Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
Type:
Grant
Filed:
September 11, 2017
Date of Patent:
March 16, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a chemical structure of formula (I) or formula (II), and methods of using these compounds to treat cancer in an individual.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
March 16, 2021
Assignee:
The Regents of the University of Colorado, A Body Corporate
Abstract: This invention provides chromatographic methods for the purification of a cystathionine ?-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
Type:
Grant
Filed:
January 10, 2020
Date of Patent:
March 9, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Richard Carrillo, Jan P. Kraus, Tomas Majtan, David Naveh
Abstract: The disclosure relates to multilayer polymeric matrix based medical devices. In one example, a device comprises an inner first polymeric matrix and an outer second polymeric matrix. The addition of second polymeric matrix modifies bulk properties of each matrix thus resulting in a device where specific bulk properties are incorporated. The disclosure also relates to methods of manufacturing various embodiments of medical devices and their uses.
Type:
Grant
Filed:
August 27, 2015
Date of Patent:
March 9, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO
Inventors:
Devatha P. Nair, Eric Dailing, Jeffrey W. Stansbury, Malik Y. Kahook
Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
Type:
Grant
Filed:
May 9, 2016
Date of Patent:
March 2, 2021
Assignees:
Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
Inventors:
Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
February 16, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Jeffrey S. Kieft, Erich G. Chapman, David A. Costantino, Jay R. Hesselberth, Andrea MacFadden, Benjamin Akiyama
Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.
Type:
Application
Filed:
October 23, 2020
Publication date:
February 11, 2021
Applicant:
The Regents of the University of Colorado, a body corporate
Abstract: A slotted cannula for surgical procedures is disclosed. The slotted cannula has an elongated semi-circular body comprising a cavity extending along a longitudinal axis of the semi-circular body, the cavity having an open distal end and an open proximate end and an integrally formed outward bend extending curvilinear from the cavity on the proximate end and at least one fold line across the width of the cannula, perpendicular to the longitudinal axis. The cannula can be bent or broken along the at least one fold line to adjust the operable length of the cannula during a surgical procedure.
Type:
Application
Filed:
December 3, 2018
Publication date:
February 11, 2021
Applicant:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), Mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.
Type:
Grant
Filed:
August 13, 2019
Date of Patent:
February 9, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: The present invention includes compounds of the class anthracycline that have been modified to include photo-activated prodrug anthracycline compounds that are useful in the treatment of cancer. One example composition of the invention may include photodoxazolidine which may be synthesized in two steps from 4,5-dimethoxy-2-nitrobenzyl alcohol and doxazolidine. In this embodiment commercial 4,5-dimethoxyl-2-nitrobenzyl alcohol reacts with p-nitrophenylchloroformate to give the p-nitrophenyl carbonate of the benzyl alcohol derivative. The p-nitrophenyl carbonate is then reacted with doxazolidine to give the exemplary photodoxazolidine composition.
Type:
Grant
Filed:
April 27, 2016
Date of Patent:
February 9, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Tad H. Koch, Benjamin L. Barthel, Hang Hubert Yin, Ryo Tamura, Alla Balabanova
Abstract: The invention relates to the use of adenosine monophosphate deaminase 2 (AMPD2) inhibitors alone or in combination with various agents to treat a wide variety of diseases including, but not limited to, sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions. Embodiments of the invention may also relate to stimulation of AMPD2 activity to treat anorexia nervosa or stimulate food intake in a subject.
Type:
Grant
Filed:
April 12, 2017
Date of Patent:
February 9, 2021
Assignee:
Regents of the University of Colorado, A Body Corporate
Inventors:
Richard J Johnson, Ana Andres Hernando, Miguel A Lanaspa Garcia
Abstract: Various embodiments of the present invention generally relate to prosthetic partial finger designs that can mimic the last two joints of the finger. Some embodiments include a proximal phalange, a distal phalange coupled to the proximal phalange, and a knuckle track (e.g., formed in an arc). The knuckle track can be moveably coupled to the proximal phalange an may include multiple teeth formed on which the proximal phalange slides along. A ratcheting mechanism can contact the multiple teeth to allow sliding in only a first direction while the ratcheting mechanism is engaged. Some embodiments include a release mechanism (e.g., a button) configured to disengage the ratcheting mechanism from the multiple teeth to allow the distal phalange to slide in a second direction. In some embodiments, the device may include a spring-back capability that automatically extends the finger after reaching full finger flexion, enabling one-handed use.
Type:
Grant
Filed:
November 19, 2019
Date of Patent:
February 2, 2021
Assignees:
The Regents of the University of Colorado, a body corporate, Point Designs LLC
Inventors:
Jacob Segil, Stephen Huddle, Levin Sliker, Richard Weir
Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
February 2, 2021
Assignee:
The Regents of the University of Colorado
Abstract: Devices and methods for labeling and mounting suspended cells in a controllable area are disclosed. The devices and methods utilize polycarbonate filters. The filters are employed both to capture the cells and as a substrate for labeling. This disclosure provides a device for cell capture and staining. This device utilizes a stack comprising a filter sandwiched between two o-rings (an “OFO stack”) in which the o-rings both seat the device and, based on their outer diameter and cross-section, determine the cell capture area. In one embodiment, an alignment plate is affixed to an output head of the device, the alignment plate having one or more through holes, a diameter of the one or more through holes matching an outer diameter of the OFO stack.
Type:
Grant
Filed:
November 19, 2015
Date of Patent:
January 26, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Gregory Futia, Emily A. Gibson, Kian Behbakht
Abstract: The present disclosure provides an adjustable endoscopic surgical device for illuminating a tissue surface with diffuse and oblique light. In some embodiments, light emanates from the sides of an optical fiber, which is optionally formed at least in part into a loop shape.
Type:
Grant
Filed:
December 4, 2018
Date of Patent:
January 26, 2021
Assignee:
The Regents of the University of Colorado
Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.
Type:
Application
Filed:
July 27, 2020
Publication date:
January 14, 2021
Applicants:
The Regents of the University of Colorado, A Body Corporate, University of Wyoming
Inventors:
Ronggui YANG, Xiaobo YIN, Gang TAN, Dongliang ZHAO, Yaoguang MA, Yao ZHAI
Abstract: In one aspect, the present disclosure may provide devices or systems configured to receive indications of geographic areas, each corresponding to distribution networks, and determine whether the distribution networks overlap. The processor(s) may also be configured to receive parameter value(s) obtained by a device within one distribution network at a location within an overlapping area, and cause device(s) within another distribution network to modify operation based on the parameter value(s). In another aspect, the present disclosure may provide devices that include a voltage sensor to measure a voltage of a power distribution network at a power consumption location that corresponds to the device. The device may be configured to provide at least one cable service to the power consumption location via a cable television (CATV) distribution network and output an indication the measured voltage value.
Type:
Grant
Filed:
November 9, 2018
Date of Patent:
January 12, 2021
Assignees:
Alliance for Sustainable Energy, LLC, The Regents of the University of Colorado, a body corporate
Inventors:
Robert Fraser Cruickshank, III, Bri-Mathias Scott Hodge, Anthony Reed Florita
Abstract: Methods for treating and preventing neurodegenerative disease, neurological injury, including stroke, via administration of Transient receptor potential M2 (TRPM2)-inhibitors. The inhibitors may be administered in conjunction with another therapeutic agent or therapeutic regimen. The peptides may be administered to a human male. The peptides may be administered within eight hours of a neurological injury, such as a stroke.
Type:
Grant
Filed:
February 23, 2017
Date of Patent:
January 12, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: Hydraulically-amplified, self-healing, electrostatic transducers that harness electrostatic and hydraulic forces to achieve various actuation modes. Electrostatic forces between electrode pairs of the transducers generated upon application of a voltage to the electrode pairs draws the electrodes in each pair towards each other to displace a liquid dielectric contained within an enclosed internal cavity of the transducers to drive actuation in various manners. The electrodes and the liquid dielectric form a self-healing capacitor whereby the liquid dielectric automatically fills breaches in the liquid dielectric resulting from dielectric breakdown. Due to the resting shape of the cavity, a zipping-mechanism allows for selectively actuating the electrodes to a desired extent by controlling the voltage supplied.
Type:
Application
Filed:
March 4, 2019
Publication date:
January 7, 2021
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell, Timothy G. Morrissey
Abstract: Described herein are novel fMRI-based neurologic signatures that predict fibromyalgia (FM), clinical severity, and treatment outcomes. Further described are methods for diagnosing FM and for predicting or evaluating efficacy of a treatment of FM based on the neurologic signature.
Type:
Grant
Filed:
August 25, 2017
Date of Patent:
January 5, 2021
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE