Abstract: Provided herein are isolated antibodies or antibody fragments thereof that immunospecifically bind to platelet factor 4 (PF4). In some embodiments the isolated antibodies or antigen-binding fragments thereof comprise a light chain CDR and framework region comprising SEQ ID NO: 4 and a heavy chain CDR and framework region comprising SEQ ID NO: 10. Also provided herein are methods for treating heparin-induced thrombocytopenia (HIT) and methods for reducing the likelihood that subject will become afflicted with HIT. Further disclosed are uses of the isolated antibodies or antibody fragments in the treatment of HIT or the manufacture of compositions for the treatment of HIT.
Type:
Grant
Filed:
May 11, 2018
Date of Patent:
December 13, 2022
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Mark I. Greene, Zheng Cai, Zhiqiang Zhu, Douglas B. Cines
Abstract: A contrast-enhanced digital tomosynthesis system with a source configured to emit penetrating particles toward an object, a detector configured to acquire a series of projection images of the object in response to the penetrating particles from the source, a positioning apparatus configured to position the source relative to the object and the detector, and an imaging system coupled to the source, the detector, and the positioning apparatus. The imaging system is configured to control the positioning apparatus to position the source and detector relative to the object, control the source and the detector to acquire the series of projection images, and construct a tomographic volume capable of exhibiting super-resolution morphology and contrast-enhancement arising from injection of an exogenous contrast agent from data representing the acquired series of projection images or a subset thereof.
Type:
Grant
Filed:
December 4, 2014
Date of Patent:
December 6, 2022
Assignees:
The Trustees of the University of Pennsylvania, Real Time Tomography, LLC
Inventors:
Andrew D. A. Maidment, Brian Lee, Susan Ng, Peter A. Ringer, Johnny Kuo, Raymond J. Acciavatti
Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.
Type:
Application
Filed:
May 12, 2022
Publication date:
December 1, 2022
Applicant:
The Trustees of the University of Pennsylvania
Inventors:
Igor Bargatin, Zhipeng Lu, Mohsen Azadi
Abstract: A system for physics-based learning and computation including two networks, each having a plurality of identical edges and feedback circuitry to compare the voltage drop at a given edge of the first network with the voltage drop at the corresponding edge of the second network. In both networks, at least one corresponding node is designated for input and at least one corresponding node is designated for output. In the first network, the at least one output node remains free and produces output voltage in response to the input voltage(s). In the second network, the at least one output node is clamped at voltage(s) closer to the desired value for the specified input voltage(s). Feedback circuitry compares voltages across corresponding edges and adjusts their effective resistances in order to learn.
Type:
Application
Filed:
May 20, 2022
Publication date:
December 1, 2022
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Samuel Dillavou, Douglas Durian, Andrea J. Liu, Menachem Stern, Marc Z. Miskin
Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Type:
Application
Filed:
May 3, 2022
Publication date:
November 24, 2022
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Abstract: Techniques are described for metadata processing that can be used to encode an arbitrary number of security policies for code running on a processor. Metadata may be added to every word in the system and a metadata processing unit may be used that works in parallel with data flow to enforce an arbitrary set of policies. In one aspect, the metadata may be characterized as unbounded and software programmable to be applicable to a wide range of metadata processing policies. Techniques and policies have a wide range of uses including, for example, safety, security, and synchronization. Additionally, described are aspects and techniques in connection with metadata processing in an embodiment based on the RISC-V architecture.
Type:
Grant
Filed:
December 12, 2016
Date of Patent:
November 22, 2022
Assignees:
THE CHARLES STARK DRAPER LABORATORY, INC., THE NATIONAL INSTITUTE FOR RESEARCH IN DATA PROCESSING AND AUTOMATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Abstract: Microfluidic devices having a construct formed from perfluoropolyether and poly(ethylene glycol) diacrylate. The construct includes an inlet for receiving a continuous phase fluid, an inlet for receiving a dispersed phase fluid, and a plurality of channels extending through the construct. The plurality of channels are in fluid communication with both the inlet of the continuous phase fluid and the inlet of the dispersed phase fluid. The construct further includes a plurality of microdroplet generators configured to produce microdroplets, each of the microdroplet generators in fluid communication with the plurality of channels. Additionally, the construct includes an outlet formed in the construct and in fluid connection with the plurality of microdroplet generators.
Type:
Grant
Filed:
March 21, 2019
Date of Patent:
November 15, 2022
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Daeyeon Lee, David Issadore, Sagar Prasad Yadavali, Heon-Ho Jeong
Abstract: The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
Type:
Grant
Filed:
March 10, 2022
Date of Patent:
November 15, 2022
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Saar Gill, Michael Klichinsky, Carl H. June
Abstract: Methods for inhibiting impaired neurogenesis and/or synaptogenesis in neurons in a subject with or suspected of having Alzheimer's Disease (AD), methods for improving and/or slowing the decline of cognitive function after onset of neuropathology and cognitive dysfunction, which neuropathology and cognitive dysfunction are caused by AD, methods for improving and/or slowing the decline of memory before onset of symptoms of AD, methods for increasing concentration and duration of dantrolene in the brain, and methods for improving and/or slowing the decline of memory after onset of symptoms of AD, the methods comprising intranasally administering to a subject in need thereof an amount of a pharmaceutical composition comprising dantrolene effective to inhibit over-activation of N-methyl-D-aspartate (NMVDA) receptor and/or ryanodine receptor (RyR). Methods further comprise administering a therapeutically effective amount of a glutamate receptor antagonist to the subject.
Type:
Application
Filed:
June 29, 2020
Publication date:
November 10, 2022
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions to image, diagnose or treat a disease.
Type:
Application
Filed:
November 22, 2021
Publication date:
November 10, 2022
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Andrew TSOURKAS, Linghan Mei, Fabiana Zappala
Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.
Type:
Grant
Filed:
May 12, 2020
Date of Patent:
November 8, 2022
Assignees:
Southwest Research Institute, The Trustees of the University of Pennsylvania
Inventors:
Jian Ling, Kreg A. Zimmern, Michael C. Milone
Abstract: Methods, devices, and systems for processing information are disclosed. An example device may comprise a metastructure comprising a plurality of physical features configured to transform an analog signal according to a kernel of an integral equation. The device may comprise one or more waveguides coupled to the metastructure and configured to recursively supply a transformed analog output signal of the metastructure to an input of the metastructure to iteratively cause one or more transformed analog signals output from the metastructure to converge to an analog signal representing a solution to the integral equation.
Type:
Grant
Filed:
April 17, 2019
Date of Patent:
November 8, 2022
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Nader Engheta, Brian Edwards, Nasim Mohammadi Estakhri, Mario Junior Mencagli
Abstract: Provided herein are adeno-associated viruses and methods for using same to treat or prevent disorders that affect the inner ear of a subject.
Type:
Application
Filed:
January 22, 2021
Publication date:
November 3, 2022
Applicants:
The United States of America as represented by the Secretary, Department of health and Human Svcs., The Trustees of the University of Pennsylvania
Abstract: Automated devices for detecting and removing dental biofilms are described herein. In some embodiments, the disclosed subject matter includes a device for administering a suspension comprising iron oxide nanoparticles to teeth to chemically treat and mechanically remove dental biofilms. In some embodiments, disclosed subject matter includes a device for administering a suspension comprising iron oxide nanoparticles and hydrogen peroxide to teeth to kill bacteria within a biofilm matrix and degrade the biofilm matrix and assembling the iron oxide nanoparticles into autonomous magnetic bristles or antimicrobial robots to mechanically remove biofilm. Devices and methods for real-time detection of dental plaque and monitoring of removal of dental plaque are also disclosed herein.
Type:
Application
Filed:
October 29, 2020
Publication date:
November 3, 2022
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Hyun Koo, Edward Steager, Elizabeth Hunter, Alaa Babeer
Abstract: The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.
Type:
Grant
Filed:
October 1, 2018
Date of Patent:
November 1, 2022
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.
Type:
Grant
Filed:
August 1, 2018
Date of Patent:
October 25, 2022
Assignees:
The Trustees of the University of Pennsylvania, The Research Foundation for The State University of New York
Inventors:
Thomas F. Floyd, Arjun G Yodh, Rickson C Mesquita
Abstract: The disclosed subject matter provides compositions and methods for treating dental caries. The composition can include an effective amount of a mannan degrading enzyme. The effective amount of the mannan degrading enzyme can be present to treat dental caries of a subject.
Type:
Application
Filed:
April 12, 2022
Publication date:
October 20, 2022
Applicant:
The Trustees of the University of Pennsylvania
Abstract: Compositions and regimens useful in treating Wilson's Disease are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human ATP7B.
Type:
Grant
Filed:
December 29, 2017
Date of Patent:
October 18, 2022
Assignee:
The Trustees of the University of
Pennsylvania
Inventors:
James M. Wilson, Jenny Agnes Sidrane, Lakshmanan Govindasamy
Abstract: The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
October 18, 2022
Assignees:
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC., The United States of America, as represented by the Secretary, Department of Health and Human Service, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Hengli Tang, Emily M. Lee, Wei Zheng, Ruili Huang, Miao Xu, Wenwei Huang, Khalida Shamim, Guoli Ming, Hongjun Song