Abstract: The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.

Abstract: A wound dressing is made from a tubular inner layer and at least one outer layer disposed radially beyond the inner layer. The inner layer permits egress of fluid from weeping wounds, prevents desiccation of skin disposed beneath the inner layer, and prevents desiccation of ointment disposed between the inner layer and the skin. The at least one outer layer absorbs fluids that leak through the inner layer, protects the inner layer from outside contaminants, and prevents fluids from escaping. The at least one outer layer is affixed to the inner layer, and each of the layers is elastic in at least the radial direction. Optionally, a layer of ointment may be applied to an inner surface of the inner layer. Note that the tubular inner layer may be either pre-formed or formed at the time of application.

Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.

Abstract: Mechanisms compressive sampling to detect direction of arrival (DoA) of a signal of interest (SoI), comprising: in each of a plurality of receiver paths, receiving the SoI and producing a received signal using an antenna; and using a modulator to: receive a modulator input signal (MIS) based on the received signal produced by the antenna in the path; modulate the MIS at multiple points in time (MPIT) based on different ones of a plurality of pseudo-random numbers; and produce a plurality of modulated output signals in response to the modulating of the MIS at the MPIT; summing across the receiver paths the one of the modulated output signals produced by each of the receiver paths for each of the MPIT, to produce a plurality of sum signals each corresponding to one of the MPIT; and performing a compressed sensing recovery algorithm to recover the DoA of the SoI.

Abstract: The present subject matter relates to the use of one or more inhibitors to treat a disease, e.g., cancer, in a subject. The presently disclosed subject matter provides for compositions and methods for treating a subject using a cancer transition inhibitor, an inhibitor that reduces the expression level of a marker of the transition of adipose-derived stromal cells (ASCs) to COL11A1-expressing cancer-associated fibroblasts (CAFs).

Abstract: Methods and systems for automating carbon footprinting are disclosed. In some embodiments, the methods include a plurality of steps. In some embodiments, related to predetermined resources associated with an item from predetermined data sources is obtained. Then, estimated emission factors are calculated for each of the resources. Next, a contributory uncertainty of the data and of the emission factors is determined. Then, a user is guided based on a comparison of the respective contributory uncertainty of data related to the resources or emission factors. Next, both data related to the resources and the estimated emission factors of the resources are utilized to determine a carbon footprint of the item.

Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

Abstract: A millimeter scale weak grating coupler comprising a silicon waveguide having bars of overlay material of length (a) disposed periodically at a period (?) adjacent the silicon waveguide whereby a uniform grating output is achieved.

Abstract: This invention provides nucleotide analogues each of which comprises a tag comprising one or more Forster resonance energy transfer (FRET) acceptor fluorophores, a nucleotide polymerase having one or more FRET donor fluorophores, and methods for sequencing single-stranded.

Abstract: Methods and pharmaceutical compositions for treatment of amyloid deposition diseases using chimeric (e.g., mouse-human) antibody are disclosed, including a method for treating amyloid deposition diseases with cardiac involvement by administering pharmaceutical compositions comprising a chimeric anti-amyloid fibril antibody. The methods herein can improve myocardial function in patients diagnosed with light chain amyloid light chain amyloidosis (ALA) having a cardiac involvement in as little as three weeks after treatment.

Abstract: The present subject matter relates to techniques for hierarchical deep transcoding. The disclosed system can include a processor that can be configured to receive a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and reconstruct a latent source space from the fMRI data and/or the EEG data by decoding the EEG data and/or the fMRI data to a latent source space. The fMRI data and the EEG data can be simultaneously acquired.

Abstract: The invention provides nucleotide analogues and methods of use thereof for sequencing by synthesis using energy transfer dye pairs.

Abstract: A limb tracking biofeedback platform and rehabilitation therapy methodology for spasticity patients improves and maintains limb functionality permitting compliance monitoring, patient encouragement and biofeedback outside the presence of a therapist. The method includes defining a desired therapeutic limb motion, and a goal for repetitions of the therapeutic motion over a given period. The platform includes at least one sensor coupled to the patient's limb which is configured to track at least one of limb movement and orientation. Tracked movement and/or orientation data is transmitted to a platform controller which calculates a number of therapeutic movements of the patient's limb based upon the tracked movement and/or orientation data. Biofeedback to the patient is provided by displaying at least the number of therapeutic movements. Typically reminder prompts and positive reinforcement of goals achieved are also displayed to the patient. The therapist can also have access to the recorded data.

Abstract: Methods, systems and media for evaluating layered computer security products are provided. In some embodiments, the method comprises: (a) identifying portions of attack data associated with an attack; (b) linking the portions of attack data; (c) testing security products using the linked attack data, at least two of the security products using different portions of the linked attack data; (d) storing the results of the testing; (e) repeating (a)-(d) for multiple attacks; receiving information identifying a subset of the security products from a remote computing device; identifying a first set of detected attacks for each of the plurality of security product using the stored results; determining a number of attacks in a union of each of the first sets of identified attacks; determining a detection rate for the identified security products based on the union and the number of tested attacks; and causing the detection rate to be presented.

Abstract: Circuits for identifying interferers using compressed-sampling, comprising: a low noise amplifier (LNA); a passive mixer having a first input coupled to an output of the LNA; a local oscillator (LO) source having an output coupled to a second input of the passive mixer; a low pass filter having an input coupled to an output of the passive mixer; an analog-to-digital converter (ADC) having an input coupled to the output of the low pass filter; a digital baseband (DBB) circuit having an input coupled to an output of the ADC; and a compression-sampling digital-signal-processor (DSP) having an input coupled to the output of the DBB circuit, wherein the compression-sampling DSP is configured to output identifiers of frequency locations of interferers, wherein, in a first mode, the LO source outputs a modulated LO signal that is formed by modulating an LO signal with a pseudo-random sequence.

Abstract: Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated).

Abstract: A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and filter assembly comprising a filter membrane and a border configured to engage the tubular body. The filter membrane and the border are each formed from material that is sectionable.

Abstract: The present disclosure provides, inter alia, specially designed DNA adaptors and methods of preparing the same. Methods and kits for carrying out and detecting marker-free precision genome editing and genetic variation using such adaptors are also provided.

Abstract: A system for treatment of brines includes one or more membrane-less electrolyzers. An influent flow chamber flows an influent stream to a porous anode and cathode. electrochemical reactions at the anode and cathode result in acidic and alkaline effluent streams respectively, including liquid and gaseous streams. The alkaline effluent can be combined with a brine feed stream, resulting in precipitation of alkali earth metals cations by reaction with hydroxyls to form alkali earth metal hydroxides (M(OH)2, M=Mg2+, Ca2+). These M(OH)2 are of interest as a carbon-free feedstock material for cement manufacturing. Additionally, carbon dioxide, such as from flue gas, can be combined with the alkaline effluent to form alkali earth metal carbonates or be concentrated and released upon neutralization of carbon dioxide saturated alkaline effluent with the acidic effluent.