Abstract: The disclosed subject matter provides for genetically modified cells, e.g., fungal cells, that autonomously generates and/or secretes one or more skin therapeutics, and methods of use thereof. In certain embodiments, the present disclosure provides genetically-engineered fungal cells that generate and secrete growth factors, protease inhibitors, cytokines and/or chemokines and methods of use thereof, e.g., for treating skin conditions.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn.

Abstract: Disclosed herein is a different and novel approach to cancer vaccines using a subject's own dendritic cells (DC's) and macrophages (Mphs) in combination to present cancer antigens to the immune system. Further disclosed are methods of producing monocyte-derived autologous DCs and Mphs loaded ex vivo with particular whole irradiated cancer cells which generates optimally activated immunostimulatory antigen-presenting cells (APCs) as a superior method for stimulating robust and long-lasting immunity to a particular cancer in vivo as compared with more traditional vaccination methods. Compositions, methods of use and methods for preparation of these DC's and Mphs with cancer cells are also disclosed herein.

Abstract: An exemplary catheter can be provided, which can include, for example a source fiber(s) configured to (i) receive a near infrared spectroscopic (NIRS) radiation, and (ii) provide the NIRS radiation to a portion(s) of a sample(s), a detection fiber(s) configured to receive a return radiation from the sample(s) that can be based on the NIRS radiation that was provided to the portion(s) of the sample(s), and an ablation electrode(s) configured to ablate the sample(s) based on the return radiation. The source fiber(s), the detection fiber(s), and the ablation electrode(s) can be integrated into the single sheath. The ablation electrode(s) can be a radiofrequency ablation electrode.

Abstract: Systems and methods for performing bioremediation using the Geobacillus sp. bacterial strain are provided which are capable of effectively degrading 1,4-dioxane and/or per- and polyfluoroalkyl substances (PFAS) and/or BaP and efficiently degrading other ring-based organic contaminants. The exemplary bioremediation methods include steps for administering an effective, degrading amount of the bacteria to soil containing excess amounts of 1,4-dioxane and/or PFAS and/or BaP and incubating the bacteria administered to the soil at a given temperature and for a duration that are suitable for promoting incubation and reducing and the concentration of 1,4-dioxane and/or PFAS and/or BaP below a maximum concentration, as might be specified by a regulatory body.

Abstract: A robotic assistant provides active support for disabled users and may take the approximate form of a cane or a walker.

Abstract: A method for optical super-multiplexing using polyynes to provide enhanced images from stimulated Raman microscopy is disclosed. In some exemplary embodiments, the polyynes are organelle-targeted or spectral barcoded. Imaging can be enhanced by using the polyynes to image whole live cells or specific organelles within live cells. The polyynes can also be used in optical data storage (i.e., encoding) and identification (i.e., decoding) applications.

Abstract: A method for interacting with an object includes identifying, via a keypoint classifier, one or more uncertainty regions in an environment based on an estimated trajectory of an object in the environment. The method also includes planning an interaction with the object based on identifying the one or more uncertainty regions, the planned interaction being within a region of the environment that is different from the one or more uncertainty regions. The method further includes interacting with the object based on planning the interaction.

Abstract: Incorporation of deuterium into the lipids, proteins, and/or genetic material in cells, tissues, organs, or organisms, including animals, such as humans, and plants, by administration of heavy water, allows for the spectral determination of levels of lipids, proteins, and/or genetic material using Raman spectroscopy, such as stimulated Raman spectroscopy. Following administration of a drug, changes in the relative amounts of lipid, protein, and/or genetic materials can be determined, and the efficacy, or lack thereof, of the administered drug can be determined.

Abstract: An apparatus for fabricating non-planar coils includes a rotating table driven by a first motor; a wire approach height adjustment arm driven by a second motor; and a synchronization module configured such that a wire traversing from the height adjustment arm to a bobbin on the rotating table passes into a non-planar groove cut in the bobbin without damaging the wire. Performing magnetic resonance (MR) measurements includes a plurality of coil units configured for generating a gradient or shim magnetic field. The coil unit includes a plurality of coil windings, and each coil winding is separated longitudinally from an adjacent coil winding. A single pair of electrically conducting leads is configured to cause current to flow through all of the plurality of coil windings in the coil unit. Techniques include methods to fabricate and operate the apparatus.

Abstract: A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

Abstract: The present disclosure relates to radiolabeled compounds and methods of uses for diagnosis, monitoring, and treatment of various degenerative neurological disorders, neuropsychiatric disorders, brain injuries, vascular diseases, and cancers. Radiolabled compounds for imaging of microtubules or microtubules and other targets using positron-emission tomography (PET) are specifically disclosed.

Abstract: Aspects of the present disclosure generally relate to catalyst compositions including metal chalcogenides, processes for producing such catalyst compositions, processes for enhancing catalytic active sites in such catalyst compositions, and uses of such catalyst compositions in, e.g., processes for producing conversion products. In an aspect, a process for forming a catalyst composition is provided. The process includes introducing an electrolyte material and an amphiphile material to a metal chalcogenide to form the catalyst composition. In another aspect, a catalyst composition is provided. The catalyst composition includes a metal chalcogenide, an electrolyte material, and an amphiphile material. Devices for hydrogen evolution reaction are also provided.

Abstract: The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I): wherein R1, R2, R2?, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.

Abstract: Aspects provide fluid responsive actuators and methods of using fluid responsive actuators capable of generating a power-to-volume ratio sufficient to inject a drug from a syringe within an injection period from about 1 to about 60 seconds after exposure of the fluid responsive elements to a fluid. The fluid responsive actuators can be used to inject viscous drugs to a patient.

Abstract: The present invention relates to the treatment of chronic obstructive pulmonary disease (COPD). More specifically, embodiments of the invention provide a pharmaceutical carrier and a compound that inhibit the induction of MMP-1 expression by cigarette smoke.

Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Abstract: The present disclosure provides a compound having the structure:

Abstract: The current invention is a method of treating, preventing, reducing and/or abolishing edema and/or intracranial pressure in a subject by the administration of hyaluronidase. The edema in the brain and intracranial pressure can be the result of a traumatic event, disease or condition including but not limited to a traumatic brain injury, a stroke, a brain tumor, and post-operative swelling.