Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of tumors, containing a novel pyrazolopyrimidine compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered in combination with other anticancer agents, and thus can be effectively used as a composition for preventing or treating cancer.

Abstract: The disclosure provides a method and device for correction of the multi-channel capacitive sensor. The method includes: under calibrating mode, inputting the calibration signal from the calibration capacitance network module to the multi-channel capacitive sensor, and measuring the output complex voltage at each calibration frequency point; selecting any channel as a reference channel, combining each-channel three-admittance parameters with the output complex voltages at each calibration frequency point, calculating each-channel amplitude-phase correction coefficient relative to the reference channel; under operating mode, inputting a carrier signal to the multi-channel capacitive sensor through the multiple DoF sensitive probe, and measuring the output complex voltages under actual operation; and multiplying the output complex voltages by the correction coefficients, thereby obtaining the multiple sensing channel output signals.

Abstract: Various implementations described herein relate to devices, systems, and methods for inducing and/or causing cellular migration and uses thereof. Implementations described herein can be used to cause a portion of a cell population to migrate in response to a differential stimulus. Implementations described herein can be used to isolate and characterize the portion of the cell population. Implementations described herein can be used for research, diagnostic, or therapeutic purposes.

Abstract: The present disclosure relates to a technology for developing a water-repellent stainless steel (SUS 316L) surface for improving a corrosion inhibition (corrosion resistance) efficiency. According to the method for forming a hydrophobic and corrosion resistant oxide film on a stainless steel surface according to the present disclosure, uniform porous oxide film may be formed without a pre-patterning process for forming uniform porous oxide films of the related art to achieve excellent hydrophobicity and corrosion resistance, thereby being applied to medical devices, marine transportation vehicles, land transportation vehicles, air transportation vehicles, water and sewage pipes, water and sewage filters, and the like, including stainless steel and also be useful as a machine learning database for developing stainless steel surface treatment technology.

Abstract: A robotic system to assist a surgeon during ankle fracture procedures includes an imaging system configured to be at least one of mounted on or arranged adjacent to a robotic device. The system includes a passive arm, a separate actuatable section, and a controller configured to communicate with the actuatable section. The passive arm is structured to be placed on a side of a patient's leg fixed to a platform and the passive arm comprises a fastening mechanism structured to be attached to a tibia of the patient's leg. The actuatable section is structured to be placed on a side of said patient's leg fixed to the platform and the actuatable section comprises a fastening mechanism structured to be attached to a fibula of the patient's leg.

Abstract: A precombustion chamber igniter with a retractable electric glow plug and a cold start control method for a methanol engine are provided. The precombustion chamber igniter includes a fuel injector, a spark plug, and an electric glow plug. The electric glow plug is retractable and has two working positions, at a first position, a heating segment is wholly located in an injection chamber to provide heat energy for the injection chamber, and at a second position, the heating segment is partially located in the injection chamber and passes through a first through hole, and the rest of the heating segment is located in a main combustion chamber of an engine, to provide heat energy for the injection chamber and the main combustion chamber. In a cold start stage of the engine, the heating segment of the electric glow plug is controlled to be located at the second position.

Abstract: It is an object of the present invention to provide a drug for preventing or treating a liver disease associated with fibrosis, the drug containing microRNAs as an active ingredient. A pharmaceutical composition for preventing or treating a liver disease associated with fibrosis, the pharmaceutical composition containing at least one kind of microRNAs selected from miR 1237-5p, miR 204-3p, miR 7977, miR 6089, and miR 5787 as an active ingredient, is produced.

Abstract: A large-tonnage disc-shaped suspension ceramic insulator includes a ceramic insulator body, and a metal pin and a metal cap coaxially assembled with the ceramic insulator body through adhesive material, assembly interfaces of the ceramic insulator body, the metal cap, and the metal pin are coated with a primer; the adhesive material includes an expansion agent; and the expansion agent is configured to make the adhesive material expand after hardening so as to create a prestress between the ceramic insulator body and the metal pin as well as the metal cap. The present disclosure achieves overall compressive prestress distribution of the ceramic insulator product, mitigating thermal stress caused by temperature changes and improving the tensile strength of the large-tonnage disc-shaped suspension ceramic insulator assembly. By treating the assembly interfaces with the primer, the present disclosure significantly improves the assembly strength of the ceramic insulator/metal assembly.

Abstract: This application relates to the development and use of lignin-based carbon materials which can be used for energy storage and environmental applications. Included are methods of preparing microporous activated carbon having a controlled, often high surface area and a controlled often high mesopore ratio, and a method of preparing carbon dots, for example carbon quantum dots.

Abstract: A chimeric endolysin ClyRD of the present disclosure has antibacterial activity against bacteria that may cause foodborne diseases. Therefore, the chimeric endolysin ClyRD may be used as a natural controlling agent, a therapeutic agent or a preventive agent in the food industry.

Abstract: A machining and positioning system for aerospace irregular parts and a discrete intelligent production line therefor are provided, which relates to the field of aerospace irregular part machining. In view of the problem that complex repeated positioning and poor positioning stability is required during the transportation and processing of aerospace irregular parts, a self-positioning device, a clamping device, and a support device are used to form a follow-up clamping and positioning system for the irregular part casing, reducing complex repeated positioning. The support block of the support device can fit to the inner wall of the casing, collect the support force using piezoelectric plates, and feedback and adjust the thrust of the support block based on the magnitude of the cutting radial force, maintaining stable support of the support block for the casing and meeting production needs.

Abstract: Disclosed are a cell-level analysis method of a memory and a computing device for performing the same. The cell-level analysis method of a memory is a cell-level analysis method of a memory that is executed in a computing device including one or more processors and a memory storing one or more programs executed by the one or more processors, the cell-level analysis method including acquiring information on a location of each cell in the memory, generating graph-structured data for a target cell based on the location of each cell in the memory, and training a graph neural network model to predict one or more of an electrical characteristic of the target cell and a program and verify level (PV level) of the target cell by inputting the graph-structured data into the graph neural network model.

Abstract: Example systems and methods for AI capability assessment include query-based assessment of sequential decision making agents (SDMAs) in stochastic settings with minimal assumptions on SDMA internals.

Abstract: A durable solid and liquid repellant material is provided having an elastomeric matrix with a plurality of lubricating domains distributed therein formed by a partial crosslinking reaction between an elastomeric precursor having a first reactive functional group and a polyol having a second reactive functional group. The polyol has a limited solubility circle. The first reactive functional group is selected from the group consisting of: alkene, amine, carboxylic acid, hydroxyl, isocyanate, and combinations thereof and the second reactive group is selected from the group consisting of: amine, carboxylic acid, hydroxyl group, and combinations thereof. The partially crosslinked elastomeric matrix has a crosslink density of greater than or equal to about 200 mol/m3 and less than or equal to about 2,000 mol/m3. Methods for forming the durable solid and liquid repellant material are also provided.

Abstract: Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite as well as properties (e.g. particle size, crystallite size, pore size, surface area) of these spinel ferrite nanoparticles are described. Methods of preventing or reducing microbe growth on a surface by applying these spinel ferrite nanoparticles onto the surface in the form of a suspension or an antimicrobial product are also described.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.

Abstract: Methods for stabilizing laser-induced graphene (LIG) through composite formation and compositions thereof. Using infiltration methods and/or lamination methods, LIG composites (LIGCs) with physical properties can be engineered on various substrate materials. The physical properties include surface properties, such as superhydrophobicity and antibiofouling; the LIGCs are also useful in antibacterial applications, Joule-heating applications, and as resistive memory device substrates. Further, methods for fabricating and using LIG for flexible and embeddable gas sensors.

Abstract: A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

Abstract: Aspects of the present disclosure are directed to a method for synthesizing carbon quantum dots. The method includes reacting a mixture of a fruit waste material and deionized water hydrothermally in an autoclave at a reaction temperature in a range of 150° C. to 250° C. to form a carbon quantum dot containing suspension, centrifuging the carbon quantum dot containing suspension to separate the carbon quantum dots from a hydrochar, and filtering the carbon quantum dot containing suspension to obtain the carbon quantum dots. The carbon quantum dots have a size ranging from 2 to 10 nm. The carbon quantum dots have a Stokes shift of at least 150 nm at an excitation wavelength of 360 nm or lower.

Abstract: A physical method for regulating molecular transport within a brain extracellular space includes: applying an external pressure to brain tissue of an animal, wherein a rhythm of applying the external pressure is related to intrinsic rhythmicity of the animal. An apparatus for regulating molecular transport within a brain extracellular space includes: a detection mechanism (10), a pressurization mechanism (30), and a control mechanism (50). The detection mechanism (10) is capable of detecting intrinsic rhythmicity of an animal. The pressurization mechanism (30) is capable of applying an external pressure to brain tissue of the animal. The control mechanism (50) is capable of control the pressurization mechanism (10) based on a detection result of the detection mechanism (30), such that a rhythm of applying the external pressure by the pressurization mechanism (30) is related to the intrinsic rhythmicity of the animal.