Abstract: Disclosed in the present invention is a synthesis method for high-purity cholesterol. The cholesterol is synthesized by using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, which is also referred to as bisnoralcohol or BA, as a raw material, and by means of steps of oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, and deprotection or hydrolysis reaction, and the purity can reach 99% or above. Aiming at defects of conventional animal-derived cholesterol, in the present invention, the cholesterol is synthesized from plant-derived raw material BA; thus, high safety is achieved, the risk of pathogenic bacteria and virus infection is avoided, high synthesis yield, high product purity, and environmental friendliness are achieved, and industrial production is facilitated.

Abstract: Phase-based optoretinography (ORG) is performed using tissue velocity obtained from a modified optical coherence tomography (OCT) system. A swept-source generated OCT A-scan is used to assemble a 2-dimensional profile of the retinal tissue (B-scan) by laterally scanning the imaging beam. These B-scans can be taken at multiple time-points and assembled into a M-scan, which displays motion of a particular cross-section of retinal tissue (after correction for bulk motion). The method captures the changes between each timestep of the M-scan to deduce tissue velocities of the COST, ROST, and IS/OS, among others. An initial contraction of outer segments is detected in outer segments, followed by an elongation shortly thereafter. The tissue velocity measurements can be used to infer retinal dysfunction without the need for costly and computationally expensive scans using adaptive optics.

Abstract: An imaging structure identification system includes an optical imaging system configured to illuminate a liquid biopsy sample for a subject. The liquid biopsy sample has one or more biological structures that are labeled with one or more fluorophores associated with a fluorescence assay for a disease state allowing detection of emitted electromagnetic radiation from the liquid biopsy sample as image data. The system also includes a processing system configured to identifying the subject as being at reduced risk for having the disease state if the subject profile is similar to the first predetermined profile for subjects not being in the disease state. However, if the subject profile is not similar to the first predetermined profile for subjects not being in the disease state it is not determinative if the subject is in the disease state.

Abstract: A first-dimension-guided differential scaling algorithm of the contour plot in comprehensive two-dimensional gas chromatography (2D GC) system is developed by incorporating both 1D and 2D chromatograms obtained by first and second detectors. This differential scaling method is shown to significantly improve 2D GC results in terms of retention time accuracy and consistency, peak width and hence peak capacity, and analyte quantification accuracy, which are inevitably affected by the modulation period and phase shift in modulation when the conventional contour plot reconstruction methods. Furthermore, the differential scaling method is shown to better handle the coelution and missing peak issues often encountered in the conventional methods. Finally, the differential scaling method exhibits high versatility in detector selection, which greatly broadens the 2D GC utility and can be easily adapted to other 2D chromatography systems.

Abstract: The present invention discloses a one-way limiting expandable artificial heart valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3) wherein the valve seat (1) comprises a one-way limiting expandable annular metal seat (4), the annular metal seat (4) is composed of three sections of seat body units (5), the head end of each section of seat body unit (5) is sequentially provided with a first rivet (8), a limiting protrusion (7) and a first long circular groove (6), the tail end of each section of seat body unit (5) is sequentially provided with a second long circular groove (9), a second limiting hole (11) and a first limiting hole (10), and a second rivet (12), and the artificial heart valve has a normal use original state and a one-way limiting expansion state.

Abstract: Disclosed herein are monospecific and bispecific antibodies that comprise a ALPPL2/ALPP-binding variable region. The bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (ALPPL2/ALPP) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., CD3) expressed by immune effector cells.

Abstract: The present disclosure relates to a photoresist composition including a tin-oxo cluster, an oxidizing agent, and a polar organic solvent in which when irradiated with ultraviolet, bonds constituting the cluster are broken to form cross-linking between the clusters

Abstract: A method of forming an electrode including dissolving a copper salt and benzene-1,3,5-tricarboxylate in a solvent and heating to a temperature of 60° C. to 100° C. to form a framework. Further, the method includes mixing a zinc salt and the framework to form a zinc doped framework and heating the zinc doped framework to a temperature of 300° C. to 600° C. under air to form ZnCuO nanoparticles. Furthermore, the method includes mixing the ZnCuO nanoparticles, a binding compound, and a conductive carbon compound in a solvent to form a suspension. Moreover, the method includes coating a substrate with the suspension and drying to form the electrode and the ZnCuO nanoparticles have an oval shape with an average size of 50 nm to 200 nm.

Abstract: Methods of using the small molecule STAT3 inhibitor LLL 12B in the treatment of cancer, such as triple-negative breast cancer (TNBC) and pancreatic cancer, either alone or in combination with additional therapeutic agents, such as PARP inhibitors and CDK inhibitors, are provided.

Abstract: Trans-splicing RNA (tsRNA) The invention concerns a trans-splicing RNA (tsRNA) molecule comprising at least one or multiple unstructured target binding domains complementary to at least one or multiple precursor messenger RNA (pre-mRNA) targets and adapted to prevent off-target trans-splicing by the inclusion of a safety domain; a cell or vector or therapeutic or composition or pharmaceutical composition comprising said tsRNA; and a method for killing cells or treating a disease or for imaging or for a cosmetic application using said tsRNA. The invention has use in the medical, cosmetic, and veterinary field.

Abstract: The present disclosure provides an operation method of a prediction system of significant congenital heart disease in infants in infants, which includes steps as follows. The continuous wavelet transformation is performed on the electrocardiogram to obtain the processed electrocardiogram; the processed electrocardiogram is oversampled to obtain multiple electrocardiogram segments; the transfer learning through multiple pre-trained models based on the multiple electrocardiogram segments is used to establish a significant congenital heart disease model.

Abstract: A voltage mode weak-PUF circuit with rich challenge-response pairs comprises four decoders, two PUF arrays, a sequential control circuit and a voltage comparator. One-to-two PUF arrays are used to replace existing one-to-one PUF arrays to increase the number of challenge-response pairs by 2N times, from 2N realized by the one-to-one PUF arrays to 2N×2N, wherein N=a+b. Each PUF cell comprises m*n PUF cells and n transmission gates, and adopts a simple common-source amplifier structure formed by a first PMOS transistor, a first NMOS transistor and a second NMOS transistor, wherein any one PUF cell in one PUF array can be compared with any one PUF cell in the other PUF array to generate an output response. The number of output responses is 2N, so the proportion of the PUF cells for generating one challenge-response pair is 2N/2N=1/2N, and the reuse rate of the same PUF cell is merely 1/2N.

Abstract: The present disclosure addresses the problem of providing a method for imparting liquid repellency to fibers even when the amount of water and/or a surfactant is reduced, preferably without using water and/or a surfactant. Provided is a method for producing liquid-repellent fibers, the method comprising a fiber treatment step in which supercritical carbon dioxide is used as a treatment medium and a fiber base material is treated with a repellent containing a liquid-repellent compound, whereby liquid repellency can be imparted to the fibers even when the amount of water and/or a surfactant is reduced, preferably without using water and/or a surfactant.

Abstract: A multi-lead electrocardiogram (ECG) signal classification method based on self-supervised learning relates to the technical field of ECG signal classification. The method includes: processing an original signal through different data augmentation methods, designing an appropriate encoder module, extracting a feature of an ECG signal through a large amount of easily available unlabeled data such that an encoder learns more class information of the ECG signal, fine-tuning the model encoder with a small amount of labeled data for feature optimization, and continuously optimizing a parameter of a feature extractor by training a model such that a generated feature well reflects a structure and information of input data. Through self-supervised learning, the method reduces obstacles caused by performing ECG signal classification through a large amount of expensive manually labeled data, improving the generalization ability of the model.

Abstract: A High Voltage Complementary Metal-Oxide-Semiconductor, HV-CMOS, sensor comprising a p-substrate having a topside and a backside; wherein the topside comprises: an array of mutually spaced apart pixel structures, including a first pixel structure, therein and/or thereon, wherein the first pixel structure comprises: a set of PMOS and NMOS transistors, including a first PMOS transistor having an n-well, SN, layer, and a first NMOS transistor having a p-well, SP, layer; a deep n-well, DN, structure having a DN layer; a p-type buried, BP, layer disposed to mutually isolate the SN layer and the DN layer; an n-type buried, BN, layer providing a SN/BN/DN stack; and a set of contacts, including a first contact, electrically coupled to the DN layer via the SN/BN/DN stack; wherein the backside comprises: a doped p+ layer therein and/or thereon; and wherein the sensor comprises an HV bias contact electrically coupled only to the p+ layer, for backside biasing thereof.

Abstract: Provided herein are compositions, systems, and methods to provide two gene editing-based approaches that can be used to correct the CD35 SCID-causing C202T mutation (TGA?CGA). In certain embodiments one approach involves CRISPR/Cas9 homology-directed repair (HDR)-mediated correction with a single-strand oligodeoxynucleotide (ssODN) homologous donor. In certain embodiments another approach comprises Adenine Base Editing (ABE)-correction, to precisely revert the CD35 SCID-causing C202T mutation (TGA?CGA).

Abstract: A manipulator execution path planning method for a complex space guided measurement task, includes: determining a measurement space of a manipulator and a starting point and a target point of a path; determining an obstructed space and a free space of the measurement space and a proportion of the obstructed space in the measurement space using a collision algorithm, and classifying and constructing a space compression model according to the proportion of the obstructed space in the measurement space to compress the measurement space and remove an invalid space; finding candidate paths for connecting the starting point and the target point by constructing an adjacent node tree connected topology network; finding a required path in the candidate paths, and performing high-order curve fitting to obtain a final path; discretizing the final path, and solving joint angles of the manipulator to obtain a joint track.

Abstract: A method for ammonia (NH3) decomposition to hydrogen (H2) and nitrogen (N2) includes introducing and passing a H2-containing feed gas stream into a reactor containing an industrial waste-based nickel (Ni-SMR) catalyst at a temperature of 500 to 900° C. to form a reduced Ni-SMR catalyst; introducing and passing an NH3-containing feed gas stream through the reactor in contact with the reduced Ni-SMR catalyst at a temperature of 100 to 1000° C. thereby converting at least a portion of the NH3 to H2 and regenerating the Ni-SMR catalyst particles to form a regenerated Ni-SMR catalyst, and producing a residue gas stream leaving the reactor; and separating the H2 from the residue gas stream to generate a H2-containing product gas stream.

Abstract: An electrode including a substrate, a binding compound, and a composite. The composite includes jute-activated carbon and a nickel-cobalt-layered double hydroxide (NiCoLDH). Particles of the NiCoLDH are in the form of nanoflowers with an average size of 5-15 ?m. The nanoflowers comprise nanosheets with an average thickness of 5-20 nm. The particles of the jute-activated carbon are in the form of interconnected nanosheets, which form a porous carbon framework. The porous carbon framework connects the nanoflowers, thereby forming an interconnected structure in the composite. A mixture of the composite and the binding compound is coated on the surface of the substrate. The electrode can be included in supercapacitors and power banks.

Abstract: A pharmaceutical composition for treating retinitis pigmentosa that includes statin-loaded nanoparticles. The pharmaceutical composition is used in a method of treating retinitis pigmentosa involving administering to a subject in need thereof the pharmaceutical composition that includes statin-loaded nanoparticles.