Abstract: A method for diagnosing Non-Small Cell Lung Cancer (NSCLC) from a sample extracted from a subject by testing the sample for the presence of biomarkers, the biomarkers being autoantibodies against XAGE1D, LRRFIP2 and GAGE2C. Also claimed are a method of manufacturing a kit, and compositions comprising a panel of said antigens or exosomal autoantibodies.
Type:
Application
Filed:
December 12, 2019
Publication date:
August 18, 2022
Applicants:
SENGENICS SDN BHD, NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Jonathan Michael BLACKBURN, Arif ANWAR, Boon Cher GOH, Lingzhi WANG, Sok Hwee Esther CHEOW, Ross Andrew SOO, Win Lwin THUYA
Abstract: Methods of treating and preventing fibrosis and pathological inflammation through inhibition of WWP2 are disclosed, as well as agents for use in such methods.
Type:
Application
Filed:
June 12, 2020
Publication date:
August 11, 2022
Applicant:
National University of Singapore
Inventors:
Enrico Giuseppe Petretto, Aida Moreno Moral
Abstract: Methods and systems including a set of interacting nucleic acid structures for use in detecting and/or identifying a target comprising: a nucleic acid sequence capable of being conjugated to a moiety directed to the target; and a nucleic acid nanostructure comprising a segment sequence complementary to a portion of the nucleic acid sequence capable of being conjugated to a moiety directed to the target. The moiety directed to the target may be an antibody, and the nucleic acid nanostructure may be a tetrahedron.
Type:
Application
Filed:
May 19, 2020
Publication date:
July 28, 2022
Applicants:
NATIONAL UNIVERSITY OF SINGAPORE, NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE. LTD.
Abstract: Chalcogen silane precursors are described. Methods for depositing a silicon nitride (SixNy) film on a substrate are described. The substrate is exposed to the chalcogen silane and a reactant to deposit the silicon nitride (SixNy) film. The exposures can be sequential or simultaneous. The chalcogen silane may be substantially free of halogen. The chalcogen may be selected from the group consisting of sulfur (S), selenium (Se), and tellurium (Te).
Type:
Application
Filed:
January 18, 2021
Publication date:
July 21, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Chandan Kr Barik, Michael Haverty, Muthukumar Kaliappan, Cong Trinh, Bhaskar Jyoti Bhuyan, John Sudijono, Anil Kumar Tummanapelli, Richard Ming Wah Wong, Yingqian Chen
Abstract: Molybdenum(VI) coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Application
Filed:
January 12, 2021
Publication date:
July 14, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong, Mark Saly, Bhaskar Jyoti Bhuyan, Feng Q. Liu
Abstract: Molybdenum(IV) and molybdenum(III) coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Application
Filed:
January 12, 2021
Publication date:
July 14, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
Abstract: Molybdenum(0) coordination complexes comprising at least one cycloheptatriene ligand and optionally one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Application
Filed:
January 12, 2021
Publication date:
July 14, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
Abstract: Dinuclear molybdenum coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a dinuclear molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Application
Filed:
January 12, 2021
Publication date:
July 14, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
Abstract: Molybdenum(0) coordination complexes comprising an arene ligand and one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Application
Filed:
January 12, 2021
Publication date:
July 14, 2022
Applicants:
Applied Materials, Inc., National University of Singapore
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
Abstract: The invention provides a method of treating a subject afflicted with fragile X syndrome (FXS) or a FXS related disorder, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine effective to treat the subject.
Type:
Application
Filed:
January 31, 2022
Publication date:
June 30, 2022
Applicants:
PRILENIA NEUROTHERAPEUTICS LTD., NATIONAL UNIVERSITY OF SINGAPORE, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors:
Michael HAYDEN, Mahmoud Abdulhossein POULADI
Abstract: A method of, and module for, converting position or momentum correlation of correlated photon pairs to a polarization entangled photon pair, and a source for polarization entangled photon pairs. The method comprises a conversion step of separating the correlated photon pairs into first and second groups based on their generated position at the crystal (position correlation) or their direction about the propagation axis (momentum correlation) and rotating a polarization of the first correlated photon pair group such that the polarization of the first correlated pair group is at 90 degrees relative to the polarization of the second correlated photon pair group; and a combining step of combining the first and second correlated photon pairs such that at least respective portions of respective spatial distributions of the first and second photon pair groups overlap with negligible wavelength dependent phase difference.
Type:
Application
Filed:
October 4, 2019
Publication date:
June 30, 2022
Applicant:
NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Chithrabhanu PERUMANGATT, Lohrmann ALEXANDER, Alexander LING
Abstract: Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
June 21, 2022
Assignees:
NKARTA, INC., NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Jun Hao Leong, Noriko Shimasaki, See Voon Seow, Dario Campana, James Barnaby Trager, Alexandra Leida Liana Lazetic, Chao Guo, Luxuan Guo Buren, Shyam Sashikant Masrani
Abstract: A spin-orbit torque device 100 is described. In an embodiment, the spin-orbit torque device 100 comprises: a first pinning region 106 having a first fixed magnetization direction; a second pinning region 108 having a second fixed magnetization direction which is in a different direction to the first fixed magnetization direction; a magnetic layer 102 having a switchable magnetization direction; and a spin source layer 104 configured to generate a spin current for propagating a domain wall between the first and second pinning regions 106, 108 to switch the switchable magnetization direction of the magnetic layer 102 between the first and second fixed magnetization directions.
Abstract: The present disclosure relates generally to the field of immunology. In particular, the disclosure relates to an immune cell expressing a CAR, wherein the immune cell has been modified such that the expression and/or function of LCK has been reduced or eliminated. The disclosure also relates to methods for treating a disease in a subject.
Type:
Application
Filed:
February 27, 2020
Publication date:
May 26, 2022
Applicant:
NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Ling WU, Nicholas Robert John GASCOIGNE, Joanna BRZOSTEK
Abstract: The invention relates to a bread-based beverage comprising probiotics selected from Lactobacilli, Bifidobacteria, Saccharomyces yeast, or a combination thereof, wherein the probiotics has a live probiotic cell count of >5.0 log CFU/mL. There is also provided a method of preparing the bread-based beverage thereof, comprising mixing bread with water to form a mixture; adding probiotics to the mixture to form an inoculated mixture and fermenting the inoculated mixture to form the beverage.
Type:
Application
Filed:
April 1, 2020
Publication date:
May 26, 2022
Applicant:
NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Shao Quan LIU, Mingzhan TOH, Thuy Linh NGUYEN
Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
Type:
Grant
Filed:
February 21, 2020
Date of Patent:
May 24, 2022
Assignees:
National University of Singapore, Singapore Health Services PTE LTD.
Inventors:
Stuart Alexander Cook, Sebastian Schaefer, Anissa Anindya Widjaja
Abstract: A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.
Type:
Grant
Filed:
April 16, 2019
Date of Patent:
May 10, 2022
Assignees:
NATIONAL UNIVERSITY OF SINGAPORE, NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD
Abstract: A dielectric elastomeric material having a permittivity of 20-65 at 103 Hz is provided. The dielectric elastomeric material is formed from a composition comprising: a polymer comprising at least one acrylate monomer; a cross-linker; and a photoinitiator. A conductive elastomer comprising the dielectric elastomeric material, as well as a method of forming the dielectric elastomeric material, are also provided.
Type:
Application
Filed:
October 29, 2021
Publication date:
May 5, 2022
Applicant:
NATIONAL UNIVERSITY OF SINGAPORE
Inventors:
Jun Ding, Ramadan Abdelhamid Yousef Mohamed Borayek, Habimana Jean Willy
Abstract: The present disclosure provides a recombinant, probiotic lactic acid bacterium, wherein the bacterium comprises a non-replicating plasmid vector comprising (a) a tumor suppressor gene or anti-inflammatory gene operably linked to a first promoter that directs expression of the tumor suppressor gene or anti-inflammatory gene in a mammalian cell, and (b) an adhesin gene operably linked to a second promoter that directs expression of the adhesin gene in the bacterium. The present disclosure also provides uses of the recombinant bacterium, and methods of constructing the recombinant bacterium. The present disclosure also provides a method of treating cancer in a subject, wherein the method comprises administering a pharmaceutically effective amount of a recombinant, probiotic lactic acid bacterium, wherein the bacterium comprises a non-replicating plasmid vector comprising an adhesin gene operably linked to a promoter that directs expression of the adhesin gene in the bacterium.
Abstract: Methods of treating and preventing hepatotoxicity through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
May 3, 2022
Assignees:
Singapore Health Services PTE LTD., National University of Singapore
Inventors:
Stuart Alexander Cook, Sebastian Schaefer, Anissa Widjaja