Abstract: A method for manufacturing a personalized naturally designed mitral valve prosthesis to precisely fit a specific patient for which the valve prosthesis is made for is provided. The method includes measuring size and shape of a mitral valve of the specific patient by using imaging methods, calculating geometry and dimensions of annular ring, leaflets and chords per the specific patient based on validated algorithms, and cutting and connecting the annular ring, leaflets and chords to form a personalized prosthesis mitral valve.

Abstract: Methods and systems for detecting visual relations in a video are disclosed.

Abstract: Ultrasound imaging methods for identifying an anatomical feature of a spine are described. In an embodiment, the method comprises: receiving a transverse ultrasound image of a portion of the spine; extracting features of the portion of the spine from the image based on a distinct pattern associated with the anatomical feature of the spine; identifying a midline of the portion of the spine in the image; extracting midline features using pixel intensity values of the image; and identifying, based on a combination of the extracted features of the portion of the spine and the extracted midline features, the anatomical feature in the image. In another embodiment, the method comprises: receiving a paramedian sagittal ultrasound image of a portion of the spine; identifying morphological features of the image; and determining if the portion of the spine includes a sacrum using a Support Vector Machine classifier.

Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

Abstract: The present invention relates to a biodegradable alloy of Formula (I): Mg—Zn—X, wherein X represents —Ca—Mn or —Dy—Sr, wherein Zn is about 0.1 wt % to about 3.0 wt %, Dy is about 0.1 wt % to about 0.7 wt %, Sr is about 0.1 wt % to about 0.9 wt %, Ca is about 0.1 wt % to about 1.5 wt %, Mn is about 0.1 wt % to about 0.9 wt % and Mg is balance with impurities. The present invention further relates to a method for producing alloys, wherein the method comprises: (a) placing alloy components in a crucible, wherein the alloy components are placed in the crucible in a multilayer arrangement; (b) melting the alloy components at about 700° C. to about 850° C.; (c) stirring the melt of step (b) at about 400 rpm to about 500 rpm; (d) atomizing the melt of step (c) into millimeter size droplets using jets of inert gas; and (e) cooling and depositing the atomized alloy melt to obtain an ingot.

Abstract: Exemplary processing methods may include flowing a first deposition precursor into a substrate processing region to form a first portion of an initial compound layer. The first deposition precursor may include an aldehyde reactive group. The methods may include removing a first deposition effluent including the first deposition precursor from the substrate processing region. The methods may include flowing a second deposition precursor into the substrate processing region. The second deposition precursor may include an amine reactive group, and the amine reactive group may react with the aldehyde reactive group to form a second portion of the initial compound layer. The methods may include removing a second deposition effluent including the second deposition precursor from the substrate processing region. The methods may include annealing the initial compound layer to form an annealed carbon-containing material on the surface of the substrate.

Abstract: Devices and methods for analysing extracellular vesicle glycans are described. According to an embodiment, a microfluidic device comprises an inlet portion configured to receive a fluid sample; a mixing portion fluidically coupled to the inlet portion and configured to facilitate mixing between the fluid sample and magnetic nanoparticles functionalized to bind with extracellular vesicles and aggregate to vesicle glycans in the fluid sample; a magnetic separation portion fluidically coupled to the mixing portion and configured to separate clusters of magnetic nanoparticles from the fluid sample; and a magnetic sensor configured to measure magnetic properties of the fluid sample after it has passed through the magnetic separation portion. The magnetic nanoparticles may configured to aggregate in the presence of respective lectins when bound with extracellular vesicles carrying target glycans. In a specific embodiment, the magnetic particles comprise a magnetic polycore coated with polydopamine.

Abstract: Novel cyclic silicon precursors and oxidants are described. Methods for depositing silicon-containing films on a substrate are described. The substrate is exposed to a silicon precursor and a reactant to form the silicon-containing film (e.g., elemental silicon, silicon oxide, silicon nitride). The exposures can be sequential or simultaneous.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A soft, flexible microtube sensor and associated method of sensing force are described. A liquid metallic alloy is sealed within a microtube as thin as a strand of human hair to form the physical force sensing mechanism. The sensor is hardly distinguishable with the naked eye, and can be used for the continuous biomonitoring of physiological signals, such as unobtrusive pulse monitoring. Also described is a method of fabricating the microtube sensor and wearable devices incorporating one or more microtube sensors.

Abstract: There is provided a multi-layered membrane for separating components in an aqueous sample. There is also provided a method of preparing said multi-layered membrane, a method of separating blood plasma from a whole blood sample and a diagnostic device for separation of blood plasma from a whole blood sample.

Abstract: The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA; and a method for killing cells or treating a disease using said tsRNA.

Abstract: Methods and compositions that provide an environment that promotes enhanced protein expression and/or folding are provided. More particularly, engineered thermostable ferritin assemblies capable of encapsulating polypeptides, nucleic acids or small molecules, which includes a modified ferritin subunit which lacks an unstructured carboxy-terminal sequence are provided. Methods and compositions for delivery of protein therapeutics are also provided.

Abstract: Disclosed herein is a polymeric film, the film comprising a polymeric matrix material, a plurality of perovskite nanocrystals and/or aggregates of perovskite nanocrystals dispersed throughout the polymeric matrix material. There is also disclosed a perovskite polymer resin composition, a perovskite-polymer resin composition, a perovskite ink and a method of forming a luminescent film using any one of the compositions or ink. Preferably, the perovskite material is a lead halide perovskite containing a cation selected from Cs, an alkylammonium ion, or a formamidinium ion. The polymeric matrix is preferably formed from monomers comprising a vinyl or an acrylate group.

Abstract: There is provided a multi-layered membrane comprising a top layer, a bottom layer, and a spacer layer; wherein said spacer layer is interposed between said top layer and said bottom layer; wherein said top layer, said bottom layer and said spacer layer are each independently composed of one or more selective layers, each selective layer comprising a 2D material; wherein said spacer layer comprises at least one channel for receiving a fluid; wherein said bottom layer comprises a hole with an area in the range of 1 ?m2 to 1 mm2; and wherein said hole is capable of being in fluid communication with said at least one channels of said spacer layer. There is also provided a method to synthesize the top layer of a multi-layered membrane as disclosed herein, methods for separating a plurality of ions or molecules in a fluid stream, a device comprising a multi-layered membrane as disclosed herein, and use of the method or the device as disclosed herein in osmotic power generation.

Abstract: A method of detecting at least one contaminant in a flow of a liquid fuel includes measuring one or more parameters of a flow of the liquid fuel. Based on the measured one or more parameters, one or more properties of the liquid fuel are determined. A plurality of features are from selected ones of the one or more parameters and one or more properties. A trained classification model is applied on the extracted features to determine a type and a quantity of at least one contaminant in the liquid fuel.

Abstract: Disclosed is a device for incision and insertion of a ventilation tube during myringotomy, comprising a cutter member configured to make an incision; a holder member configured to dispose the ventilation tube in an orientation in which a longitudinal axis of the ventilation tube is substantially perpendicular to the cutter member; and a pusher member configured to apply a pushing force to a first end of the ventilation tube in a direction substantially perpendicular to the longitudinal axis, the first end of the ventilation tube being disposed closer to the cutter member than a second end of the ventilation tube; wherein the holder member comprises a pivot element configured to releasably engage the second end of the ventilation tube such that the ventilation tube is pivotable under the pushing force applied to the first end of the ventilation tube by the pusher member, for insertion of the first end of the ventilation tube into the incision.

Abstract: Various embodiments may relate to an electrode. The electrode may include an electrode core including an electrode active material. The electrode may also include one or more monolayer amorphous films. Each of the one or more monolayer amorphous films may be a continuous layer surrounding the electrode core.

Abstract: A method and a system of detecting winding fault during online operation of an electrical machine, said method comprising, acquiring a set of signals from the machine over a period, said set of signals comprising two or more magnetic flux signals, each flux signal obtained from a respective flux sensor positioned on the external surface of the machine; extracting an internal winding fault indicator from the set of signals; comparing the internal winding fault indicator with a baseline indicator; and determining the internal winding fault when the internal winding fault indicator deviates from the baseline indicator by a threshold.