Patents Assigned to The Research Foundation of the State University of New York
  • Patent number: 10155115
    Abstract: A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 18, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Mark Stewart, Isaac Naggar, Jason Lazar
  • Patent number: 10153201
    Abstract: A transistor device includes a substrate; a source region and a drain region formed over the substrate; and a source/drain contact formed in contact with at least one of the source region and the drain region, the source/drain contact including a conductive metal and a bilayer disposed between the conductive metal and the at least one of the source and drain region, the bilayer including a metal oxide layer in contact with the conductive metal, and a silicon dioxide layer in contact with the at least one of the source and drain region.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: December 11, 2018
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, GLOBALFOUNDRIES INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK SUNY POLYTECHNIC INSTITUTE
    Inventors: Huiming Bu, Hui-feng Li, Vijay Narayanan, Hiroaki Niimi, Tenko Yamashita
  • Publication number: 20180348998
    Abstract: The system, method, and computer readable medium described herein provide improvements in the ways that user interfaces present multi-dimensional relationships between data samples to a user. The disclosed user interface framework provides users with a visualization of the complex relationships between data samples having multi-dimensional attributes which allows the users to quickly and intuitively grasp the relationships between data samples for a large number of attributes at a glance and in a single data map visualization.
    Type: Application
    Filed: June 4, 2018
    Publication date: December 6, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Klaus Mueller, Shenghui Cheng
  • Publication number: 20180340049
    Abstract: The present disclosure is directed to films. The films can include polyamic acid (PAA). Methods of making and using the film for food product coverings is also included.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Omowunmi A. Sadik, Idris Yazgan
  • Publication number: 20180340935
    Abstract: The instant application relates to methods for determining pancreatic cancer patient outcome and directing treatment to subjects with pancreatic cancer. The present disclosure further provides methods for measuring expression levels of cytokeratin 17 in a subject having pancreatic cancer, such as pancreatic ductal adenocarcinoma, in order to determine the subject's survival rate and clinical outcome.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 29, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Kenneth R. SHROYER, Luisa F. ESCOBAR-HOYOS
  • Publication number: 20180333580
    Abstract: Sensory information can be delivered to a subject mammal, for example, for restoring a sense of cutaneous touch and limb motion to the subject mammal. A biomimetic electrical signal is generated based on (a) a stimulation reference signal applied to a somatosensory region of a nervous system of a reference mammal, (b) a stimulated-response signal acquired from a sensory cortex of the reference mammal in response to application of the stimulation reference signal to the thalamic nucleus, and (c) a natural-response signal acquired from the sensory cortex in response to peripheral touch stimuli and/or peripheral nerve stimulation of the reference mammal. The biomimetic electrical signal is applied to a somatosensory region of a nervous system of the subject mammal to induce an activation response, in a sensory cortex of the subject mammal.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 22, 2018
    Applicant: The Research Foundation for the State University of New York
    Inventors: John S. CHOI, Joseph T. FRANCIS
  • Publication number: 20180336117
    Abstract: Systems and methods for utilizing cooperation facilitators to achieve joint message and network state cooperation in accordance with various embodiments of the invention are disclosed. One embodiment of the invention includes: a plurality of transmitters; a receiver that has access to at least partial network state information and that includes a decoder configured to decode signals received via a multiple terminal channel from the plurality of transmitters using the at least partial network state information; and a cooperation facilitator. In addition, at least some of the plurality of transmitters are configured to transmit message information to the cooperation facilitator and the cooperation facilitator is configured to generate cooperation parameters based upon the message information and the manner in which state information is utilized by the receiver to decode signals received via the multiple terminal channel.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 22, 2018
    Applicants: California Institute of Technology, The Research Foundation for the State University of New York
    Inventors: Parham Noorzad, Michelle Effros, Michael Langberg
  • Publication number: 20180333151
    Abstract: The present disclosure is directed to a surgical device and method of using the same. The surgical device includes a proximal ring, a distal ring, wherein the distal ring is operably connected to the proximal ring with a sleeve, the sleeve extending about a circumference of the proximal ring and a circumference of the distal ring, a film, a distal end of the film attached to a portion of the distal ring, wherein the film is configured to extend past the sleeve and past the distal ring, and wherein a proximal portion of the film comprises an opening and a channel and a draw string extending through the channel and exposed to an exterior of the device through the opening.
    Type: Application
    Filed: December 2, 2016
    Publication date: November 22, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Hsingli Kai HSI, Mark TALAMINI
  • Patent number: 10133852
    Abstract: Disclosed is a method and system for prediction of an optimized crystal structure using an evolutionary algorithm that includes inputting characterization information of a chemical structure and input parameters, generating a first generation of crystal structures from the characterization information using symmetrical initialization, optimizing the chemical structure of the first generation of crystal structures according to the input parameters, inputting the optimized first generation of crystal structures into a niching algorithm, producing a child group of crystal structures from the parent group of crystal structures using a variation operator, and adding the child group of crystal structures to an optimal group of crystal structures to form a next generation, with the niching algorithm selecting an optimal group of crystal structures and a parent group of crystal structures from the first generation of crystal structures, with an antiseed created for population diversity and every structure produced by
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: November 20, 2018
    Assignee: The Research Foundation of The State University of New York
    Inventors: Andriy O. Lyakhov, Artem R. Oganov, Qiang Zhu
  • Patent number: 10130723
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 20, 2018
    Assignees: The Regents of the University of California, The Research Foundation for the State University of New York
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • Patent number: 10130535
    Abstract: A four bar apparatus and method are provided for lifting, lowering, providing exercise and facilitating self-propelled transit. The apparatus includes an actuator and interconnected four-bar lifting mechanism, which includes a crank, a coupler, a rocker, and a frame. Each of the crank, coupler, rocker and frame are rotatably interconnected, and operation of the actuator moves a lift point of the coupler, with the lift point connectable to a vest-type garment or belt worn by a user of the apparatus, with the lift point following a J shape path or an S shape path to lift the user from a shoulder or hip area, respectively.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: November 20, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Anurag Purwar, Bipin Birari
  • Publication number: 20180326171
    Abstract: A system and method for relief of negative lung pressure during acute laryngospasm or upper airway obstruction, providing a non-toxic gas cartridge capable of supplying between 0.5-5 liters of gas during a procedure, a valve adapted to commence and stop gas release, and a trans-cricothyroid cartilage inflation needle for acutely relieving the negative pressure in the chest. The needle may also be used to insert a guidewire to assist in endotracheal tube insertion.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 15, 2018
    Applicant: The Research Foundation for the State University of New York
    Inventors: Mark Stewart, Richard Kollmar, Krishnamurthi Sundaram, Joshua Silverman, Ko Nakase, Hamid Arjomandi
  • Patent number: 10123959
    Abstract: The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: November 13, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Marie A. Badalamente, Alexander B. Dagum
  • Patent number: 10124194
    Abstract: A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: November 13, 2018
    Assignees: The Research Foundation for State University of New York, The Board of Regents, The University of Texas System
    Inventors: F. Avraham Dilmanian, Sunil Krishnan, John Gordon Eley
  • Publication number: 20180319860
    Abstract: Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. Methods and compositions for treating amyloid-based disease in a subject in need thereof, by administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof are also disclosed.
    Type: Application
    Filed: July 11, 2018
    Publication date: November 8, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Daniel RALEIGH, Hui WANG, Ping CAO, Andisheh ABEDINI
  • Patent number: 10117990
    Abstract: A microfluidic intravital window includes an intravital imaging window adapted for implantation adjacent target tissue of a live animal, and a microfluidic fluid source and delivery system physically integrated into the window for controlled delivery of fluids to target tissue via the window. The microfluidic fluid source and delivery system is self-contained and completely located within the intravital imaging window, and includes at least one preloaded fluid reservoir, at least one fluid port in fluidic communication with both the at least one preloaded fluid reservoir and the target tissue, and at least one light activated fluid flow control device situated between the at least one preloaded fluid reservoir and at least one fluid port, to facilitate simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: November 6, 2018
    Assignees: The Research Foundation for the State University of New York, Albert Einstein College of Medicine, Inc.
    Inventors: James Castracane, Logan Butt, David Entenberg, Lauren Sfakis, John Condeelis
  • Patent number: 10118890
    Abstract: The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl)—NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 6, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Ming-Yu Ngai, Katarzyna N. Hojczyk
  • Patent number: 10112023
    Abstract: A device, system, and method for isolating a ventilator from one or more patients in which the delivery conditions of gas delivered to an isolation device from a ventilator may drive the delivery of breathing-gas delivered to one or more patients, the breathing-gas having the same or different delivery conditions. In one embodiment, an isolation device may have a housing and a movable partition. The movable partition may be joined to the housing, The movable partition may have a patient side on a first side of the partition and an actuating side on a second side of the partition. The isolation device may include an inlet pressure regulator on the actuating side and/or an exhaust pressure regulator on the patient side. These regulators may alter the delivery conditions (including, but not limited to, pressure and volume) of breathing-gas delivered to a patient.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: October 30, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Bradley P. Fuhrman, Mark S. Dowhy
  • Patent number: 10112150
    Abstract: Membranes of the present disclosure possess very thin barrier layers, with high selectivity, high throughput, low fouling, and are long lasting. The membranes include graphene and/or graphene oxide barrier layers on a nanofibrous supporting scaffold. Methods for forming these membranes, as well as uses thereof, are also provided. In embodiments, an article of the present disclosure includes a nanofibrous scaffold; at least a first layer of nanoporous graphene, nanoporous graphene oxide, or combinations thereof on at least a portion of a surface of the nanofibrous scaffold; an additive such as crosslinking agents and/or particles on an outer surface of the at least first layer of nanoporous graphene, nanoporous graphene oxide, or combinations thereof.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: October 30, 2018
    Assignee: The Research Foundation for the State University of New York
    Inventors: Benjamin Chu, Benjamin S. Hsiao, Hongyang Ma, Zhe Wang
  • Patent number: 10114129
    Abstract: A detector for detecting a single x-ray photon with high temporal resolution and high efficiency includes a semiconductor substrate, the semiconductor substrate including element(s) from each of Groups III and V of the Periodic Table of Elements, and pixels on the substrate. Each pixel includes a semiconductor transistor including an epitaxial layer having element(s) from each of Groups III and V of the Periodic Table of Elements, an anode electrically connected to a gate of the semiconductor transistor, and a cathode electrically connected to a drain of the semiconductor transistor. Photon(s) are caused to impinge the single-photon detector along a y-direction (long side of pixel) to provide adequate stopping power, and electron-hole pairs generated by the photon(s) are collected along an x-direction or z-direction (short sides of pixel) to provide short transit time. Detectors form an array of pixels for x-ray imaging with temporal resolution of single photons.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: October 30, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Michael Yakimov, Serge Oktyabrsky