Patents Assigned to The United States of America, As Represented By
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Patent number: 11933922Abstract: Hybrid subtractive-additive production of a superconducting multi-layer transition-edge sensor includes: forming a superconductor layer; forming a patterning photoresist on the superconductor layer; forming a sensor pattern in the patterning photoresist; subtractively forming, from the superconductor layer, the superconductor sensor layer; removing the patterning photoresist from the superconductor sensor layer; forming a template photoresist on the superconductor sensor layer; forming an inverse normal metal layer pattern in the template photoresist and exposing a bilayer portion of the superconductor sensor layer for addition of a normal metal layer; and additively forming the normal metal layer on the superconductor sensor layer such that the sensor pattern is interposed between the normal metal layer and the substrate.Type: GrantFiled: March 5, 2021Date of Patent: March 19, 2024Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCEInventors: Daniel Richard Schmidt, Joel Calvin Weber
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Patent number: 11936421Abstract: An optically-monitored and/or optically-controlled electronic device is described. The device includes at least one of a semiconductor transistor or a semiconductor diode. An optical detector is configured to detect light emitted by the at least one of the semiconductor transistor or the semiconductor diode during operation. A signal processor is configured to communicate with the optical detector to receive information regarding the light detected. The signal processor is further configured to provide information concerning at least one of an electrical current flowing in, a temperature of, or a condition of the at least one of the semiconductor transistor or the semiconductor diode during operation.Type: GrantFiled: February 23, 2023Date of Patent: March 19, 2024Assignees: THE REGENTS OF THE UNIVERISTY OF CALIFORNIA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVYInventors: Keith Corzine, Todd Weatherford, Matthew Porter
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Patent number: 11931045Abstract: A junctional tourniquet apparatus and related methods of use. An exemplary tourniquet has an inverted cone shape, wherein a narrower end has a mushroom shaped base that is pressed against a compression target and a broader end has a plurality of pass-through slots for straps. Another exemplary tourniquet has a broad plate component and a handle component. The handle component has a mushroom shaped base on a first end and a handle on a second end. The handle component passes through the center of the plate component with threads that allow the handle component to compress a target by twisting the handle.Type: GrantFiled: January 7, 2022Date of Patent: March 19, 2024Assignee: The United States of America, Represented by the Secretary of the NavyInventors: Joseph Thomas Burkart, Danielle E. Cafasso, Robert Henry Hayford, Huckelberry Finne, Jose Ramirez Vargas, Michael P Abbott
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Publication number: 20240084034Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.Type: ApplicationFiled: October 31, 2023Publication date: March 14, 2024Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARYInventors: John M. MARIS, Kristopher R. BOSSE, Dimiter DIMITROV, Zhongyu ZHU, Dontcho V. JELEV
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Publication number: 20240085131Abstract: A mounting platform is provided for securing munitions. The platform includes a flat plate, a front block and a rear block. The plate includes a plurality of cutout holes. The front block has a first saddle disposed between first flanking ends and at least one extension at one of the flanking ends for inserting into a first opening of the cutouts. The rear block has a second saddle disposed between second flanking ends at least one extension for inserting into a second opening of the cutouts. The munitions are disposable atop the first and second saddles of the front and rear blocks. The munitions are restrained axially against a rear stop block and laterally by the saddles and straps.Type: ApplicationFiled: September 12, 2022Publication date: March 14, 2024Applicant: United States of America, as represented by the Secretary of the NavyInventors: James E. Howell, Matthew James O'Neill, Jonathan F. Pfab, Vernon Todd Davis, Vincent J. Vendetti, Carl S. Lynn, IV
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Publication number: 20240084008Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.Type: ApplicationFiled: November 6, 2023Publication date: March 14, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Rimas J. Orentas, Ira H. Pastan, Dimiter S. Dimitrov, Crystal L. MacKall
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Publication number: 20240085585Abstract: Examples are directed toward systems and methods relating to security screening. For example, a screening system includes a sensor array to sense a gravitational field caused by an item, and a conveyor to convey the item through sensing positions for scanning by the sensor array. A controller acquires weight measurement information from sensor elements, and gravitational measurement information from the sensor array. The conveyor incrementally advances the item through additional sensing positions to acquire weight measurement information and gravitational measurement information. The controller performs tomographic reconstruction to generate a tomographic image of the item, using a generated weight map as a static weight input vector and using a generated mass map as a static mass input vector for the tomographic reconstruction.Type: ApplicationFiled: November 24, 2023Publication date: March 14, 2024Applicant: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventor: James Henry Remer
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Publication number: 20240082177Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.Type: ApplicationFiled: November 10, 2023Publication date: March 14, 2024Applicants: MESHABERASE, LLC, The United States of America, as Represented by the Secretary, Department of Health & Human ServicesInventors: Benjamin Rubin, Mark Gilbert, Jinkyu Jung
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Publication number: 20240085292Abstract: A test fixture is provided for dropping an article from a height to a floor, with the article oriented in relation to the floor at a select angle. The fixture includes a column frame, an overhead beam, a carriage, first and second guy wires, first and second spools, and first and second chains. The frame supports first and second guide arms on opposing sides. The overhead beam has a distance span substantially parallel to the floor. The carriage is disposed substantially parallel to the floor and has first and second opposing guides separated by the span. The guy wires attach to the beam separated the span and pass through the guide arms. The first and second spools to receive the corresponding guy wires. The first and second chains suspend the article from the carriage above the floor. Upon release of the guy wires, the carriage falls until contact with the guide arms while the article contacts the floor.Type: ApplicationFiled: September 12, 2022Publication date: March 14, 2024Applicant: United States of America, as represented by the Secretary of the NavyInventors: Sloan C. Burns, Luke Andrew Martin, II
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Publication number: 20240084007Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.Type: ApplicationFiled: November 6, 2023Publication date: March 14, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Rimas J. Orentas, Ira H. Pastan, Dimiter S. Dimitrov, Crystal L. MacKall
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Publication number: 20240083754Abstract: Disclosed is a method of irradiating a composition having water and hydrogen-terminated nanodiamonds with light that generates water-solvated electrons from the nanodiamonds. The method can be used to degrade fluoroalkyl compounds such as perfluorooctane sulfonate.Type: ApplicationFiled: November 21, 2023Publication date: March 14, 2024Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Bradford B. Pate, William Maza, Vanessa Breslin, Paul A. DeSario, Tatyana I. Feygelson, Albert Epshteyn, Jeffrey C. Owrutsky, Carlos Hangarter
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Patent number: 11926656Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus (EBV) infection in mammals, and methods of using those compositions of matter for the detection, diagnosis and treatment of EBV infection are described. Also described are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.Type: GrantFiled: December 16, 2021Date of Patent: March 12, 2024Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
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Patent number: 11926911Abstract: A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps of pumping a solution comprising a compound of Formula I into a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator; applying an electrical current through the microfluidic electrochemical reactor; and performing oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula IIType: GrantFiled: January 12, 2023Date of Patent: March 12, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Thorsten G. Schroer, Gregory E. LeCroy, Miguel Aguila, Mayra R. Rodriguez, Tyler J. Downard, Brianna L. MacLeod
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Patent number: 11925558Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.Type: GrantFiled: May 26, 2020Date of Patent: March 12, 2024Assignee: The United States of America, As Represented By The Secretary, Department of Health and Human ServicesInventors: June-Hong Kim, Robert J. Lederman, Ozgur Kocaturk
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Patent number: 11925664Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.Type: GrantFiled: June 12, 2020Date of Patent: March 12, 2024Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
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Patent number: 11926686Abstract: Shape-programmable liquid crystal elastomers. The shape-programmable liquid crystal elastomers being synthesized by filling an alignment cell with liquid crystal monomers. The liquid crystal monomers align to a surface of the alignment cell and then are polymerized with a dithiol chain transfer agent. The alignment cell is configured to impose a director orientation on a portion of the shape-programmable liquid crystal elastomer. For some embodiments, liquid crystal elastomer laminates are prepared by arranging a plurality of liquid crystal elastomers such that a director orientation of each liquid crystal elastomer of the plurality is in registered alignment with an adjacent liquid crystal elastomer of the plurality. The arrangement is secured and the plurality of liquid crystal elastomers cured.Type: GrantFiled: November 23, 2021Date of Patent: March 12, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Nicholas P Godman, Timothy J White, Hilmar Koerner, Benjamin A Kowalski, Anesia D Auguste, Tyler C Guin
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Patent number: 11926398Abstract: A diving helmet apparatus includes a diving helmet that is based on a 98th percentile anthropomorphic head form. The helmet is relatively smaller and lighter than convention diving helmets. The center-of-gravity and center-of-buoyancy of the helmet are co-located to reduce diver fatigue. The apparatus has unique neck dam latch devices that use cam mechanisms. The neck dam and the opening in the helmet that receives the diver's head both have a substantially oval shape that contributes to a significant reduction in the volume of the helmet. The apparatus also uses unique face mask latch devices. The neck dam and face mask latch devices allow a diver to easily secure and remove the helmet and face mask without the assistance of dive tenders.Type: GrantFiled: May 29, 2019Date of Patent: March 12, 2024Assignee: United States of America as represented by the Secretary of the NavyInventor: Edward Downs, Jr.
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Patent number: 11926726Abstract: The invention relates to nanohybrids that are gold nanorod J-aggregates having a broadened surface plasmonic resonance band, processes of making such gold nanorod J-aggregates and products comprising such gold nanorod J-aggregates. Such gold nanorod J-aggregates exhibit broad localized surface plasmonic reasonable range from 800 nm to 2000 nm.Type: GrantFiled: November 18, 2020Date of Patent: March 12, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Loon-Seng Tan, Zhenning Yu, Kyoungweon Park, Richard A. Vaia
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Patent number: 11926507Abstract: A hook assembly includes a first hook having a first open end and a second hook having a second open end. The first hook is parallel to the second hook where the first open end is adjacent to the second open end. Extensions extend from each of the first hook and the second hook. The extensions extend perpendicular to a hook plane of the first hook and the second hook members. The first hook is a mirror image of the second hook. A hinge connects the first hook to the second hook. The hinge is located at an opposite end of the hook from where the extensions are located. A resilient member exerts a constant force at the hinge to bias the first hook and the second hook toward an open position.Type: GrantFiled: August 18, 2021Date of Patent: March 12, 2024Assignee: The United States of America as represented by the Secretary of the NavyInventors: Lee Foltz, Adam Pegouske
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Patent number: 11927433Abstract: Embodiments are directed to direct impingement cook-off mitigation systems. As assembled, a munition fuzewell is torqued into the aft end of a munition. During a cook-off event, the expanding gases from the booster energetic will burn instead of detonating. The hot expanding booster gases are vented to the munition's main fill energetic causing the main fill energetic to burn concurrently with the booster energetic. The combined expanding gases from both the booster and main fill energetics are then vented through longitudinal vents.Type: GrantFiled: June 17, 2021Date of Patent: March 12, 2024Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Benjamin M. Blazek, Lee R. Hardt
