Abstract: According to various embodiments, a method for generating a compact and accurate neural network for a dataset that has initial data and is updated with new data is disclosed. The method includes performing a first training on the initial neural network architecture to create a first trained neural network architecture. The method additionally includes performing a second training on the first trained neural network architecture when the dataset is updated with new data to create a second trained neural network architecture. The second training includes growing one or more connections for the new data based on a gradient of each connection, growing one or more connections for the new data and the initial data based on a gradient of each connection, and iteratively pruning one or more connections based on a magnitude of each connection until a desired neural network architecture is achieved.

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.

Abstract: According to various embodiments, a method for reducing heading error in a magnetometer that uses Rb-87 atoms is disclosed. The method includes varying a direction and magnitude of a magnetic field at different spin polarization regimes. According to various embodiments, a magnetometer adapted for reduced heading error is disclosed. The magnetometer includes a multipass cell containing Rb-87 vapor, a pump laser operated in a pulse mode that is synchronous with a Larmor frequency, and two orthogonal probe lasers configured to rotate to vary a direction and magnitude of a magnetic field at different spin polarization regimes.

Abstract: Disclosed is a process to make nanoparticles highly loaded with water soluble actives, including biologics such as proteins and peptides, which are stabilized by random copolymers. The random copolymers used have all been approved by the FDA for oral formulations. The nanoparticles have a hydrophilic core and a hydrophobic corona and can be further processed through a number of different routes. The process to make these particles is highly scalable and could be used industrially.

Abstract: The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.

Abstract: The present invention relates to compositions comprising isolated, single stranded RNA molecules and pharmaceutically acceptable carriers suitable for injection. The present invention relates to methods for stimulating an immune response and treating tumors. The present invention further relates to kits comprising a cancer vaccine and compositions of the present invention for use as an adjuvant to cancer vaccines.

Abstract: Nanoemulsion compositions, processes, and methods that include dihydromyricetin (DHM).

Abstract: A cell-based device and method are disclosed for in vitro testing of compositions or compounds for irritation potential. Both the device and method comprise a) a confluent layer of corneal epithelial cells supported on a chemically patterned hydrogel, where the cells are aligned with the chemical pattern, b) a collector to receive effluent fluid, and optionally c) a detector. The device and method can also comprise an extracellular matrix (ECM) assembled by corneal keratocytes supported on the chemically patterned hydrogel. The cell-based device and method provide simple replacements for the in vivo Draize rabbit eye irritation test.

Abstract: A 10-formyl-THF pathway for producing NADPH is useful in the diagnosis and treatment of cancer and metabolic disease, in the development of new antineoplastic agents and/or regimens, in the development of new methods for measuring metabolic pathway activity, and in the development of new therapeutics for treating metabolic disease.

Abstract: Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. The exhaust may reduce pressure buildup in the nozzles and between the nozzles and the substrate, leading to improved deposition profiles, resolution, and improved nozzle-to-nozzle uniformity. The exhaust may be in fluid communication with an ambient vacuum, or may be directly connected to a vacuum source.

Abstract: According to various embodiments, a method for detecting security vulnerabilities in at least one of cyber-physical systems (CPSs) and Internet of Things (IoT) devices is disclosed. The method includes constructing an attack directed acyclic graph (DAG) from a plurality of regular expressions, where each regular expression corresponds to control-data flow for a known CPS/IoT attack. The method further includes performing a linear search on the attack DAG to determine unexploited CPS/IoT attack vectors, where a path in the attack DAG that does not represent a known CPS/IoT attack vector represents an unexploited CPS/IoT attack vector. The method also includes applying a trained machine learning module to the attack DAG to predict new CPS/IoT vulnerability exploits. The method further includes constructing a defense DAG configured to protect against the known CPS/IoT attacks, the unexploited CPS/IoT attacks, and the new CPS/IoT vulnerability exploits.

Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional neural tissues for use in methods including regenerative medicine, wound repair and transplantation.

Abstract: Disclosed is a spectroscopic device, system, and method for measuring the concentration of one or more molecular species of interest in a gas, liquid or solid sample, where the device may be portable, may be commercially manufactured, and/or may be adapted to existing systems and/or integrated with new systems to provide optical gas sensing for such systems. The disclosed devices, systems, and methods can be particularly useful in monitoring the purity of, e.g., a certain gas species, including determining whether a gas mixture contains certain gas species above a set concentration limit.

Abstract: A system and method for monitoring the pressure of an injection site, utilizing a fluid operating in the laminar regime flowing through a calibrated tube, and measuring a pressure at one end of the calibrated tube with a pressure sensor, as well as a fluid velocity with a flow sensor, such as an elastic filament velocimeter, that comprises a nano-scale sensing element. Additional elements may be utilized, including the use of data acquisition units, processors, user interfaces, pumps, syringes, and control loops.

Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes a plurality of voltage splitting units (VSUs) coupled to a plurality of current splitting units (CSUs). The VSUs are connected to each other in series and the CSUs are connected to each other in parallel. The VSUs each have a fixed voltage conversion ratio and are operated at a lower frequency than the CSUs. The CSUs each have an adjustable voltage conversion ratio and are operated at a higher frequency than the VSUs.

Abstract: Disclosed is a method and system for the phase separation of folded domains, and more particularly, to inducing clusters of folded domains as part of a drug-based screening application. The system and method utilize one or more first fusion proteins (100, 101), each first fusion protein comprising a first region (110) fused to a second region (120), the first region (110) comprising at least one light sensitive protein (115) or cognate partner of a light sensitive protein (116), and the second region (120) comprising one or more folded RNA binding domains (RBDs), disordered RBDs, folded non-RBD domains, or combination thereof (125).

Abstract: According to various embodiments, a direct magnetic gradiometer having intrinsic subtraction of rotation signals from two oppositely polarized atomic ensembles within a single multi-pass cell is disclosed. The gradiometer includes three convex spherical mirrors aligned in a V-shape geometry. The three convex spherical mirrors include a front mirror and two back mirrors. The gradiometer further includes a probe laser beam. The laser beam is configured to be initially focused at a near-zero angle into a hole at a center of the front mirror such that the laser beam expands at the back mirrors and nearly overlaps with itself while undergoing multiple reflections between the front and back mirrors. The laser beam is further configured to be refocused to the front mirror at different spots in a number equal to half of total beam passes before exiting.

Abstract: Disclosed is a system and method for shaped incoherent light for control (SILC). More particularly, disclosed is a method for controlling the evolution of photo-responsive systems (including chemical species, biochemical species or material compounds) using a device capable of producing shaped incoherent light for such control. The disclosed device integrates a polychromatic incoherent source in an adaptive feedback control loop.

Abstract: According to some embodiments, a system for widening and densifying a scrape-off layer (SOL) in a field reversed configuration (FRC) fusion reactor is disclosed. The system includes a gas box at one end of the reactor including a gas inlet system and walls of suitable heat bearing materials. The system further includes an exit orifice adjoining the gas box, wherein the exit orifice has a controllable radius and length to allow plasma to flow out from the gas box to populate the SOL with the plasma. The system may also include fusion products, which decrease in speed in the plasma in the SOL, allowing energy to be extracted and converted into thrust or electrical power and further allowing ash to be extracted to reduce neutron emissions and maintain high, steady-state fusion power.

Abstract: A pluggable trust architecture addresses the problem of establishing trust in hardware. The architecture has low impact on system performance and comprises a simple, user-supplied, and pluggable hardware element. The hardware element physically separates the untrusted components of a system from peripheral components that communicate with the external world. The invention only allows results of correct execution of software to be communicated externally.