Patents Assigned to The Trustees of Columbia University in the City of New York
  • Publication number: 20220193457
    Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
    Type: Application
    Filed: March 9, 2022
    Publication date: June 23, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
  • Publication number: 20220194823
    Abstract: A system for treatment of brines includes one or more membrane-less electrolyzers. An influent flow chamber flows an influent stream to a porous anode and cathode. electrochemical reactions at the anode and cathode result in acidic and alkaline effluent streams respectively, including liquid and gaseous streams. The alkaline effluent can be combined with a brine feed stream, resulting in precipitation of alkali earth metals cations by reaction with hydroxyls to form alkali earth metal hydroxides (M(OH)2, M=Mg2+, Ca2+). These M(OH)2 are of interest as a carbon-free feedstock material for cement manufacturing. Additionally, carbon dioxide, such as from flue gas, can be combined with the alkaline effluent to form alkali earth metal carbonates or be concentrated and released upon neutralization of carbon dioxide saturated alkaline effluent with the acidic effluent.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 23, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Daniel Esposito, Shiho Kawashima, Xueqi Pang
  • Publication number: 20220177959
    Abstract: Disclosed herein are highly accurate approaches for single molecule electronic nanopore-based SBS.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 9, 2022
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Carl W. Fuller, Shiv Kumar, Sergey Kalachikov, Xiaoxu Li, Irina Morozova, James Russo, Steffen Jockusch
  • Publication number: 20220181028
    Abstract: System and methods for diagnosing nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) in patients are disclosed. The system can comprise one or more processors and one or more computer-readable non-transitory storage media coupled to the one or more of processors including instructions operable when executed by one or more of the processor. The system can be configured to select at least one patient with a risk indicator using an electronic health record (EHR) database, determine that the at least one patient fails to meet exclusion criteria, and display the at least one patient in response to the determination. The risk indicator can be associated with NAFLD and/or NASH. Methods for diagnosing NAFLD/NASH in patients are disclosed are also provided.
    Type: Application
    Filed: February 24, 2022
    Publication date: June 9, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Anna BASILE, Julia WATTACHERIL, Nicholas TATONETTI
  • Patent number: 11355167
    Abstract: In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: June 7, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Mingoo Seok, Zhewei Jiang, Jae-sun Seo, Shihui Yin
  • Patent number: 11349186
    Abstract: A circuit comprising a differential transmission line and eight switches provides non-reciprocal signal flow. In some embodiments, the circuit can be driven by four local oscillator signals using a boosting circuit. The circuit can be used to form a gyrator. The circuit can be used to form a circulator. The circuit can be used to form three-port circulator than can provide direction signal flow between a transmitter and an antenna and from the antenna to a receiver. The three-port circulator can be used to implement a full duplex transceiver that uses a single antenna for transmitting and receiving.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 31, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Aravind Nagulu, Harish Krishnaswamy
  • Patent number: 11344534
    Abstract: The invention provides for methods for treating pancreatic cancer, reducing or inhibiting pancreatic tumor cells, inhibiting or treating pancreatic cancer metastases, and inhibiting pancreatic cancer stem cell growth in a subject by administering a cholinergic agonist.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: May 31, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Timothy C. Wang, Bernhard Renz
  • Patent number: 11331392
    Abstract: The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: May 17, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jeffrey T. Koberstein, Sanjoy Samanta, Chathuranga De Silva
  • Patent number: 11331656
    Abstract: The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: May 17, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Tomislav Rovis, Cedric Theunissen
  • Patent number: 11333874
    Abstract: In some embodiments of SCAPE imaging systems, a Powell lens is used to expand light from a light source into a sheet of illumination light. An optical system sweeps the sheet of illumination light through a sample, and forms an image at an intermediate image plane from detected return light. A camera captures images of the intermediate image plane. In some embodiments of SCAPE imaging systems, an optical system sweeps the sheet of illumination light through a sample, and forms an image at an intermediate image plane from detected return light. A camera captures images of the intermediate image plane. In the latter embodiments, the optical system is deliberately misaligned with respect to a true alignment position so that a significant portion of light that would be lost at the true alignment position will arrive at the camera.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: May 17, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Elizabeth M. C. Hillman, Venkatakaushik Voleti
  • Patent number: 11331041
    Abstract: An exemplary system, method and computer-accessible medium for determining an effect(s) of a convulsive stimulation therapy(ies) on a patient(s) can be provided, which can include, for example, receiving first information related to a visual network or a default mode network of a brain of the patient(s), receiving second information related to a subgenual ACC or a default mode (DMN network of the brain of the patient(s), and determining the effect(s) of the convulsive stimulation therapy(ies) based on a relationship between the first information and the second information. The convulsive stimulation therapy(ies) can be an electroconvulsive therapy or a magnetic seizure therapy.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 17, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Daniel Javitt, Joan Prudic, Stefan Rowny, Marta Moreno
  • Patent number: 11324779
    Abstract: Spheroid microtissues that can mimic native tissue-like structure and function, spheroid production methods that are high-throughput, suitable for efficient production, maintainable over long-term culture, and/or offer repeatable control over size distribution. Spheroids that have blood vessels, including spheroids with functional, blood-perfused vascular networks upon injection in vivo. Dissolvable hydrogel microwell arrays for high throughput parallel formation of spheroids in a single pipetting step and easy retrieval for downstream applications. A method to produce prevascularized microtissues in sufficient numbers to form a macrotissue in vivo for therapeutic purposes. This method is based on sacrificial release of dissolvable microwell templates, a novel and scalable strategy which enables gentle harvesting of microtissues with control over size and composition.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 10, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ninna S. Rossen, Samuel K. Sia, Brian M. Gillette
  • Publication number: 20220137017
    Abstract: The present disclosure provides, method, a system, and apparatus for identifying odorants. For example, the apparatus performs sensing an odorant using an olfactory sensor, encoding the sensed odorant to an electrical signal using an input processor, determining an identity representation of the odorant based on the encoded electrical signal, and determining odorant information using a time-dependent hash code based on the identity representation of the odorant.
    Type: Application
    Filed: December 14, 2020
    Publication date: May 5, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Aurel A. Lazar, Tingkai Liu, Chung-Heng Yeh
  • Publication number: 20220135564
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and methods of using the compound to treat pain, depressive disorders, mood disorders, anxiety disorders, opioid use disorder, and opioid withdrawal symptoms.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 5, 2022
    Applicants: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Andrew C. Kruegel, Dalibor Sames, Jonathan A. Javitch, Susruta Majumdar
  • Patent number: 11317787
    Abstract: The disclosed subject matter includes devices and systems for extending the imaging capability of swept, confocally aligned planar excitation (SCAPE) microscopes to in vivo applications. In embodiments, the SCAPE microscope can be implemented as an endoscopic or laparoscopic inspection instrument.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: May 3, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Elizabeth Marjorie Clare Hillman
  • Publication number: 20220127151
    Abstract: A method and system for producing highly activated silicate material, wherein the silicate source material is provided for reaction with a reforming agent in a reforming process. The reforming process is a hydrothermal process and/or a high temperature silicate reforming (HTSR) process. A heat source heats reaction materials to a reaction temperature in the presence of a reaction medium. For the hydrothermal reaction process, the reaction medium and heat source are an exhausted steam that is a byproduct of another industrial process. For the HTSR process, the silicate source material and the heat source are a molten slag byproduct from another industrial process.
    Type: Application
    Filed: November 24, 2021
    Publication date: April 28, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ah-Hyung Alissa PARK, Xiaozhou ZHOU, Chengchuan ZHOU
  • Patent number: 11311193
    Abstract: An exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided, which can include, for example, receiving imaging information of a portion(s) of a head of the patient(s), and determining the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: April 26, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Daniel Javitt, Joan Prudic, Stefan Rowny, Marta Moreno
  • Patent number: 11311629
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 26, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kam W. Leong, Yeh-Hsing Lao, Tzu-Chieh Ho, Smruthi Suryaprakash
  • Publication number: 20220119825
    Abstract: The present disclosure relates to intercellular signaling between genetically-engineered cells and, more specifically, to a scalable peptide-GPCR intercellular signaling system. The present disclosure provides an intercellular signaling system that includes at least two cells that have been genetically-engineered to communicate with each other, methods of use and kits thereof.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 21, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Virginia Cornish, James Brisbois, Sonja Billerbeck, Miguel Jimenez
  • Patent number: 11310249
    Abstract: Mechanisms for defending a computing system from attack are presented. The mechanisms include: maintaining a round counter that tracks a round number for a local host; determining a location in a graph for each of a plurality of hosts including the local host; determining monitor hosts of the plurality of hosts that are monitoring the local host; determining monitoree hosts of the plurality of hosts that are being monitored by the local host; sending a message to each of the monitor hosts identifying a value of the round counter; forwarding a first set of heartbeat messages from previous monitoree hosts to the monitor hosts; attempting to receive messages from the monitoree hosts; determining whether any messages were not received from the monitoree hosts; and in response to determining that one or more messages were not received from the monitoree hosts, generating an alert.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: April 19, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yuan Jochen Kang, Salvatore Stolfo