Patents Assigned to The Research Foundation of the State University of New York
  • Publication number: 20180303958
    Abstract: The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IX? reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 25, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Wadie F. BAHOU, Song WU
  • Patent number: 10106794
    Abstract: The disclosure relates to synthetic oligonucleotides that are unique in that they are RNA molecules that have the capacity to form a hydrogel. Also disclosed are DNA oligonucleotides that encode the RNA oligos so that the oligos can be prepared using in vitro transcription. The disclosure further pertains to pharmaceutical compositions comprising these hydrogels.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: October 23, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Li Niu, Zhen Huang
  • Publication number: 20180296656
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 18, 2018
    Applicants: BROOKHAVEN SCIENCE ASSOCIATE, LLC, RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
    Inventors: Brian A. Crowe, Ian Livey, Maria O'rourke, Michael Schwendinger, John J Dunn, Benjamin J Luft
  • Publication number: 20180296454
    Abstract: Compositions comprising serine and an organic mono- or multi-phosphate salt and methods of using such compositions to treat and/or prevent periodontal disease and/or dental calculus are provided.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Israel Kleinberg, Robi Chatterjee
  • Patent number: 10101219
    Abstract: A system, a method of use, and a Carbon Nanotube (CNT) condensation sensor for determining a dew point and/or ice point is provided. For example, a sensing system may include a thermal device configured to generate heating or cooling to change a temperature of a surface, a temperature sensor for measuring the temperature of the surface, a controller configured to control the thermal device, a carbon nanotube (CNT) condensation sensor mounted on the surface having a moisture sensitive resistance and a processor configured to determine one or more parameters based on the moisture sensitive resistance of the CNT condensation sensor and the temperature measured by the temperature sensor. The one or more parameter can be used to determine the dew point and/or ice point. A method for forming a carbon nanotube (CNT) condensation sensor is also provided.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 16, 2018
    Assignees: The Research Foundation for The State University of New York, Cosa Xentaur
    Inventors: Vladimir Samuilov, John Lewis Ayres
  • Patent number: 10086074
    Abstract: Provided are compositions comprising porphyrin-phospholipid nanovesicles (PoP-NVs) which can be loaded with cargo. Methods for release of cargo from the PoP-NVs triggered by near infrared (NIR) light are also disclosed.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: October 2, 2018
    Assignees: The Research Foundation for The State University of New York, Health Research, Inc.
    Inventors: Jonathan Lovell, Ravindra Pandey, Kevin Carter, Shuai Shao
  • Publication number: 20180273573
    Abstract: Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant Staphylococcus aureus).
    Type: Application
    Filed: October 3, 2016
    Publication date: September 27, 2018
    Applicants: Memorial Sloan-Kettering Cancer Center, The Research Foundation for The State University of New York
    Inventors: Derek Shieh Tan, Christopher E. Evans, Indrajeet Sharma, Peter J. Tonge, Joe S. Matarlo
  • Patent number: 10076481
    Abstract: Compositions comprising serine and an organic mono- or multi-phosphate salt and methods of using such compositions to treat and/or prevent periodontal disease and/or dental calculus are provided.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: September 18, 2018
    Assignee: The Research Foundation for the State University of New York
    Inventors: Israel Kleinberg, Robi Chatterjee
  • Patent number: 10079003
    Abstract: Methods and systems of displaying an image of an object are described. The displayed image is comprised of at least two parts that are displayed so as to present a unified image of the object. One part of the image is derived using a first temporal filter and the other part of the image is derived using a second temporal filter.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: September 18, 2018
    Assignee: The Research Foundation for the State University of New York
    Inventors: Stephen Rudin, Daniel R. Bednarek
  • Publication number: 20180261843
    Abstract: Bimetallic polyanionic materials, such as silver vanadium phosphorus oxide (Ag2VO2PO4, SVOP), are promising cathode materials for Li batteries due in part to their large capacity and high current capability. A new synthesis of Ag2VO2PO4 based on microwave heating is disclosed, where the reaction time is reduced by approximately 100 times relative to other reported methods, and the crystallite size is controlled via synthesis temperature, showing a linear positive correlation of crystallite size with temperature. Reaction times of an hour or less are sufficient to render phase-pure material after reaction at 50° C. to 180° C., significantly lower than the temperatures reported for other methods. Crystallite sizes between 42 nm and 60 nm are achieved by the novel method, smaller than by other methods. Silver/vanadium atomic ratios of 1.96 to 2.04 in the as-synthesized SVOP result and appear temperature-dependent.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Kenneth J. TAKEUCHI, Esther S. TAKEUCHI, Amy C. MARSCHILOK
  • Patent number: 10071965
    Abstract: The present invention provides novel 2-pyridone compounds and 4-pyridone compounds and methods of treating a subject infected with a pathogen of Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis, Burkholderia pseudomallei, Yersinia pestis, Escherichia coli and Proteus mirabilisone.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 11, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Peter Tonge, Pan Pan
  • Patent number: 10072060
    Abstract: Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. Methods and compositions for treating amyloid-based disease in a subject in need thereof, by administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof are also disclosed.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: September 11, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Daniel Raleigh, Hui Wang, Ping Cao, Andisheh Abedini
  • Patent number: 10071031
    Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 11, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Marvin Cohen, Susanne Cohen, Robert G. Flynn
  • Patent number: 10071990
    Abstract: A technique is provided to visualize microtubules in live cells that does not require genetic manipulation or microinjection. Moreover, this method also avoids perturbation of the endogenous microtubule network that occurs with taxol treatment. This technique exploits tyrosination and detyrosination of tubulin, a posttranslational modification cycle specific to the C-terminus of ?-tubulin. Specifically, cells are grown in medium supplemented with a tyrosine derivative possessing a reactive functional group. The cellular enzyme tubulin tyrosine ligase attaches the unnatural amino acid to a single site on tubulin. Addition of fresh medium containing a suitably derivatized fluorophore then yields fluorescent tubulin, which incorporate into cellular microtubules. Importantly, the tubulin labeling approach demonstrated here does not detrimentally affect microtubule network or cell morphology. Thus we present a simple, robust labeling technique that allows microscopic analysis of microtubules in live cells.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 11, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Susan Bane Tuttle, Kamalika Mukherjee
  • Patent number: 10071143
    Abstract: Provided is a non-surgical method of treatment of carpal tunnel syndrome by administering an effective amount of purified collagenase I and II by injection onto a transverse carpal ligament, without penetrating the transverse carpal ligament. The purified collagenase I and II are obtained from Clostridium histolyticum, and the effective amount is a dose comprising a concentration of approximately 0.29 mg of the purified collagenase I and II to one ml diluent.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: September 11, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Marie A. Badalamente, Edward Wang
  • Publication number: 20180250422
    Abstract: The present disclosure is directed to adeno -associated viral vector monoclonal antibody constructs and compositions thereof, methods of improving locomotor function after spinal cord injury, methods of treating neurodegenerative diseases.
    Type: Application
    Filed: May 15, 2018
    Publication date: September 6, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Victor L. Arvanian, Joel M. Levine
  • Patent number: 10064842
    Abstract: The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP2, as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: September 4, 2018
    Assignees: WASHINGTON UNIVERSITY, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Jianmin Cui, Ira S. Cohen, Xiaoqin Zou
  • Patent number: 10064922
    Abstract: Methods and compositions to reduce immunogenicity of proteins are disclosed. Compositions comprising therapeutic proteins (such as Factor VIII or any other protein or peptide) complexed with liposomes comprising PS and PC (PS liposomes), or comprising PS, PI and PC and, optionally, cholesterol (PS/PI liposomes) may be used.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: September 4, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventor: Sathy V. Balu-Iyer
  • Patent number: 10064554
    Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 4, 2018
    Assignees: The Trustees of the University of Pennsylvania, The Research Foundation of State University of New York
    Inventors: Thomas F. Floyd, Arjun G Yodh, Rickson C. Mesquita
  • Publication number: 20180245285
    Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes.
    Type: Application
    Filed: March 21, 2018
    Publication date: August 30, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Thomas E. Amidon, Raymond Francis, Gary M. Scott, Jeremy Bartholomew, Bandaru V. Ramarao, Christopher D. Wood