Abstract: The present disclosure provides methods for generating lung progenitor cells, and populations of cells made using the methods. The lung progenitors and related compositions can be used as therapeutic treatments for various pulmonary disorders or related injuries.

Abstract: The present invention relates to a computer-vision based autonomous steerable catheter device and methods of using the same for targeted delivery of a liquid microvolume into the interior of a lung.

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

Abstract: The systems described herein can be used to modulate either the phase, the amplitude, or both of an input light wave using micro-resonators to achieve desired degrees and/or types of modulation.

Abstract: In one aspect the present invention is directed to mutant Neutrophil gelatinase-associated lipocalin (NGAL) proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract.

Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

Abstract: A static random-access memory (SRAM) system includes SRAM cells configured to perform exclusive NOR operations between a stored binary weight value and a provided binary input value. In some embodiments, SRAM cells are configured to perform exclusive NOR operations between a stored binary weight value and a provided ternary input value. The SRAM cells are suitable for the efficient implementation of emerging deep neural network technologies such as binary neural networks and XNOR neural networks.

Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the consumption of alcohol in a patient. These compounds may be used in treat or prevent alcoholism or an alcohol abuse disorder and show an improved pharmaceutical profile relative to other commonly used compounds.

Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.

Abstract: Disclosed herein are compositions and methods relating to agents that target a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific cell-surface antigen for immunotherapy of hematological malignancies.

Abstract: The subject invention provides a method for treating a non-alcoholic fatty liver disease (NAFLD) disease in a subject afflicted therewith comprising administering to the subject a pharmaceutical composition comprising an amount of a compound which is a non-retinoid retinol-binding protein 4 (RBP4) antagonist effective to treat the subject, thereby treating the subject. The subject invention provides a method for treating gout in a subject afflicted therewith comprising administering to the subject a pharmaceutical composition comprising an amount of a compound which is a retinol-binding protein 4 (RBP4) antagonist effective to treat the subject, thereby treating the subject.

Abstract: A heating and/or cooling temperature adjusting apparatus disposed proximate a point of use comprising a heat exchange structure, at least one thermal mass unit comprised of a material which changes phase at a predetermined temperature, and a housing which at least partially encloses the heat exchange structure and thermal mass unit. Additionally, a plurality of thermal mass units can be employed, each with equivalent, or differing, temperature threshold points for conversion between solid, liquid or gaseous phases. The presence of the thermal mass unit at the point of use allows for the heating/cooling system to rapidly adjust the temperature of the room while simultaneously decreasing the duty cycle of the heating/cooling generator (e.g. boiler).

Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.

Abstract: Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated.

Abstract: This invention relates to the treatment of fatty liver disease. More specifically, embodiments of the invention provide a pharmaceutical carrier and a compound that reduces adipsin activity in liver cells.

Abstract: Mechanisms for recovering data symbols in multiple-input, multiple-output (MIMO) receivers, the mechanisms comprising receiving, at Na antennas that each have an output: first signals corresponding to Np pilot symbols transmitted from each of K transmitters for a total of Np*K transmitted pilot symbols; and second signals corresponding to a plurality of transmitted data symbols transmitted from the K transmitters, wherein Np is less than Na, and wherein K is less than Na; receiving, at a hardware processor, first digital signals representing the Np*K transmitted pilot symbols; receiving, at the hardware processor, second digital signals representing the plurality of transmitted data symbols; and recovering the plurality of transmitted data symbols using the second digital signals and no more pilot symbols than the Np*K transmitted pilot symbols represented by the first digital signals using the hardware processor.

Abstract: Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount of (R,S)-ketamine or (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) is administered to a female or male subject prior to a stressor.

Abstract: Disclosed are methods, systems, devices, and other implementations, including a voltage converter device that includes one or more inductive elements to deliver inductor current to an output section of the voltage converter device, at least one switching device to control current flow at the output section of the voltage converter device, and a controller to controllably vary, according to a predictive model, a subsequently applied switching frequency to the at least one switching device to maintain zero-voltage switching based, at least in part, on the inductor current of the one or more inductive elements.

Abstract: Engineered skin substitutes comprising an outer-facing portion and an inner-facing portion and methods of making the same are provided. The skin substitutes are configured to conform to a shape and a dimension of a body part of a subject, and have at least one surface that circles back on itself so as to enclose at least a portion of the body part. In some instances, dermis and epidermal layers can be formed in an air liquid interface. The exemplary skin substitutes are wearable and can be made to conform to a generic body part or a specific body part from a three-dimensional representation of the body part.

Abstract: Circuits for a receiver, comprising: M first mixers that each receive an input signal, that are each clocked by a different phase of a first common clock frequency, and that each provide an output, wherein M is a count of the first mixers; and M sets of N second mixers, wherein N is a count of the second mixers in each of the M sets, wherein each second mixer in each set of N second mixers receives as an input the output of a corresponding one of the M first mixers, wherein each of the N second mixers in each of the M sets are clocked by a different phase of a second common clock frequency, and wherein each of the second mixers has an output.