Patents Assigned to The Research Foundation of the State University of New York
  • Patent number: 10350147
    Abstract: Described herein are three-dimensional (3D) culture systems that can be used to produce enamel organoids that generate enamel products. The invention features methods of culturing a variety of cell types to produce such enamel organoids; the organoids themselves; enamel products generated by the organoids; and methods of fashioning the enamel products into surgical restorations, including dental restorations and other prostheses.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: July 16, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Stephanos Kyrkanides, Li Ma, Sabine Brouxhon
  • Patent number: 10343916
    Abstract: Provided are methods for forming graphene or functionalized graphene thin films. Also provided are graphene and functionalized graphene thin films formed by the methods. For example, electrophoretic deposition methods and stamping methods are used. Defect-free thin films can be formed. Patterned films can be formed. The methods can provide conformal coatings on non-planar substrates.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: July 9, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Sarbajit Banerjee, Vincent Lee, Luisa Whitaker
  • Patent number: 10343918
    Abstract: The method of the present disclosure is directed towards the formation of a three-dimensional carbon structure and includes the steps of adding a radical initiator to an amount of carbon starting material, forming a mixture, placing the mixture in a mold, maintaining the mixture and the mold at an elevated temperature for a period of time to form a thermally cross-linked molded mixture and removing the thermally cross-linked molded mixture from the mold. The disclosure also includes a three-dimensional carbon structure, with that structure including a thermally cross-linked carbon base material in a predetermined formation.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: July 9, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Balaji Sitharaman, Gaurav Lalwani
  • Publication number: 20190201365
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Application
    Filed: February 15, 2019
    Publication date: July 4, 2019
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Patent number: 10335045
    Abstract: Recent studies in computer vision have shown that, while practically invisible to a human observer, skin color changes due to blood flow can be captured on face videos and, surprisingly, be used to estimate the heart rate (HR). While considerable progress has been made in the last few years, still many issues remain open. In particular, state-of-the-art approaches are not robust enough to operate in natural conditions (e.g. in case of spontaneous movements, facial expressions, or illumination changes). Opposite to previous approaches that estimate the HR by processing all the skin pixels inside a fixed region of interest, we introduce a strategy to dynamically select face regions useful for robust HR estimation. The present approach, inspired by recent advances on matrix completion theory, allows us to predict the HR while simultaneously discover the best regions of the face to be used for estimation.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 2, 2019
    Assignees: Universita degli Studi Di Trento, Fondazione Bruno Kessler, The Research Foundation for the State University of New York, University of Pittsburgh of the Commonwealth of Higher Education
    Inventors: Niculae Sebe, Xavier Alameda-Pineda, Sergey Tulyakov, Elisa Ricci, Lijun Yin, Jeffrey F. Cohn
  • Patent number: 10333017
    Abstract: Thin-film photovoltaic devices and methods of their use and manufacture are disclosed. More particularly, polycrystalline CuIn(1-x)GaxSe2 (CIGS) based thin-film photovoltaic devices having independently tunable sublayers are disclosed. Also provided are methods of producing an n-doped graphene.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 25, 2019
    Assignees: Brookhaven Science Associates, LLC, The Research Foundation for the State University of New York
    Inventors: Nanditha M. Dissanayake, Matthew Eisaman, Ahsan Ashraf, Nancy Goroff, Xiuzhu Ang
  • Publication number: 20190183796
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicants: TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor Amiji, Iwao Ojima
  • Patent number: 10316294
    Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: June 11, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Steffen Mueller, Eckard Wimmer, Bruce Futcher, Steven Skiena, Chen Yang
  • Patent number: 10315155
    Abstract: Membranes are provided for filtering a gas, in some cases air. Membranes using a highly porous cellulose nano fibrous barrier layer with a highly porous (surface-charged) substrate can exhibit high flux, high retention, and low pressure drop in air filtration of toxic aromatic gases, fumes, bacteria, viruses, dusts, and particulate matters.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: June 11, 2019
    Assignee: The Research Foundation for the State University of New York
    Inventors: Benjamin Chu, Benjamin S. Hsiao, Hongyang Ma
  • Patent number: 10308856
    Abstract: A class of paste materials for thermal, and mechanical bonding, and in some cases electrical interconnection, of two solid surfaces includes particles and an organic vehicle which is partially or completely removed during processing. The paste includes hybrids of inorganic materials for meeting the thermal, electrical and mechanical bonding functionality requirements and organic materials for meeting the process, application and protection requirements. The inorganic materials include high thermal and optionally electrical conductivity materials in forms from nanoparticles to micro-powders. The organic materials may include small molecules, surfactant, oligomers, and polymers.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 4, 2019
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Hao Wang, Bahgat Sammakia
  • Publication number: 20190161514
    Abstract: The present invention provides a compound having the structure: for use in combination with an anti-tuberculosis drug for treating a subject infected with M. tuberculosis.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 30, 2019
    Applicant: The Research Foundation for the State University of New York
    Inventors: Nicole Sampson, Xinxin Yang, Tianao Yuan
  • Patent number: 10300000
    Abstract: The present invention provides a method of treating a subject afflicted with hyperpigmentation or of lightening the skin tone of a subject comprising administering to the subject an amount of a compound having the structure: or a salt or ester thereof, so as to thereby treat the subject or lighten the skin tone of the subject.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: May 28, 2019
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Shilpi Goenka, Sanford Simon
  • Patent number: 10294470
    Abstract: Systems and methods are provided for improving action potential morphology in iPSC-derived cardiac myocytes and utilizing such myocytes. Improved morphology may include, for example, physiological resting membrane potentials. Membrane voltages of the myocyte are measured and a synthetic inward rectifying current is applied to the myocyte based on the membrane voltage.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Randall Lee Rasmusson, Glenna C. L. Bett
  • Patent number: 10294290
    Abstract: The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for example, to a disease such as osteoporosis or an injury such as a bone fracture). The compositions can also be administered prophylactically. For example, they can be administered to help maintain bone health as a patient ages. More specifically, the compositions include polypeptides that constitute (or that include) a fragment of a calcitonin receptor (CR) and polypeptides that constitute (or include) biologically active variants of those fragments. Sequence-specific formulas are provided herein, and polypeptides conforming to those formulas, as well as nucleic acids encoding them, expression vectors, host cells, pharmaceutical formulations, and methods of their preparation and use are within the scope of the present invention.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventor: Srinivas Pentyala
  • Patent number: 10294567
    Abstract: Aqueous dispersions of artificially synthesized, mussel-inspired polyopamine nanoparticles were inkjet printed on flexible polyethylene terephthalate (PET) substrates. Narrow line patterns (4 ?m in width) of polydopamine resulted due to evaporatively driven transport (coffee ring effect). The printed patterns were metallized via a site-selective Cu electroless plating process at a controlled temperature (30° C.) for varied bath times. The lowest electrical resistivity value of the plated Cu lines was about 6 times greater than the bulk resistivity of Cu. This process presents an industrially viable way to fabricate Cu conductive fine patterns for flexible electronics at low temperature, and low cost.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for the State University of New York
    Inventors: Siyuan Ma, Liang Liu, Vadim Bromberg, Timothy Singler
  • Patent number: 10295548
    Abstract: Compositions and methods for accurate and sensitive quantitation of T-tau and P-tau are disclosed.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventor: Richard Rubenstein
  • Patent number: 10294478
    Abstract: The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Hua Shi, Daiying Xu, Vamsee Krishna Chatakonda
  • Patent number: 10295745
    Abstract: A photonic structure can include in one aspect one or more waveguides formed by patterning of waveguiding material adapted to propagate light energy. Such waveguiding material may include one or more of silicon (single-, poly-, or non-crystalline) and silicon nitride.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 21, 2019
    Assignee: The Research Foundation for The State University of New York
    Inventors: Douglas Coolbaugh, Thomas Adam, Gerald L. Leake
  • Publication number: 20190144808
    Abstract: The present disclosure is directed to a plate. The plate can include one or more wells, wherein each of the one or more wells comprises a bottom surface, a pit formed in the bottom surface, and a pit barrier formed around a periphery of the pit.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 16, 2019
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jian CAO, Vincent ALFORD, Yizhi MENG
  • Publication number: 20190144951
    Abstract: The present disclosure relates to compositions and methods for diagnosing, prognosing, monitoring, and treating a patient with prostate cancer. In particular, the disclosure relates to ncRNAs as diagnostic markers for determination of proper treatment administration.
    Type: Application
    Filed: June 8, 2017
    Publication date: May 16, 2019
    Applicants: miR Scientific, LLC, The Research Foundation for The State University of New York
    Inventors: Martin TENNISWOOD, Wei-Lin Winnie WANG, Gregory DIRIENZO, Tucker CONKLIN