Patents Assigned to The Royal Institution of the Advancement of Learning/McGill University
  • Patent number: 10584159
    Abstract: Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 10, 2020
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Université de Montréal
    Inventors: Stéphane Alain Laporte, Yoon Namkung, Michel Bouvier, Christian Le Gouill, Mireille Hogue, Viktoriya Lukasheva, Hiroyuki Kobayashi, Denis Deblois, Étienne Durette
  • Patent number: 10576447
    Abstract: InGaN offers a route to high efficiency overall water splitting under one-step photo-excitation. Further, the chemical stability of metal-nitrides supports their use as an alternative photocatalyst. However, the efficiency of overall water splitting using InGaN and other visible light responsive photocatalysts has remained extremely low despite prior art work addressing optical absorption through band gap engineering. Within this prior art the detrimental effects of unbalanced charge carrier extraction/collection on the efficiency of the four electron-hole water splitting reaction have remained largely unaddressed. To address this growth processes are presented that allow for controlled adjustment and establishment of the appropriate Fermi level and/or band bending in order to allow the photochemical water splitting to proceed at high rate and high efficiency. Beneficially, establishing such material surface charge properties also reduces photo-corrosion and instability under harsh photocatalysis conditions.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 3, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Zetian Mi, Md Golam Kibria, Mohammad Faqrul Alam Chowdhury
  • Patent number: 10577349
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 3, 2020
    Assignees: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Ze'ev Ronai, Anthony B. Pinkerton, Yongmei Feng, Ivan Topisirovic, Kevin Brown, Christian A. Hassig
  • Patent number: 10569225
    Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 25, 2020
    Assignees: National Research Council of Canada, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Kebin Li, Teodor Veres, Tohid Fatanat Didar, Maryam Tabrizian
  • Patent number: 10567010
    Abstract: Methods and systems for encoding data are described herein. The method comprises inputting data to a first pipeline of a non-systematic polar encoder capable of encoding a polar code of length nmax, extracting, via at least one first multiplexer of size log nmax×1, a first polar code of length n<nmax at a first location along the first pipeline to generate a first encoded output, modifying the first encoded output to set frozen bits to a known value to obtain a modified first encoded output, inputting the modified first encoded output to a second pipeline of the non-systematic polar encoder, and extracting, via at least one second multiplexer of size log nmax×1, a second polar code of length n<nmax at a second location along the second pipeline to generate a second encoded output, the second encoded output corresponding to a systematically encoded polar code of length n.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: February 18, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Warren Gross, Gabi Sarkis, Pascal Giard
  • Patent number: 10553751
    Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organising InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: February 4, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Zetian Mi, Songrui Zhao, Renjie Wang
  • Patent number: 10544131
    Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: January 28, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Patrick Harran, James H. Frederich, Gordon Shore, Mai Nguyen
  • Patent number: 10527908
    Abstract: There is described a method of tuning an output optical pulse. The method generally has: generating a seed optical pulse, the seed optical pulse having a tunable parameter; propagating the seed optical pulse into and along one of a plurality of optical fibers each having a hollow core extending along a given length, the optical fibers having a parameter being different from one another; pumping a gas inside the hollow core of the one of the optical fibers, said pumping having a tunable parameter; the propagation of the seed optical pulse into and along the one of the optical fibers modifying the seed optical pulse into the output optical pulse; and tuning the output optical pulse by modifying the tunable parameter of the seed optical pulse, modifying the one of the optical fibers along which the seed optical pulse is propagated and modifying the tunable parameter of said pumping.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 7, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventor: Patanjali Kambhampati
  • Patent number: 10507263
    Abstract: Borate-glass biomaterials comprising: aNa2O. bCaO. cP2O5. dB2O3 wherein a is from about 1-40 wt %, b is from about 10-40 wt %, c is from about 1-40 wt %, and d is from about 35-80 wt %; and wherein the biomaterial has a surface area per mass of more than about 5 m2/g. Methods of making and uses of these biomaterials.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: December 17, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Showan Nazhat, William Cole Lepry
  • Patent number: 10501414
    Abstract: This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods for treating certain conditions.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: December 10, 2019
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, FLORIDA INSTITUTE OF TECHNOLOGY
    Inventors: William S. Powell, Joshua Rokach
  • Patent number: 10499822
    Abstract: Small implantable silicon-based devices offer an ability to revolutionize the management of trauma victims. For example, implantable pressure sensors allow the devastating outcomes of compartment syndrome to be minimized through continuous or periodic monitoring whilst being compatible with the ongoing drives to increase out-patient care and reduced hospitalization time. Further, small implantable silicon-based sensor microsystems according to embodiments of the invention whilst being capable of measuring pressures under diverse conditions are easily used by nurses in hospital settings as well as also being easily deployed by paramedical personnel in cases of accidents, natural disasters, war, etc. Beneficially, the implantable sensor microsystem will not interfere with movement of the patient during stabilization, surgery, intensive care stay, outpatient management, etc.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: December 10, 2019
    Assignee: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Edward Harvey, Vamsy Chodavarapu, Charles Allan
  • Patent number: 10495568
    Abstract: An apparatus for analysing a sample of granular material, such as soil, is described. An elongated housing has a channel extending therethrough to define an optical path. A cavity is defined within the top of the housing to receive the sample, and a transparent sample-receiving surface is disposed within the cavity at a first elevation from the bottom of the housing. A lens assembly is positioned within the optical path at a second, lower, elevation. The lens assembly magnifies an image formed by light beams reflected by or transmitted through the sample. An image capturing device is disposed across the optical path at a third elevation that is lower than the second elevation. The image capturing device is thus lower than both the lens assembly and the transparent sample-receiving surface. A light source is mounted within the housing to emit light toward the sample-receiving surface.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 3, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Viacheslav Adamchuk, Asim Biswas, Long Qi, Maxime Leclerc, Bharath Sudarsan, Wenjun Ji
  • Patent number: 10469235
    Abstract: Internet routers are a key component in today's Internet. Each router forwards received packets toward their final destinations based upon a Longest Prefix Matching (LPM) algorithm select an entry from a routing table that determines the closest location to the final packet destination among several candidates. Prior art solutions to LPM lookup offer different tradeoffs and that it would be beneficial for a design methodology that provides for low power large scale IP lookup engines addressing the limitations within the prior art. According to embodiments of the invention a low-power large-scale IP lookup engine may be implemented exploiting clustered neural networks (CNNs). In addition to reduced power consumption embodiments of the invention provide reduced transistor count providing for reduced semiconductor die footprints and hence reduced die cost.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: November 5, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Warren Gross, Naoya Onizawa
  • Patent number: 10420757
    Abstract: The current disclosure relates to methods for treating pancreatic cancer or chronic pancreatitis in a subject comprising administering an antagonist of a dopamine receptor to the subject wherein the dopamine receptor is, in some specific cases dopamine receptor D2 (DRD2). The antagonist in some specific cases is an RNAi construct, an antibody, or a small molecule and in more specific cases pimozide or L-741,626. The disclosure also relates to diagnostic methods comprising the detection of the expression of DRD2 in pancreatic tissue and kits for doing the same.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: September 24, 2019
    Assignees: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Pouria Jandaghi, Jörg Hoheisel, Yasser Riazalhosseini
  • Patent number: 10407556
    Abstract: Many different substrates are used in tissue engineering as platforms to enhance cell attachment, proliferation and activity, either in-vitro, to multiply specific cell lines, or in-vivo, to induce shorter healing time of injured or missing tissue. However, their hydrophobicity and lack of specific functionalities make them non-ideal for cell adhesion and growth. Treating the surfaces by exposing them to a series of steps including, but not limited to, a diazonium based wet chemistry allows one or more functional groups to be applied to the surface improving cell adhesion and growth. Embodiments of the invention exploiting PDLLA, PMMA and roughed PEEK are demonstrated including both a one-stage and a two-stage process, and at times a vacuum treatment, allowing modification of inner and outer surfaces.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: September 10, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Marta Cerruti, Hesameddin Mahjoubi
  • Patent number: 10394978
    Abstract: Herein provided are methods and systems for generating finite element modelling results. Finite element method (FEM) data relating to establish a FEM problem to be solved for a portion of a physical system being analyzed is received. A FEM mesh comprising at least FEM mesh node locations relating to the portion of the physical system is generated. FEM mesh values for each FEM mesh node location are automatically generated with a microprocessor. A factor graph model comprising a plurality of random variable nodes and a plurality of factor nodes is automatically generated with a microprocessor based upon the FEM mesh node locations. A set of belief propagation update rules are automatically executed upon the factor graph model using Gaussian function parametrization and the FEM mesh values. The belief propagation update rules are iteratively executed until a predetermined condition has been met.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: August 27, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Dennis Giannacopoulos, Yousef El Kurdi, Warren Gross
  • Patent number: 10390162
    Abstract: The method can include depositing a graphene oxide containing material from solution to form a laminar nano-structure of graphene oxide paper, and assembling at least a portion of the graphene oxide paper as a diaphragm of the acoustic transducer. The acoustic transducer can be a magnetic induction based microphone, a diaphragm loudspeaker, or a magnetic induction based loudspeaker, for instance.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: August 20, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Peter Gaskell, Robert-Eric Gaskell, Thomas Szkopek, Jung Wook Hong
  • Patent number: 10377715
    Abstract: The invention relates to 18-20 member bi-polycyclic compounds, methods of making these compounds, and methods of using them in treating hyperproliferative disorders (e.g., cancer) and non-malignant tumors; promoting muscle formation; inhibiting muscle degeneration or the loss of muscle mass or muscle function; and myofibers ex vivo.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: August 13, 2019
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/ McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Patent number: 10376611
    Abstract: A synthetic bone graft is described which is adapted to be received within a bone defect and which is structurally load-bearing. The bone graft comprises an entirely synthetic graft body corresponding in shape and size to the bone defect. The graft body is composed of a plurality of superimposed multilayered structures, each of the multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween. The biomineral layer has a stiffness that is greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is less than that of the biomineral layer.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: August 13, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Francois Barthelat, Michael Tanzer, Sacha Cavelier
  • Patent number: D863367
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: October 15, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Viacheslav Adamchuk, Antoine Pouliot, Trevor Stanhope