Patents Assigned to The Regents of the University of Colorado
  • Modular intraocular lens designs, tools and methods
    Patent number: 11076948
    Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: August 3, 2021
    Assignees: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. Kahook, Glenn Sussman, Rudolph F. Zacher, Paul J. McLean, Harvey Uy, Robert Cionni, Kerry Solomon
  • CRISPR enabled multiplexed genome engineering
    Patent number: 11078498
    Abstract: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 3, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Andrew Garst, Ryan T Gill
  • Methods and devices for real-time detection of fouling chemistry
    Patent number: 11067511
    Abstract: Methods and devices for real-time detection of fouling chemistry are described herein. In one aspect, a method of detecting and characterizing fouling of a membrane used for separation in a fluid-based system can include illuminating the membrane with one or more light sources, collecting Raman spectroscopy data from the membrane, and based on the Raman data, determining at least one selected from the group consisting of: presence or absence of membrane fouling, severity of membrane fouling, and composition of the membrane fouling, where the Raman spectroscopy is selected from the group consisting of Coherent Anti-Stokes Raman Scattering (CARS), Stimulated Raman Scattering (SRS), and spontaneous Raman Scattering.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: July 20, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Joseph J. Brown, Omkar D. Supekar, Victor M. Bright, Juliet T. Gopinath, Alan R. Greenberg
  • Quantum tunneling matter-wave transistor system
    Patent number: 11069790
    Abstract: The present invention provides an matter-wave transistor in which the flow of particles (e.g., atoms and molecules) through the transistor is a result of resonant tunneling from a source well, through a gate well and into a drain well (as opposed to being a result of collisions, as in a classical atomtronic transistor). The transistor current of matter-wave particles can be controlled as a function of the breadth of resonant tunneling conditions of the gate well. For example, the resonant tunneling conditions of a gate well that does not include a dipole-oscillating Bose-Einstein condensate (DOBEC) can be broadened by including a DOBEC in the gate well. Similarly, the breadth of resonant tunneling conditions of the gate well can be changed by changing the particle population of a DOBEC in the gate well.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: July 20, 2021
    Assignees: ColdQuanta, Inc., The Regents of the University of Colorado
    Inventors: Dana Zachary Anderson, Brad Anthony Dinardo
  • BIOPRINTER AND METHODS OF MANUFACTURING AN ORGANOMIMETIC DEVICE
    Publication number: 20210213673
    Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
    Type: Application
    Filed: February 11, 2019
    Publication date: July 15, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Kambez Benam, Alexander Kaiser
  • Cobinamide Compounds as a Cyanide, Sulfide, or Methane-Thiol Antidote
    Publication number: 20210213031
    Abstract: Methods and compositions for treating cyanide, sulfide, or methane-thiol exposure in a subject. The compositions may include one or more cobinamide compounds, such as an amino-tetrazole-cobinamide and/or a di-(amino-tetrazole)-cobinamide.
    Type: Application
    Filed: June 4, 2019
    Publication date: July 15, 2021
    Applicants: The Regents of the University of California, The Regents of the university of Colorado
    Inventors: Gerard Boss, Adriano Chan, Matthew Brenner, Sari Brenner Mahon, Vikhyat Bebarta
  • MAP44 POLYPEPTIDES AND CONSTRUCTS BASED ON NATURAL ANTIBODIES AND USES THEREOF
    Publication number: 20210213110
    Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.
    Type: Application
    Filed: December 7, 2020
    Publication date: July 15, 2021
    Applicant: The Regents of The University of Colorado, A Body Corporate
    Inventors: V. Michael Holers, Nirmal Banda, Liudmila Kulik
  • CURABLE POLY(RTIL)-BASED MIXED-MATRIX MEMBRANES AND METHODS USING SAME
    Publication number: 20210205762
    Abstract: The invention includes compositions and methods for promoting gas mixtures separations, such as a carbon dioxide and methane mixture. The composition of the invention is based on a curable polymerized room-temperature ionic liquid [poly(RTIL)].
    Type: Application
    Filed: May 29, 2019
    Publication date: July 8, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: DOUGLAS L. GIN, COLLIN ANDREW DUNN, ZOBAN SINGH, RICHARD D. NOBLE
  • GENETICALLY ENCODED SYSTEM FOR CONSTRUCTING AND DETECTING BIOLOGICALLY ACTIVE AGENTS
    Publication number: 20210206813
    Abstract: This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
    Type: Application
    Filed: January 5, 2021
    Publication date: July 8, 2021
    Applicant: The Regents of the University of Colorado, a Body Corporate
    Inventors: Jerome Fox, Ankur Sarkar, Akarawin Hongdusit, Edward Kim
  • Compounds and methods for treating autoimmunity
    Patent number: 11052060
    Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: July 6, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
    Inventors: Steve Orndorff, Aaron Michels
  • Intraocular lens designs for improved stability
    Patent number: 11045309
    Abstract: Intraocular lenses (IOLs) that improve lens stability by, for example, increasing anterior-posterior stiffness of the IOL, increasing anterior-posterior dimensions of the IOL and/or increasing contact area with the equator of the bag to resist movement of the IOL as the bag collapses over time. These IOLs may be non-modular (single component) or modular (multiple component). In modular embodiments, the IOL system may include intraocular base and optic components, which, when combined, form a modular IOL.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: June 29, 2021
    Assignees: The Regents of the University of Colorado, Alcon Inc.
    Inventors: Malik Y. Kahook, Glenn Sussman, Rudolph F. Zacher, Paul J. McLean, Robert E. Atkinson
  • Nanoporous lyotropic liquid crystal polymer membranes with reversibly tuned pore size and selectivity, and methods using same
    Patent number: 11046826
    Abstract: The invention includes methods of reversibly tuning the effective pore size and/or solute rejection selectivity of a nanoporous lyotropic liquid crystal (LLC) polymer membrane. The membranes of the invention have high levels of pore size uniformity, allowing for size discrimination separation, and may be used for separation processes such as liquid-phase separations.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: June 29, 2021
    Assignee: The Regents of the University of Colorado
    Inventors: Douglas L. Gin, Richard D. Noble, Sarah Marie Dischinger, Blaine M. Carter
  • Selective inhibition of V1b for treating fatty liver
    Patent number: 11033601
    Abstract: Disclosed herein are methods and compositions for treating nonalcoholic fatty liver disease. Specifically exemplified herein is administration of compositions comprising a V1b inhibitor or V1a agonist or V1a stabilizer.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 15, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Richard J. Johnson, Miguel A. Lanaspa Garcia, Thomas Jensen
  • High Strain Peano Hydraulically Amplified Self-Healing Electrostatic (HASEL) Transducers
    Publication number: 20210172460
    Abstract: High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
    Type: Application
    Filed: December 10, 2020
    Publication date: June 10, 2021
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Christoph Matthias Keplinger, Xingrui Wang, Shane Karl Mitchell
  • PORPHENE, A HETEROCYCLIC ANALOG OF GRAPHENE, METHODS OF MAKING AND USING THE SAME
    Publication number: 20210171704
    Abstract: Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Josef Michl, Thomas Frank Magnera
  • High speed two-dimensional imaging with an analog interface
    Patent number: 11032498
    Abstract: A quantitative pulse count (event detection) algorithm with linearity to high count rates is accomplished by combining a high-speed, high frame rate camera with simple logic code run on a massively parallel processor such as a GPU. The parallel processor elements examine frames from the camera pixel by pixel to find and tag events or count pulses. The tagged events are combined to form a combined quantitative event image.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: June 8, 2021
    Assignee: The Regents of the University of Colorado, a body
    Inventors: Justin Waugh, Daniel S. Dessau, Stephen P. Parham, Thomas Nummy, Justin Griffith, Xiaoqing Zhou, Haoxiang Li
  • Enhanced superconducting transition temperature in electroplated rhenium
    Patent number: 11018290
    Abstract: This disclosure describes systems, methods, and apparatus for multilayer superconducting structures comprising electroplated Rhenium, where the Rhenium operates in a superconducting regime at or above 4.2 K, or above 1.8 K where specific temperatures and times of annealing have occurred. The structure can include at least a first conductive layer applied to a substrate, where the Rhenium layer is electroplated to the first layer. A third layer formed from the same or a different conductor as the first layer can be formed atop the Rhenium layer.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: May 25, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, The Government of the United States of America, as represented by the Secretary of Commerce National Institute of Standards and Technology
    Inventors: Donald David, David Pappas, Xian Wu
  • Administration of oral methyldopa
    Patent number: 11013707
    Abstract: Methods of administering methyldopa to a subject in a fasting state to increase bioavailability of the methyldopa.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 25, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
    Inventors: Steve Orndorff, Aaron Michels
  • Sustained release formulation of interleukin-10 for wound treatment and related methods
    Patent number: 11013787
    Abstract: A sustained release formulation of interleukin-10 for wound treatment and related methods is provided.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: May 25, 2021
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF COLORADO FOR AND ON BEHALF OF THE UNIVERSITY OF COLORADO DENVER
    Inventors: Sundeep Govind Keswani, Paul Laszlo Bollyky, Swathi Balaji, Timothy M. Crombleholme
  • Fin blade
    Patent number: D921197
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: June 1, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Jonathan Todd Bravman