Abstract: A method is provided for treating a subject suffering from a chronic infection that involves the brain. The chronic infection may range from those causing only mild cognitive impairment, to those present in individuals who have been diagnosed with Alzheimer's Disease. The method includes forming a composition containing (a) an anti-infective peptoid, and (b) a blood-brain barrier (BBB) manipulator that enhances the ability of the anti-infective peptoid to cross the BBB; and administering a therapeutic amount of the composition to a subject in need thereof.

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

Abstract: A method includes: 1) performing an atomic layer deposition cycle including (a) introducing precursors into a deposition chamber housing a substrate to deposit a material on the substrate; and (b) introducing a passivation gas into the deposition chamber to passivate a surface of the material; and 2) repeating 1) a plurality of times to form a film of the material.

Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: We provide a wide-field time-resolved imaging apparatus using resonant drive. We also identify ideal configurations of electro-optic (EO) modulator crystals for wide-field imaging. These techniques enable compact and low-cost LIDAR imaging devices. Resonant drive affords modulation of various EO modulators at high voltage by means of resonant voltage enhancement. Further, it enables operation of imaging modulators at high frequencies which would otherwise not be possible with conventional pulsed drivers—this leads to improved LIDAR accuracy and dynamic range. Resonant drive uniquely enables Pockels cell LIDAR beyond normal flash mode by allowing for multiple pulses or multiple cycles of amplitude modulated illumination to be present simultaneously in a scene. This corresponds to illumination and modulation waveforms having a defined phase relationship where time-of-flight is encoded in the phase of the returning light waveform.

Abstract: According to certain aspects, an electric-propulsion thruster is used as part of a base or platform which also includes a power converter, having a plurality of inductors and other electrical components, and a printed circuit board (PCB). The PCB includes a layer at which the other electrical components and printed circuit inductor traces, for the plurality of inductors, are secured. The electric-propulsion thruster includes a housing (e.g., as part of the base or platform) providing a cavity and having at least one structurally-rigid side wall along the cavity, where the PCB is integrated with the electric-propulsion thruster for a compact arrangement which can be used to propel the apparatus. Such a compact design might be used as an important part of thruster spacecraft architecture such as micro-satellites (e.g., CubeSats).

Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

Abstract: A metallic glass coating material is composed of an alloy of Fe, B, and one of the metals Nb, Mo, Zr, or W. The ratios of Fe, B, and the metal are predetermined using machine learning predictions and high-throughput experiments. In one example, the material is an alloy of Fe, Nb, Mo and B, of the form Fex(Nb, Mo)yBz, where x is in the range 18-28, y is in the range 35-45, and z is in the range 32-42. In another example, the material may be the alloy Fe23(Nb, Mo)40B37. The alloy may be doped with Zr and/or W, where the Zr and/or W comprises at most 10% of the alloy.

Abstract: Systems and methods for generating and evaluating driving scenarios with varying difficulty levels is provided. The disclosed systems and methods may be used to develop a suite of regression tests that track the progress of an autonomous driving stack. A robustness trace of a temporal logic formula may be computed from an always-eventually fragment using a computation graph. The robustness trace may be approximated by a smoothly differentiable computation graph, which can be implemented in existing machine learning programming frameworks. The systems and methods provided herein may be useful in automatic test case generation for autonomous or semi-autonomous vehicles.

Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: Disclosed herein are apparatus for a cooler device includes a manifold constructed at least partially of silicon oxide. The manifold includes an array of inlet channels and an array of outlet channels. Each inlet channel has a first depth. The array of outlet channels are interlaced with the array of inlet channels, Each outlet channel has a second depth that is larger than the first depth. Each of the array of outlet channels has a pair of sidewalls separating each outlet channel from adjacent inlet channels of the array of inlet channels.

Abstract: Many embodiments describe a scalable scheme for performing quantum computation in a synthetic time dimension which uses a single coherently controlled atom. Quantum operations applied to the atomic qubit can be teleported onto the photonic qubits via projective measurement, and arbitrary quantum circuits can be compiled into a sequence of these teleported gates. The synthetic time dimension can negate the need for many identical quantum emitters to be integrated into a photonic circuit, and the single atom may provide effective all-to-all connectivity between photonic qubits.

Abstract: A method for MR imaging includes acquiring with an MR imaging apparatus undersampled k-space imaging data having one or more temporal dimensions and two or more spatial dimensions; transforming the undersampled k-space imaging data to image space data using zero-filled or sliding window reconstruction and sensitivity maps; decomposing the image space data into a compressed representation comprising a product of spatial and temporal parts, where the spatial part comprises spatial basis functions and the temporal part comprises temporal basis functions; processing the spatial basis functions and temporal basis functions to produce reconstructed spatial basis functions and reconstructed temporal basis functions, wherein the processing iteratively applies conjugate gradient and convolutional neural network updates using 2D or 3D spatial and 1D temporal networks; and decompressing the reconstructed spatial basis functions and reconstructed temporal basis functions to produce a reconstructed MRI image having one or

Abstract: A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte.

Abstract: An electrochemical device includes an anode having sodium or lithium; a cathode having a carbonaceous material; a separator; and an electrolyte that includes a metal halide, a fluorinated electrolyte compound, and thionyl chloride; wherein the electrochemical device is a primary battery or a secondary battery.

Abstract: Systems and method for light field imaging with mirror arrays in accordance with embodiments of the invention are illustrated. One embodiment includes a light field imaging system, including a mirror array where each mirror in the mirror array is positioned to reflect light from a target object towards a lens such that a different view of the target object is visible in each mirror from the viewpoint of the lens. The system further includes a lens configured to focus the reflected light, a sensor configured to capture an image depicting a plurality of reflections of the target object, a processor, and a memory containing a light field imaging application that directs the processor to obtain the captured image, extract a light field of the target object based on the plurality of reflections of the target object, and construct a three-dimensional model of the target object based on the light field.