Patents Assigned to The Trustees of the University of Pennsylvania
  • Compositions and methods of stimulating and expanding T cells
    Patent number: 11471487
    Abstract: The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured T cells expand at least 10 fold. The invention further includes an expanded population of T cells, compositions comprising the cells and methods of treatment.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: October 18, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Xiaojun Liu, Carl H. June
  • Methods for detecting genomic DNA methylation
    Patent number: 11473131
    Abstract: The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present disclosure provides a diagnostic method that includes obtaining a biological sample from the subject; determining the methylation status of one or more genomic DNA loci in one or more cells of the biological sample; and diagnosing a disease and/or disorder in the subject, wherein the methylation status of the one or more genomic DNA loci indicates the presence of the disease and/or disorder in the subject.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 18, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Martin Carroll, Stephen Master, Gerald Wertheim, Marlise Luskin
  • TERT immunogenic compositions and methods of treatment using the same
    Patent number: 11464841
    Abstract: Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: October 11, 2022
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Jian Yan
  • Assay for Assessing Heart Failure
    Publication number: 20220317133
    Abstract: A method of immunoassay for detecting and/or monitoring a cardiovascular disease in a patient and/or assessing the likelihood of or the severity of a cardiovascular disease in a patient, comprising contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of the C5 domain of the ?3 chain of type VI collagen, and/or contacting a biofluid sample from the patient with a monoclonal antibody that specifically binds to a C-terminal neo-epitope of the N-terminal propeptide of type III collagen.
    Type: Application
    Filed: June 5, 2020
    Publication date: October 6, 2022
    Applicants: Nordic Bioscience A/S, Bristol-Myers Squibb Company, The Trustees of the University of Pennsylvania
    Inventors: Federica Genovese, Morten Karsdal, Lei Zhao, David Gordon, Zhaoqing Wang, Julio Alonso Chirinos Medina
  • Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
    Patent number: 11459390
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 4, 2022
    Assignees: Novartis AG, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jennifer Brogdon, Hilmar Erhard Ebersbach, David Glass, Thomas Huber, Julia Jascur, Carl H. June, Jihyun Lee, Joan Mannick, Michael C. Milone, Leon Murphy, Avery D. Posey, Huijuan Song, Yongqiang Wang, Lai Wei, Qilong Wu, Qiumei Yang, Jiquan Zhang
  • 2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
    Patent number: 11459295
    Abstract: The invention includes 2-?-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are (R)-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 4, 2022
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, VANDERBILT UNIVERSITY
    Inventors: Trevor M. Penning, Adegoke Adeniji, Lawrence J. Marnett
  • Fibrosis model on a chip
    Patent number: 11453848
    Abstract: The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 27, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dongeun Huh, Mark Mondrinos
  • Methods of increasing response to cancer radiation therapy
    Patent number: 11446516
    Abstract: Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: September 20, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark Greene, Hongtao Zhang, Hiromichi Tsuchiya, Yasuhiro Nagai, Lian Lam, Aaron Runkle, Jeffrey Drebin, Mei Qing Ji
  • Compositions and methods comprising KLK3 or FOLH1 antigen
    Patent number: 11446369
    Abstract: The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: September 20, 2022
    Assignees: ADVAXIS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Yvonne Paterson, John Rothman, Vafa Shahabi
  • Modified immune cells having enhanced function and methods for screening for same
    Patent number: 11447769
    Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: September 20, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Jiangtao Ren
  • Amphiphilic dye-coated inorganic nanoparticle clusters
    Patent number: 11446391
    Abstract: The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: September 20, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, Jayesh Thawani, Ahmad Amirshaghaghi, Lesan Yan, Zhiliang Cheng
  • TREATMENT OF CANCER WITH CDK INHIBITORS
    Publication number: 20220288067
    Abstract: The present invention relates to methods of treating cancer by administration of a cyclin dependent kinase (CDK) inhibitor to a subject.
    Type: Application
    Filed: April 24, 2020
    Publication date: September 15, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Irfan ASANGANI
  • Quantification and staging of body-wide tissue composition and of abnormal states on medical images via automatic anatomy recognition
    Patent number: 11443433
    Abstract: Quantification of body composition plays an important role in many clinical and research applications. Radiologic imaging techniques such as Dual-energy X-ray absorptiometry, magnetic resonance imaging (MRI), and computed tomography (CT) imaging make accurate quantification of the body composition possible. This disclosure presents an automated, efficient, accurate, and practical body composition quantification method for low dose CT images; method for quantification of disease from images; and methods for implementing virtual landmarks.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: September 13, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jayaram K. Udupa, Tiange Liu, Drew A. Torigian, Dewey Odhner, Yubing Tong
  • Atomic description of immune complex that causes heparin-induced thrombocytopenia
    Patent number: 11435362
    Abstract: The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: September 6, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Douglas B. Cines, Zheng Cai, Zhiqiang Zhu
  • Anti-factor D antibodies and uses thereof
    Patent number: 11434279
    Abstract: This invention relates to selective inhibition of the alternative pathway (AP) of the complement system using an anti-factor D antibody. Specifically, the invention relates to methods of treating an AP-mediated disease or AP-mediated disorder in an individual by contacting the individual with an anti-factor D antibody.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: September 6, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Wenchao Song, Lin Zhou, Sayaka Sato, Takashi Miwa, Damodar Gullipalli, Madhu Golla
  • Apparatus and methods for improving catheter function
    Patent number: 11433435
    Abstract: An ultrasonication apparatus is provided for improving catheter function. The ultrasonication apparatus includes a transducer configured to produce ultrasonic waves for ultrasonication and a chamber for containing a fluid having a passage for receiving a catheter. The chamber is adapted to receive the ultrasonic waves from the transducer.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: September 6, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jayesh P. Thawani, Jared M. Pisapia, Hongjie Zhu, M. Sean Grady, Andrew Tsourkas
  • COMPOSITIONS AND METHODS FOR IN UTERO GENE EDITING FOR MONOGENIC LUNG DISEASE
    Publication number: 20220275402
    Abstract: Compositions and methods for in utero gene editing in mammalian lung cells are disclosed.
    Type: Application
    Filed: April 6, 2020
    Publication date: September 1, 2022
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: William H. Peranteau, Edward E. Morrisey, Michael F. Beers, Kiran Musunuru
  • Control of multi-drone fleets with temporal logic objectives
    Patent number: 11429118
    Abstract: Methods, systems, and computer readable media for controlling a fleet of drones. A method includes receiving a mission specification for each drone of one or more drones, each mission specification including spatio-temporal requirements for the drone. The method includes generating, for each drone, a low-rate trajectory for the drone by performing a robustness maximization of satisfying the mission specification over a low-rate sequence of waypoints for the drone based on a mapping between low-rate trajectories and high-rate trajectories. The method includes transmitting, to each drone, the low-rate trajectory for the drone, causing a local controller of each drone to control the drone by generating a high-rate trajectory using the low-rate trajectory and the mapping between low-rate trajectories and high-rate trajectories.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: August 30, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Mangharam, Yash Vardhan Pant, Houssam Abbas, Rhudii A. Quaye
  • Apparatus, method, and system to dynamically deploy wireless infrastructure
    Patent number: 11429407
    Abstract: CRYSTAL “Cognitive radio you share, trust and access locally” (CRYSTAL) is a virtualized cognitive access point that may provide for combining multiple wireless access applications on a single hardware platform. Radio technologies such as LTE (Long-Term Evolution), WiMax (Worldwide Interoperability for Microwave Access), GSM (Global System for Mobile Communications), and the like can be supported. CRYSTAL platforms can be aggregated and managed as a cloud, which provides a model for access point sharing, control, and management. CRYSTAL may be used for scenarios such as neighborhood spectrum management. CRYSTAL security features allow for home/residential as well as private infrastructure implementations.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: August 30, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jonathan M. Smith, Eric R. Keller, Thomas W. Rondeau, Kyle B. Super
  • Cancer vaccines and methods of treatment using the same
    Patent number: 11419925
    Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 23, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Jian Yan, Karuppiah Muthumani, Jewell Walters