comprising an electrode catalyst assembly, and a two-dimensional (2D) amorphous carbon, wherein the 2D amorphous carbon has a crystallinity (C)?0.8.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 7, 2021
    Assignee: National University of Singapore
    Inventors: Barbaros Ozyilmaz, Henrik Andersen, Chee Tat Toh
  • SARS-CoV-2 surrogate virus neutralization assay test kit
    Patent number: 11112412
    Abstract: A kit, composition and method for detection of antibodies to severe acute respiratory syndrome related coronavirus (SARSr-CoV), and for diagnosis of SARSr-CoV infection.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: September 7, 2021
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventor: Linfa Wang
  • Polysaccharide aerogel
    Patent number: 11103845
    Abstract: Disclosed herein is a polysaccharide aerogel comprising cotton cellulose fibres and a method of preparing the polysaccharide aerogel. The method comprises: mixing cotton cellulose fibres and a cross-linker to form a mixture; sonicating the mixture; freezing the sonicated mixture; and freeze drying the frozen mixture to form an aerogel. A further embodiment provides a polysaccharide aerogel comprising cotton cellulose fibres and paper cellulose fibres in a weight ratio of 1:1 to 1:6 and a method of preparation thereof wherein in the mixing step, the paper cellulose fibres are added to the cotton cellulose fibres to form a mixture.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 31, 2021
    Assignee: National University of Singapore
    Inventors: Hai Minh Duong, Nhan Phan-Thien, Bowen Gu, Mark Pyne Pennefather, Thanh Xuan Nguyen
  • LI-ION THIN FILM MICROBATTERY AND METHOD OF FABRICATING THE SAME
    Publication number: 20210257677
    Abstract: A Li-ion thin film microbattery, a microbattery array, a method of fabricating a Li-ion thin film microbattery and a method of fabricating a microbattery array. The Li-ion thin film microbattery comprises a Li-free cathode comprising a transition metal oxide thin film; an anode comprising a lithiated Ge or Si thin film; and an electrolyte film disposed between the cathode and the anode; wherein a Li-source of the Li-ion thin film microbattery is provided by means of the lithiated Ge or Si thin film.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 19, 2021
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Daniele Perego, Rajamouly Omampuliyur Swaminathan, Ye Lin Thu, Shao-Horn Yang, Wee Kiong Choi, Carl Vernette Thompson, II
  • SELF-POWERED TRIBOELECTRIC BASED DEVICES
    Publication number: 20210257932
    Abstract: A self-powered triboelectric based device, a self-powered triboelectric based device, a user interface, a method of providing user input, an energy harvesting device, a method of harvesting energy, a submersion-detecting device, and a method of submersion-detecting.
    Type: Application
    Filed: July 11, 2019
    Publication date: August 19, 2021
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chengkuo LEE, Qiongfeng SHI
  • Methods and Compositions for the Treatment of Steatosis-Associated Disorders
    Publication number: 20210251922
    Abstract: The present disclosure is directed to methods of treating a steatosis-associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage.
    Type: Application
    Filed: March 2, 2021
    Publication date: August 19, 2021
    Applicants: Duke University, National University of Singapore
    Inventors: Dwight D. Koeberl, Paul M. Yen, Benjamin L. Farah
  • IL-11R? antibodies
    Patent number: 11084878
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 10, 2021
    Assignees: National University of Singapore, Singapore Health Services PTE LTD., Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Subpixel circuitry for driving an associated light element, and method, display system and electronic device relating to same
    Patent number: 11087674
    Abstract: Disclosed is a subpixel circuit 310 comprising: a first switching device 311 responsive to a digital periodic signal VP to provide a digital control signal VC relating to a digital data signal VD, the digital periodic signal VP defining 2N+1 time slots within each frame cycle, where N is a predetermined integer. The digital data signal VD has a predetermined value at a predetermined one of the 2N+1 time slots; and the subpixel circuit 310 further comprises a second switching device 312 responsive to the control signal Vc to drive an associated light emitting element 320.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: August 10, 2021
    Assignees: Nanyang Technological University, Massachusetts Institute of Technology, National University of Singapore
    Inventors: Joseph Sylvester Chang, Wei Shu, Yong Qu, Eugene A. Fitzgerald, Li Zhang, Eng Kian Kenneth Lee, Soo Jin Chua, Siau Ben Chiah
  • IL-11 antibodies
    Patent number: 11084874
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 10, 2021
    Assignees: Singapore Health Services PTE LTD., National University of Singapore, Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • A CROSS-LINKED POLYMERIC MEMBRANE
    Publication number: 20210236998
    Abstract: There is provided a method of forming a cross-linked polymeric membrane, the method comprising: providing a polymeric membrane; and contacting the polymeric membrane with a cross-linking solution comprising at least one cross-linker to form the cross-linked polymeric membrane, wherein the at least one cross-linker comprises at least three halide-containing groups. There is also provided a cross-linked polymeric membrane.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 5, 2021
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Mohammad Hossein DAVOOD ABADI FARAHANI, Tai-Shung CHUNG
  • IL-11 antibodies
    Patent number: 11078268
    Abstract: IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 3, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer