Patents Assigned to The Research Foundation of the State University of New York
  • Performance of capacitors
    Patent number: 11664172
    Abstract: A capacitor may be configured with a dielectric laminate disposed on ordered or non-ordered structures. Materials for the dielectric laminate have high dielectric constant and reduce leakage current to increase breakdown voltage of the device. These materials may include titanium dioxide (TiO2) and silicon dioxide (SiO2). In one implementation, the capacitor may reside on a substrate. The capacitor may have structure (e.g., nano-tubes, nano-holes, etc;) disposed on the substrate having a surface area greater than the surface area of the substrate and a laminate conformally coating the structure, the laminate comprising a first layer and a second layer with materials that configure the capacitor with an energy density of at least 60 Wh/Kg.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 30, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventors: James N Turner, Tara Prasad Dhakal, Ganesh Sainadh Gudavalli, Pravakar Prasad Rajbhandari
  • MODIFIED SHORT-INTERFERING RNA COMPOSITIONS AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20230151363
    Abstract: The present disclosure provides modified short-interfering ribosomal nucleic acid compositions that have one or more uracil bases replaced a 5-fluorouracil molecule. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within an siRNA nucleotide sequence with a 5-fluorouracil increases the ability of the short interfering RNA to inhibit cancer progression and tumorigenesis when compared to known cancer therapeutics. As such, the present disclosure provides various short-interfering nucleic acid compositions having 5-fluorouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.
    Type: Application
    Filed: March 18, 2021
    Publication date: May 18, 2023
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jingfang JU, Andrew FESLER
  • Functional, segregated, charged telodendrimers and nanocarriers and methods of making and using same
    Patent number: 11649326
    Abstract: Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: May 16, 2023
    Assignee: The Research Foundation for the State University of New York
    Inventors: Juntao Luo, Xu Wang, Changying Shi
  • Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease
    Patent number: 11643394
    Abstract: The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: May 9, 2023
    Assignees: Icahn School of Medicine at Mount Sinai, The United States Government as represented by the Department of Veterans Affairs, The Research Foundation for the State University of New York
    Inventors: Sandeep Mallipattu, Bhaskar Das
  • Diagnosis of mild traumatic brain injury
    Patent number: 11642069
    Abstract: A stimulus is displayed in a visual field on a stimulus side (e.g., right or left) of a subject. An input is received from an input side of the subject. Where the input side is contralateral to the first stimulus side, a crossed reaction time is determined as a span of time between displaying the stimulus and receiving the input. Where the input side is ipsilateral to the stimulus side, an uncrossed reaction time is determined as a span of time between displaying the stimulus and receiving the input. A crossed-uncrossed difference time can be determined as a difference between the crossed reaction time and the uncrossed reaction time. The crossed reaction time, the uncrossed reaction time, and/or the crossed-uncrossed difference time can be used to determine a severity of Traumatic Brain Injury of the subject.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: May 9, 2023
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Peter John Bergold, William Winzer Lytton, Joshua Michael Skolnick
  • MUSCLE REGENERATION
    Publication number: 20230127290
    Abstract: The invention provides anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy, as well as a method for promoting muscle regeneration in a subject with a myopathy, the method comprising providing the subject with a therapeutically effective amount of an elastase inhibitor. Further provided is a pharmaceutical composition comprising anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy. Elastase inhibitors may have a protective effect on muscle progenitor cells and their regenerative potential, which aids muscle cell regeneration. By protecting regenerative potential of muscle progenitor cells, elastase inhibitors enable or enhance the gown of new or existing muscle fibres.
    Type: Application
    Filed: October 28, 2022
    Publication date: April 27, 2023
    Applicant: The Research Foundation for The State University of New York
    Inventor: Addolorata PISCONTI
  • NEUTRON ABSORBING EMBEDDED HYDRIDE SHIELD
    Publication number: 20230132031
    Abstract: A composite structure is disclosed comprising a neutron-absorbing metal hydride phase contained within a matrix having a density of greater than 95%. In various embodiments the metal hydride is a hydride of one or more of the following: Gadolinium, Hafnium, Europium, Samarium. The composite structure is utile as a shield for fusion or fission reactors.
    Type: Application
    Filed: March 23, 2021
    Publication date: April 27, 2023
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Lance Snead, Jason Trelewicz
  • HIGH RESOLUTION AND HIGH SENSITIVITY PET SCANNER WITH PRISM-PET DETECTOR MODULES
    Publication number: 20230129006
    Abstract: The disclosure relates to a device and positron emission tomography (PET) scanner for acquiring a PET image and a system for generating the PET image. The disclosure describes a device that may have one or more moveable portions. The device may comprise an upper portion and a lower portion. The upper portion and lower portion define a cavity for a patient. At least one of the upper portion or the lower potion may be movable. The upper and lower portions may comprise a cap and wings, respectively, At least one of the caps and/or wings may comprise one or more detection modules. The wings may also move with respect to a corresponding cap.
    Type: Application
    Filed: February 24, 2021
    Publication date: April 27, 2023
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Eric PETERSEN, Amir H. GOLDAN, Andrew LABELLA, Wei ZHAO, Adrian HOWANSKY
  • Photonics light signal transmission
    Patent number: 11635568
    Abstract: There is set forth herein a photonics device. The photonics device can comprise a substrate, a conductive material formation, a dielectric stack, and a barrier layer. The photonics device can transmit a light signal.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: April 25, 2023
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Douglas Coolbaugh, Gerald L. Leake, Jr.
  • Automatic Clustering for Self-Organizing Grids
    Publication number: 20230120968
    Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.
    Type: Application
    Filed: October 5, 2022
    Publication date: April 20, 2023
    Applicant: The Research Foundation for the State University of New York
    Inventors: Nael Abu-Ghazaleh, Weishuai Yang, Michael Lewis
  • System and method for dual-use computed tomography for imaging and radiation therapy
    Patent number: 11628312
    Abstract: A system and method for delivering microbeam radiation therapy (MRT) includes a computed tomography scanner (“CT”) configured to generate tomographic images of a subject, or patient, the scanner including an imaging apparatus, a gantry with an opening for positioning the patient therein, an axis of rotation around which the gantry rotates, and an x-ray source mounted to and rotatable with the gantry. The system includes a bed for patient positioning within the gantry opening and a multi-slit collimator removably mounted downstream of the x-ray source for delivering an array of microbeams of MRT to a targeted portion of the patient. Switching between MRT and CT is provided, and MRT modes of operation include a stationary mode, and continuous and step-wise rotational modes.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 18, 2023
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: F. Avraham Dilmanian, Mark Schweitzer, Jameson Baker, Renee Cattell
  • Method for inhibiting growth of bacteria
    Patent number: 11617741
    Abstract: Provided is a method for inhibiting the growth of Gram-positive bacteria, including contacting said bacteria with a first compound and a second compound, wherein the first compound is a compound of Formula I: and the second compound is an antibiotic other than a compound of Formula I. Also provided is a composition including the first compound and the second compound.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 4, 2023
    Assignees: HEALTH RESEARCH, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, DUKE UNIVERSITY
    Inventors: Ville Vare, Kathleen McDonough, Ryan Schneider, Paul Agris, Thorsten Seyler
  • Compositions and devices for removal of endotoxins and cytokines from fluids
    Patent number: 11612681
    Abstract: Provided are sorption materials and devices using the sorption materials, and methods of using the sorption materials and devices containing the sorption materials. In various examples, the sorption materials bind to various inflammation stimulating and/or mediating molecules, which are often associated with systemic infections and systemic inflammation associated with conditions such as, for example, sepsis.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 28, 2023
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Juntao Luo, Lili Wang, Changying Shi
  • Biomarker detection device
    Patent number: 11612888
    Abstract: The disclosure is directed to a device that includes an upper container configured to receive a fluid sample collected from a mammal into a first opening, the first opening opposite a second opening and a membrane covering at least a portion of the second opening, the membrane configured to allow transmission of a portion of the fluid sample through the membrane.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: March 28, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventors: Srinivas Pentyala, Sahana Pentyala
  • NITROGEN SENSOR APPARATUS FOR SIMULTANEOUSLY MEASURING NITRATE/NITRITE AND AMMONIUM IN WASTEWATER AND METHOD OF OPERATING SAME
    Publication number: 20230088167
    Abstract: A detection system and method for simultaneously determining the concentration of ammonium and nitrate/nitrite in samples such as surface water and wastewater. The detection system and method herein can further comprise a cleaning loop and a calibration loop and can be used in situ and over long periods of time without replacement or frequent maintenance and upkeep.
    Type: Application
    Filed: March 2, 2021
    Publication date: March 23, 2023
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventor: Qingzhi ZHU
  • Curcumin analogues as zinc chelators and their uses
    Patent number: 11608309
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 21, 2023
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL INC.
    Inventors: Francis Johnson, Lorne Golub
  • Robotic gripper with variable stiffness actuators and methods for same
    Patent number: 11607817
    Abstract: Safety is one of the most important factors in the robot interaction with unknown and dynamic environments. Recent studies have shown that the use of compliant components as a solution to the safety issue, especially in the physical human-robot interaction. To overcome performance degradation caused by including compliant elements into the systems, variable stiffness approaches have been introduced at the cost of an extra actuator. A variable stiffness gripper is presented. Embodiments of the disclosed gripper may have, for example, with two parallel fingers (jaws). Compliance of the system may be generated by using magnets as the nonlinear springs. Based on the presented design, the position and stiffness level of the fingers can be adjusted simultaneously by changing the air gap between the magnets.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: March 21, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventor: Ehsan T. Esfahani
  • COMBINATION TAXOID NANOEMULSION WITH IMMUNOTHERAPY IN CANCER
    Publication number: 20230082272
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 16, 2023
    Applicants: TargaGenix, Inc., The Research Foundation for the State University of New York, Northeastern University
    Inventors: James E. EGAN, Mansoor M. AMIJI, Iwao OJIMA
  • Nanostructured fibrous membranes for membrane distillation
    Patent number: 11596886
    Abstract: Membranes suitable for use in membrane distillation are provided. Such membranes may include nano-fibrous layers with adjustable pore sizes. The membranes may include a hydrophobic nanofibrous scaffold and a thin hydrophilic protecting layer that can significantly reduce fouling and scaling problems.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: March 7, 2023
    Assignee: The Research Foundation for the State University of New York
    Inventors: Benjamin Chu, Benjamin S. Hsiao
  • Piezoelectric energy harvesting using a nonlinear buckled beam and method for same
    Patent number: 11601073
    Abstract: An energy harvester includes a frame having a base, a first side member affixed to the base, and a second side member affixed to the base and spaced apart from the first side member. A beam is coupled between the first side member of the frame and the second side member of the frame. The beam has a substrate layer with a first end affixed to the first side member of the frame, a second end affixed to the second side member of the frame, a first face, and a second face opposite to the first face. The substrate is elastically deformable in response to the vibratory force. The beam further includes a first piezoelectric layer joined to the first face of the substrate layer and having a terminal for electrical connection to a load, the first piezoelectric layer comprising at least one piezoelectric patch.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: March 7, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventors: Mohammad Amin Karami, Mohammad Hossein Ansari