Abstract: This disclosure provides a system and method for producing ultrasound images based on Full Waveform Inversion (FWI). The system captures acoustic/(an)elastic waves transmitted through and reflected and/or diffracted from a medium. The system performs an FWI process in a time domain in conjunction with an accurate wave propagation solver. The system produces 3D maps of physical parameters that control wave propagation, such as shear and compressional wavespeeds, mass density, attenuation, Poisson's ratio, bulk and shear moduli, impedance, and even the fourth-order elastic tensor containing up to 21 independent parameters, which are of significant diagnostic value, e.g., for medical imaging and non-destructive testing.

Abstract: Systems and methods are described, and one system includes a three-dimensional (3D) geometric tracker connected to a multiband (MB) inverse synthetic aperture array radar (ISAR), and a classification/alarm logic. The MB ISAR includes spatially distributed radar transmitters (TXs) and receivers (RXs), a TX/RX allocation logic, and a tomographic (TM) image logic. The TX/RX allocation logic is configured to receive 3D tracking data from the 3D geometric tracker, indicating subject 3D position and 3D orientation and, in response, dynamically allocate TXs and RXs to maintain MB illumination of and maintain MB reception of multiple scatter angles from subjects. The TM image processor is configured to construct TM images from the scatter angles, using 3D tracking data, for input to the classification and alarm logic. Optionally, the TX/RX resource allocation logic is configured to receive situation feedback data, for feedback adjusting of allocation of TXs and RXs.

Abstract: According to various embodiments, a machine-learning based system for coronavirus detection is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and questionnaire data from a user interface. The processors are further configured to train at least one neural network based on raw physiological data and questionnaire data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one coronavirus inference model. The processors are also configured to output a coronavirus-based decision by inputting the received physiological data and questionnaire data into the generated coronavirus inference model.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.

Abstract: The present disclosure relates, in general, to a fusion protein construct comprising RNase L and a split reporter system, and methods of using the reporter for detecting 2?-5? linked oligoadenylates (2-5A) and double stranded RNA in vivo.

Abstract: Various embodiments comprise systems, methods, mechanisms, apparatus, and improvements thereof providing a machine learning based inverse design method for mm-wave/RF power amplifiers (PAs). Methods according to embodiments provide for efficiently synthesizing power amplifier matching circuit (output matching/output power combiner/backoff efficient output power combiner, interstage matching and input matching/input power divider and phase shifter) for a close to optimum solution in terms of matching bandwidth, efficiency and load modulation, which can exceed the performance limitations of traditional matching network designs.

Abstract: Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle ? relative to the substrate, wherein ? is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle ?N relative to the substrate, wherein for each ?N, ? is greater than about 0° and less than about 180°. For at least a first of the ?N, ?N is greater than about 0° and less than about 85°, and for at least a second of the ?N, ?N is greater than about 95° and less than about 180°.

Abstract: The microlens amplitude masks for flying pixel removal in time-of-flight imaging includes systems, devices, methods, and instructions for image depth determination, including receiving an image, adding noise to the image, determining a set of correlation images, each correlation image having a varying phase offset, for each pixel of the image, generating a masked pixel by applying a mask array, and for each masked pixel, determining the depth of the masked pixel to generate a depth map for the image on a per pixel basis.

Abstract: Disclosed herein is the detection of dangerous dielectric materials (explosives) and dangerous non-explosive and/or prohibited items. The detection is based on a broad bandwidth nonlinear radar system, driven by a highly stable optical frequency comb. The disclosed approach allows for the spatial resolution of the interrogated object in complex settings. Detection of dangerous materials and non-explosive chemical prohibited items is disclosed.

Abstract: Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective.

Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB.

Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.

Abstract: Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites.

Abstract: Disclosed is a high-throughput transcriptional assay format in Actinomycete bacteria, and Streptomyces spp. in particular, that leverages eGFP, inserted both at a neutral site and inside the biosynthetic cluster of interest, as a read-out for secondary metabolite synthesis. Using this approach, a silent gene cluster in Streptomyces albus J1074 was induced. The cytotoxins etoposide and ivermectin were revealed as potent inducers, allowing the isolation and structural characterization of nearly 20 novel small molecule products of the chosen cluster. One of these molecules is a novel antifungal, while several others inhibit a cysteine protease implicated in cancer. Studies addressing the mechanism of induction by the two elicitors led to the identification of a pathway-specific transcriptional repressor that silences the gene cluster under normal growth conditions.

Abstract: This invention relates generally to the field of quasicrystalline strictures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for pre-selected range of wavelengths propagating in multiple directions.

Abstract: The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization.

Abstract: Methods, devices, and systems are described for storing and transferring quantum information. An example device may comprise at least one semiconducting layer, one or more conducting layers configured to define at least two quantum states in the at least one semiconducting layer and confine an electron in or more of the at least two quantum states, and a magnetic field source configured to generate an inhomogeneous magnetic field. The inhomogeneous magnetic field may cause a first coupling of an electric charge state of the electron and a spin state of the electron. The device may comprise a resonator configured to confine a photon. An electric-dipole interaction may cause a second coupling of an electric charge state of the electron to an electric field of the photon.

Abstract: A method and system for mass and heat exchange, where water is preferentially absorbed by a non-toxic, non-corrosive liquid desiccant after passing through a hydrophilic, non-porous membrane. Optionally, mixing stages are provided to reduce the surface concentration of water at the desiccant-membrane interface.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto.

Abstract: In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.