Abstract: The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y??(I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and ? is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

Abstract: The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

Abstract: The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.

Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

Abstract: The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.

Abstract: A portable self medication management system and method of provided. For example, the system may include a removable tote and docking station. The removable tote including a plurality of receptacles, communicating section for transferring data to and from a docking station and a power reception station for receiving power from the docking station. The docking station including a scanner, a display screen, a controller, a storage device, communicating sections for transmitting data to the removable tote and other external devices and a power transmitting section for transferring power to the removable tote.

Abstract: This disclosure provides a novel role for microRNA (miR) regulation of lipid metabolism via the MTP pathway, leading to reductions in apoB secretion and blood lipid levels. MiR regulation of the MTP pathway is shown herein to reduce hyperlipidemia and atherosclerosis in vivo. Therefore, inhibition of MTP expression and activity by miR regulation is identified as a new therapeutic target for treatment of cardiovascular disease and conditions or diseases associated with cardiovascular disease such as hyperlipidemia, atherosclerosis, and metabolic syndrome. Treatment of cardiovascular disease and associated conditions or diseases with the novel MTP inhibitors of the invention, such as miR-30c homologs or miR-30c agonists, reduces MTP-associated lipid production without side effects that occur with other methods of MTP inhibition.

Abstract: A deodorant composition comprising arginine, bicarbonate, zinc and carbonate, preferably arginine bicarbonate and zinc carbonate (ABZC), and one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras—generally to reduce axillary odor, promote the growth of Staphylococcus epidermidis bacteria, inhibit the growth of Corynebacterium striatum bacteria, or any or all of the preceding.

Abstract: The disclosure provides a method of oil delivery to a chainsaw chain blade using a gerotor pump in sequence with flow control valves to provide lubrication to the chain blade to reduce friction with the chainsaw bar guide and prevent overheating and damage to the chain blade or guide bar.

Abstract: A field shaping multi-well avalanche detector and method for fabrication thereof are disclosed. The field shaping multi-well avalanche detector provides stable avalanche multiplication gain in direct conversion amorphous selenium radiation detectors. The detector provides stable avalanche multiplication gain by eliminating field hot-spots using high-density avalanche wells with insulated wells and field-shaping within each well.

Abstract: A micromechanical structure, comprising a substrate having a through hole; a residual portion of a sacrificial oxide layer peripheral to the hole; and a polysilicon layer overlying the hole, patterned to have a planar portion; a supporting portion connecting the planar portion to polysilicon on the residual portion; polysilicon stiffeners formed extending beneath the planar portion overlying the hole; and polysilicon ribs surrounding the supporting portion, attached near a periphery of the planar portion. The polysilicon ribs extend to a depth beyond the stiffeners, and extend laterally beyond an edge of the planar portion. The polysilicon ribs are released from the substrate during manufacturing after the planar region, and reduce stress on the supporting portion.

Abstract: A checkpointing method for creating a file representing a restorable state of a virtual machine in a computing system, comprising identifying processes executing within the virtual machine that may store confidential data, and marking memory pages and files that potentially contain data stored by the identified processes; or providing an application programming interface for marking memory regions and files within the virtual machine that contain confidential data stored by processes; and creating a checkpoint file, by capturing memory pages and files representing a current state of the computing system, which excludes information from all of the marked memory pages and files.

Abstract: Methods for distributed storage in accordance with embodiments of the invention enable secret sharing. One embodiment includes encoding source data using an encoding system to produce a plurality of sets of encoded data, where: the source data can be recovered from at least a portion of less than all of the plurality of sets of encoded data; and the source data cannot be recovered using less than a threshold number of the plurality of sets of encoded data; storing each of the plurality of sets of encoded data on a storage device from a set of storage devices on which encoded data is stored; determining a set of storage devices that are available using a decoding system, where the set of storage devices that are available does not include all of the storage devices in the set of storage devices on which encoded data is stored.

Abstract: The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

Abstract: An airfoil blade assembly including a blade which includes a lift generating section with a first profiled body defined between a pressure surface and a suction surface. The first profiled body extends from a first leading edge to a first trailing edge with a first chord extending form the first leading edge to the first trailing edge and being perpendicular to the radial direction. At least one flow deflector extends along either the pressure surface or the suction surface within the lift generating section of the blade. The at least one flow deflector defines a second profiled body extending between a second leading edge and a second trailing edge with a second chord extending between the second leading edge and the second trailing edge. The second profiled body defines an outer surface facing away from respective pressure surface or suction surface along which the flow deflector extends.

Abstract: A new and distinct cultivar of strawberry plant (Fragaria×ananassa), was developed from seed produced by a hand pollinated cross between ‘NJ01-73-3’ and ‘NJ03-232-2’. The new strawberry plant named ‘NJ08-08-6’ is distinguished by its highly vigorous, upright growth habit, high productivity, uniform fruit color and shape, and excellent fruit quality and flavor.

Abstract: A new and distinct cultivar of strawberry plant (Fragaria×ananassa), was developed from seed produced by a hand pollinated cross between ‘NJ96-12-1’ and ‘Camarosa’ (U.S. Plant Pat. No. 8,708). The new strawberry named ‘NJ99-204-1’ is distinguished by its ability to produce large, smooth, long wedge and conical shaped fruit, with attractive red color and excellent flavor. ‘NJ99-204-1’ plants have vigorous growth and an upright form.

Abstract: A new cranberry variety distinguished by mid-season ripening, round to ovate fruit, high productivity, and moderate fruit anthocyanin development, as compared to the currently cultivated commercial varieties.

Abstract: A new cranberry variety distinguished by early mid-season ripening period, precocious cropping, high productivity, and moderate-to-high fruit anthocyanin development, as compared to the currently cultivated commercial varieties.