Patents Assigned to The Regents of the University of Colorado
  • Patent number: 10935559
    Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 2, 2021
    Assignees: Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • Patent number: 10920224
    Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: February 16, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Jeffrey S. Kieft, Erich G. Chapman, David A. Costantino, Jay R. Hesselberth, Andrea MacFadden, Benjamin Akiyama
  • Publication number: 20210038255
    Abstract: A slotted cannula for surgical procedures is disclosed. The slotted cannula has an elongated semi-circular body comprising a cavity extending along a longitudinal axis of the semi-circular body, the cavity having an open distal end and an open proximate end and an integrally formed outward bend extending curvilinear from the cavity on the proximate end and at least one fold line across the width of the cannula, perpendicular to the longitudinal axis. The cannula can be bent or broken along the at least one fold line to adjust the operable length of the cannula during a surgical procedure.
    Type: Application
    Filed: December 3, 2018
    Publication date: February 11, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Omer Mei-Dan, Jacob Segil
  • Publication number: 20210043321
    Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Robin Deterding, Tam Vu
  • Patent number: 10913790
    Abstract: A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), Mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: February 9, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Leland Shapiro
  • Patent number: 10912770
    Abstract: The invention relates to the use of adenosine monophosphate deaminase 2 (AMPD2) inhibitors alone or in combination with various agents to treat a wide variety of diseases including, but not limited to, sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions. Embodiments of the invention may also relate to stimulation of AMPD2 activity to treat anorexia nervosa or stimulate food intake in a subject.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: February 9, 2021
    Assignee: Regents of the University of Colorado, A Body Corporate
    Inventors: Richard J Johnson, Ana Andres Hernando, Miguel A Lanaspa Garcia
  • Patent number: 10912767
    Abstract: The present invention includes compounds of the class anthracycline that have been modified to include photo-activated prodrug anthracycline compounds that are useful in the treatment of cancer. One example composition of the invention may include photodoxazolidine which may be synthesized in two steps from 4,5-dimethoxy-2-nitrobenzyl alcohol and doxazolidine. In this embodiment commercial 4,5-dimethoxyl-2-nitrobenzyl alcohol reacts with p-nitrophenylchloroformate to give the p-nitrophenyl carbonate of the benzyl alcohol derivative. The p-nitrophenyl carbonate is then reacted with doxazolidine to give the exemplary photodoxazolidine composition.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Tad H. Koch, Benjamin L. Barthel, Hang Hubert Yin, Ryo Tamura, Alla Balabanova
  • Patent number: 10910106
    Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 2, 2021
    Assignee: The Regents of the University of Colorado
    Inventors: Robin Deterding, Tam Vu
  • Patent number: 10905570
    Abstract: Various embodiments of the present invention generally relate to prosthetic partial finger designs that can mimic the last two joints of the finger. Some embodiments include a proximal phalange, a distal phalange coupled to the proximal phalange, and a knuckle track (e.g., formed in an arc). The knuckle track can be moveably coupled to the proximal phalange an may include multiple teeth formed on which the proximal phalange slides along. A ratcheting mechanism can contact the multiple teeth to allow sliding in only a first direction while the ratcheting mechanism is engaged. Some embodiments include a release mechanism (e.g., a button) configured to disengage the ratcheting mechanism from the multiple teeth to allow the distal phalange to slide in a second direction. In some embodiments, the device may include a spring-back capability that automatically extends the finger after reaching full finger flexion, enabling one-handed use.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: February 2, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, Point Designs LLC
    Inventors: Jacob Segil, Stephen Huddle, Levin Sliker, Richard Weir
  • Patent number: 10898371
    Abstract: The present disclosure provides an adjustable endoscopic surgical device for illuminating a tissue surface with diffuse and oblique light. In some embodiments, light emanates from the sides of an optical fiber, which is optionally formed at least in part into a loop shape.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: January 26, 2021
    Assignee: The Regents of the University of Colorado
    Inventor: Jeffrey L. Olson
  • Patent number: 10900874
    Abstract: Devices and methods for labeling and mounting suspended cells in a controllable area are disclosed. The devices and methods utilize polycarbonate filters. The filters are employed both to capture the cells and as a substrate for labeling. This disclosure provides a device for cell capture and staining. This device utilizes a stack comprising a filter sandwiched between two o-rings (an “OFO stack”) in which the o-rings both seat the device and, based on their outer diameter and cross-section, determine the cell capture area. In one embodiment, an alignment plate is affixed to an output head of the device, the alignment plate having one or more through holes, a diameter of the one or more through holes matching an outer diameter of the OFO stack.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: January 26, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Gregory Futia, Emily A. Gibson, Kian Behbakht
  • Publication number: 20210010764
    Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.
    Type: Application
    Filed: July 27, 2020
    Publication date: January 14, 2021
    Applicants: The Regents of the University of Colorado, A Body Corporate, University of Wyoming
    Inventors: Ronggui YANG, Xiaobo YIN, Gang TAN, Dongliang ZHAO, Yaoguang MA, Yao ZHAI
  • Patent number: 10892838
    Abstract: In one aspect, the present disclosure may provide devices or systems configured to receive indications of geographic areas, each corresponding to distribution networks, and determine whether the distribution networks overlap. The processor(s) may also be configured to receive parameter value(s) obtained by a device within one distribution network at a location within an overlapping area, and cause device(s) within another distribution network to modify operation based on the parameter value(s). In another aspect, the present disclosure may provide devices that include a voltage sensor to measure a voltage of a power distribution network at a power consumption location that corresponds to the device. The device may be configured to provide at least one cable service to the power consumption location via a cable television (CATV) distribution network and output an indication the measured voltage value.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: January 12, 2021
    Assignees: Alliance for Sustainable Energy, LLC, The Regents of the University of Colorado, a body corporate
    Inventors: Robert Fraser Cruickshank, III, Bri-Mathias Scott Hodge, Anthony Reed Florita
  • Patent number: 10889625
    Abstract: Methods for treating and preventing neurodegenerative disease, neurological injury, including stroke, via administration of Transient receptor potential M2 (TRPM2)-inhibitors. The inhibitors may be administered in conjunction with another therapeutic agent or therapeutic regimen. The peptides may be administered to a human male. The peptides may be administered within eight hours of a neurological injury, such as a stroke.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: January 12, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Paco S. Herson
  • Publication number: 20210003149
    Abstract: Hydraulically-amplified, self-healing, electrostatic transducers that harness electrostatic and hydraulic forces to achieve various actuation modes. Electrostatic forces between electrode pairs of the transducers generated upon application of a voltage to the electrode pairs draws the electrodes in each pair towards each other to displace a liquid dielectric contained within an enclosed internal cavity of the transducers to drive actuation in various manners. The electrodes and the liquid dielectric form a self-healing capacitor whereby the liquid dielectric automatically fills breaches in the liquid dielectric resulting from dielectric breakdown. Due to the resting shape of the cavity, a zipping-mechanism allows for selectively actuating the electrodes to a desired extent by controlling the voltage supplied.
    Type: Application
    Filed: March 4, 2019
    Publication date: January 7, 2021
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell, Timothy G. Morrissey
  • Patent number: 10881322
    Abstract: Described herein are novel fMRI-based neurologic signatures that predict fibromyalgia (FM), clinical severity, and treatment outcomes. Further described are methods for diagnosing FM and for predicting or evaluating efficacy of a treatment of FM based on the neurologic signature.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: January 5, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Tor Wager, Marina Lopez-Sola
  • Patent number: 10874745
    Abstract: Antimicrobial agents, including antimicrobial peptides (AMPs), and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptide variants that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPs change selectivity from broad spectrum antimicrobial activity to Gram-negative selectivity.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 29, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Robert S. Hodges, Ziqing Jiang, Lajos Gera, Colin T. Mant
  • Publication number: 20200385715
    Abstract: Embodiment disclosed herein concern compositions and methods for altering bacterial fitness. In certain aspects, altering bacterial fitness slows or prevents development of adaptive resistance to antibiotics in bacteria. In certain embodiments disclosed herein, bacterial fitness is altered by perturbing expression of a group of target genes.
    Type: Application
    Filed: May 11, 2017
    Publication date: December 10, 2020
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Anushree Chatterjee, Peter Otoupal
  • Patent number: 10857106
    Abstract: Methods for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual comprise delivering to the respiratory track of the individual an inhalable dry powder composition including an effective amount of myo-inositol.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 8, 2020
    Assignees: The Regents of the University of Colorado, a Body Corporate, Aktiv-Dry LLC
    Inventors: Robert E. Sievers, Stephen Cape, David McAdams, J'aime Manion, Pankaj Pathak
  • Patent number: 10852294
    Abstract: The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 1, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Gregory Thomas Everson