Abstract: RF co-designed bandpass filters/isolators (BPFIs) are based on series-cascaded non-reciprocal resonant stages, microwave resonators and multi-resonant cells. The non-reciprocal stages are shaped by an in-parallel cascaded transistor-based path and a transmission line (TL) that result in a zero-phase resonance in the forward direction and high isolation in the reversed one. This includes coupling routing diagrams (CRDs) of BPFs that result in low- and high-order transfer functions with and without transmission zeros in their forward direction and high levels of isolation in the reverse one. BPFIs provide alternative-type of filtering responses (e.g., flat-passband, quasi-elliptic) with and without gain in the forward direction and high levels of isolation in the reversed one. BPFIs include five planar microstrip/lumped element (LE) prototypes using hybrid combinations of non-reciprocal resonant stages, microwave resonators and multi-resonant cells.

Abstract: An ophthalmic implant configured for peri-operative, intra-operative, or post-operative assembly and disassembly. Drug delivery devices may be implanted with an intraocular lens, and later removed and replaced with new drug delivery devices.

Abstract: The present disclosure relates in one aspect to methods of preparing non-homogeneous polymer materials wherein light is used to control structure and/or composition. In certain embodiments, the present disclosure provides methods for creating gradient index optical elements including holographic elements.

Abstract: Transformerless stacked active bridge (TSAB) direct current (DC)-to-DC power converters designed based on parent switched capacitor (SC) converter topologies. The TSAB DC-to-DC power converter includes the SC converter. The SC converter includes a plurality of switches and a plurality of capacitors. Each capacitor of the plurality of capacitors is electrically coupled to at least one of the plurality of switches. The plurality of capacitors includes tree capacitors, and link capacitors forming a loop with at least one of the tree capacitors. The TSAB DC-to-DC power converter includes at least one inductor electrically coupled in series to at least one of the link capacitors. The TSAB DC-to-DC power converters provide high efficiency bi-directional operation without requiring isolation transformers.

Abstract: Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.

Abstract: Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.

Abstract: Embodiments herein relate to novel compositions and methods for treating viral infections and viral infection-related conditions. In some embodiments, compositions include, but are not limited to, at least one pro-inflammatory cytokine. In accordance with these embodiments, a proinflammatory cytokine can include Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) alone or in combination with other agents administered separately or together. In some embodiments, compositions including GM-CSF can be administered to a subject exposed to, suspected of having been exposed to, or having a viral infection. In other embodiments, the compositions treat, ameliorate or prevent a complication related to viral infection including, but not limited to, a central nervous system infection or condition and a lung infection or condition.

Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.

Abstract: Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.

Abstract: A thermal ground plane (TGP) is disclosed. A TGP may include a first planar substrate member comprising copper and a second planar substrate member comprising a metal, wherein the first planar substrate member and the second planar substrate member enclose a working fluid. The TGP may include a first plurality of pillars disposed on an interior surface of the first planar substrate and a mesh layer disposed on the top of the first plurality of pillars, wherein the mesh layer comprises at least one of copper, polymer encapsulated with copper, or stainless steel encapsulated with copper. The TGP may also include a second plurality of pillars disposed on an interior surface of the second planar substrate member within an area defined by the perimeter of the second planar substrate member and the second plurality of pillars extend from the second planar substrate member to the mesh layer.

Abstract: A quaternary ammonium salt comprising a chromophore constituent, a tertiary amine cation constituent connected to the para-position of the chromophore constituent via a methylene linkage, and a borate anion constituent, wherein chromophore constituent is a 3-ketocoumarin constituent or a benzophenone constituent. Also, a photobase-redox initiating system comprising the quaternary ammonium salt and a peroxide.

Abstract: Various embodiments of the disclosed technology present a structural foundation for volumetric flow reconstructions for expiratory modeling enabled through multi-modal imaging for pulmonology. In some embodiments, this integrated multi-modal system includes infrared (IR) imaging, thermal imaging of carbon dioxide (CO2), depth imaging (D), and visible spectrum imaging. These multiple image modalities can be integrated into flow models of exhale behaviors enable the creation of three-dimensional volume reconstructions based on visualized CO2 distributions over time, formulating a four-dimensional exhale model which can be used to estimate various pulmonological traits (e.g., breathing rate, flow rate, exhale velocity, nose/mouth distribution, tidal volume estimation, and CO2 density distributions).

Abstract: Methods, systems, and methods of manufacture for soft robotic actuators are described herein. In one aspect, a soft robotic actuator can include an elastomeric material defining a cavity; a volume of liquid metal (LM) positioned within the cavity; and an energy source coupled to the LM, where the energy source is adapted or configured to alter a temperature of the volume of LM, whereby altering the temperature of the volume of LM initiates an actuation of the elastomeric material.

Abstract: A nanophononic metamaterial-based thermoelectric energy conversion device and processes for fabricating a nanophononic metamaterial-based thermoelectric energy conversion device is provided. In one implementation, for example, a nanophononic metamaterial-based thermoelectric energy conversion device includes a first conductive pad, a second conductive pad, and a plurality of strip units. In one implementation, the first conductive pad is coupled to a first connection of the thermoelectric energy conversion device, and the second conductive pad is coupled to a second connection of the thermoelectric energy conversion device. The plurality of strip units are connected in series between the first and second conductive pads and provide a parallel heat transfer pathway. The strip units include a nanostructure design comprising a nanophononic metamaterial.

Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.

Abstract: The present disclosure provides techniques for estimating network states using asynchronous measurements by leveraging network inertia. For example, a device configured in accordance with the techniques of the present disclosure may receive electrical parameter values corresponding to at least one first location within a power network and determine, based on the electrical parameter values and a previous estimated state of the power network, an estimated value of unknown electrical parameters that correspond to a second location within the power network. The device may further cause at least one device within the power network to modify operation based on the estimated value of the unknown electrical parameters. The leveraging of network inertia may obviate the need for probabilistic models or pseudo-measurements.

Abstract: A record linking platform having a computer system with a processor, multiple databases each having records, such as private health information. Each of the multiple databases are not in direct communication with one another. A control center is in communication with the different entities, the control center configured to: generate a site configuration file, a key configuration file, and a broker configuration file. A keymaster configured to: receive the key configuration file, generate a hash key, and transmit the hash key to the databases. The databases configured to: receive the site configuration file and the hash key; process the records to generate evaluation records data that conform to a data model specified in the site configuration file; and encrypt the evaluation records using the hash key. An honest broker configured to: receive the broker configuration file and the encrypted evaluation records; and link the encrypted evaluation records without decrypting.

Abstract: Medical devices including balloons and balloons are provided that include an elongate body and an inflatable balloon defining a longitudinal axis, the inflatable balloon being attached to and partially surrounding at least a section of the elongate body. The medical device further includes a plurality of protrusions extending from the inflatable balloon. When the inflatable balloon is in an unstrained state, each of the plurality of protrusions extends in a first transverse direction relative to the longitudinal axis. In certain implementations, the inflatable balloon may also be configured to collapse such that, when in a collapsed state, an untextured portion of the inflatable balloon extends to a radius and the plurality of protrusions does not extend beyond the radius.

Abstract: The present invention provides novel markers of treatment response in a subject infected with Mycobacterium, which allow for quantifying treatment impact on the physiologic state of the Mycobacterium.

Abstract: The present disclosure relates to methods and compositions for reprogramming cells to a pluripotent state. In particular, it relates to an integration- and feeder cell-free method for reprogramming primary human fibroblast cells to induced pluripotent stem cells (iPSCs).