Abstract: Circuits for receivers including: N first mixers that each receive an input signal, are each clocked by a different phase of a first common clock frequency, and each provide an output; and for each N first mixer: a set of M second mixers, wherein each second mixer receives as an input the output of a same one of the N first mixers unique to the set, wherein each of M second mixer is clocked by a different phase of a second common clock frequency, and wherein each second mixer has an output; a set of M resistors having a first side and a second side, wherein the first side is connected to the output of a corresponding one of the set of M second mixers; and a set of M trans-impedance amplifiers that each having an input connected to the second side of a corresponding one of the resistors.

Abstract: A biopolymer composition can be formed based, at least in part, on a recombinantly expressed protein, expressed from a DNA coding sequence of a source protein, and the recombinantly expressed protein can optionally comprise one or more tags that enhance the crosslinking capacity of the protein. It was determined that such biopolymer composition can be suitable for use to obtain, for example, a biodegradable textile that exhibits a functional characteristic associated with the recombinantly expressed protein.

Abstract: In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments.

Abstract: An exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided, which can include, for example, receiving imaging information of a portion(s) of a head of the patient(s), and determining the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

Abstract: Automated cerebral microbleed detection is performed in extracted T2*-weighted image data, including gradient echo (GRE) image data and susceptibility-weighted imaging (SWI) image data. The image data is resampled and potential 2D regions of interest (ROI) having a circular or ellipsoidal shape are identified based in part on a respective intensity of associated resampled image pixels. The number of 2D ROIs are reduced by size, edge, and/or cerebrospinal fluid (CSF) mask exclusion, and then merged to form 3D ROIs. False positive 3D ROIs are removed and the remaining ROIs stored for review by a trained rater. The embodiments of the present disclosure outperform visual ratings of cerebral microbleeds, reducing the time to visually rate the scans while retaining sensitivity to the microbleeds themselves. These embodiments also exhibit higher sensitivity in longitudinal identification of microbleed locations, and are suited to longitudinal examination of cerebrovascular disease, e.g.

Abstract: Systems and methods for detecting concussions in real-time are provided. An exemplary system of detecting concussions in real time includes an accelerometer to measure acceleration event and generate an accelerometry signal. The system includes a plurality of electrodes to detect an electroencephalogram (EEG) and each of the electrodes can be attached to a top region of the headgear through a flexible shaft. The system further includes a signal processing circuit to amplify, filter and broadcast an electroencephalogram (EEG) signal to a local wireless receiving unit.

Abstract: In an aspect, compositions, methods, and devices described herein provide a safer platform for the ex vivo expansion of cells for immunotherapeutic purposes that eradicates the possibility of having activating substrate transferred into the patient while maintaining and improving upon the level of cell activation and proliferation.

Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.

Abstract: The present subject matter relates to techniques for single transducer harmonic motion imaging. The disclosed system can include a transducer. The transducer can be configured to generate an amplitude-modulated acoustic radiation force (AM-ARF) by sinusoidally modulating a duration of an excitation pulse of an acoustic radiation force, induce a harmonic motion on a target tissue using the AM-ARF, and simultaneously track the harmonic motion by collecting a tracking pulse. The tracking pulse can be interleaved between the excitation pulse.

Abstract: Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.

Abstract: The present disclosure relates to systems and methods for providing a hybrid brain-computer-interface (hBCI) that can detect an individual's reinforcement signals (e.g., level of interest, arousal, emotional reactivity, cognitive fatigue, cognitive state, or the like) in and/or response to objects, events, and/or actions in an environment by generating reinforcement signals for improving an AI agent controlling the environment, such as an autonomous vehicle. Although the disclosed subject matter is discussed within the context of an autonomous vehicle virtual reality game in the exemplary embodiments of the present disclosure, the disclosed system can be applicable to any other environment in which the human user's sensory input is to be used to influence actions within the environment. Furthermore, the systems and methods disclosed can use neural, physiological, or behavioral signatures to inform deep reinforcement learning based AI systems to enhance user comfort and trust in automation.

Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.

Abstract: Described here are techniques for identifying risk of primary graft dysfunction (PGD) of a subject. The disclosed method can include collecting serum of the subject, measuring a level of a PGD marker from the serum, wherein the PGD marker comprises plasma kallikrein (KLKB1), providing a PGD risk value that is quantified based on the level of the PGD marker using an adaptive Monte Carlo cross-validation (MCCV) model, and identifying the risk of PGD based on the PGD risk value.

Abstract: A framework for a few-shot learning method is disclosed. In a first part, self-supervision and classification supervision are used to train a feature extractor. An example self-supervision method comprises running grayscale images through an edge filter, normalizing the filtered images, setting the normalized images to ground truth, generating feature-extracted images, using a decoder to reconstruct images from the feature-extracted images, determining a loss between the reconstructed images and the ground truth images, and using the loss to update parameters of the feature extractor. In a second part, a few-shot adaptation process is performed to adapt the model to a novel rapid test kit.

Abstract: A structured material is provided that includes a substrate and a porous structured polymer layer disposed thereon. The porous structured polymer layer includes a plurality of voids, and has a high hemispherical reflectance a high a hemispherical thermal emittance. The structured material is thus particularly advantageous for cool-roof coatings, enabling surfaces coated by the material to stay cool, even under strong sunlight. The material can be produced via structuring of polymers in a mixture including a solvent and a non-solvent. Sequential evaporation of the solvent and the non-solvent provide a polymer layer with the plurality of voids.

Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).

Abstract: The present disclosure provides methods for generating lung progenitor cells, and populations of cells made using the methods. The lung progenitors and related compositions can be used as therapeutic treatments for various pulmonary disorders or related injuries.

Abstract: The present invention relates to a computer-vision based autonomous steerable catheter device and methods of using the same for targeted delivery of a liquid microvolume into the interior of a lung.

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.