Patents Assigned to The Trustees of Columbia University in the City of New York
  • Publication number: 20200163646
    Abstract: Techniques for mapping behavior of a heart include acquiring a series of two or more images of the heart. The series of images is taken at one or more pixel locations, each pixel location corresponding to a region of the heart. Image data corresponding to the pixel locations can be obtained, and a periodicity of the image data measured for each of the pixel locations over the series of images. The periodicity corresponds to an electromechanical signal of the heart in the region corresponding to the measured one or more pixel locations.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 28, 2020
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Jean Provost, Alok Gambhir, Alexandre Costet, Elaine Wan, Julien Grondin
  • Publication number: 20200165211
    Abstract: In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer, for example, lymphoid leukemia. The disclosure further provides for compounds which inhibit two phosphoinositide 3-kinase (PI3K) isoforms, y and ?, pharmaceutical compositions comprising said compounds, and methods of using said compounds and pharmaceutical compositions for treatment, amelioration, and/or prevention of non-Hodgkin lymphoma.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 28, 2020
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Donald W. LANDRY, Shi-Xian DENG, Xiaoming XU, Thomas DIACOVO
  • Patent number: 10663361
    Abstract: Achieving high spatial resolution in contact sensing for robotic manipulation often comes at the price of increased complexity in fabrication and integration. One traditional approach is to fabricate a large number of taxels, each delivering an individual, isolated response to a stimulus. The proposed sensors include a continuous volume of soft material, e.g., a transparent polymer, and light emitting diodes configured to emit light into the transparent volume that can be received by photodetectors. The location and depth of indentations can be measured between all pairs of light emitting diodes and photodetectors in the set, and this rich signal set can contain the information needed to pinpoint contact location with high accuracy using regression algorithms.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: May 26, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Matei Ciocarlie, Pedro Piacenza, Ioannis Kymissis
  • Patent number: 10662472
    Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3?-position of the deoxyribose.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: May 26, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki
  • Patent number: 10662463
    Abstract: This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer-conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 26, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Youngjin Cho, Shiv Kumar, Sergey Kalachikov, Chuanjuan Tao, Minchen Chien, James J. Russo
  • Patent number: 10660919
    Abstract: Disclosed herein are methods of administering an agent targeting a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific cell-surface antigen for immunotherapy of hematological malignancies.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 26, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Siddhartha Mukherjee, Florence Borot, Abdullah Mahmood Ali
  • Publication number: 20200155746
    Abstract: A wearable ultrafiltration apparatus is provided. The apparatus can include a first ultrafilter for filtering a patient's blood along a first fluid path and a second ultrafilter for filtering the patient's blood along a second fluid path. The apparatus can also include a valve being positionable in a first position for directing the patient's blood along the first fluid path. The valve can also be positioned in a second position for directing the patient's blood along the second fluid path. When the valve is in the first position, blood can flow along the first fluid path and prevent blood from flowing along the second fluid path. When the valve is in the second position, blood can flow along the second fluid path and prevent blood from flowing along the first fluid path. When the valve is in the first position, the second ultrafilter can be idle and capable of being serviced or replaced and when the valve is in the second position, the first ultrafilter can be idle and capable of being serviced or replaced.
    Type: Application
    Filed: October 22, 2019
    Publication date: May 21, 2020
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Robert J. von Gutfeld, Arthur Autz, Edward F. Leonard, Stanley Cortell
  • Patent number: 10657645
    Abstract: The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from molecular Magnetic Resonance Imaging (MRI) data where two groups differ and measuring MRI signal within determined critical areas in a new subject in order to assign risk or diagnosis.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: May 19, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ramin Parsey, Arthur Mikhno
  • Patent number: 10653648
    Abstract: The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: May 19, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Owen Anthony O'Connor, Jennifer Effie Amengual, Donald W. Landry, Ottavio Arancio, Luigi Scotto, Shixian Deng, Rosa Purgatorio, Jole Fiorito
  • Publication number: 20200147415
    Abstract: Techniques for selective modulation of motor neuronal activity in a peripheral nervous system using a focused ultrasound assembly are provided. Methods include adjusting a pulse repetition frequency parameter of a focused ultrasound to selectively modulate a location on a peripheral nerve and modulating the peripheral nerve with the focused ultrasound to increase a temperature of the peripheral nerve. The modulating can comprise one or more of exciting and inhibiting the peripheral nerve with the focused ultrasound, either separately or in combination. Methods can further include locating the peripheral nerve using an imaging probe, monitoring a physiological response to the modulating, and changing the one or more ultrasound parameters in response to the physiological response. Systems for use in the modulation of peripheral nerves are also provided.
    Type: Application
    Filed: January 14, 2020
    Publication date: May 14, 2020
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Matthew Downs, Stephen Lee, Min Gon Kim, Hermes Arytto Salles Kamimura
  • Publication number: 20200153740
    Abstract: Method for unified networking for a device in heterogeneous mobile environments includes maintaining and monitoring active network interfaces, managing the location of the device, managing network access security, enabling disruption tolerance support for applications, enabling service sharing and session mobility, managing system parameters for one or more active application sessions, managing storage functionality in one or more memory devices, and maintaining a mapping for one or more flows corresponding to the one or more active application sessions, maintaining one or more policies, and performing flow control decisions based upon the policies using a policy engine. The method can also include monitoring for network events, evaluating whether to perform a handover based upon policies, and providing seamless secure handovers in a heterogeneous mobile environment. A device, non-transitory computer-readable medium, and a system for unified networking are also provided.
    Type: Application
    Filed: January 16, 2020
    Publication date: May 14, 2020
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Amandeep SINGH, Gaston S. ORMAZABAL, Henning G. SCHULZRINNE
  • Patent number: 10650519
    Abstract: The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from PET data where two groups differ and measuring PET signal within determined critical areas in a new subject in order to assign risk or diagnosis.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ramin Parsey, Arthur Mikhno
  • Patent number: 10648028
    Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3?-position of the deoxyribose.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Zengmin Li, John Robert Edwards, Yasuhiro Itagaki
  • Patent number: 10647709
    Abstract: The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 12, 2020
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Gregory R. J. Thatcher, Isaac Thomas Schiefer, Ottavio Arancio, Mauro Fa
  • Patent number: 10647726
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew Wasmuth, Donald W. Landry
  • Patent number: 10648026
    Abstract: This invention provides nucleoside polyphosphate analogs each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs; and methods for determining the sequence of a single-stranded DNA or RNA using said nucleoside polyphosphate analogs. This invention also provides methods for detecting the interaction of a plurality of predetermined compounds, at least one of which having attached thereto a tag comprising a plurality of Raman-scattering moieties.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Shiv Kumar, Mirkó Palla, James J. Russo
  • Patent number: 10650087
    Abstract: Systems and methods are presented for content extraction from markup language text. The content extraction process may parse markup language text into a hierarchical data model and then apply one or more filters. Output filters may be used to make the process more versatile. The operation of the content extraction process and the one or more filters may be controlled by one or more settings set by a user, or automatically by a classifier. The classifier may automatically enter settings by classifying markup language text and entering settings based on this classification. Automatic classification may be performed by clustering unclassified markup language texts with previously classified markup language texts.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: May 12, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Suhit Gupta, Gail Kaiser, Salvatore J. Stolfo
  • Publication number: 20200138787
    Abstract: A composition for opththalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and an ophthalmically suitable carrier or excipient is provided.
    Type: Application
    Filed: May 20, 2019
    Publication date: May 7, 2020
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: David Choohyun Paik, Stephen Lewis Trokel
  • Patent number: 10640457
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: May 5, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yan Feng, Mauro Fa, Ottavio Arancio, Shixian Deng, Donald W. Landry, Yitshak Francis
  • Patent number: 10639185
    Abstract: Active wearable body brace embodiments provide selectable conformation control of the interface between the trunk of a human subject and the brace, which conformation may be varied over time and responsively to feedback and an updateable prescription. Further active wearable body brace embodiments provide selectable movement control of the interface between the trunk of a human subject and the brace with up to six degrees of freedom between elements to allow a controller to implement operations such as muscle challenges, active support, and passive-like support where actuators mimic springs. Further embodiments may also provide detection functions such as quantifying muscle weakness. The features of these embodiments may be combined in various ways to provide still further embodiments.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: May 5, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sunil K. Agrawal, Joon-Hyuk Park, Paul Stegall