Abstract: The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y (I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
Type:
Grant
Filed:
June 20, 2012
Date of Patent:
August 16, 2016
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Richard H. Ebright, David Degen, Yu Zhang, Yon Ebright
Abstract: The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP2, as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.
Type:
Application
Filed:
April 25, 2016
Publication date:
August 11, 2016
Applicants:
Washington University, The Research Foundation for The State University of New York, Curators of the University of Missouri
Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
Type:
Grant
Filed:
January 15, 2015
Date of Patent:
August 9, 2016
Assignee:
The Research Foundation for The State University of New York
Inventors:
Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
Abstract: The present invention relates to a novel use of naturally occurring plants, mushroom, extracts thereof that exhibit properties as HCV NS5B polymerase inhibitors.
Type:
Application
Filed:
April 1, 2016
Publication date:
July 28, 2016
Applicant:
Rutgers, The State University
Inventors:
James E. Simon, Qingli Wu, Neerja Kaushik-Basu
Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
November 24, 2015
Publication date:
July 28, 2016
Applicants:
The Research Foundation for The State University of New York, Chem-Master International, Inc.
Inventors:
Lorne M. GOLUB, Francis JOHNSON, Galina I. BOTCHKINA, Iwao OJIMA
Abstract: Provided is a method for obtaining a conformal mapping of first image data corresponding to a source mesh to a target mesh, by generating a template of the source mesh and a template of the target mesh, processing the generated source mesh template and the generated target mesh template to obtain a conformal mapping from the source mesh to the target mesh, mapping the first image data corresponding to the source mesh to second image data corresponding to the target mesh according to the obtained conformal mapping, and outputting a mapped texture corresponding to the mapped second image data to the display corresponding to the target mesh.
Type:
Grant
Filed:
February 10, 2015
Date of Patent:
July 26, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: An energy generating device utilizing mechanical vibration power is provided. The energy generating device includes a first body for reciprocating according to vibration motions; an anchored second body; a rack coupled to one of the first body and the anchored second body; a gear assembly engaged with the rack and coupled to the other one of the first body and the anchored second body such that the gear assembly drives a generator via a rotational movement in a single direction according to each of upward and downward movement of the rack relative to the gear assembly; and the generator engaged with the gear assembly for receiving the rotational movement output from the gear assembly and outputting a direct current according to the rotational input from the gear assembly.
Type:
Grant
Filed:
April 16, 2012
Date of Patent:
July 19, 2016
Assignee:
The Research Foundation for The State University of New York
Inventors:
Lei Zuo, Gopinath Reddy Penamalli, John Wang, Rui He Zheng, Xiao Hui Lei, Jorge F. Lam-Ki, Zhongjie Li, Teng Lin
Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
Type:
Application
Filed:
December 17, 2015
Publication date:
July 14, 2016
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
Abstract: Disclosed is a process for fabricating microporous, open-cell foam of a hierarchical structure from a composition comprising a foamable liquid polymer, a curing agent for the polymer, a blowing agent and a filler that functions as a viscosity modifier for the foam-forming composition. By appropriate selection of materials, microporous, open-cell polymer foam is producible which, due to its hydrophobic character, is capable of absorbing relatively low surface tension liquids, e.g., hydrocarbon oils, and reject high surface tension liquids, e.g., water. These foams may be applied in maritime oil spill clean-up operations.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
July 12, 2016
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Shahab Shojaei-Zadeh, Michael Fechtmann
Abstract: Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid.
Type:
Grant
Filed:
March 18, 2014
Date of Patent:
July 12, 2016
Assignees:
Rutgers, The State University of New Jersey, The Trustees of the University of Pennsylvania
Inventors:
Kathryn E. Uhrich, Dana Graves, Keisuke Wada, Joseph P. Fiorellini, Michelle Morano, Roselin Rosario-Meléndez, Sabrina Sachiko Snyder
Abstract: Apparatus and methods of use thereof for the production of carbon-based and other nanostructures, as well as fuels and reformed products, are provided.
Type:
Grant
Filed:
February 24, 2012
Date of Patent:
July 12, 2016
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Stephen D. Tse, Nasir K. Memon, Bernard H. Kear
Abstract: The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.
Type:
Application
Filed:
December 28, 2015
Publication date:
July 7, 2016
Applicants:
Rutgers, The State University of New Jersey, New Jersey Institute of Technology
Inventors:
Arkady Mustaev, Maxim Kozlov, Salvatore Marras, Lev Krasnoperov, Laura Wirpsza, Shyamala Pillai
Abstract: The described invention provides a packaged electrochemical device comprising an electrochemical battery, further comprising at least one electrochemical cell stack and a barrier packaging material. The present invention further provides a method of fabricating the packaged electrochemical device. The present invention further provides a flexible multifunctional liquid-based thermogalvanic cell that converts and stores electricity derived from low grade temperature differentials that exist in ubiquitous scenarios.
Type:
Application
Filed:
September 18, 2015
Publication date:
June 30, 2016
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Glenn G. Amatucci, Irene Plitz, Anna B. Halajko, Linda Wu Sung
Abstract: A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.
Type:
Grant
Filed:
March 20, 2015
Date of Patent:
June 28, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: Datacenter clusters often employ live virtual machine (VM) migration to efficiently utilize cluster-wide resources. Gang migration refers to the simultaneous live migration of multiple VMs from one set of physical machines to another in response to events such as load spikes and imminent failures. Gang migration generates a large volume of network traffic and can overload the core network links and switches in a data center. The present technology reduces the network overhead of gang migration using global deduplication (GMGD). GMGD identifies and eliminates the retransmission of duplicate memory pages among VMs running on multiple physical machines in the cluster. A prototype GMGD reduces the network traffic on core links by up to 51% and the total migration time of VMs by up to 39% when compared to the default migration technique in QEMU/KVM, with reduced adverse performance impact on network-bound applications.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
June 21, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: A composition including arginine or a salt thereof, a zinc salt, preferably arginine bicarbonate and zinc carbonate (ABZC), in combination, plus one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras, generally to inhibit the growth of pathogenic Staphylococcus aureus bacteria and also promote the growth of non-pathogenic Staphylococcus epidermidis bacteria, and methods for using such composition.
Type:
Grant
Filed:
September 29, 2015
Date of Patent:
June 21, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: Hand pointing has been an intuitive gesture for human interaction with computers. A hand pointing estimation system is provided, based on two regular cameras, which includes hand region detection, hand finger estimation, two views' feature detection, and 3D pointing direction estimation. The technique may employ a polar coordinate system to represent the hand region, and tests show a good result in terms of the robustness to hand orientation variation. To estimate the pointing direction, Active Appearance Models are employed to detect and track, e.g., 14 feature points along the hand contour from a top view and a side view. Combining two views of the hand features, the 3D pointing direction is estimated.
Type:
Grant
Filed:
September 3, 2015
Date of Patent:
June 21, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: Relational clustering has attracted more and more attention due to its phenomenal impact in various important applications which involve multi-type interrelated data objects, such as Web mining, search marketing, bioinformatics, citation analysis, and epidemiology. A probabilistic model is presented for relational clustering, which also provides a principal framework to unify various important clustering tasks including traditional attributes-based clustering, semi-supervised clustering, co-clustering and graph clustering. The model seeks to identify cluster structures for each type of data objects and interaction patterns between different types of objects. Under this model, parametric hard and soft relational clustering algorithms are provided under a large number of exponential family distributions.
Type:
Grant
Filed:
March 30, 2015
Date of Patent:
June 21, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: A plastication unit for an injection molding machine, combining a heated plastication barrel with an entrance port and an exit port on opposing ends of the barrel; a hopper positioned to deliver ingredients to be compounded for injection molding to the entrance port of the barrel; and a helical plastication screw rotatably carried within the barrel and running the length of the barrel between the entrance and exit ports, which is operable to rotate and transmit the ingredients along the length of the barrel; wherein the plastication screw has at least one axial fluted extensional mixing element segment and the ingredients include at least one polymer for injection molding. Methods for injection molding with the plastication unit of the present invention and articles formed by the inventive methods are also disclosed.
Type:
Application
Filed:
April 23, 2012
Publication date:
June 16, 2016
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Thomas Nosker, Jennifer Lynch, Keith Luker
Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes.
Type:
Application
Filed:
February 24, 2016
Publication date:
June 16, 2016
Applicant:
The Research Foundation for The State University of New York
Inventors:
Thomas E. Amidon, Raymond Francis, Gary M. Scott, Jeremy Bartholomew, Bandaru V. Ramarao, Christopher D. Wood